G2C::Electrophysiology

PSD-93 knock-out mouse

S.G.N. Grant and the G2C Consortium

Corresponding email: Seth.Grant@ed.ac.uk  

 

Overview: Effect sizes (Cohen d) for 18 electrophysiology variables

Mutant slices showed medium overall electrophysiological difference from wildtype slices, with only one variable, burst 8-10 ave amplitude vs burst 2-4, significantly increased in these mutant slices. Note that in the theta burst analysis, the tenth burst is analysed as representative of individual burst amplitude. Definitions of variables may be found below.

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The G2CMine data warehouse provides slice group summaries and individual mouse observations from the PSD-93 knock-out line phenotyping.

 

Variables shown are: Max fEPSP amplitude, Maximum field excitatory postsynaptic potential (fEPSP) amplitude. PPF at 50ms, ampl ratio, Paired pulse facilitation (PPF), pulses separated by 50ms, amplitude ratio. Burst 1, PPF at 10ms, ampl ratio, Paired pulse facilitation (PPF), pulses separated by 10ms, amplitude ratio, observed during first two pulses of the first 100Hz burst during theta-burst stimulation. Burst 1, EPSP3 depr, ampl ratio, Depression observed in third fEPSP relative to the second fEPSP of the first 100Hz burst, amplitude ratio. Burst 1, ave amplitude, Average amplitude of four fEPSPs in first burst. Burst 2, ave amplitude, Average amplitude of four fEPSPs in second burst. Burst 3, ave amplitude, Average amplitude of four fEPSPs in third burst. Burst 4, ave amplitude, Average amplitude of four fEPSPs in fourth burst. Burst 5, ave amplitude, Average amplitude of four fEPSPs in fifth burst. Burst 6, ave amplitude, Average amplitude of four fEPSPs in sixth burst. Burst 7, ave amplitude, Average amplitude of four fEPSPs in seventh burst. Burst 8, ave amplitude, Average amplitude of four fEPSPs in eighth burst. Burst 9, ave amplitude, Average amplitude of four fEPSPs in ninth burst. Burst 10, ave amplitude, Average amplitude of four fEPSPs in tenth burst. Burst 2-4 ave amplitude vs Burst 1, Facilitation observed in average amplitude of bursts 2-4, relative to average amplitude of burst 1. Burst 8-10 ave amplitude vs Burst 2-4, Depression observed in average amplitude of bursts 8-10, relative to average amplitude of bursts 2-4. LTP vs PTP, amplitude ratio, Reduction in potentiation from immediately after theta-burst stimulation to one hour later, fEPSP amplitude ratio. LTP based on amplitude, Long term potentiation, ratio of amplitudes of fEPSPs in test pathway and control pathway.

 

Variable Units Wildtype slices (animals) Wildtype mean (SEM) Mutant slices (animals) Mutant mean (SEM) P(animals) P(mutation)
Max fEPSP amplitude µV 15 (5) 2820 (110) 23 (8) 2910 (130) 0.56 0.66
PPF at 50ms, ampl ratio % 15 (5) 180.4 (4.9) 23 (8) 193.8 (3.1) 0.038 * 0.093
Burst 1, PPF at 10ms, ampl ratio % 15 (5) 192.3 (10.5) 23 (8) 204.6 (4.8) 0.014 * 0.41
Burst 1, EPSP3 depr, ampl ratio % 15 (5) 66.5 (3.9) 23 (8) 61.9 (1.8) 0.51 0.26
Burst 1, ave amplitude µV 15 (5) 1137 (58) 23 (8) 1211 (61) 0.43 0.44
Burst 2, ave amplitude µV 15 (5) 2030 (100) 23 (8) 2249 (105) 0.74 0.13
Burst 3, ave amplitude µV 15 (5) 2220 (110) 23 (8) 2400 (110) 0.69 0.23
Burst 4, ave amplitude µV 15 (5) 2310 (110) 23 (8) 2460 (110) 0.64 0.32
Burst 5, ave amplitude µV 15 (5) 2300 (110) 23 (8) 2420 (110) 0.57 0.45
Burst 6, ave amplitude µV 15 (5) 2260 (110) 23 (8) 2340 (110) 0.52 0.64
Burst 7, ave amplitude µV 15 (5) 2200 (120) 23 (8) 2260 (110) 0.47 0.76
Burst 8, ave amplitude µV 15 (5) 2140 (110) 23 (8) 2170 (110) 0.44 0.88
Burst 9, ave amplitude µV 15 (5) 2100 (110) 23 (8) 2110 (110) 0.48 0.98
Burst 10, ave amplitude µV 15 (5) 2060 (110) 23 (8) 2060 (110) 0.43 0.97
Burst 2-4 ave amplitude vs Burst 1 % 15 (5) 188.5 (6.4) 23 (8) 192.3 (3) 0.045 * 0.66
Burst 8-10 ave amplitude vs Burst 2-4 % 15 (5) 96.2 (1.6) 23 (8) 88.6 (1.4) 0.017 * 0.029 *
LTP vs PTP, amplitude ratio % 15 (5) 75.4 (1.7) 23 (8) 74.7 (1) 0.95 0.58
LTP based on amplitude % 15 (5) 176.9 (6.8) 23 (8) 163.8 (3.1) 0.094 0.14

