G2C::Proteomics

PSD95 mediates assembly of postsynaptic Arc complexes associated with schizophrenia, intellectual disability and cognitive variation.

Esperanza Fernandez1 and Seth GN Grant2*

*Corresponding author: Seth.Grant@ed.ac.uk

  1. VIB Dept. of Molecular and Developmental Genetics, KU Leuven Medical School, Campus Gasthuisberg, Herestraat 49, Box 602, 3000 Leuven, Belgium
  2. Genes to Cognition Programme, Molecular Neuroscience, Centre for Clinical Brain Science and Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, UK

 

Overview

Arc is a highly studied neuronal protein yet little is known about its protein interactions, assembly into multiprotein complexes or role in disease. To address these issues we applied an integrated proteomic and genetic strategy using targeted Tandem Affinity Purification (TAP) tagging in mice, biochemical and proteomic characterization of native complexes in wild type and mutant mice, and human genetic analyses of disease and intelligence.

TAP tagging enabled efficient purification and identification of many novel interacting proteins, of which PSD95/Dlg4 was the most abundant. Arc and PSD95 resided in 1.5 MDa postsynaptic complexes and knockout of PSD95 depleted Arc from the complexes and synapse.

Human genetic studies identified mutations and variants in Arc interacting proteins that are enriched in schizophrenia, intellectual disability, epilepsy and normal variation in intelligence.

These studies reveal that the postsynaptic complexes assembled by Arc and PSD95 are important in the continuum of cognitive variation spanning intelligence and mental illness.

Figures

Sheet #1
Combined + Kirov.

Table 1. Human genetics

All Arc interactors


N=107
Arc interactors with increased expression in PSD95/Dlg4-/- mice
N=11
Arc interactors with increased expression in PSD95/Dlg4-/- mice
N=24
Arc interactors that are known direct PSD95 interacting proteins
N=18
Mutation class Disease Study Design P O/E P O/E P O/E P O/E
LoFAutismDe novo0.0027611/4.01.000000/0.40.002106/1.20.000028/0.8
EpilepsyDe novo0.007683/0.41.000000/00.116461/0.11.000000/0.1
IDDe novo0.000028/0.51.000000/00.000025/0.10.000183/0.1
SchizophreniaDe novo0.045583/0.80.082401/0.10.025482/0.20.011642/0.2
SchizophreniaCase/Control0.0290056/380.3400012/90.0480015/90.310006/6
Nonsyn.AutismDe novo0.0002646/25.90.718312/2.50.0266015/8.50.0000818/5.8
EpilepsyDe novo0.0000216/2.51.000000/0.30.051663/0.80.110542/0.6
IDDe novo0.0000215/2.01.000000/0.20.000028/0.60.000028/0.4
SchizophreniaDe novo0.0022814/5.70.020223/0.60.011306/1.80.009205/1.3
SchizophreniaCase/Control0.02800187/1840.2300022/210.0200061/480.0140040/31
SilentAutismDe novo0.693917/8.11.000000/0.70.513433/2.70.570872/1.9
EpilepsyDe novo1.000000/0.71.000000/0.11.000000/0.21.000000/0.2
IDDe novo1.000000/0.41.000000/01.000000/0.11.000000/0.1
SchizophreniaDe novo0.517772/1.71.000000/0.21.000000/0.60.340271/0.4
CNVsSchizophreniaDe novo0.001170.125530.004120.00412

(*) For de novo studies, O/E indicates the observed versus expected (under a null model) number of mutations in that class.
For the SCZ case/control study, O/E indicates the number of case versus control mutations.

Supplementary Tables

Supplementary Table   1.
MS data obtained from a single step and tandem affinity purifications.
Supplementary Table   2.
Known Arc interactors.
Supplementary Table   3.
iBAQ intensity numbers of Arc and PSD95.
Supplementary Table   4.
iBAQ intensity numbers of the ARC-core interactors.
Supplementary Table   5.
Biological process and Molecular Function of 107 Arc interactors.
Supplementary Table   6.
Biological process ontology of 107 Arc interactors.
Supplementary Table   7.
MS data obtained from a single step purifications from ArcTAP/+ and ArcTAP/TAP crossed with PSD95/Dlg4 knokout mice.
Supplementary Table   8.
Arc gene set enrichment in schizophrenia, epilepsy, autism and intellectual disability.
Supplementary Table   9.
Map of Arc complex to OMIM disorders.
Supplementary Table 10.
Mammalian Phenotype Ontology of ARC interactors.
Supplementary Table 11.
Arc gene set association with general cognitive ability.
Supplementary Table 12.
Oligos used in this study.

Supplementary Table 1. Ms data obtained from a single step and tandem affinity purifications.

