G2C::Synapse Proteomics Datasets

Introduction

Links are provided to the synapse proteomics datasets from Genes to Cognition (G2C) Programme publications in the G2Cdb database. These can be browsed, compared and downloaded online. For each dataset the original proteomics results are given mapped back to the relevant species gene identifiers, and to orthologous genes in another mammalian species.

If you wish to search for the presence of an individual gene or protein of interest in all the warehoused synapse proteomics lists, simply paste the protein or gene identifier into the top right-hand search box, and select the 'Gene lists' tab from the G2Cdb::Gene report (e.g. Grin1, PSD-95, Shank2).

 

Synapse proteomics reports

Comparative analysis of human and mouse postsynaptic proteomes identifies high compositional conservation and abundance differences for key synaptic proteins

Bayés À, Collins MO, Croning MDR, van de Lagemaat LN, Choudhary JS, Grant SGN. [23071613]

Description Protein count Original species proteomics Orthologous list
Cortex PSD full protein list 1556 Mus musculus (view) Homo sapiens (view)
Cortex PSD consensus proteins 984 Mus musculus (view) Homo sapiens (view)

(View - MICROSITE)

 

Characterisation of the proteome, diseases and evolution of the human postsynaptic density

Bayés À, van de Lagemaat LN, Collins MO, Croning MDR, Whittle IR, Choudhary JS, Grant SGN. [21170055]

Description Protein count Original species proteomics Orthologous list
Cortex PSD full protein list 1461 Homo sapiens (view) Mus musculus (view)
Cortex PSD consensus proteins 748 Homo sapiens (view) Mus musculus (view)

(View - MICROSITE)

 

Targeted TAP purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

Fernandez E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MDR, Zografos L, Armstrong JD, Choudhary JS, Grant SGN. [19455133]

Description Protein count Original species proteomics Orthologous list
TAP PSD-95 'core' protein list 120 Mus musculus (view) Homo sapiens (view)

(View MICROSITE)

 

Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.

Collins MO, Husi H, Yu L, Brandon JM, Anderson CN, Blackstock WP, Choudhary JS and Grant SG. [16635246]

Description Protein count Original species proteomics Orthologous list
AMPA receptor complex 10 Mus musculus (view) Homo sapiens (view)
Clathrin-coated vesicle 150 Mus musculus (view) Homo sapiens (view)
mGluR5 receptor complex 64 Mus musculus (view) Homo sapiens (view)
Mitochondrial proteome 91 Mus musculus (view) Homo sapiens (view)
NRC/MASC complex 186 Mus musculus (view) Homo sapiens (view)
Postsynaptic proteome (PSP) 1121 Mus musculus (view) Homo sapiens (view)
PSD complex 1080 Mus musculus (view) Homo sapiens (view)
Synaptosome 152 Mus musculus (view) Homo sapiens (view)

 

References

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© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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