 

Basal Synaptic Transmission

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Variables shown are: Max fEPSP amplitude, Maximum field excitatory postsynaptic potential (fEPSP) amplitude.

 

Variable Units Wildtype slices (animals) Wildtype mean (SEM) Mutant slices (animals) Mutant mean (SEM) P(animals) P(mutation)
Max fEPSP amplitude µV 15 (5) 2820 (110) 23 (8) 2910 (130) 0.56 0.66

 

Paired Pulse Facilitation

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Variables shown are: PPF at 50ms, ampl ratio, Paired pulse facilitation (PPF), pulses separated by 50ms, amplitude ratio.

 

Variable Units Wildtype slices (animals) Wildtype mean (SEM) Mutant slices (animals) Mutant mean (SEM) P(animals) P(mutation)
PPF at 50ms, ampl ratio % 15 (5) 180.4 (4.9) 23 (8) 193.8 (3.1) 0.038 * 0.093

 

Theta Burst Stimulation

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Variables shown are: Burst 1, PPF at 10ms, ampl ratio, Paired pulse facilitation (PPF), pulses separated by 10ms, amplitude ratio, observed during first two pulses of the first 100Hz burst during theta-burst stimulation. Burst 1, EPSP3 depr, ampl ratio, Depression observed in third fEPSP relative to the second fEPSP of the first 100Hz burst, amplitude ratio. Burst 1, ave amplitude, Average amplitude of four fEPSPs in first burst. Burst 2, ave amplitude, Average amplitude of four fEPSPs in second burst. Burst 3, ave amplitude, Average amplitude of four fEPSPs in third burst. Burst 4, ave amplitude, Average amplitude of four fEPSPs in fourth burst. Burst 5, ave amplitude, Average amplitude of four fEPSPs in fifth burst. Burst 6, ave amplitude, Average amplitude of four fEPSPs in sixth burst. Burst 7, ave amplitude, Average amplitude of four fEPSPs in seventh burst. Burst 8, ave amplitude, Average amplitude of four fEPSPs in eighth burst. Burst 9, ave amplitude, Average amplitude of four fEPSPs in ninth burst. Burst 10, ave amplitude, Average amplitude of four fEPSPs in tenth burst. Burst 2-4 ave amplitude vs Burst 1, Facilitation observed in average amplitude of bursts 2-4, relative to average amplitude of burst 1. Burst 8-10 ave amplitude vs Burst 2-4, Depression observed in average amplitude of bursts 8-10, relative to average amplitude of bursts 2-4.

 

Variable Units Wildtype slices (animals) Wildtype mean (SEM) Mutant slices (animals) Mutant mean (SEM) P(animals) P(mutation)
Burst 1, PPF at 10ms, ampl ratio % 15 (5) 192.3 (10.5) 23 (8) 204.6 (4.8) 0.014 * 0.41
Burst 1, EPSP3 depr, ampl ratio % 15 (5) 66.5 (3.9) 23 (8) 61.9 (1.8) 0.51 0.26
Burst 1, ave amplitude µV 15 (5) 1137 (58) 23 (8) 1211 (61) 0.43 0.44
Burst 2, ave amplitude µV 15 (5) 2030 (100) 23 (8) 2249 (105) 0.74 0.13
Burst 3, ave amplitude µV 15 (5) 2220 (110) 23 (8) 2400 (110) 0.69 0.23
Burst 4, ave amplitude µV 15 (5) 2310 (110) 23 (8) 2460 (110) 0.64 0.32
Burst 5, ave amplitude µV 15 (5) 2300 (110) 23 (8) 2420 (110) 0.57 0.45
Burst 6, ave amplitude µV 15 (5) 2260 (110) 23 (8) 2340 (110) 0.52 0.64
Burst 7, ave amplitude µV 15 (5) 2200 (120) 23 (8) 2260 (110) 0.47 0.76
Burst 8, ave amplitude µV 15 (5) 2140 (110) 23 (8) 2170 (110) 0.44 0.88
Burst 9, ave amplitude µV 15 (5) 2100 (110) 23 (8) 2110 (110) 0.48 0.98
Burst 10, ave amplitude µV 15 (5) 2060 (110) 23 (8) 2060 (110) 0.43 0.97
Burst 2-4 ave amplitude vs Burst 1 % 15 (5) 188.5 (6.4) 23 (8) 192.3 (3) 0.045 * 0.66
Burst 8-10 ave amplitude vs Burst 2-4 % 15 (5) 96.2 (1.6) 23 (8) 88.6 (1.4) 0.017 * 0.029 *

