G2C is moving to Edinburgh University
Professor Seth Grant is pleased to announce his group is returning to Edinburgh University where he has been on the faculty since 1994.
The G2C Programme will continue its study of postsynaptic proteins in brain function and disease in the The Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, College of Medicine & Veterinary Medicine based at the Chancellor's Building adjacent to the Royal Infirmary of Edinburgh in the Little France district of Edinburgh.

During the last few years the G2C team has identified key sets of human brain proteins that are responsible for a wide range of brain diseases.

Seth said "Understanding these proteins and their role in brain disease is a key objective in the coming years and will benefit from closer collaboration with Edinburgh groups in the outstanding setting of the Little France site".

The G2C lab will continue to take an integrated and multidisciplinary approach combining genomics, genetics and proteomics with animal and human studies, and brain evolution.

Seth will be recruiting

  • Informaticians and computational biologists.
  • Postdoctoral scientists to study the molecular biology and proteomics of synaptic complexes.
  • Postdoctoral scientists to study molecular imaging of brain tissues.
  • Research assistants for molecular studies.

Recent lab papers

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SG, Krappmann D, Ueffing M, Lickert H.
Dev Cell. 2011 Sep 13;21(3):479-91. PubMed: 21920314, Full Text
Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder. Frank RA, McRae AF, Pocklington AJ, van de Lagemaat LN, Navarro P, Croning MD, Komiyama NH, Bradley SJ, Challiss RA, Armstrong JD, Finn RD, Malloy MP, MacLean AW, Harris SE, Starr JM, Bhaskar SS, Howard EK, Hunt SE, Coffey AJ, Ranganath V, Deloukas P, Rogers J, Muir WJ, Deary IJ, Blackwood DH, Visscher PM, Grant SG.
PLoS One. 2011 Apr 29;6(4):e19011. PubMed: 21559497, Full Text
The human postsynaptic density shares conserved elements with proteomes of unicellular eukaryotes and prokaryotes. Emes RD, Grant SG.
Front Neurosci. 2011 Mar 31;5:44. PubMed: 21503141, Full Text
Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro. MacLaren EJ, Charlesworth P, Coba MP, Grant SG.
Mol Cell Neurosci. 2011 Jun;47(2):93-9. Epub 2011 Mar 30. PubMed: 21440632, Full Text
Characterization of the proteome, diseases and evolution of the human postsynaptic density. Bayes A, van de Lagemaat LN, Collins MO, Croning MD, Whittle IR, Choudhary JS, Grant SG.
Nat Neurosci. 2011 Jan;14(1):19-21. Epub 2010 Dec 19. PubMed: 21170055, Full Text, Website
Genome variation and complexity in the autism spectrum. van de Lagemaat LN, Grant SG.
Neuron. 2010 Jul 15;67(1):8-10. PubMed: 20624587, Full Text
In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93. Delint-Ramirez I, Fernandez E, Bayes A, Kicsi E, Komiyama NH, Grant SG.
J Neurosci. 2010 Jun 16;30(24):8162-70. PubMed: 20554866, Full Text
Confirmed rare copy number variants implicate novel genes in schizophrenia. Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MDR, Malloy MP, Muir WJ, Pickard BS, Deary IJ, Blackwood DH, Carter NP, Grant SG.
Biochem Soc Trans. 2010 Apr;38(2):445-51. PubMed: 20298200, Website