Protein group IDProtein IDsMajority protein IDsProtein nameGene namesGene name representativePeptides 1S-ARC14Peptides 1S-ARC15Peptides 1S-Cont16Peptides 1S-PSD95mut01Peptides 1S-PSD95mut02Peptides 1S-PSD95mut03Peptides Tandem-ARC02Peptides Tandem-ARC03Peptides Tandem-ARC05Peptides Tandem-Cont01Peptides Tandem-Cont02Peptides Tandem-Cont03PSMs 1S-ARC14PSMs 1S-ARC15PSMs 1S-Cont16PSMs 1S-PSD95mut01PSMs 1S-PSD95mut02PSMs 1S-PSD95mut03PSMs Tandem-ARC02PSMs Tandem-ARC03PSMs Tandem-ARC05PSMs Tandem-Cont01PSMs Tandem-Cont02PSMs Tandem-Cont03Intensity 1S-ARC14Intensity 1S-ARC15Intensity 1S-Cont16Intensity Tandem-ARC02Intensity Tandem-ARC03Intensity Tandem-ARC05Intensity Tandem-Cont01Intensity Tandem-Cont02Intensity Tandem-Cont03Intensity average controlRatio Intensity Tandem-ARC02/average controlRatio Intensity Tandem-ARC03/average controlRatio Intensity Tandem-ARC05/average control# replicates enriched (Tandem)Ratio Intensity 1S-ARC14/ContRatio Intensity 1S-ARC15/ContRatio M/L 1S-PSD95mut01Ratio M/L 1S-PSD95mut02Ratio M/L 1S-PSD95mut03Average 1S ratio# replicates enriched (1 step)# replicates enriched (1 + Tandem)Total PSD-95 complex (# replicates)PSD-95 Core ComplexPSD-95 Interactor
1001Q62108 Q62108-3 Q62108-2 G3UZL5Q62108 Q62108-3 Q62108-2Disks large homolog 4Dlg4Dlg43532030343234373500015416219021814911615311846827000303500002654500034237000311850002S specific2S specific2S specific31S specific1S specific13.75523.04419.25718.685585YESYES
1263Q91XM9Q91XM9Disks large homolog 2Dlg2Dlg21923018232216221600052591029770283126459540050403002719200381490046448002S specific2S specific2S specific31S specific1S specific12.33026.59015.43518.118585YESYES
1447Q9WV31Q9WV31Activity-regulated cytoskeleton-associated proteinArcArc111608108151918000406235382245606418669000225020003348900042493000615410002S specific2S specific2S specific31S specific1S specific15.66016.48316.43316.192585YES
1106Q811D0Q811D0Disks large homolog 1Dlg1Dlg11111015141881181001210453834475318365006802104397506472008234702S specific2S specific2S specific31S specific1S specific10.56411.26222.22014.682585YES
822P63017 Q504P4 D3Z5E2 D3YW43P63017 Q504P4Heat shock cognate 71 kDa proteinHspa8Hspa811113611654500013143213110546983270966660265242460602636604473302S specific2S specific2S specific337.07136.4453.36410.4205.40918.542581
390Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 D3YUQ0 F6PZ09 F6XIT3 F7CDH3 F7DAP1 F7BZ55 F6VJ78 F6XRZ6 F7AYY9 F6TDF4 F6SK63 F7BXL9Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18Disintegrin and metalloproteinase domain-containing protein 22Adam22Adam2276061412710600012922332681277291002567604599606757803645302S specific2S specific2S specific31S specific1S specific8.2125.1483.9515.770585YESYES
663Q80TN1 P11798 F8WIS9 F6WHR9 D3Z7K9 F8WHB5 P11798-2 F8WIR6 D6RDQ8 E9QAJ4 E9PYZ8Q80TN1 P11798 F8WIS9Calcium/calmodulin-dependent protein kinase type II subunit alphaCamk2aCamk2a240344463000257131381312104490241630472920166930011911002S specific2S specific2S specific31S specific1S specific7.4997.4185.6446.854585YESYES
785P60202 F8WGE4 P60202-2P60202 F8WGE4 P60202-2Myelin proteolipid proteinPlp1Plp1330421212000347333127445306138403308505522905304502S specific2S specific2S specific31S specific1S specific10.91711.07930.05217.349585YES
110B1AZP2-2 B1AZP2 B7ZNS2 B1AZP2-3 F6YMR0 E9PUF2B1AZP2-2 B1AZP2 B7ZNS2Disks large-associated protein 4Dlgap4Dlgap42203109111000223171521116791121757162046670847752S specific2S specific2S specific31S specific1S specific3.2116.32412.9157.483585YESYES
762P52189 Q8R435P52189 Q8R435Inward rectifier potassium channel 4Kcnj4Kcnj412022211100013355111230378667541107163280663342S specific2S specific2S specific31S specific1S specific2.6072.7406.0863.811585YESYES
79E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7IQ motif and SEC7 domain-containing protein 2Iqsec2Iqsec294019302733100010454836464362291027004070054271322S specific2S specific21S specific1S specific5.9698.62911.0198.539575YES
941Q3UVU8Q3UVU8Disks large-associated protein 1Dlgap1Dlgap1550711101210005716242012127932014083070581351642S specific2S specific21S specific1S specific4.3648.8677.2266.819575YESYES
342P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 D3YYZ2P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4Polyubiquitin-C Ubiquitin Ubiquitin-related 1 Ubiquitin-related 2 Polyubiquitin-B Ubiquitin Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40Ubc Ubb 2810422J05Rik Rps27a Uba52 Gm7866Ubb23012220100071152421256070435230156790890032S specific2S specific21S specific1S specific6.3248.2439.3937.987571
725P35438 P35438-2P35438 P35438-2Glutamate [NMDA] receptor subunit zeta-1Grin1Grin114025311100015466112126627766677458650042S specific2S specific21S specific1S specific6.50012.9533.5577.670575YESYES
1059Q6PIC6 Q8VCE0 Q9WV27 Q9Z1W8 E9QNX7 Q64436 Q91WH7Q6PIC6 Q8VCE0Sodium/potassium-transporting ATPase subunit alpha-3Atp1a3Atp1a381129863440001515216161067910845001082100556141757702996704887702S specific2S specific2S specific319.50019.4572.3067.9403.17710.47647
526F8WIG2 Q68EF6F8WIG2 Q68EF6Brain-enriched guanylate kinase-associated proteinBegainBegain3200221020003242127411317709620851045502S specific2S specific21S specific1S specific5.4506.2795.864464YESYES
579O08553O08553Dihydropyrimidinase-related protein 2Dpysl2Dpysl218161471284140013749212533184141444190056101002455600213600793332404808327.68327.625.6509.52728.87731.8092.2854.2999.0007.7925.03736
836P68369 P05214 Q3UX10P68369 P05214Tubulin alpha-1A chain Tubulin alpha-3 chainTuba1a Tuba3aTuba1a35132334400111184227342122214004754300829390939190107120011833002286202286204.1084.6865.17632.6785.7329.6626.024364YES
835P68368P68368Tubulin alpha-4A chainTuba4aTuba4a1202111120001351111310004020342040927033093012004002S specific2S specific2S specific31S specific1S specific2.1802.5012.34136
1438Q9R111 D3YU09Q9R111 D3YU09Guanine deaminaseGdaGda1215012980000001718372014475340068530001S specific1S specific11.04215.91317.03914.665555YESYES
1460Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 A2A599Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98V-type proton ATPase 116 kDa subunit a isoform 1Atp6v0a1Atp6v0a16614460000007102107115086004181203351215.17712.4776.65214.0894.78410.63655
740P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 F6ZRK3P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6Excitatory amino acid transporter 2Slc1a2Slc1a255032200000014106643537302766001S specific1S specific4.1184.3254.3404.261555YES
969Q5SXR6 Q68FD5 E9Q434 F6Z1R4Q5SXR6 Q68FD5Clathrin heavy chain 1CltcCltc420372000000424144123220763161S specific1S specific3.0034.5033.0203.509554YES
870P99024 G3UZR1P99024Tubulin beta-5 chainTubb5Tubb558477625300268523112121120550028861009331403030003169205042401256201256202.4122.5234.01421.2923.0931.9616.5123.5813.28835
1131Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6Disks large-associated protein 2Dlgap2Dlgap2000313102120006251821245006392022S specific2S specific22.5415.0535.3424.312355YESYES
976Q60771Q60771Claudin-11Cldn11Cldn111001111100001321114448590900724822S specific2S specific21S specific24.8948.89016.89235
166CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 G3UZ07 E9Q606 E9QAZ1 F8WGM8 E9Q2D1 F6WX90CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4"Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed"ActbActb15131314139667013444543343133121314151146000014296000113790003897800623180028384006994614589007644235.0998.1523.71331.0071.2561.5333.8129.0933.34025
837P68372P68372Tubulin beta-4B chainTubb4bTubb4b795997252001111661920272521114840086726052344030212260360323462S specific2S specific2S specific32.1941.6572.0703.9435.8643.14625
676P15105 D3YVK1 D3Z121P15105 D3YVK1Glutamine synthetaseGlulGlul3331111310006105211231109200017017006546804711107870301450802S specific2S specific2S specific31.6682.5992.7542.341255YES
582O08599-2O08599-2Syntaxin-binding protein 1Stxbp1Stxbp1110001313000111313206822131372805262681320302S specific2S specific2S specific31S specific1S specific1S specific255YES
461F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2Myelin basic proteinMbpMbp000332233000552255527996967705245002S specific2S specific2S specific32.7715.1233.94725
597O35449O35449Proline-rich transmembrane protein 1Prrt1Prrt11200001110001211135022561664312563148586972S specific2S specific2S specific31S specific1S specific1S specific254YES
30A2AHY8A2AHY8Pet2 proteinPet2Pet2110000111000221114135609100301605001025902641002S specific2S specific2S specific31S specific1S specific1S specific25
574G5E902 Q8VEM8G5E902 Q8VEM8"Phosphate carrier protein, mitochondrial"Slc25a3Slc25a301111111100011231111284240398344848471652950262S specific2S specific2S specific37.1363.4842.2794.300251
531P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7Histone H2A.x Histone H2A type 1 Histone H2A type 2-A Histone H2A type 3 Histone H2A type 1-F Histone H2A type 1-K Histone H2A type 2-C Histone H2A Histone H2A.J Histone H2A.Z Histone H2A.V Histone H2A type 1-H Histone H2A type 2-BH2afx Hist1h2ab Hist2h2aa1 Hist3h2a Hist1h2af Hist1h2ak Hist2h2ac Hist1h2aa H2afj H2afz H2afv Hist1h2ah Hist1h2al Hist2h2abH2afx00011011200132213125222098288431260191871918713.1455.12322.477312.9246.8849.90425
718P31650P31650Sodium- and chloride-dependent GABA transporter 3Slc6a11Slc6a1153010200000074222677402444201S specific1S specific5.5397.9686.75444
661P11499 E9PX27 E9Q0C3 E9Q3D6 D3Z1R1P11499Heat shock protein HSP 90-betaHsp90ab1Hsp90ab1431332000000431574210110167080392585.3524.2562.6921.8804.5883.754441
1138Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3Brain-specific angiogenesis inhibitor 1-associated protein 2Baiap2Baiap2150382000000174132970071870901S specific1S specific2.4243.2196.1183.921445YESYES
426P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2Glutamate receptor 2Gria2Gria23304540000003378796924638901S specific1S specific3.8263.7692.0833.226445YES
465F6SEU4F6SEU4Ras GTPase-activating protein SynGAPSyngap1Syngap1310415100000003293825350651S specific2.7987.0935.7815.224445YESYES
887Q3UY21 Q61885 Q29ZQ5Q3UY21 Q61885 Q29ZQ5Myelin-oligodendrocyte glycoproteinMogMog1202100000001262767281590101S specific1S specific8.1313.3845.757442
403E9Q8N8 O88343 O88343-2 A7E1Z5E9Q8N8 O88343 O88343-2Electrogenic sodium bicarbonate cotransporter 1Slc4a4Slc4a412023400000023771164249896741S specific1S specific0.9784.0695.2343.427444YES
88B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8Glutamate receptor 3 Glutamate receptor 4Gria3 Gria4Gria312023100000022242533631147501S specific1S specific2.9149.0996.007444YES
20A2AEG6 P35803 E9QPU6 P35803-8 P35803-3A2AEG6 P35803 E9QPU6 P35803-8 P35803-3Neuronal membrane glycoprotein M6-bGpm6bGpm6b1101110000001122176939512391S specific1S specific3.4893.4533.47144
1237Q8VDN2 E9QAV3Q8VDN2 E9QAV3Sodium/potassium-transporting ATPase subunit alpha-1Atp1a1Atp1a1641474223000113212469610165178552S specific11S specific1S specific3.7083.70834
683P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 D3Z0Z9 E9PX99 F6QXU4P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4Glyceraldehyde-3-phosphate dehydrogenaseGapdh Gm10293 Gm4609 Gm10358 Gm2606 Gm5559 Gm10291 Gm6316 Gm10481 Gm10566 Gm8055 Gm10290 Gm3222 Gm6981 Gm7293 Gm5507 Gm10313Gapdh3332223320103734653321924661990704071138492505322S specific2S specific22.2714.8901.5724.9703.426245YES
1036Q6P1J1 P97427 E9Q756Q6P1J1 P97427 E9Q756Dihydropyrimidinase-related protein 1Crmp1Crmp145102021100033211740177330870557813902S specific2S specific21S specific1S specific1S specific24
1403Q9JIA1 D3YW56Q9JIA1Leucine-rich glioma-inactivated protein 1Lgi1Lgi1130110011000133211121559293645900389212S specific2S specific21S specific1S specific0.7061.4811.094245YES
754P48962 P51881 Q3V132P48962 P51881ADP/ATP translocase 1 ADP/ATP translocase 2Slc25a4 Slc25a5Slc25a42000002210002221134186859869530718462S specific2S specific2S specific31S specific1S specific144YES
217Q6PIE5 D3YYN7 D3YVX6Q6PIE5 D3YYN7 D3YVX6Sodium/potassium-transporting ATPase subunit alpha-2Atp1a2Atp1a288279623300034752142150942121S specific1S specific2.4865.1063.79633
833P63328 P63328-2 Q4V9X0P63328 P63328-2 Q4V9X0Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformPpp3caPpp3ca713310000000012173283347014824003815421.84538.8533.86921.522335YES
693P18872 P18872-2 D3Z2M7 F7BLT7 Q66L47 Q8CGK7 P50149 Q3V3I2 Q9DC51 P20612 A2AE32 Q8C040 A2AE31 A2A610P18872 P18872-2 D3Z2M7 F7BLT7Guanine nucleotide-binding protein G(o) subunit alphaGnao1Gnao1753101000000107421435650383940985344.4213.8971.2479.9294.874335YES
759P50516 P50516-2 D3Z1B9 D3YWH3 D3YZ23P50516 P50516-2V-type proton ATPase catalytic subunit AAtp6v1aAtp6v1a36001100000059311812905062201S specific1S specific10.36910.369331
800P61264 Q00262 Q80W45 Q3TJ55P61264Syntaxin-1BStx1bStx1b521121000000861562514800438580782956.5755.6022.1933.0744.361335YES