 

Long Term Potentiation

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Variables shown are: LTP vs PTP, amplitude ratio, Reduction in potentiation from immediately after theta-burst stimulation to one hour later, fEPSP amplitude ratio. LTP based on amplitude, Long term potentiation, ratio of amplitudes of fEPSPs in test pathway and control pathway.

 

Variable Units Wildtype slices (animals) Wildtype mean (SEM) Mutant slices (animals) Mutant mean (SEM) P(animals) P(mutation)
LTP vs PTP, amplitude ratio % 15 (5) 75.4 (1.7) 23 (8) 74.7 (1) 0.95 0.58
LTP based on amplitude % 15 (5) 176.9 (6.8) 23 (8) 163.8 (3.1) 0.094 0.14

Hippocampal brain slices summarised by genotype, followed by a list of the animals from which they were prepared.

View experimental protocols.

 

Hippocampal Slice Electrophysiology Cohort Summary

GenotypeCount
WT5
mutant8

 

Individual Mice

Mouse IDGenotype
wA254975214WT
wA064d67824WT
wA2094b4b7eWT
wAd8b134bbfWT
wAd130cc5f5WT
mAef5b6bd09mutant
mA07462cdebmutant
mA68a3e5064mutant
mA7352e648cmutant
mA5f2a3ee3bmutant
mA37ddb5816mutant
mA4e28ece77mutant
mAa6e7bda0bmutant

Field EPSP (Maximum)

Mouse IDGenotypeSlice NumberRecording ChannelFile Name
mAef5b6bd09 mutant 1 55A ef5b6bd09_slice_1-2-x-3.zip
mAef5b6bd09 mutant 2 61A ef5b6bd09_slice_1-2-x-3.zip
mA4e28ece77 mutant 1 55A 4e28ece77_slices_1-2-x-3.zip
mA4e28ece77 mutant 2 52A 4e28ece77_slices_1-2-x-3.zip
mA4e28ece77 mutant 3 52B 4e28ece77_slices_1-2-x-3.zip
mA7352e648c mutant 1 26A 7352e648c_slices_1-2-x-3.zip
mA7352e648c mutant 2 52A 7352e648c_slices_1-2-x-3.zip
mA7352e648c mutant 3 52B 7352e648c_slices_1-2-x-3.zip
mAa6e7bda0b mutant 1 58A a6e7bda0b_slices_1-2-x-3.zip
mAa6e7bda0b mutant 3 52B a6e7bda0b_slices_1-2-x-3.zip
mA68a3e5064 mutant 1 58A 68a3e5064_slices_1-2-3-4.zip
mA68a3e5064 mutant 3 46B 68a3e5064_slices_1-2-3-4.zip
mA68a3e5064 mutant 4 61B 68a3e5064_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 1 58A 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 2 44A 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 3 46B 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 4 71B 5f2a3ee3b_slices_1-2-3-4.zip
mA07462cdeb mutant 1 62A 07462cdeb_slices_x-1-2-3.zip
mA07462cdeb mutant 2 67B 07462cdeb_slices_x-1-2-3.zip
mA37ddb5816 mutant 1 47A 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 2 52A 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 3 15B 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 4 62B 37ddb5816_slices_1-2-3-4.zip
wAd8b134bbf WT 1 46A d8b134bbf_slices_1-2-x-3.zip
wAd8b134bbf WT 2 52A d8b134bbf_slices_1-2-x-3.zip
wAd8b134bbf WT 3 52B d8b134bbf_slices_1-2-x-3.zip
wA254975214 WT 1 87A 254975214_slices_1-2-x-x.zip
wA254975214 WT 2 52A 254975214_slices_1-2-x-x.zip
wAd130cc5f5 WT 1 15A d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 2 52A d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 3 15B d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 4 61B d130cc5f5_slices_1-2-3-4.zip
wA2094b4b7e WT 1 53A 2094b4b7e_slices_x-1-2-3.zip
wA2094b4b7e WT 2 45B 2094b4b7e_slices_x-1-2-3.zip
wA2094b4b7e WT 3 43B 2094b4b7e_slices_x-1-2-3.zip
wA064d67824 WT 1 41A 064d67824_slices_x-1-2-3.zip
wA064d67824 WT 2 47B 064d67824_slices_x-1-2-3.zip
wA064d67824 WT 3 43B 064d67824_slices_x-1-2-3.zip

