G2C::Mice Resources

Genes to Cognition makes available the knock-out and transgenic mice lines generated as part of the research programme.

The mice listed below are available to interested researchers.

 

Available Mouse Lines (July 2013)

Colony Name Description Gene Affected Mutation Type PubMed ID Vector type Strain Available
Β-PIX Β-PIX knock-out Arhgef7 Null target C57BL/6J Request
CENTG2 CENTG2 knock-out Agap1 Null target C57BL/6J Request
CITRON CITRON knock-out Cit Null target C57BL/6J Request
CYFIP1 CYFIP1 knock-out Cyfip1 Null target C57BL/6J Request
CYFIP1 (flp) CYFIP1 conditional knock-out Cyfip1 Conditional Null target C57BL/6J Request
DREBRIN1 DREBRIN1 knock-out Dbn1 Null target C57BL/6J Request
DUSP7 DUSP7 knock-out Dusp7 Null target C57BL/6J Request
GKAP GKAP knock-out Dlgap1 Null target C57BL/6J Request
GKAP2 GKAP2 knock-out Dlgap2 Null target C57BL/6J Request
GKAP4 GKAP4 knock-out Dlgap4 Null trap C57BL/6J Request
GRIN1 GRIN1 knock-out Grin1 Null target C57BL/6J Request
GRIN1 (flp) GRIN1 conditional knock-out Grin1 Conditional Null target C57BL/6J Request
GRIT GRIT knock-out Arhgap32 Null trap C57BL/6J Request
MAGUIN-1 MAGUIN-1 knock-out Cnksr2 Null target C57BL/6J Request
NR2B-2ACTR NR2B C-terminal domain replaced with corresponding NR2A C-terminal domain Grin2b Knock-in [23201971] target C57BL/6J Request
NR2A-2BCTR NR2A C-terminal domain replaced with corresponding NR2B C-terminal domain Grin2a Knock-in [23201971] target C57BL/6J Request
PSD-93 PSD-93 knock-out Dlg2 Null [18936077] target C57BL/6J Request
PSD-95-GK PSD-95 guanylate kinase domain deletion, causing null Dlg4 Null [14980210] target C57BL/6J Request
SAP102 SAP102 knock-out Dlg3 Null [17344405] target C57BL/6J Request
SHANK2 SHANK2 knock-out Shank2 Null target C57BL/6J Request
SynGAP SynGAP knock-out Syngap1 Null [12427827] target C57BL/6J Request
TAP-PSD-95 TAP-tagged PSD-95 Dlg4 Knock-in [19455133] target C57BL/6J Request
TNiK TNIK knock-out Tnik Null [23035106] target C57BL/6J Request

 

References

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© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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