283E9PUA3 Q8R0S2-2 Q8R0S2E9PUA3 Q8R0S2-2 Q8R0S2IQ motif and SEC7 domain-containing protein 1Iqsec1Iqsec12004105131000141356.0574.12210.8487.009335YES
761P51863P51863V-type proton ATPase subunit d 1Atp6v0d1Atp6v0d12422200000002523262476215750225582.7709.5643.1845.172335YES
763P52480-2 P52480 G3X925 P53657 E9Q509P52480-2 P52480Pyruvate kinase isozymes M1/M2Pkm2Pkm2121110001000221221126590148760337963.7464.4020.8673.0953.028335YES
728P35802P35802Neuronal membrane glycoprotein M6-aGpm6aGpm6a210100000100222166345854391S specific1S specific6.9376.937331
742P46460 G3UX86 G3UX98P46460Vesicle-fusing ATPaseNsfNsf120101000000121232535438381S specific1S specific0.9478.5104.728335YES
1070Q76JQ1 Q8C4G9 E9PYX2Q76JQ1 Q8C4G9 E9PYX2G protein-coupled receptor 123Gpr123Gpr12311001000000011327490134001S specific1S specific7.4147.414334YES
1078Q7TNS5Q7TNS5Novel protein similar to F-box and leucine-rich repeat protein 17B630019K06RikB630019K06Rik110110000000121225569370251S specific1S specific6.4556.455335YES
753P48722 P48722-2 E0CY23 F6SMW7 F6TFH3P48722 P48722-2 E0CY23Heat shock 70 kDa protein 4LHspa4lHspa4l110110000000112221376142601S specific1S specific4.2301.5262.87833
457Q9QYS2 F6QVY9Q9QYS2 F6QVY9Metabotropic glutamate receptor 3Grm3Grm30002210000005425.98111.1953.4086.861331
1377Q9DB72Q9DB72BTB/POZ domain-containing protein 17Btbd17Btbd170002420000003734.3153.81814.0407.39133
99Q6PFD5 B1AS06Q6PFD5 B1AS06Disks large-associated protein 3Dlgap3Dlgap30002811000000716224.3108.8645.9816.385335YESYES
562G3X9V4 Q01097G3X9V4 Q01097Glutamate [NMDA] receptor subunit epsilon-2Grin2bGrin2b0001420000002733.8208.7474.7515.773335YESYES
1163Q8BX10 Q8BX10-2 F6YJC6Q8BX10 Q8BX10-2 F6YJC6"Serine/threonine-protein phosphatase PGAM5, mitochondrial"Pgam5Pgam5010000321000132110077164170357992S specific2S specific21S specific1S specific134YES
776P57780P57780Alpha-actinin-4Actn4Actn4000000135200017521306800312770779762S specific2S specific2S specific331
707P28652 Q5SVI3 Q5SVJ0 Q5SVI2 Q5SVI0 Q5SVJ1 Q5SVI9 Q5SVI1 Q68EG2 Q3TY93P28652 Q5SVI3 Q5SVJ0 Q5SVI2 Q5SVI0 Q5SVJ1 Q5SVI9 Q5SVI1 Q68EG2 Q3TY93Calcium/calmodulin-dependent protein kinase type II subunit betaCamk2bCamk2b13012323200012356531S specific3.8383.838225YES
281P48453 E0CZ78 P48453-2 G3X8U7 E9Q6P2 Q80XK0 P48455 G3X8V4P48453 E0CZ78 P48453-2 G3X8U7 E9Q6P2Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatasePpp3cbPpp3cb36010000000014616561881201S specific1S specific1S specific225YES
1365Q9D6R2 Q9D6R2-2Q9D6R2 Q9D6R2-2"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial"Idh3aIdh3a2410000000002414915571444139983.5125.1044.308221
271O35526 D6RFB9O35526 D6RFB9Syntaxin-1AStx1aStx1a2310100000002712213540431000580043.6817.4315.55622
876Q03265 D3Z6F5 D6RJ16Q03265 D3Z6F5"ATP synthase subunit alpha, mitochondrial ATP synthase subunit alpha"Atp5a1Atp5a1142132000000152152105020307730405862.5887.5822.3422.3993.728224YES
849P70441P70441Na(+)/H(+) exchange regulatory cofactor NHE-RF1Slc9a3r1Slc9a3r1230001000000331890281416701S specific1S specific1S specific225YES
409P31648 E9Q9F4P31648 E9Q9F4Sodium- and chloride-dependent GABA transporter 1 TransporterSlc6a1Slc6a1220000000000232003103219501S specific1S specific1S specific22
41A2ALV3 Q62420 Q8BXU5 F6ZL13 A2ALV1 Q62419 Q62421A2ALV3 Q62420 Q8BXU5 F6ZL13 A2ALV1Endophilin-A1Sh3gl2Sh3gl222000000000022110930694421S specific1S specific1S specific221
981Q60932 Q60932-2 F2Z471Q60932 Q60932-2Voltage-dependent anion-selective channel protein 1Vdac1Vdac1132200000000132384551191410618801.3663.0932.5172.325225YES
524F8WI94 O55143 O55143-2 Q64518 E9Q559 Q64518-3 B1ATS5 Q64518-2 Q8R429 B1ATS4F8WI94 O55143 O55143-2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Atp2a2Atp2a2220110000000221140732373061S specific1S specific1S specific22
736P40142P40142TransketolaseTktTkt1300000000001311497659641S specific1S specific1S specific221
1156Q8BVE3Q8BVE3V-type proton ATPase subunit HAtp6v1hAtp6v1h120001000000221759071321601S specific1S specific2.3472.34722
825P63085 E9QAJ2 F6VEI7P63085 E9QAJ2Mitogen-activated protein kinase 1Mapk1Mapk12100000000002133507276531S specific1S specific1S specific225YES
1171Q8C0M9Q8C0M9L-asparaginaseAsrgl1Asrgl11200000000001232181473211S specific1S specific1S specific221
96B1AQZ0 B1AQY9 B7ZC46 Q8CHH9-2 Q8CHH9 F7C5C1 E0CYM4B1AQZ0 B1AQY9 B7ZC46 Q8CHH9-2 Q8CHH9Septin-8Sep-08sept81200000000001228267998951S specific1S specific1S specific22
873Q02053Q02053Ubiquitin-like modifier-activating enzyme 1Uba1Uba11200000000001223619428691S specific1S specific1S specific221
1034Q571J7 Q6P1F6 Q9CWU3 Q8BG02Q571J7 Q6P1F6 Q9CWU3Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPpp2r2aPpp2r2a12000100000012121893213331S specific1S specific1S specific22
1409Q9JKC6Q9JKC6Cell cycle exit and neuronal differentiation protein 1Cend1Cend10301100000004227938701S specific15.7812.0228.90222
295E9PV66E9PV66Myo18bMyo18bMyo18b11100000000121211716500103260058454188121881229.36517.66523.51522
1203Q8K2B3Q8K2B3"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"SdhaSdha1100000000002172706290981S specific1S specific1S specific224YES
518F8WHB1 Q9R0K7 Q6DIB8F8WHB1 Q9R0K7Plasma membrane calcium-transporting ATPase 2Atp2b2Atp2b211002000000011364467729081S specific1S specific1.9301.930221YES
1368Q9D8N0Q9D8N0Elongation factor 1-gammaEef1gEef1g1100000000001141660393391S specific1S specific1S specific221
501F7C0H6 Q5M8N0F7C0H6 Q5M8N0CB1 cannabinoid receptor-interacting protein 1Cnrip1Cnrip11100000000001137567526761S specific1S specific1S specific22
828P63141P63141Potassium voltage-gated channel subfamily A member 2Kcna2Kcna21100000000001135615418181S specific1S specific1S specific225YESYES
660G3UWA6 P10852G3UWA6 P108524F2 cell-surface antigen heavy chainSlc3a2Slc3a21101000000101232328264432161361613610.0001S specific1S specific0.3790.37922
1082Q7TSJ2 Q7TSJ2-2 D3Z6W1 Q7TSJ2-3Q7TSJ2 Q7TSJ2-2 D3Z6W1 Q7TSJ2-3Microtubule-associated protein 6Map6 Mtap6Mtap61100000000001120711298651S specific1S specific1S specific22
816P62874P62874Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Gnb1Gnb11100000000001116246298011S specific1S specific1S specific223
1313Q9CPQ1Q9CPQ1Cytochrome c oxidase subunit 6CCox6cCox6c110000000000118079.2243941S specific1S specific1S specific22
333E9Q557 E9PZW0E9Q557 E9PZW0DesmoplakinDspDsp000132011121153111211237429149205058603145540.8502.0032.7797.4775.12822
1159Q8BWF0Q8BWF0"Succinate-semialdehyde dehydrogenase, mitochondrial"Aldh5a1Aldh5a101001000000011169641S specific14.13814.138221
1197Q8K0T0 Q4FZ95 A3QM89 Q7M6W1Q8K0T0Reticulon-1Rtn1Rtn101010000000012139351S specific2.6952.69522
985Q61171 D3Z4A4Q61171 D3Z4A4Peroxiredoxin-2Prdx2Prdx210001100000112117.1635.1846.173223YES
55A2ARP8 Q9QYR6-2 Q9QYR6A2ARP8 Q9QYR6-2 Q9QYR6Microtubule-associated protein 1A MAP1 light chain LC2Mtap1a Map1aMtap1a0002110000004226.7261.7537.1955.225222
549G3UYQ4G3UYQ4Adenylate kinase domain-containing 1Akd1Akd10001110000004415.22932.70718.96822
908Q3TXX4Q3TXX4Vesicular glutamate transporter 1Slc17a7Slc17a7000101000000213.9113.0013.45622
472F6VAN0F6VAN0Atf6Atf6Atf6000110000000122.5874.5003.54322
724P35436P35436Glutamate [NMDA] receptor subunit epsilon-1Grin2aGrin2a0001520000001933.6503.8473.748225YESYES
669P14094P14094Sodium/potassium-transporting ATPase subunit beta-1Atp1b1Atp1b1000000011000111576501354702S specific2S specific225YES
54P30275 A2ARP5 B0R0E9 B0R0E8 B0R0F0P30275 A2ARP5 B0R0E9 B0R0E8"Creatine kinase U-type, mitochondrial"Ckmt1Ckmt10000000110001160173326122S specific2S specific221
1362Q9D6F9Q9D6F9Tubulin beta-4A chainTubb4aTubb4a574786242001115.8285.82811
237P54227 D3Z5N2 D3Z1Z8P54227 D3Z5N2 D3Z1Z8StathminStmn1Stmn15620000000005723623206901301591302.2774.3373.30711
1003Q62188 E9PWE8 Q3TT92 D3YUS0 D3Z567Q62188 E9PWE8 Q3TT92Dihydropyrimidinase-related protein 3Dpysl3Dpysl346301000000032142810447513.1913.19111
1108Q8BFZ3Q8BFZ3Beta-actin-like protein 2Actbl2Actbl2221222111001174569001S specific1S specific11
1339Q9CYT6 D3YTR7Q9CYT6 D3YTR7Adenylyl cyclase-associated protein 2 Adenylyl cyclase-associated proteinCap2Cap22438550000002441712163847906195304105900.9371.5091.1521.6362.9441.63611
979Q60864Q60864Stress-induced-phosphoprotein 1Stip1Stip1511010000000611129187038065334038.7381.1404.939111
745P46660P46660Alpha-internexinInaIna140000000000141188901S specific1S specific111
1253Q91V12-4 Q91V12-2 E9PYH2 Q91V12 Q91V12-3Q91V12-4 Q91V12-2 E9PYH2 Q91V12 Q91V12-3Cytosolic acyl coenzyme A thioester hydrolaseAcot7Acot72210000000002313752695742231951.6184.1282.873115YES
692F8WGL3 P18760 E9Q1T2 P45591F8WGL3 P18760 E9Q1T2Cofilin-1Cfl1 Gm6180Cfl112000000000012638141S specific1S specific114YES
735P40124 B1ARS0P40124 B1ARS0Adenylyl cyclase-associated protein 1 Adenylyl cyclase-associated proteinCap1Cap11113340000001117665283558487697330.7580.8391.5061.6627.9272.538111
1407Q9JJV2 Q9JJV2-3 Q9JJV2-2 D3YWS3Q9JJV2 Q9JJV2-3 Q9JJV2-2 D3YWS3Profilin-2 ProfilinPfn2Pfn211210000000011211710134110299970.5701.1373.4241.71111
1309Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2Protein phosphatase 1BPpm1bPpm1b201103000000211415522175780.8831.33110.1814.13211
1471B7ZNM7 Q9Z2Q6 Q52KH2B7ZNM7 Q9Z2Q6 Q52KH2Septin-5Sept5Sept50200000000002455551S specific1S specific113YES
806P62259 D6REF3 F6WA09 O70456P62259 D6REF3 F6WA0914-3-3 protein epsilonYwhaeYwhae0200000000002425671S specific1S specific113YES
627P00405 Q7JCZ1P00405 Q7JCZ1Cytochrome c oxidase subunit 2Mtco2 mt-Co2Mtco211000000000011273581S specific1S specific11
343E9QK41 Q8K4G5 E9Q9C2 E9Q9C1 E9Q9C9 E9Q9C0 E9Q9C8 Q8K4G5-2 E9Q9C4 E9Q1E8 E9Q9C7 Q8K4G5-4 E9Q030 Q8K4G5-3 E9Q9D2 E9Q9D1 E9Q9Q7 F6YHE5 Q8K4G5-5E9QK41 Q8K4G5 E9Q9C2 E9Q9C1 E9Q9C9 E9Q9C0 E9Q9C8 Q8K4G5-2 E9Q9C4 E9Q1E8 E9Q9C7 Q8K4G5-4 E9Q030 Q8K4G5-3 E9Q9D2 E9Q9D1 E9Q9Q7Actin-binding LIM protein 1Ablim1Ablim10100110100001112221131S specific1S specific115YES
726P35486P35486"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial"Pdha1Pdha111000000000011126711S specific1S specific115YES
620O88737 O88737-2O88737 O88737-2Protein bassoonBsnBsn1100010000001119577.11S specific1S specific11
1221Q8R191Q8R191Synaptogyrin-3Syngr3Syngr31101000000001119149.71S specific1S specific11
1293Q99KI0Q99KI0"Aconitate hydratase, mitochondrial"Aco2Aco211002100000011413.2163.216114YES
101Q60631 B1AT92 Q60631-2 B1AT95Q60631 B1AT92 Q60631-2 B1AT95Growth factor receptor-bound protein 2Grb2Grb21000000000001422731S specific1S specific112
1145Q8BMF4Q8BMF4"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial"DlatDlat1000000000001418021S specific1S specific11
204O08788 E9Q3M3 E9Q586 D3YX34 O08788-2O08788 E9Q3M3 E9Q586 D3YX34 O08788-2Dynactin subunit 1Dctn1Dctn11000000000001287231S specific1S specific11
510Q62277 F8WGK2 F6VR28Q62277 F8WGK2SynaptophysinSypSyp1000000000001281751S specific1S specific111
654P09411 P09041P09411Phosphoglycerate kinase 1Pgk1Pgk110001000000011200701S specific1S specific115YES
1405Q9JIS5Q9JIS5Synaptic vesicle glycoprotein 2ASv2aSv2a1000000000001151611S specific1S specific11
332E9PZJ8E9PZJ8Activating signal cointegrator 1 complex subunit 3Ascc3Ascc30100000000001193280001S specific1S specific11
1363Q9D6J5Q9D6J5"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial"Ndufb8Ndufb801000000000021044801S specific1S specific11
613Q76LV0 O70325 O70325-2Q76LV0 O70325 O70325-2"Glutathione peroxidase Phospholipid hydroperoxide glutathione peroxidase, mitochondrial"Gpx4Gpx40100000000001576121S specific1S specific113YES
1289Q99JI4Q99JI426S proteasome non-ATPase regulatory subunit 6Psmd6Psmd60100000000001561431S specific1S specific11
727P35762 Q91V78P35762 Q91V78CD81 antigenCd81Cd810100000000002490961S specific1S specific11
760P50518P50518V-type proton ATPase subunit E 1Atp6v1e1Atp6v1e10100000000001391821S specific1S specific11
1199Q8K183 D3Z7R1Q8K183Pyridoxal kinasePdxkPdxk0100000000001269191S specific1S specific111
1119Q8BGZ1 F2Z3Z1Q8BGZ1 F2Z3Z1Hippocalcin-like protein 4Hpcal4Hpcal40100000000001266471S specific1S specific11
834P67778P67778ProhibitinPhbPhb0100000000001254731S specific1S specific111
212P42208 E9Q3V6 D3Z3C0 D3YYB1 F6WYM0 D3Z1S1 D3YZU7 F6UKN5P42208 E9Q3V6 D3Z3C0 D3YYB1 F6WYM0 D3Z1S1 D3YZU7 F6UKN5Septin-2Sept2sept20100000000001244981S specific1S specific111
1262Q91X97Q91X97Neurocalcin-deltaNcaldNcald0100000000001236891S specific1S specific111
544O70585 G3UYM7 O70585-2 G3UZ87 Q8C8Z9 Q8K0N0 G3UY34 G3UXK0 G3UZJ3 G3UXI3 E9QAY9 G3UXH9 G3UYK9 G3UYN2 G3UX96O70585 G3UYM7 O70585-2 G3UZ87 Q8C8Z9 Q8K0N0 G3UY34 G3UXK0 G3UZJ3 G3UXI3 E9QAY9 G3UXH9Dystrobrevin betaDtnbDtnb010100000010111197661S specific0.3140.31411
52A2AQR0 Q64521A2AQR0 Q64521"Glycerol-3-phosphate dehydrogenase, mitochondrial"Gpd2Gpd20100000000001171421S specific1S specific111
858P84084 E9Q2C2 D3YV25P84084ADP-ribosylation factor 5Arf5Arf50100000000001150811S specific1S specific11
695P19783P19783"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial"Cox4i1Cox4i10100000000001149351S specific1S specific11
709P28663 D6RHL2P28663 D6RHL2Beta-soluble NSF attachment proteinNapbNapb0100000000001146071S specific1S specific111