Paired Pulse Facilitation

Mouse IDGenotypeSlice NumberRecording ChannelFile Name
mAef5b6bd09 mutant 1 55A ef5b6bd09_slice_1-2-x-3.zip
mAef5b6bd09 mutant 2 61A ef5b6bd09_slice_1-2-x-3.zip
mA4e28ece77 mutant 1 55A 4e28ece77_slices_1-2-x-3.zip
mA4e28ece77 mutant 2 52A 4e28ece77_slices_1-2-x-3.zip
mA4e28ece77 mutant 3 52B 4e28ece77_slices_1-2-x-3.zip
mA7352e648c mutant 1 26A 7352e648c_slices_1-2-x-3.zip
mA7352e648c mutant 2 52A 7352e648c_slices_1-2-x-3.zip
mA7352e648c mutant 3 52B 7352e648c_slices_1-2-x-3.zip
mAa6e7bda0b mutant 1 58A a6e7bda0b_slices_1-2-x-3.zip
mAa6e7bda0b mutant 3 52B a6e7bda0b_slices_1-2-x-3.zip
mA68a3e5064 mutant 1 58A 68a3e5064_slices_1-2-3-4.zip
mA68a3e5064 mutant 3 46B 68a3e5064_slices_1-2-3-4.zip
mA68a3e5064 mutant 4 61B 68a3e5064_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 1 58A 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 2 44A 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 3 46B 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 4 71B 5f2a3ee3b_slices_1-2-3-4.zip
mA07462cdeb mutant 1 62A 07462cdeb_slices_x-1-2-3.zip
mA07462cdeb mutant 2 67B 07462cdeb_slices_x-1-2-3.zip
mA37ddb5816 mutant 1 47A 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 2 52A 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 3 15B 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 4 62B 37ddb5816_slices_1-2-3-4.zip
wAd8b134bbf WT 1 46A d8b134bbf_slices_1-2-x-3.zip
wAd8b134bbf WT 2 52A d8b134bbf_slices_1-2-x-3.zip
wAd8b134bbf WT 3 52B d8b134bbf_slices_1-2-x-3.zip
wA254975214 WT 1 87A 254975214_slices_1-2-x-x.zip
wA254975214 WT 2 52A 254975214_slices_1-2-x-x.zip
wAd130cc5f5 WT 1 15A d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 2 52A d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 3 15B d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 4 61B d130cc5f5_slices_1-2-3-4.zip
wA2094b4b7e WT 1 53A 2094b4b7e_slices_x-1-2-3.zip
wA2094b4b7e WT 2 45B 2094b4b7e_slices_x-1-2-3.zip
wA2094b4b7e WT 3 43B 2094b4b7e_slices_x-1-2-3.zip
wA064d67824 WT 1 41A 064d67824_slices_x-1-2-3.zip
wA064d67824 WT 2 47B 064d67824_slices_x-1-2-3.zip
wA064d67824 WT 3 43B 064d67824_slices_x-1-2-3.zip