387Q9D6M3 E9Q6M6 E9PY45 E9PV90 E9Q579Q9D6M3 E9Q6M6 E9PY45 E9PV90 E9Q579Mitochondrial glutamate carrier 1Slc25a22Slc25a220100000000001124741S specific1S specific111
932Q3UNH4Q3UNH4G protein-regulated inducer of neurite outgrowth 1Gprin1Gprin101000100000012120861S specific1S specific11
897Q8BW96 Q8BW96-3 Q8BW96-2 Q3TDM2Q8BW96 Q8BW96-3 Q8BW96-2 Q3TDM2Calcium/calmodulin-dependent protein kinase type 1DCamk1dCamk1d0100000000001111191S specific1S specific11
1302Q99M71 Q99M71-2Q99M71 Q99M71-2Mammalian ependymin-related protein 1Epdr1Epdr10100000000001110901S specific1S specific11
1072Q76MZ3 G3UWS4 Q3TTF6 Q7TNP2 G3UWL2 G3UXQ1Q76MZ3Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPpp2r1aPpp2r1a0100000000001110691S specific1S specific111
211Q91YS4 D3YXZ3 E9QL75 O88448 D3Z5Y7 Q9DBS5Q91YS4 D3YXZ3 E9QL75 O88448 D3Z5Y7Kinesin light chain 2Klc2Klc20100000000001110381S specific1S specific11
703P26443 F7CFA5P26443 F7CFA5"Glutamate dehydrogenase 1, mitochondrial"Glud1Glud101001000000011106031S specific0.4730.473111
739P42932P42932T-complex protein 1 subunit thetaCct8Cct80100000000001102801S specific1S specific11
852P80313P80313T-complex protein 1 subunit etaCct7Cct7010000000001119784.61S specific1S specific11
634P03930 Q7JCZ0P03930 Q7JCZ0ATP synthase protein 8Mtatp8 mt-Atp8Mtatp801000000000019279.21S specific1S specific11
508F8WGC2 Q07076F8WGC2 Q07076Annexin Annexin A7Anxa7Anxa701000000000018668.51S specific1S specific11
278P13707 E0CXN5P13707 E0CXN5"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic"Gpd1Gpd101000000000018466.91S specific1S specific111
697P20357 Q80ZL4 Q80X35 G3UZK9 Q3TLQ0 G3UZV6 G3UWW1 G3UZE9 F7ALC8 E9Q8Y2P20357Microtubule-associated protein 2Map2Map2010001000000127799.21S specific1.8181.81811
1269Q91YQ5Q91YQ5Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1Rpn1Rpn101000000000016705.61S specific1S specific11
666P12960P12960Contactin-1Cntn1Cntn101000000000015901.31S specific1S specific111
840P70168P70168Importin subunit beta-1Kpnb1Kpnb1010000000000156341S specific1S specific11
1134Q8BJY1Q8BJY126S proteasome non-ATPase regulatory subunit 5Psmd5Psmd501000000000015490.11S specific1S specific11
874Q02257Q02257Junction plakoglobinJupJup000071001001111423636501471301471302.4725.4155.41511
1307Q99MY8Q99MY8Histone-lysine N-methyltransferase ASH1LAsh1lAsh1l000100000000111.79911.79911
542Q60930 G3UX26 D3YZT5Q60930 G3UX26 D3YZT5Voltage-dependent anion-selective channel protein 2Vdac2Vdac200010000000025.5365.536115YES
1023Q66JY6Q66JY6Vav-like protein C9orf100 homolog00010000000012.6592.65911
1267Q91YL3 D6RJ84 F7CAK3Q91YL3 D6RJ84 F7CAK3Uridine-cytidine kinase-like 1 Uridine kinaseUckl1Uckl1000010000000223.85723.85711
986Q61176Q61176Arginase-1Arg1Arg100002000000032.7372.73711
680P16388P16388Potassium voltage-gated channel subfamily A member 1Kcna1Kcna1000011000000212.5822.582115YESYES
356E9Q2W9 D3Z0L8 D3Z761E9Q2W9 D3Z0L8Actinin alpha 4Actn4Actn40000008210001752582S specific111
877Q04447Q04447Creatine kinase B-typeCkbCkb1020001000001229159412495001864002S specific10.0730.0731
335E9Q019 F6TL02 P11088 F6YPY4 F7BVV1 F7CLU3E9Q019 F6TL02 P11088 F6YPY4 F7BVV1 F7CLU3FilaggrinFlgFlg00000020000023003502S specific11
433Q62415 E9QLE7 F6YJV5 E9Q889Q62415 E9QLE7 F6YJV5 E9Q889Apoptosis-stimulating of p53 protein 1Ppp1r13bPpp1r13b0010001011111222132115301157800019951002650400210840022513000.0945.14311
560Q8CGP2-2 Q921L4 Q8CBB6 P10853 P10854 Q64475 Q64478 Q64524 Q64525 Q6ZWY9 Q8CGP0 Q8CGP1 Q8CGP2 Q9D2U9 G3X9D5Q8CGP2-2 Q921L4 Q8CBB6 P10853 P10854 Q64475 Q64478 Q64524 Q64525 Q6ZWY9 Q8CGP0 Q8CGP1 Q8CGP2 Q9D2U9 G3X9D5Histone H2B Histone H2B type 1-F/J/L Histone H2B type 1-M Histone H2B type 1-B Histone H2B type 1-H Histone H2B type 2-E Histone H2B type 2-B Histone H2B type 1-C/E/G Histone H2B type 3-B Histone H2B type 1-K Histone H2B type 1-P Histone H2B type 3-AGm13646 Hist1h2bf Hist1h2bm Hist1h2bb Hist1h2bh Hist2h2be Hist2h2bb Hist1h2bc Hist3h2bb Hist1h2bk Hist1h2bp Hist3h2baHist1h2bb0000000100001769972S specific112
0A0JNY3 Q8BUV3A0JNY3 Q8BUV3Gephyrin Molybdopterin adenylyltransferase Molybdopterin molybdenumtransferaseGphnGphn0000000100001620522S specific11
830P63260 E9Q607 B1ATY1 G3UYG0P63260 E9Q607 B1ATY1"Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed"Actg1Actg11513131413966701381081210
1077Q7TMM9Q7TMM9Tubulin beta-2A chainTubb2aTubb2a57578525300211144162900165080722692.2542.2840.9732.0291.8850
348E9Q1Z0E9Q1Z04732456N10Rik4732456N10Rik4732456N10Rik3400211132131344433430
90P07356 B0V2N7 B0V2N5 B0V2N8P07356 B0V2N7 B0V2N5 B0V2N8Annexin A2 AnnexinAnxa2Anxa245300100000046421366003277601827000.7481.7941.2710
773P56480P56480"ATP synthase subunit beta, mitochondrial"Atp5bAtp5b433110000000554322536802290502046101.2401.1191.2522.3731.49603YES
770Q9CZ46 P55821Q9CZ46 P55821Stathmin-2Stmn2Stmn2232000000000222670001599201.6701.6700
1246Q8VGN0Q8VGN0Olfactory receptor 1233Olfr1233Olfr123311100011111132541226640
645P07901 B7ZC50 B7ZC49 A2A6A2P07901Heat shock protein HSP 90-alphaHsp90aa1Hsp90aa1320333000000201
1345Q9D051Q9D051"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial"PdhbPdhb13200000000013245046165380786940.5722.1021.33705YES
1301Q99LX0 A2A813 A2A815 A2A816 A2A817Q99LX0 A2A813 A2A815 A2A816 A2A817Protein DJ-1Park7Park72110100000002111122270220231143601.0690.1930.63104YES
732P38647 Q7TSZ0P38647 Q7TSZ0"Stress-70 protein, mitochondrial"Hspa9Hspa9211011000000211216267722095380551.6470.5812.0021.41001
690P17897P17897Lysozyme C-1Lyz1Lyz100010011100051110
256D3Z623D3Z6239330159F19Rik9330159F19Rik9330159F19Rik0000001110005170
848P70398 Q4FE56 F8VPU6P70398 Q4FE56Probable ubiquitin carboxyl-terminal hydrolase FAF-X Ubiquitin carboxyl-terminal hydrolaseUsp9xUsp9x0000001111111212310
712Q3U9N4 P28798Q3U9N4 P28798Granulins Acrogranin Granulin-1 Granulin-2 Granulin-3 Granulin-4 Granulin-5 Granulin-6 Granulin-7GrnGrn1110000000002111701002999901767100.9631.6981.3300
978Q60829 Q60829-2Q60829 Q60829-2Protein phosphatase 1 regulatory subunit 1BPpp1r1bPpp1r1b1110000000001116573248547592551.1090.8190.9640
100Q9DCX2 G3X9L6 B1ASE2Q9DCX2 G3X9L6 B1ASE2"ATP synthase subunit d, mitochondrial"Atp5h Gm10250Atp5h1110000000001116126359250286642.1372.0672.1020
267P47754 D6RCW7P47754 D6RCW7F-actin-capping protein subunit alpha-2Capza2Capza21110000000001115987377836491101.2191.5851.40204YES
1180Q8C845 Q9D8Y0 Q9D4J1Q8C845 Q9D8Y0EF-hand domain-containing protein D2Efhd2Efhd21110000000001114790038793540860.8860.7170.8010
815P62814 Q91YH6P62814"V-type proton ATPase subunit B, brain isoform"Atp6v1b2Atp6v1b21120000000001124477841603287151.5591.4491.50401
1449Q9WV69 Q9WVM2 E9Q1G7 Q8JZV5Q9WV69 Q9WVM2 E9Q1G7 Q8JZV5DematinEpb49 Epb4.9Epb49 Epb4.91110000000001112681849592280120.9571.7701.3640
1076Q7TMF3Q7TMF3NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Ndufa12Ndufa121110000000001112058613243153351.3420.8641.1030
1316Q9CQ75Q9CQ75NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2Ndufa2Ndufa21110000000001117411.8134366660.31.1132.0171.5650
1344Q9CZY3 E9PY39 B7ZBY7 D3Z1I3 D3YXL3 Q9CZY3-2 D3Z6R2 B7ZBY6Q9CZY3 E9PY39 B7ZBY7 D3Z1I3 D3YXL3 Q9CZY3-2Ubiquitin-conjugating enzyme E2 variant 1Ube2v1 Gm20431 Gm8325 Gm5830Ube2v1021000000000212137701726001.2391.23903
87B0QZN5 P63044 F6Q6A5 P63024 D3YTU0 Q62442 Q62442-2B0QZN5 P63044 F6Q6A5 P63024Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 3Vamp2 Vamp3Vamp20210000000003270060281212.4912.49103YES
706P27773 F6Q404P27773Protein disulfide-isomerase A3Pdia3Pdia302210000000022170049512721.3661.36601
1353Q9D2M8 Q9D2M8-2 A6X925 B2KF55Q9D2M8 Q9D2M8-2Ubiquitin-conjugating enzyme E2 variant 2Ube2v2Ube2v20210000000001124613295970.8320.83202
793P60879 P60879-2P60879 P60879-2Synaptosomal-associated protein 25Snap25Snap2511000100000022101
892Q3TBD8Q3TBD8Rhobtb2Rhobtb2Rhobtb2100000100000110
864P97350P97350Plakophilin-1Pkp1Pkp1000111101000453110
314E9PX96 Q3SXH3E9PX96 Q3SXH3Seminal vesicle antigenSvaSva0000101100001110
867P97393P97393Rho GTPase-activating protein 5Arhgap5Arhgap5000000110000310
1144Q8BMC1Q8BMC1V-type proton ATPase subunit G 3Atp6v1g3Atp6v1g3000000011000110
919Q3UEB3 Q3UEB3-2 Q3UEB3-3Q3UEB3 Q3UEB3-2 Q3UEB3-3Poly(U)-binding-splicing factor PUF60Puf60Puf600110000000001126189424440.6170.6170
750P47757 P47757-2 A2AMW0 F7CAZ6 F6YHZ8 F6QJN8P47757 P47757-2 A2AMW0F-actin-capping protein subunit betaCapzbCapzb0110000000001124651152951.6121.6120
392E9Q793E9Q7934931429I11Rik4931429I11Rik4931429I11Rik010100000000210
573G5E8Z1G5E8Z1Gm6788Gm6788Gm6788010100000000120
341Q61699 E9Q0U7 Q61699-2 D3Z027Q61699 E9Q0U7 Q61699-2Heat shock protein 105 kDaHsph1Hsph101000000000010
297Q61026 E9PV80Q61026 E9PV80Nuclear receptor coactivator 2Ncoa2Ncoa201000000000010
1245Q8VFH0Q8VFH0Olfr1361Olfr1361Olfr136101000000000010
506F8VPQ1 Q8CIQ7 F6VMI1 F7CVM6F8VPQ1 Q8CIQ7 F6VMI1 F7CVM6Dedicator of cytokinesis protein 3Dock3Dock301000000000010
647P08032P08032"Spectrin alpha chain, erythrocyte"Spta1Spta10001101000004210
638A6ZI44 P05064 D3YWI1 D3YV98 Q9CPQ9 D3Z510 A6ZI47A6ZI44 P05064 D3YWI1 D3YV98 Q9CPQ9 D3Z510Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase AAldoa Aldoart1Aldoa0001000100002101
1127Q8BI79-2 Q8BI79 Q8BI79-3Q8BI79-2 Q8BI79 Q8BI79-3Coiled-coil domain-containing protein 40Ccdc40Ccdc4000011001001011110
1276Q91ZX7 Q3U5J2Q91ZX7Prolow-density lipoprotein receptor-related protein 1 Low-density lipoprotein receptor-related protein 1 85 kDa subunit Low-density lipoprotein receptor-related protein 1 515 kDa subunit Low-density lipoprotein receptor-related protein 1 intracellular domainLrp1Lrp100010110000012102YES
1022Q64727Q64727VinculinVclVcl00000010000010
117Q9ERG2 B2RQS1 B3STQ1Q9ERG2 B2RQS1 B3STQ1Striatin-3Strn3Strn300000010000010
1304Q99ML6Q99ML6Slc25a2Slc25a2Slc25a2000000010010320
123O88532 B2RUG7 F6V459O88532 B2RUG7 F6V459Zinc finger RNA-binding proteinZfrZfr000000010001110
2Q05BA5 A2A468 E9QPU8 O09000Q05BA5 A2A468 E9QPU8 O09000Nuclear receptor coactivator 3Ncoa3Ncoa300000001000010
206D3YX99 Q9CQH3 D3Z6W9 F6Y6V5 D3Z568D3YX99 Q9CQH3 D3Z6W9 F6Y6V5 D3Z568"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial"Ndufb5Ndufb5001000010000110
847P70388 Q5SV02 E9QPC6 P70388-2 P70388-3P70388 Q5SV02 E9QPC6 P70388-2 P70388-3DNA repair protein RAD50Rad50Rad5000000001000010
940Q3UVT7 Q9JHU2 D3Z486Q3UVT7 Q9JHU2 D3Z486PalmdelphinPalmdPalmd00000001000010
973Q60604 Q60604-2Q60604 Q60604-2AdseverinScinScin00000001000010
245D3Z3A8 Q8C170-2 Q8C170D3Z3A8 Q8C170-2 Q8C170Unconventional myosin-IXaMyo9aMyo9a00000000100010
34F8WIR7 A2AIY8 Q8VD37 Q8VD37-3 D3YVG6 Q8VD37-4 Q8VD37-2 E9QMC8 F7CPX0 E9PVY1 Q8VD37-5 A2AIY5F8WIR7 A2AIY8 Q8VD37 Q8VD37-3 D3YVG6 Q8VD37-4 Q8VD37-2 E9QMC8 F7CPX0 E9PVY1SH3-containing GRB2-like protein 3-interacting protein 1Sgip1Sgip10001110000002112.1200.9751.5480
571G5E8N5 P06151 P00342 D3YZQ9 D3YZE4 D3Z736 D3YVR7G5E8N5 P06151L-lactate dehydrogenase L-lactate dehydrogenase A chainLdhaLdha0001110000001112.0412.3332.18701
400E9QLA0 Q8CAQ8-5 Q8CAQ8 Q8CAQ8-2 E9QAY3 Q8CAQ8-3 E9Q800 E9QAY6E9QLA0 Q8CAQ8-5 Q8CAQ8 Q8CAQ8-2 E9QAY3 Q8CAQ8-3 E9Q800 E9QAY6Mitochondrial inner membrane proteinImmtImmt000101000000111.9921.99201
275Q9D0M5 D6RIN4Q9D0M5 D6RIN4"Dynein light chain 2, cytoplasmic"Dynll2Dynll200010000000021.9781.9780
1452Q9Z0E0 Q9Z0E0-2Q9Z0E0 Q9Z0E0-2NeurochondrinNcdnNcdn000101000000111.8231.82301
982Q61074Q61074Protein phosphatase 1GPpm1gPpm1g00010000000011.3151.3150
1369Q9D8U8Q9D8U8Sorting nexin-5Snx5Snx500010000000010.8130.8130
1308Q99N03 Q99N03-2Q99N03 Q99N03-2Membrane-spanning 4-domains subfamily A member 10Ms4a10Ms4a1000010000000010.7140.7140
1173Q8C1X1 A6H5Z3 A6H5Z3-2Q8C1X1 A6H5Z3 A6H5Z3-2Exocyst complex component 6BExoc6bExoc6b000110000000310.6250.6840.6550
1420Q9QWK4Q9QWK4CD5 antigen-likeCd5lCd5l00010000000010.3630.3630
521F8WHW6 O70161 O70161-3 O70161-2 F7C0X9 F6SMP3F8WHW6 O70161 O70161-3 O70161-2 F7C0X9Phosphatidylinositol 4-phosphate 5-kinase type-1 gammaPip5k1cPip5k1c000210000000210.3281.3870.8580
65Q99PL5 A2AVJ7 Q99PL5-2 E9PUZ4 Q99PL5-3 Q99PL5-4Q99PL5 A2AVJ7 Q99PL5-2 E9PUZ4 Q99PL5-3 Q99PL5-4Ribosome-binding protein 1Rrbp1Rrbp10001110000004430.1580.3260.0900.1910
710P28665 P28666P28665 P28666Murinoglobulin-1 Murinoglobulin-2Mug1 Mug2Mug1 Mug20004110000008220.1452.1942.1391.4930
651P08551 P31001 P20152 E9PZV5P08551Neurofilament light polypeptideNeflNefl00001000000011.8931.89304YES
733P39053-3P39053-3Isoform 3 of Dynamin-1Dnm1Dnm100001000000021.8801.8800
626O89053 G3UYK8 D3YW57 D3YXM2 G3UX53O89053 G3UYK8Coronin-1ACoro1aCoro1a00001000000010.9260.9260
496F7B0R9 E9Q3M9 E9Q887F7B0R9 E9Q3M9 E9Q8872010300C02Rik2010300C02Rik2010300C02Rik00001000000010.8610.8610
1382Q9DBZ5 Q3TY56 Q9DBZ5-2Q9DBZ5 Q3TY56 Q9DBZ5-2Eukaryotic translation initiation factor 3 subunit KEif3kEif3k00001000000010.7880.7880
320Q03391 E9PYG0Q03391 E9PYG0Glutamate [NMDA] receptor subunit epsilon-4Grin2dGrin2d000120000000140.7860.78605YESYES
1176Q8C5U4Q8C5U4Uncharacterized protein C17orf74 homolog00001000000010.7840.7840

Supplementary Table 2. Known Arc interactors.

Protein ID Gene Name Protein Name PMID Interaction Detection Method ARC Complex
P28652 Camk2b Calcium/calmodulin-dependent protein kinase type II subunit beta 22579289 Fluorescence resonance energy transfer, pull down, two hybrid, confocal microscopy, anti bait coimmunoprecipitation Yes
P35438 P35438-2 Grin1 Glutamate [NMDA] receptor subunit zeta-1 16635246 10862698 Anti bait coimmunoprecipitation, affinity chromatography, coimmunoprecipitation Yes
G3X9V4 Q01097 Grin2b Glutamate [NMDA] receptor subunit epsilon-2 10862698 Affinity chomatography Yes
P49768 Psen1 Presenilin-1 22036569 Coimmunoprecipitation, anti tag coimmunoprecipitation No
Q62108 Q62108-3 Q62108-2 G3UZL5 Dlg4 Disks large homolog 4 19455133 Anti tag coimmunoprecipitation anti bait coimmunoprecipitation Yes
Q80TN1 P11798 F8WIS9 Camk2a Calcium/calmodulin-dependent protein kinase type II subunit alpha 22579289 Pull down Yes
P39054 Dnm2 Dynamin-2 17088211 Two hybrid, immunoprecipitation No
Q62419 Sh3gl1 Endophilin-A2 17088211 Two hybrid, immunoprecipitation No
Q62421 Sh3gl3 Endophilin-A3 17088211 Immunoprecipitation No

Supplementary Table 3. iBAQ intensity numbers of Arc and PSD95.