Long Term Potentiation

Mouse IDGenotypeSlice NumberRecording ChannelFile Name
mAef5b6bd09 mutant 1 55A ef5b6bd09_slice_1-2-x-3.zip
mAef5b6bd09 mutant 2 61A ef5b6bd09_slice_1-2-x-3.zip
mA4e28ece77 mutant 1 55A 4e28ece77_slices_1-2-x-3.zip
mA4e28ece77 mutant 2 52A 4e28ece77_slices_1-2-x-3.zip
mA4e28ece77 mutant 3 52B 4e28ece77_slices_1-2-x-3.zip
mA7352e648c mutant 1 26A 7352e648c_slices_1-2-x-3.zip
mA7352e648c mutant 2 52A 7352e648c_slices_1-2-x-3.zip
mA7352e648c mutant 3 52B 7352e648c_slices_1-2-x-3.zip
mAa6e7bda0b mutant 1 58A a6e7bda0b_slices_1-2-x-3.zip
mAa6e7bda0b mutant 3 52B a6e7bda0b_slices_1-2-x-3.zip
mA68a3e5064 mutant 1 58A 68a3e5064_slices_1-2-3-4.zip
mA68a3e5064 mutant 3 46B 68a3e5064_slices_1-2-3-4.zip
mA68a3e5064 mutant 4 61B 68a3e5064_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 1 58A 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 2 44A 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 3 46B 5f2a3ee3b_slices_1-2-3-4.zip
mA5f2a3ee3b mutant 4 71B 5f2a3ee3b_slices_1-2-3-4.zip
mA07462cdeb mutant 1 62A 07462cdeb_slices_x-1-2-3.zip
mA07462cdeb mutant 2 67B 07462cdeb_slices_x-1-2-3.zip
mA37ddb5816 mutant 1 47A 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 2 52A 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 3 15B 37ddb5816_slices_1-2-3-4.zip
mA37ddb5816 mutant 4 62B 37ddb5816_slices_1-2-3-4.zip
wAd8b134bbf WT 1 46A d8b134bbf_slices_1-2-x-3.zip
wAd8b134bbf WT 2 52A d8b134bbf_slices_1-2-x-3.zip
wAd8b134bbf WT 3 52B d8b134bbf_slices_1-2-x-3.zip
wA254975214 WT 1 87A 254975214_slices_1-2-x-x.zip
wA254975214 WT 2 52A 254975214_slices_1-2-x-x.zip
wAd130cc5f5 WT 1 15A d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 2 52A d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 3 15B d130cc5f5_slices_1-2-3-4.zip
wAd130cc5f5 WT 4 61B d130cc5f5_slices_1-2-3-4.zip
wA2094b4b7e WT 1 53A 2094b4b7e_slices_x-1-2-3.zip
wA2094b4b7e WT 2 45B 2094b4b7e_slices_x-1-2-3.zip
wA2094b4b7e WT 3 43B 2094b4b7e_slices_x-1-2-3.zip
wA064d67824 WT 1 41A 064d67824_slices_x-1-2-3.zip
wA064d67824 WT 2 47B 064d67824_slices_x-1-2-3.zip
wA064d67824 WT 3 43B 064d67824_slices_x-1-2-3.zip

Data Files

File NameSizeChecksum (SHA256)
254975214_slices_1-2-x-x.zip308402239829bbd3653052d3526de9d8e05698d56bd40ef23e2eea4d788a54cc8df4cde1
68a3e5064_slices_1-2-3-4.zip3568843992135a8471e999eea7471bdd32a796bf5e8ce38ca1508c6a09eeb8ef7da85242
a6e7bda0b_slices_1-2-x-3.zip3123415016f082b51210fd54b260e17a39c36384951ac525ff6e8f3148b8e68a88a42370
4e28ece77_slices_1-2-x-3.zip47586501089f54702c741280a78f849969bfbaa02130822e029c3b5146c2525810401ffc
07462cdeb_slices_x-1-2-3.zip3277941245167629d8429c6389904b62ba5e58d77545ee36e86bd1c2a121cb692f37618e
5f2a3ee3b_slices_1-2-3-4.zip31572705cc1cab2b1b179c41149b37cac5c624131b77a7804ff0e211a02dc9121c87cf94
d130cc5f5_slices_1-2-3-4.zip400205334869bd89f11daf03eaaa109528afb43c3560ba899eea5a29b72722c23811bfd8
7352e648c_slices_1-2-x-3.zip40466575fda98ab1aef4fabb6ee1f2bef92a6f9cf407b17dbc95ad2eb36189e4f538f57c
064d67824_slices_x-1-2-3.zip41165956ac1ed4f96fda541f8fc0fad259cc03f5ad33b6614fe1b45a9dc8f9034587db10
2094b4b7e_slices_x-1-2-3.zip32375974bd208933262b137eecca2c5d3c7c5eb766bf9ae7763e9bfdf83300e26da1b4ea
ef5b6bd09_slice_1-2-x-3.zip3782748861b207370faf57489d70265b22c2e38531188ffdf5849650a64ec1f57a9a6ef3
37ddb5816_slices_1-2-3-4.zip30936274e6ed9f920a4f94982d5be6538d82fe728055e4ba7b47fbc2499ee53b10d2c5a1
d8b134bbf_slices_1-2-x-3.zip327603730ecf6d8e2d6e793214e5826c297366ccde11eb9aa32c414bd2f385c05a265611
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