Gene Name Protein Name iBAQ 1S-ARC14 iBAQ 1S-ARC15 iBAQ Tandem-ARC02 iBAQ Tandem-ARC03 iBAQ Tandem-ARC05
Arc Activity-regulated cytoskeleton-associated protein 1244600 1500100 2232600 2832800 4102700
Dlg4 Disks large homolog 4 1463300 948450 829540 1069900 974540

Supplementary Table 4. iBAQ intensity numbers of the ARC-core interactors.

Gene Name Protein Name iBAQ Tandem-ARC02 iBAQ Tandem-ARC03 iBAQ Tandem-ARC05 Average iBAQ
Arc Activity-regulated cytoskeleton-associated protein 2232600 2832800 4102700 3056033.3
Dlg4 Disks large homolog 4 829540.0 1069900.0 974540.0 957993.3
Actb Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 194890.0 311590.0 141920.0 216133.3
Dlg2 Disks large homolog 2 61800.0 86701.0 105560.0 84687.0
Tuba1a;Tuba3a Tubulin alpha-1A chain;Tubulin alpha-3 chain 44723.0 51008.0 56346.0 50692.3
Plp1 Myelin proteolipid protein 33085.0 55229.0 53045.0 47119.7
Camk2a Calcium/calmodulin-dependent protein kinase type II subunit alpha 18917.0 66774.0 47643.0 44444.7
H2afx* Histone H2A.x 36032.0 14041.0 61609.0 37227.3
Mbp Myelin basic protein 4399.9 58064.0 43708.0 35390.6
Tuba4a Tubulin alpha-4A chain 19489.0 15759.0 57612.0 30803.3
Glul Glutamine synthetase 27712.0 46296.0 8533.8 27513.9
Tubb5 Tubulin beta-5 chain 15150.0 15846.0 25212.0 18736.0
Dlg1 Disks large homolog 1 11885.0 17492.0 22256.0 17211.0
Adam22 Disintegrin and metalloproteinase domain-containing protein 22 9999.2 14691.0 7924.5 10871.6
Actn4 Alpha-actinin-4 23759.0 5686.7 1417.7 10287.8
Hspa8 Heat shock cognate 71 kDa protein 7456.4 7989.8 13555.0 9667.1
Prrt1 Proline-rich transmembrane protein 1 7187.6 10525.0 9782.9 9165.2
Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 0.0 13138.0 11289.0 8142.3
Cldn11 Claudin-11 12986.0 10355.0 0.0 7780.3
Pet2 Pet2 protein 6978.3 4460.4 11483.0 7640.6
Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 3994.7 6810.6 11108.0 7304.4
Dpysl2 Dihydropyrimidinase-related protein 2 6890.4 2559.1 7757.3 5735.6
Kcnj4 Inward rectifier potassium channel 4 2569.2 10205.0 4145.9 5640.0
Tubb4b Tubulin beta-4B chain 1510.6 13018.0 1617.3 5382.0
Slc25a3 Phosphate carrier protein, mitochondrial 2551.8 3771.1 5001.4 3774.8
Slc25a4;Slc25a5 ADP/ATP translocase 1;ADP/ATP translocase 2 3266.6 3310.9 3421.2 3332.9
Pgam5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 8208.5 1790.0 0.0 3332.8
Stxbp1 Syntaxin-binding protein 1 2348.5 847.3 4259.2 2485.0
Gapdh* Glyceraldehyde-3-phosphate dehydrogenase 2405.7 3158.3 0.0 1854.7
Ubc* Polyubiquitin-C 3266.5 0.0 1854.2 1706.9
Dlgap4 Disks large-associated protein 4 1665.6 1085.3 1971.5 1574.1
Ckmt1 Creatine kinase U-type, mitochondrial 0.0 2865.4 1553.0 1472.8
Begain Brain-enriched guanylate kinase-associated protein 1591.9 0.0 2680.8 1424.2
Dlgap1 Disks large-associated protein 1 0.0 2714.6 1352.4 1355.7
Crmp1 Dihydropyrimidinase-related protein 1 1856.8 0.0 2141.8 1332.9
Grin1 Glutamate [NMDA] receptor subunit zeta-1 0.0 1518.8 1274.6 931.1
Lgi1 Leucine-rich glioma-inactivated protein 1 0.0 1480.6 1255.5 912.0
Dlgap2 Disks large-associated protein 2 865.5 753.9 0.0 539.8
Iqsec2 IQ motif and SEC7 domain-containing protein 2 1015.3 393.22 0.0 469.5

Supplementary Table 5. Biological process and Molecular Function of 107 Arc interactors.

Gene nameProtein IDProtein namesBiological ProcessMolecular FunctionReplicates enriched (1S)Replicates enriched (Tandem)Replicates enriched (1S plus Tandem)
Dlg1Q811D0Disks large homolog 1Adaptor/ RegulatoryTransmembrane receptor regulatory/adaptor538
Dlg2Q91XM9Disks large homolog 2Adaptor/ RegulatoryTransmembrane receptor regulatory/adaptor538
Dlg4Q62108 Q62108-3 Q62108-2 G3UZL5Disks large homolog 4Adaptor/ RegulatoryTransmembrane receptor regulatory/adaptor538
Dlgap1Q3UVU8Disks large-associated protein 1Adaptor/ RegulatoryTransmembrane receptor regulatory/adaptor527
Dlgap2Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6Disks large-associated protein 2Adaptor/ RegulatoryTransmembrane receptor regulatory/adaptor325
Dlgap3Q6PFD5 B1AS06Disks large-associated protein 3Adaptor/ RegulatoryTransmembrane receptor regulatory/adaptor33
Dlgap4B1AZP2-2 B1AZP2 B7ZNS2 B1AZP2-3 F6YMR0 E9PUF2Disks large-associated protein 4Adaptor/ RegulatoryTransmembrane receptor regulatory/adaptor538
Lgi1Q9JIA1 D3YW56Leucine-rich glioma-inactivated protein 1Adaptor/ RegulatoryReceptor binding protein Extracellular matrix224
Prrt1O35449Proline-rich transmembrane protein 1Adaptor/ RegulatoryAMPA receptor function modulator235
Rtn1Q8K0T0 Q4FZ95 A3QM89 Q7M6W1Reticulon-1Adaptor/ RegulatoryProtein binding22
Slc9a3r1P70441Na(+)/H(+) exchange regulatory cofactor NHE-RF1Adaptor/ RegulatoryScaffold protein22
Hsp90ab1P11499 E9PX27 E9Q0C3 E9Q3D6 D3Z1R1Heat shock protein HSP 90-betaChaperone/ Protein folding/ SignalingHsp 90 family chaperone44
Hspa4lP48722 P48722-2 E0CY23 F6SMW7 F6TFH3Heat shock 70 kDa protein 4LChaperone/ Protein folding/ SignalingATP binding Chaperone activity33
Hspa8P63017 Q504P4 D3Z5E2 D3YW43Heat shock cognate 71 kDa proteinChaperone/ Protein folding/ SignalingHsp 70 family chaperone538
ActbCON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 G3UZ07 E9Q606 E9QAZ1 F8WGM8 E9Q2D1 F6WX90Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed"Cytoeskeletal/ Structural/ Cell adhesionIntracellular protein transport235
Actn4P57780Alpha-actinin-4Cytoeskeletal/ Structural/ Cell adhesionstructural constituent of cytoskeleton actin binding33
Adam22Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 D3YUQ0 F6PZ09 F6XIT3 F7CDH3 F7DAP1 F7BZ55 F6VJ78 F6XRZ6 F7AYY9 F6TDF4 F6SK63 F7BXL9Disintegrin and metalloproteinase domain-containing protein 22Cytoeskeletal/ Structural/ Cell adhesionMetalloprotease538
ArcQ9WV31Activity-regulated cytoskeleton-associated proteinCytoeskeletal/ Structural/ Cell adhesionUnclassified538
BegainF8WIG2 Q68EF6Brain-enriched guanylate kinase-associated proteinCytoeskeletal/ Structural/ Cell adhesioncytoskeletal adaptor activity426
Cldn11Q60771Claudin-11Cytoeskeletal/ Structural/ Cell adhesionStructural molecule activity325
Crmp1Q6P1J1 P97427 E9Q756Dihydropyrimidinase-related protein 1Cytoeskeletal/ Structural/ Cell adhesionHydrolase activity224
DspE9Q557 E9PZW0DesmoplakinCytoeskeletal/ Structural/ Cell adhesionstructural constituent of cytoskeleton actin binding22
Gpm6aP35802Neuronal membrane glycoprotein M6-aCytoeskeletal/ Structural/ Cell adhesionMyelin protein33
Gpm6bA2AEG6 P35803 E9QPU6 P35803-8 P35803-3Neuronal membrane glycoprotein M6-bCytoeskeletal/ Structural/ Cell adhesionMyelin protein44
MbpF6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2Myelin basic proteinCytoeskeletal/ Structural/ Cell adhesionstructural constituent of myelin sheath235
Mtap1a Map1aA2ARP8 Q9QYR6-2 Q9QYR6Microtubule-associated protein 1A MAP1 light chain LC2Cytoeskeletal/ Structural/ Cell adhesionNon-motor microtubule binding protein22
Map6 Mtap6Q7TSJ2 Q7TSJ2-2 D3Z6W1 Q7TSJ2-3Microtubule-associated protein 6Cytoeskeletal/ Structural/ Cell adhesionMicrotubule binding protein22
Myo18bE9PV66Myo18bCytoeskeletal/ Structural/ Cell adhesionMotor activity structural constituent of cytoskeleton protein binding enzyme regulator activity22
Plp1P60202 F8WGE4 P60202-2Myelin proteolipid proteinCytoeskeletal/ Structural/ Cell adhesionMyelin protein538
Sept8B1AQZ0 B1AQY9 B7ZC46 Q8CHH9-2 Q8CHH9 F7C5C1 E0CYM4Septin-8Cytoeskeletal/ Structural/ Cell adhesionGTPase activity protein binding structural constituent of cytoskeleton22
Tuba1a Tuba3aP68369 P05214 Q3UX10Tubulin alpha-1A chain Tubulin alpha-3 chainCytoeskeletal/ Structural/ Cell adhesionTubulin336
Tuba4aP68368Tubulin alpha-4A chainCytoeskeletal/ Structural/ Cell adhesionTubulin336
Tubb4bP68372Tubulin beta-4B chainCytoeskeletal/ Structural/ Cell adhesionTubulin235
Tubb5P99024 G3UZR1Tubulin beta-5 chainCytoeskeletal/ Structural/ Cell adhesionTubulin325
Baiap2Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3Brain-specific angiogenesis inhibitor 1-associated protein 2Cytoeskeletal/ Structural/ Cell adhesionCytoskeletal Adaptor activity44
Atf6F6VAN0Atf6DNA/RNA bindingsequence-specific DNA binding transcription factor activity22
Eef1gQ9D8N0Elongation factor 1-gammaDNA/RNA bindingtranslation elongation factor activity22
H2afx Hist1h2ab Hist2h2aa1 Hist3h2a Hist1h2af Hist1h2ak Hist2h2ac Hist1h2aa H2afj H2afz H2afv Hist1h2ah Hist1h2al Hist2h2abP27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7Histone H2A.x Histone H2A type 1 Histone H2A type 2-A Histone H2A type 3 Histone H2A type 1-F Histone H2A type 1-K Histone H2A type 2-C Histone H2A Histone H2A.J Histone H2A.Z Histone H2A.V Histone H2A type 1-H Histone H2A type 2-BDNA/RNA bindingDNA binding235
Ckmt1P30275 A2ARP5 B0R0E9 B0R0E8 B0R0F0"Creatine kinase U-type, mitochondrial"Enzymekinase activity transferase activity22
Cox6cQ9CPQ1Cytochrome c oxidase subunit 6CEnzymecytochrome-c oxidase activity22
Akd1G3UYQ4Adenylate kinase domain-containing 1Enzymenucleotide kinase activity22
Aldh5a1Q8BWF0"Succinate-semialdehyde dehydrogenase, mitochondrial"Enzymeoxidoreductase activity22
Asrgl1Q8C0M9L-asparaginaseEnzymeArginase activity22
Dpysl2O08553Dihydropyrimidinase-related protein 2EnzymeHydrolase activity336
Gapdh Gm10293 Gm4609 Gm10358 Gm2606 Gm5559 Gm10291 Gm6316 Gm10481 Gm10566 Gm8055 Gm10290 Gm3222 Gm6981 Gm7293 Gm5507 Gm10313P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 D3Z0Z9 E9PX99 F6QXU4Glyceraldehyde-3-phosphate dehydrogenaseEnzymeoxidoreductase activity224
GdaQ9R111 D3YU09Guanine deaminaseEnzymeGuanine deaminase activity Hydrolase activity55
GlulP15105 D3YVK1 D3Z121Glutamine synthetaseEnzymeSynthetase Other ligase235
Idh3aQ9D6R2 Q9D6R2-2"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial"Enzymeoxidoreductase activity22
Mapk1P63085 E9QAJ2 F6VEI7Mitogen-activated protein kinase 1Enzymeprotein kinase activity22
Pkm2P52480-2 P52480 G3X925 P53657 E9Q509Pyruvate kinase isozymes M1/M2Enzymepyruvate kinase activity33
Prdx2Q61171 D3Z4A4Peroxiredoxin-2EnzymePeroxidase22
SdhaQ8K2B3"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"Enzymeoxidoreductase activity22
TktP40142TransketolaseEnzymeoxidoreductase activity transketolase activity22
Uba1Q02053Ubiquitin-like modifier-activating enzyme 1Enzymeligase activity22
Ubc Ubb 2810422J05Rik Rps27a Uba52 Gm7866P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 D3YYZ2Polyubiquitin-C Ubiquitin Ubiquitin-related 1 Ubiquitin-related 2 Polyubiquitin-B Ubiquitin Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40Enzymestructural constituent of ribosome nucleic acid binding527
Gnao1P18872 P18872-2 D3Z2M7 F7BLT7 Q66L47 Q8CGK7 P50149 Q3V3I2 Q9DC51 P20612 A2AE32 Q8C040 A2AE31 A2A610Guanine nucleotide-binding protein G(o) subunit alphaG-protein signalingLarge G-protein33
Gnb1P62874Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1G-protein signalingGTPase activity protein binding22
Grm3Q9QYS2 F6QVY9Metabotropic glutamate receptor 3G-protein signalingG-protein coupled receptor activity33
Syngap1F6SEU4Ras GTPase-activating protein SynGAPG-protein signalingUnclassified44
Atp1a2Q6PIE5 D3YYN7 D3YVX6Sodium/potassium-transporting ATPase subunit alpha-2Ion channelIon channel Cation transporter Other hydrolase33
Atp1a3Q6PIC6 Q8VCE0 Q9WV27 Q9Z1W8 E9QNX7 Q64436 Q91WH7Sodium/potassium-transporting ATPase subunit alpha-3Ion channelIon channel Cation transporter Other hydrolase437
Atp1b1P14094Sodium/potassium-transporting ATPase subunit beta-1Ion channelCation transporter22
Atp2a2F8WI94 O55143 O55143-2 Q64518 E9Q559 Q64518-3 B1ATS5 Q64518-2 Q8R429 B1ATS4Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Ion channelIon channel activity hydrolase activity22
Atp2b2F8WHB1 Q9R0K7 Q6DIB8Plasma membrane calcium-transporting ATPase 2Ion channelIon channel Cation transporter Other hydrolase22
Atp5a1Q03265 D3Z6F5 D6RJ16"ATP synthase subunit alpha, mitochondrial ATP synthase subunit alpha"Ion channelProton transport other hydrolase22
Atp6v0a1Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 A2A599V-type proton ATPase 116 kDa subunit a isoform 1Ion channelHydrogen transporter Synthase Other hydrolase55
Atp6v0d1P51863V-type proton ATPase subunit d 1Ion channelHydrogen transporter Synthase Other hydrolase33
Atp6v1aP50516 P50516-2 D3Z1B9 D3YWH3 D3YZ23V-type proton ATPase catalytic subunit AIon channel"hydrolase activity receptor activity anion channel activity ligand-gated ion channel activity
cation transmembrane transporter activity proton-transporting ATP synthase activity rotational mechanism single-stranded DNA binding"33
Atp6v1hQ8BVE3V-type proton ATPase subunit HIon channelhydrolase activity cation transmembrane transporter activity proton-transporting ATP synthase activity rotational mechanism22
Kcna2P63141Potassium voltage-gated channel subfamily A member 2Ion channelvoltage-gated potassium channel activity cation channel activity cation transmembrane transporter activity22
Kcnj4P52189 Q8R435Inward rectifier potassium channel 4Ion channelPotassium channel538
Vdac1Q60932 Q60932-2 F2Z471Voltage-dependent anion-selective channel protein 1Ion channelAnion channel Voltage-gated ion channel22
Atp1a1Q8VDN2 E9QAV3Sodium/potassium-transporting ATPase subunit alpha-1Ion channelIon channel Cation transporter Other hydrolase314
Pgam5Q8BX10 Q8BX10-2 F6YJC6"Serine/threonine-protein phosphatase PGAM5, mitochondrial"PhosphataseGTPase activator activity phosphatase activity123
Ppp2r2aQ571J7 Q6P1F6 Q9CWU3 Q8BG02Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPhosphataseProtein phosphatase22
Ppp3caP63328 P63328-2 Q4V9X0Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformPhosphataseProtein phosphatase Calcium binding protein33
Ppp3cbP48453 E0CZ78 P48453-2 G3X8U7 E9Q6P2 Q80XK0 P48455 G3X8V4Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatasePhosphataseProtein phosphatase Calcium binding protein22
Gpr123Q76JQ1 Q8C4G9 E9PYX2G protein-coupled receptor 123Receptor/ TransporterG-protein coupled receptor33
Gria2P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2Glutamate receptor 2Receptor/ TransporterGlutamate receptor Ion channel44
Gria3 Gria4B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8Glutamate receptor 3 Glutamate receptor 4Receptor/ TransporterGlutamate receptor Ion channel44
Grin1P35438 P35438-2Glutamate [NMDA] receptor subunit zeta-1Receptor/ TransporterGlutamate receptor Ion channel527
Grin2aP35436Glutamate [NMDA] receptor subunit epsilon-1Receptor/ TransporterGlutamate receptor Ion channel22
Grin2bG3X9V4 Q01097Glutamate [NMDA] receptor subunit epsilon-2Receptor/ TransporterGlutamate receptor Ion channel33
Slc17a7Q3TXX4Vesicular glutamate transporter 1Receptor/ TransporterCation transport22
Slc1a2P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 F6ZRK3Excitatory amino acid transporter 2Receptor/ TransporterCation transport55
Slc25a3G5E902 Q8VEM8"Phosphate carrier protein, mitochondrial"Receptor/ TransporterTransporter Mitochondrial carrier protein235
Slc25a4 Slc25a5P48962 P51881 Q3V132ADP/ATP translocase 1 ADP/ATP translocase 2Receptor/ TransporterTransporter Mitochondrial carrier protein134
Slc3a2G3UWA6 P108524F2 cell-surface antigen heavy chainReceptor/ TransporterAmino acid transporter22
Slc4a4E9Q8N8 O88343 O88343-2 A7E1Z5Electrogenic sodium bicarbonate cotransporter 1Receptor/ TransporterSodium anion transporter44
Slc6a1P31648 E9Q9F4Sodium- and chloride-dependent GABA transporter 1 TransporterReceptor/ Transporteramino acid transmembrane transporter activity22
Slc6a11P31650Sodium- and chloride-dependent GABA transporter 3Receptor/ Transporteramino acid transmembrane transporter activity cation transmembrane transporter activity44
Camk2aQ80TN1 P11798 F8WIS9 F6WHR9 D3Z7K9 F8WHB5 P11798-2 F8WIR6 D6RDQ8 E9QAJ4 E9PYZ8Calcium/calmodulin-dependent protein kinase type II subunit alphaSer/Thr KinaseNon-receptor serine/threonine protein kinase538
Camk2bP28652 Q5SVI3 Q5SVJ0 Q5SVI2 Q5SVI0 Q5SVJ1 Q5SVI9 Q5SVI1 Q68EG2 Q3TY93Calcium/calmodulin-dependent protein kinase type II subunit betaSer/Thr KinaseNon-receptor serine/threonine protein kinase22
B630019K06RikQ7TNS5Novel protein similar to F-box and leucine-rich repeat protein 17UnclassifiedUnclassified33
Btbd17Q9DB72BTB/POZ domain-containing protein 17UnclassifiedUnclassified33
Cend1Q9JKC6Cell cycle exit and neuronal differentiation protein 1UnclassifiedUnclassified22
Cnrip1F7C0H6 Q5M8N0CB1 cannabinoid receptor-interacting protein 1UnclassifiedUnclassified22
MogQ3UY21 Q61885 Q29ZQ5Myelin-oligodendrocyte glycoproteinUnclassifiedMyelin protein44
CltcQ5SXR6 Q68FD5 E9Q434 F6Z1R4Clathrin heavy chain 1Vesicular/ Trafficking/ TransportStructural molecule activity55
Iqsec1E9PUA3 Q8R0S2-2 Q8R0S2IQ motif and SEC7 domain-containing protein 1Vesicular/ Trafficking/ TransportGuanyl-nucleotide exchange factor33
Iqsec2E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7IQ motif and SEC7 domain-containing protein 2Vesicular/ Trafficking/ TransportGuanyl-nucleotide exchange factor527
NsfP46460 G3UX86 G3UX98Vesicle-fusing ATPaseVesicular/ Trafficking/ Transportprotein binding syntaxin binding33
Pet2A2AHY8Pet2 proteinVesicular/ Trafficking/ TransportGTPase activity protein binding235
Sh3gl2A2ALV3 Q62420 Q8BXU5 F6ZL13 A2ALV1 Q62419 Q62421Endophilin-A1Vesicular/ Trafficking/ Transportstructural constituent of cytoskeleton22
Stx1aO35526 D6RFB9Syntaxin-1AVesicular/ Trafficking/ Transportprotein binding22
Stx1bP61264 Q00262 Q80W45 Q3TJ55Syntaxin-1BVesicular/ Trafficking/ TransportSNARE protein33
Stxbp1O08599-2Syntaxin-binding protein 1Vesicular/ Trafficking/ Transporttransmembrane transporter activity235

Supplementary Table 6. Biological process ontology of 107 Arc interactors.

Gene Ontology (Biological Process)p valueMatching Genes
synaptic transmission9.502798918858656e-16MGI:105368 MGI:106919 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:1277959 MGI:1344351 MGI:1346065 MGI:1349763 MGI:1351340 MGI:1861691 MGI:1920211 MGI:1930705 MGI:2137336 MGI:3039785 MGI:700009 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821
sodium ion transmembrane transport9.343565096114266e-7MGI:101931 MGI:1349482 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:95627 MGI:95630
regulation of ion transport8.609842799379445e-7MGI:104743 MGI:105368 MGI:106919 MGI:107231 MGI:107672 MGI:1277959 MGI:1349482 MGI:1349763 MGI:88105 MGI:88106 MGI:88108 MGI:88256 MGI:95627 MGI:95775 MGI:95819 MGI:95820 MGI:95821 MGI:96659
nucleoside triphosphate metabolic process8.377848041797307e-7MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
single-organism localization7.28986802452463e-8MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:109355 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1914864 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2388633 MGI:3039785 MGI:700009 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96955
ion transport6.800545640904749e-13MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:106919 MGI:107164 MGI:107231 MGI:107671 MGI:107672 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1349482 MGI:1349763 MGI:1914864 MGI:1920211 MGI:1927555 MGI:2388633 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96955
purine nucleoside triphosphate metabolic process6.507522773114072e-7MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
ribonucleoside triphosphate metabolic process6.367477925933466e-7MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
purine ribonucleoside triphosphate metabolic process6.239723546620834e-7MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
establishment of localization5.357804009223438e-7MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:105384 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:109355 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1353498 MGI:1890773 MGI:1914195 MGI:1914864 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2388633 MGI:700009 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96955
cation transmembrane transport5.158252715083171e-11MGI:101931 MGI:103286 MGI:104743 MGI:105368 MGI:107671 MGI:1201778 MGI:1201780 MGI:1349482 MGI:1914864 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95627 MGI:95630 MGI:95819 MGI:95820 MGI:95821 MGI:96659
monovalent inorganic cation transport4.797168902147824e-9MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:107231 MGI:107672 MGI:1201778 MGI:1201780 MGI:1349482 MGI:1914864 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88115 MGI:95627 MGI:95630 MGI:96659
nucleobase-containing small molecule metabolic process4.5804955451400463e-10MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107231 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349763 MGI:1915084 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781 MGI:97591
transmembrane transport4.558443222839281e-9MGI:101931 MGI:103286 MGI:104743 MGI:105368 MGI:106919 MGI:107671 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1349482 MGI:1914864 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95627 MGI:95630 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96955
inorganic cation transmembrane transport4.309683804287918e-12MGI:101931 MGI:103286 MGI:104743 MGI:105368 MGI:107671 MGI:1201778 MGI:1201780 MGI:1349482 MGI:1914864 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95627 MGI:95630 MGI:95819 MGI:95820 MGI:95821 MGI:96659
inorganic ion transmembrane transport3.0916449702984284e-11MGI:101931 MGI:103286 MGI:104743 MGI:105368 MGI:107671 MGI:1201778 MGI:1201780 MGI:1349482 MGI:1914864 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95627 MGI:95630 MGI:95819 MGI:95820 MGI:95821 MGI:96659
ion transmembrane transport2.910925259596908e-11MGI:101931 MGI:103286 MGI:104743 MGI:105368 MGI:106919 MGI:107671 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1349482 MGI:1914864 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95627 MGI:95630 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96955
organonitrogen compound catabolic process2.894289850934853e-7MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1349763 MGI:1913764 MGI:1915472 MGI:1919792 MGI:2441982 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781
metal ion transport2.6814668951253684e-11MGI:101931 MGI:104560 MGI:104743 MGI:105368 MGI:106919 MGI:107164 MGI:107231 MGI:107671 MGI:1349482 MGI:1920211 MGI:1927555 MGI:2388633 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95775 MGI:95819 MGI:95820 MGI:95821 MGI:96659
regulation of transport2.365919820256129e-8MGI:101931 MGI:104560 MGI:104743 MGI:105368 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1890773 MGI:1930705 MGI:700009 MGI:88105 MGI:88106 MGI:88108 MGI:88110 MGI:88256 MGI:95627 MGI:95739 MGI:95775 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659
transport2.04658786099803e-7MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:105384 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:109355 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1353498 MGI:1890773 MGI:1914195 MGI:1914864 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2388633 MGI:700009 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96955
cell-cell signaling1.929781230495676e-11MGI:105368 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:1277959 MGI:1344351 MGI:1346065 MGI:1349763 MGI:1351340 MGI:1861691 MGI:1920211 MGI:1930705 MGI:2137336 MGI:3039785 MGI:700009 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821
regulation of membrane potential1.5792440465277355e-7MGI:106925 MGI:107164 MGI:107231 MGI:109611 MGI:1277959 MGI:1340046 MGI:1920211 MGI:88105 MGI:88108 MGI:88110 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623
regulation of synaptic transmission1.4643637216975884e-12MGI:105368 MGI:107164 MGI:107363 MGI:107672 MGI:109355 MGI:1277959 MGI:1351340 MGI:1861691 MGI:2137336 MGI:3039785 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821
single-organism transport1.3252397901351542e-7MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:109355 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1914864 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2388633 MGI:700009 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96955
nucleoside phosphate metabolic process1.2975281820121327e-7MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107231 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1915084 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
nucleotide metabolic process1.1687821187059557e-7MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107231 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1915084 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
cation transport1.117038539668867e-14MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:106919 MGI:107164 MGI:107231 MGI:107671 MGI:107672 MGI:1201778 MGI:1201780 MGI:1349482 MGI:1914864 MGI:1920211 MGI:1927555 MGI:2388633 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95775 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96955
macromolecular complex subunit organization0.04953604951651472MGI:103286 MGI:105384 MGI:107231 MGI:107363 MGI:107812 MGI:1095410 MGI:109611 MGI:1277959 MGI:1861691 MGI:1890773 MGI:1915472 MGI:2137336 MGI:2388633 MGI:2441982 MGI:3039563 MGI:87904 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:96659
amine transport0.04796313281592226MGI:1349763 MGI:95627 MGI:95821 MGI:96659
cell projection organization0.04786311910839043MGI:105368 MGI:107164 MGI:107363 MGI:107671 MGI:1201778 MGI:1277959 MGI:1349482 MGI:1349763 MGI:1861691 MGI:2137336 MGI:3039785 MGI:87904 MGI:88257 MGI:95819 MGI:97623
regulation of actin filament-based process0.04668710407102008MGI:107231 MGI:107672 MGI:109611 MGI:2137336 MGI:88105 MGI:88106 MGI:88110
response to alkaloid0.04382845305020393MGI:1277959 MGI:1919228 MGI:88106 MGI:95819
negative regulation of synaptic transmission GABAergic0.04273579020453653MGI:107363 MGI:95627
positive regulation of glutamate secretion0.04273579020453653MGI:1349763 MGI:95821
positive regulation of NFAT protein import into nucleus0.04273579020453653MGI:107163 MGI:107164
pyrimidine nucleobase catabolic process0.04273579020453653MGI:107793 MGI:1349763
positive regulation of amine transport0.041840602372496656MGI:1349763 MGI:95627 MGI:95821
dendrite development0.04069728282260573MGI:107164 MGI:1277959 MGI:2137336 MGI:3039785 MGI:88257 MGI:95819
dicarboxylic acid metabolic process0.04068210339089808MGI:1914195 MGI:1915084 MGI:2441982 MGI:95739
regulation of dendrite morphogenesis0.04068210339089808MGI:107164 MGI:2137336 MGI:88257 MGI:95819
receptor metabolic process0.039946949628423115MGI:104560 MGI:1277959 MGI:2388633 MGI:700009 MGI:95809
amino acid transmembrane transport0.03908640546845061MGI:101931 MGI:95627 MGI:95630 MGI:96955
positive regulation of organic acid transport0.039060722092860656MGI:1349763 MGI:95627 MGI:95821
neuron projection development0.03839466591582009MGI:107164 MGI:107363 MGI:107671 MGI:1277959 MGI:1349763 MGI:1861691 MGI:2137336 MGI:3039785 MGI:87904 MGI:88257 MGI:95819 MGI:97623
cardiac muscle contraction0.03752873381496758MGI:88105 MGI:88106 MGI:88108 MGI:88110
nucleoside monophosphate biosynthetic process0.036008870031625714MGI:103286 MGI:2685080 MGI:88115 MGI:97591
regulation of amine transport0.036008870031625714MGI:1349763 MGI:95627 MGI:95821 MGI:96659
dendritic spine morphogenesis0.035952352473449134MGI:1277959 MGI:2137336 MGI:88257
axon ensheathment0.034522540104647864MGI:106925 MGI:107231 MGI:1340046 MGI:96925 MGI:97623
ensheathment of neurons0.034522540104647864MGI:106925 MGI:107231 MGI:1340046 MGI:96925 MGI:97623
central nervous system maturation0.03445915103908489MGI:1929898 MGI:95819
hindbrain maturation0.03445915103908489MGI:1929898 MGI:95819
L-glutamate import0.03445915103908489MGI:101931 MGI:1920211
negative regulation of sodium ion transport0.03445915103908489MGI:1349482 MGI:88106
regulation of sodium ion transmembrane transporter activity0.033905211745402515MGI:1349482 MGI:88106 MGI:88108
regulation of the force of heart contraction0.033905211745402515MGI:88105 MGI:88106 MGI:88110
regulation of vesicle-mediated transport0.033704544137664445MGI:104560 MGI:107363 MGI:109355 MGI:1277959 MGI:1346858 MGI:1890773 MGI:1930705 MGI:700009
regulation of amino acid transport0.03088586632917008MGI:1349763 MGI:95627 MGI:95821
cellular localization0.030874800514486312MGI:104560 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1920211 MGI:1930705 MGI:2388633 MGI:3039785 MGI:700009 MGI:88108 MGI:88110 MGI:88256 MGI:95739 MGI:95821 MGI:96247 MGI:96659
dendrite morphogenesis0.029737295676778932MGI:107164 MGI:1277959 MGI:2137336 MGI:88257 MGI:95819
regulation of cell communication0.028845655297055895MGI:105368 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:109486 MGI:1196356 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1351340 MGI:1861691 MGI:2137336 MGI:3039785 MGI:3528396 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:97435
regulation of muscle contraction0.028837115642067594MGI:109611 MGI:88105 MGI:88106 MGI:88108 MGI:88110
anion transmembrane transport0.027521658154365965MGI:101931 MGI:1920211 MGI:1927555 MGI:95627 MGI:95630 MGI:96955
regulation of sodium ion transport0.027442626645029104MGI:1349482 MGI:88105 MGI:88106 MGI:88108
membrane docking0.02618826443744896MGI:104560 MGI:107363 MGI:109355 MGI:1930705
receptor internalization0.02618826443744896MGI:1277959 MGI:2388633 MGI:700009 MGI:95809
ribonucleoside monophosphate biosynthetic process0.02618826443744896MGI:103286 MGI:2685080 MGI:88115 MGI:97591
protein localization to cell junction0.026151863045172415MGI:109611 MGI:1890773
positive regulation of membrane potential0.02607916259801401MGI:1277959 MGI:95819 MGI:95820
cellular component biogenesis0.026033430281112727MGI:103286 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107812 MGI:1095410 MGI:1277959 MGI:1346065 MGI:1349482 MGI:1861691 MGI:1890773 MGI:1915472 MGI:2137336 MGI:2388633 MGI:2441982 MGI:3039563 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:96659
nucleoside triphosphate biosynthetic process0.02507535161786502MGI:103286 MGI:2685080 MGI:88115 MGI:97591
single-organism metabolic process0.02506470906817987MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107231 MGI:107793 MGI:107812 MGI:109486 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1913764 MGI:1914195 MGI:1915084 MGI:1915472 MGI:1919792 MGI:2388633 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:700009 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95821 MGI:97591 MGI:97623
neuron differentiation0.024739782520088606MGI:105368 MGI:107164 MGI:107363 MGI:107671 MGI:1277959 MGI:1344351 MGI:1349482 MGI:1349763 MGI:1861691 MGI:1929898 MGI:2137336 MGI:3039785 MGI:87904 MGI:88257 MGI:95819 MGI:97623
response to abiotic stimulus0.02442470007365292MGI:101931 MGI:105368 MGI:109355 MGI:3039785 MGI:87904 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:95781 MGI:95819 MGI:95820 MGI:95821
multicellular organismal signaling0.021937853958126495MGI:106925 MGI:109611 MGI:1340046 MGI:96659 MGI:96925 MGI:97623
neuronal action potential0.02154857085127864MGI:106925 MGI:1340046 MGI:96659 MGI:96925 MGI:97623
dicarboxylic acid transport0.02152424758462005MGI:101931 MGI:1349763 MGI:1920211 MGI:95821
purine nucleoside monophosphate biosynthetic process0.02152424758462005MGI:103286 MGI:2685080 MGI:88115 MGI:97591
purine ribonucleoside monophosphate biosynthetic process0.02152424758462005MGI:103286 MGI:2685080 MGI:88115 MGI:97591
startle response0.021301804131596453MGI:95819 MGI:95820 MGI:95821
heart process0.021125394205322476MGI:109611 MGI:88105 MGI:88106 MGI:88108 MGI:88110 MGI:95775
cellular metal ion homeostasis0.019987078275826145MGI:105368 MGI:1277959 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
heart contraction0.01997591927473515MGI:109611 MGI:88105 MGI:88106 MGI:88108 MGI:88110 MGI:95775
response to light stimulus0.019919909157218776MGI:101931 MGI:3039785 MGI:88106 MGI:88107 MGI:95781 MGI:95819 MGI:95820
neurogenesis0.019833602234701982MGI:105368 MGI:107164 MGI:107363 MGI:107671 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1349482 MGI:1349763 MGI:1861691 MGI:1929898 MGI:2137336 MGI:3039785 MGI:87904 MGI:88257 MGI:95819 MGI:95820 MGI:97623
negative regulation of heart contraction0.019763637628313326MGI:88105 MGI:88106 MGI:88110
neuron projection morphogenesis0.019693987665479334MGI:107164 MGI:107363 MGI:107671 MGI:1277959 MGI:1861691 MGI:2137336 MGI:3039785 MGI:87904 MGI:88257 MGI:95819
macromolecular complex assembly0.019578005334976042MGI:103286 MGI:107231 MGI:107363 MGI:107812 MGI:1095410 MGI:1277959 MGI:1861691 MGI:1915472 MGI:2388633 MGI:2441982 MGI:3039563 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:96659
negative regulation of sodium ion transmembrane transport0.019273193812631557MGI:1349482 MGI:88106
negative regulation of sodium ion transmembrane transporter activity0.019273193812631557MGI:1349482 MGI:88106
neurotransmitter secretion0.019017216515746296MGI:107363 MGI:109355 MGI:1930705 MGI:88110 MGI:88256
regulation of muscle system process0.018230194880476797MGI:107164 MGI:109611 MGI:88105 MGI:88106 MGI:88108 MGI:88110
adult behavior0.017117047955227113MGI:101931 MGI:1340046 MGI:1929898 MGI:88106 MGI:88107 MGI:95819
establishment of organelle localization0.016995477519180617MGI:107363 MGI:109355 MGI:1277959 MGI:1349763 MGI:1920211 MGI:1930705 MGI:700009
vesicle docking0.016542971611592593MGI:104560 MGI:107363 MGI:109355 MGI:1930705
adult locomotory behavior0.016300338553135067MGI:1340046 MGI:1929898 MGI:88106 MGI:88107 MGI:95819
memory0.016300338553135067MGI:1920211 MGI:88107 MGI:95819 MGI:95820 MGI:95821
cellular potassium ion transport0.015881347433932415MGI:104743 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:96659
potassium ion transmembrane transport0.015881347433932415MGI:104743 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:96659
positive regulation of ion transport0.01566302324848422MGI:105368 MGI:107231 MGI:1349763 MGI:88108 MGI:88256 MGI:95627 MGI:95821
plasma membrane organization0.014881850234891312MGI:104560 MGI:107231 MGI:107363 MGI:2137336 MGI:2388633 MGI:88108 MGI:88110
acidic amino acid transport0.014109606188977605MGI:101931 MGI:1920211 MGI:95627
signaling0.01353708154570135MGI:104560 MGI:105368 MGI:106919 MGI:106925 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:109486 MGI:109611 MGI:1196356 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346065 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1351340 MGI:1861691 MGI:1919228 MGI:1920211 MGI:1930705 MGI:2137336 MGI:2138865 MGI:2443181 MGI:3039563 MGI:3039785 MGI:3528396 MGI:700009 MGI:88107 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97435 MGI:97623
regulation of signaling0.013416972431500402MGI:104560 MGI:105368 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:109486 MGI:1196356 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1351340 MGI:1861691 MGI:2137336 MGI:3039785 MGI:3528396 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:97435
protein localization0.013310677876127658MGI:104560 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:109611 MGI:1277959 MGI:1344351 MGI:1346065 MGI:1346858 MGI:1349482 MGI:1890773 MGI:1930705 MGI:2388633 MGI:3039785 MGI:88108 MGI:95809 MGI:95820 MGI:95821 MGI:96247
ribonucleoside triphosphate biosynthetic process0.013007251589105758MGI:103286 MGI:2685080 MGI:88115 MGI:97591
purine nucleoside triphosphate biosynthetic process0.01209908527276262MGI:103286 MGI:2685080 MGI:88115 MGI:97591
regulation of metal ion transport0.01192075111252765MGI:105368 MGI:107231 MGI:1349482 MGI:88105 MGI:88106 MGI:88108 MGI:88256 MGI:95775
purine ribonucleoside triphosphate biosynthetic process0.011292203253484413MGI:103286 MGI:2685080 MGI:88115 MGI:97591
cellular macromolecule localization0.010825389222924MGI:104560 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1930705 MGI:2388633 MGI:3039785 MGI:88108 MGI:95821 MGI:96247
regulation of neurotransmitter secretion0.010629977844966143MGI:107363 MGI:109355 MGI:88110 MGI:88256
regulation of transmembrane transport0.010604355293953595MGI:104743 MGI:106919 MGI:1277959 MGI:1349482 MGI:88106 MGI:88108 MGI:95819 MGI:95820 MGI:96659
single-organism cellular localization0.010586586579787581MGI:104560 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:1277959 MGI:1344351 MGI:1346858 MGI:2388633 MGI:3039785 MGI:88108 MGI:95821 MGI:96247
cellular protein localization0.010247074870288994MGI:104560 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1930705 MGI:2388633 MGI:3039785 MGI:88108 MGI:95821 MGI:96247
secretion0.009646967631761804MGI:104560 MGI:105368 MGI:107163 MGI:107164 MGI:107363 MGI:109355 MGI:1349482 MGI:1349763 MGI:1930705 MGI:88110 MGI:88256 MGI:95627 MGI:95739 MGI:95821 MGI:96659
vesicle-mediated transport0.008941968724903854MGI:104560 MGI:105384 MGI:107163 MGI:107363 MGI:109355 MGI:1277959 MGI:1346858 MGI:1349763 MGI:1890773 MGI:1914864 MGI:1920211 MGI:1930705 MGI:2388633 MGI:700009 MGI:88067 MGI:95809
cellular component assembly0.00890623255773318MGI:103286 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107812 MGI:1095410 MGI:1277959 MGI:1346065 MGI:1349482 MGI:1861691 MGI:1890773 MGI:1915472 MGI:2137336 MGI:2388633 MGI:2441982 MGI:3039563 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:96659
regulation of heart contraction0.008569500212488748MGI:109611 MGI:88105 MGI:88106 MGI:88108 MGI:88110 MGI:95775
organic anion transport0.0082564445290448MGI:101931 MGI:1349482 MGI:1349763 MGI:1920211 MGI:1927555 MGI:95627 MGI:95630 MGI:95821 MGI:96955
regulation of ion transmembrane transport0.007932708027139235MGI:104743 MGI:106919 MGI:1277959 MGI:1349482 MGI:88106 MGI:88108 MGI:95819 MGI:95820 MGI:96659
regulation of system process0.006902385509986407MGI:107164 MGI:109611 MGI:1349482 MGI:1351340 MGI:88105 MGI:88106 MGI:88108 MGI:88110 MGI:95775 MGI:95820
regulation of calcium:sodium antiporter activity0.006832399595214078MGI:88106 MGI:88108
positive regulation of excitatory postsynaptic membrane potential0.006792960073743459MGI:1277959 MGI:95819 MGI:95820
pyrimidine nucleobase metabolic process0.006792960073743459MGI:107793 MGI:1346858 MGI:1349763
neuron development0.0067918889939974116MGI:105368 MGI:107164 MGI:107363 MGI:107671 MGI:1277959 MGI:1344351 MGI:1349482 MGI:1349763 MGI:1861691 MGI:2137336 MGI:3039785 MGI:87904 MGI:88257 MGI:95819 MGI:97623
sodium ion homeostasis0.006725924355111569MGI:88105 MGI:88106 MGI:88107 MGI:88108
regulation of actin filament-based movement0.006145651915364016MGI:109611 MGI:88105 MGI:88106 MGI:88110
developmental maturation0.006093516597440972MGI:107363 MGI:1277959 MGI:1344351 MGI:1920211 MGI:1929898 MGI:88257 MGI:95819 MGI:97623
organic acid transport0.006093516597440972MGI:101931 MGI:1349482 MGI:1349763 MGI:1920211 MGI:95627 MGI:95630 MGI:95821 MGI:96955
chemical homeostasis0.006059991330185312MGI:103286 MGI:105368 MGI:107163 MGI:107164 MGI:1277959 MGI:1349482 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
positive regulation of amino acid transport0.005795323818035271MGI:1349763 MGI:95627 MGI:95821
carboxylic acid transport0.005791332049141252MGI:101931 MGI:1349482 MGI:1349763 MGI:1920211 MGI:95627 MGI:95630 MGI:95821 MGI:96955
system process0.0057072852723790545MGI:105368 MGI:106919 MGI:106925 MGI:107164 MGI:107231 MGI:109611 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1351340 MGI:1920211 MGI:3039785 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88257 MGI:95627 MGI:95775 MGI:95781 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623
single-organism cellular process0.0056909297604620865MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:105384 MGI:105992 MGI:106919 MGI:106925 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107793 MGI:107812 MGI:109355 MGI:109486 MGI:1095410 MGI:109611 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346065 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1351340 MGI:1861691 MGI:1890773 MGI:1913764 MGI:1914195 MGI:1914864 MGI:1915084 MGI:1915472 MGI:1919228 MGI:1919792 MGI:1920211 MGI:1921626 MGI:1927555 MGI:1929898 MGI:1930705 MGI:2137336 MGI:2388633 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:700009 MGI:87904 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:894310 MGI:95627 MGI:95630 MGI:95678 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96925 MGI:96955 MGI:97435 MGI:97591 MGI:97623
regulation of secretion by cell0.005465926038753888MGI:104560 MGI:107163 MGI:107164 MGI:107363 MGI:109355 MGI:1349763 MGI:1930705 MGI:88110 MGI:88256 MGI:95739 MGI:95821 MGI:96659
ATP biosynthetic process0.005299766246194517MGI:103286 MGI:2685080 MGI:88115 MGI:97591
membrane depolarization0.005220428583447969MGI:107164 MGI:1277959 MGI:1920211 MGI:95819 MGI:95820 MGI:95821
regulation of anion transport0.005015676644172495MGI:106919 MGI:107672 MGI:1349763 MGI:95627 MGI:95821 MGI:96659
regulation of cardiac muscle cell contraction0.00489120844745044MGI:109611 MGI:88105 MGI:88106 MGI:88110
nitrogen compound transport0.004886041801708141MGI:101931 MGI:107163 MGI:107164 MGI:107672 MGI:1349482 MGI:1349763 MGI:1920211 MGI:95627 MGI:95630 MGI:95739 MGI:95821 MGI:96659 MGI:96955
protein complex biogenesis0.004446104817590185MGI:103286 MGI:107231 MGI:107363 MGI:107812 MGI:1095410 MGI:1277959 MGI:1861691 MGI:1915472 MGI:2388633 MGI:2441982 MGI:3039563 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:96659
protein complex assembly0.004419062293662195MGI:103286 MGI:107231 MGI:107363 MGI:107812 MGI:1095410 MGI:1277959 MGI:1861691 MGI:1915472 MGI:2388633 MGI:2441982 MGI:3039563 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:96659
cell morphogenesis involved in neuron differentiation0.004402984868404234MGI:105368 MGI:107164 MGI:107363 MGI:1277959 MGI:1349482 MGI:1861691 MGI:2137336 MGI:3039785 MGI:87904 MGI:88257 MGI:95819
protein localization to membrane0.0039877640715556195MGI:104560 MGI:107231 MGI:107363 MGI:1277959 MGI:1344351 MGI:2388633 MGI:3039785 MGI:88108 MGI:95821
neuromuscular process0.00393601520433362MGI:105368 MGI:1277959 MGI:88257 MGI:95819 MGI:95820 MGI:95821
endocytosis0.003318587988577232MGI:107363 MGI:1277959 MGI:1346858 MGI:1349763 MGI:1890773 MGI:1914864 MGI:1920211 MGI:2388633 MGI:700009 MGI:88067 MGI:95809
cation homeostasis0.0029769773861518015MGI:103286 MGI:105368 MGI:1277959 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
regulation of striated muscle contraction0.0025909282435809936MGI:109611 MGI:88105 MGI:88106 MGI:88108 MGI:88110
nucleotide phosphorylation0.002584724715833297MGI:107231 MGI:1277959 MGI:1344351 MGI:2685080
anion transport0.0025753369187779904MGI:101931 MGI:106919 MGI:107672 MGI:1349482 MGI:1349763 MGI:1920211 MGI:1927555 MGI:95627 MGI:95630 MGI:95821 MGI:96659 MGI:96955
nucleobase metabolic process0.0023005570833577946MGI:107793 MGI:1346858 MGI:1349763 MGI:95678
ion homeostasis0.0021723858601507486MGI:103286 MGI:105368 MGI:1277959 MGI:1349482 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
vesicle localization0.0019498824859583066MGI:107363 MGI:109355 MGI:1277959 MGI:1349763 MGI:1920211 MGI:1930705 MGI:700009
nucleobase catabolic process0.0017844791566105332MGI:107793 MGI:1349763 MGI:95678
regulation of neurotransmitter transport0.0016518145774731686MGI:107363 MGI:107672 MGI:109355 MGI:88110 MGI:88256
regulation of cellular localization0.0016133952625046954MGI:104560 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:1346858 MGI:1349763 MGI:1930705 MGI:2388633 MGI:88110 MGI:88256 MGI:95739 MGI:95821 MGI:96247 MGI:96659
synaptic vesicle recycling0.001577242915527637MGI:107363 MGI:1277959 MGI:1920211 MGI:700009
regulation of cardiac muscle contraction0.0014172991820145362MGI:109611 MGI:88105 MGI:88106 MGI:88108 MGI:88110
establishment of vesicle localization0.0013583927225122474MGI:107363 MGI:109355 MGI:1277959 MGI:1349763 MGI:1920211 MGI:1930705 MGI:700009
potassium ion transport0.0013252755202863395MGI:104560 MGI:104743 MGI:107231 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:96659
positive regulation of transport0.0013229676280002375MGI:101931 MGI:105368 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:109355 MGI:1349763 MGI:1890773 MGI:88108 MGI:88256 MGI:95627 MGI:95739 MGI:95821 MGI:96247
receptor localization to synapse0.001314415820847008MGI:107231 MGI:1277959 MGI:1344351
protein complex subunit organization0.0011598655329001608MGI:103286 MGI:105384 MGI:107231 MGI:107363 MGI:107812 MGI:1095410 MGI:109611 MGI:1277959 MGI:1861691 MGI:1890773 MGI:1915472 MGI:2137336 MGI:2388633 MGI:2441982 MGI:3039563 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:96659
nervous system development0.0011503576544974856MGI:101931 MGI:105368 MGI:106925 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1349482 MGI:1349763 MGI:1861691 MGI:1914195 MGI:1929898 MGI:2137336 MGI:2441982 MGI:3039785 MGI:87904 MGI:88257 MGI:95819 MGI:95820 MGI:96659 MGI:96925 MGI:97623
synaptic vesicle endocytosis0.001042813049177829MGI:107363 MGI:1277959 MGI:1920211 MGI:700009
visual learning0.0009417801771219396MGI:3039785 MGI:88106 MGI:88107 MGI:95819 MGI:95820
synaptic vesicle maturation0.0009175958233262354MGI:107363 MGI:1277959 MGI:1920211
amino acid transport0.0008502103237302624MGI:101931 MGI:1349763 MGI:1920211 MGI:95627 MGI:95630 MGI:95821 MGI:96955
cellular catabolic process0.0008150427959530967MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107793 MGI:107812 MGI:109486 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1346065 MGI:1349763 MGI:1913764 MGI:1915472 MGI:1919792 MGI:2441982 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781 MGI:98890
cognition0.0007298055320232997MGI:106919 MGI:1920211 MGI:3039785 MGI:88106 MGI:88107 MGI:95627 MGI:95819 MGI:95820 MGI:95821
regulation of secretion0.0006981624533720899MGI:104560 MGI:107163 MGI:107164 MGI:107363 MGI:109355 MGI:1349482 MGI:1349763 MGI:1930705 MGI:88110 MGI:88256 MGI:95627 MGI:95739 MGI:95821 MGI:96659
cellular cation homeostasis0.0005189142883397221MGI:103286 MGI:105368 MGI:1277959 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
associative learning0.00047620801425255263MGI:3039785 MGI:88106 MGI:88107 MGI:95819 MGI:95820 MGI:95821
monovalent inorganic cation homeostasis0.00039470570038562MGI:103286 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108
sensory perception of pain0.00037520061971660113MGI:1344351 MGI:1346858 MGI:1351340 MGI:95819 MGI:95820 MGI:95821 MGI:96659
receptor clustering0.0003381162075961348MGI:107231 MGI:1277959 MGI:1344351 MGI:3039785 MGI:95821
catabolic process0.00033585697319934017MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107793 MGI:107812 MGI:109486 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1346065 MGI:1349763 MGI:1913764 MGI:1915472 MGI:1919792 MGI:2441982 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781 MGI:95820 MGI:97591 MGI:98890
learning or memory0.0003239671192011501MGI:106919 MGI:1920211 MGI:3039785 MGI:88106 MGI:88107 MGI:95627 MGI:95819 MGI:95820 MGI:95821
calcium ion transmembrane transport0.00030879106968363114MGI:105368 MGI:107671 MGI:88106 MGI:88108 MGI:88110 MGI:95819 MGI:95820 MGI:95821
single-organism membrane organization0.00030687651853582054MGI:104560 MGI:107231 MGI:107363 MGI:109355 MGI:1277959 MGI:1344351 MGI:1930705 MGI:2137336 MGI:2388633 MGI:3039785 MGI:88108 MGI:88110 MGI:88256 MGI:95821
protein localization to synapse0.0002930354140578186MGI:107231 MGI:1277959 MGI:1344351 MGI:1346065
membrane organization0.0002472611949258734MGI:104560 MGI:107231 MGI:107363 MGI:109355 MGI:1277959 MGI:1344351 MGI:1930705 MGI:2137336 MGI:2388633 MGI:3039785 MGI:88108 MGI:88110 MGI:88256 MGI:95821 MGI:96925
cellular homeostasis0.00023968966762995858MGI:103286 MGI:105368 MGI:107163 MGI:107164 MGI:1277959 MGI:1349482 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
nucleobase-containing compound catabolic process0.00022005182293470844MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
positive regulation of synaptic transmission0.00021939758478448185MGI:109355 MGI:1277959 MGI:1861691 MGI:88257 MGI:95739 MGI:95809 MGI:95821
hydrogen ion transmembrane transport0.0002124272334804031MGI:103286 MGI:1201778 MGI:1201780 MGI:1914864 MGI:88106 MGI:88115
potassium ion homeostasis0.00018459631961971124MGI:88105 MGI:88106 MGI:88107 MGI:88108
organic substance catabolic process0.00014388445540877782MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1346065 MGI:1349763 MGI:1913764 MGI:1915472 MGI:1919792 MGI:2441982 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781 MGI:95820 MGI:97591 MGI:98890
amino acid import0.00014384334242972826MGI:101931 MGI:1920211 MGI:95627 MGI:96955
cellular sodium ion homeostasis0.00014384334242972826MGI:88105 MGI:88106 MGI:88107 MGI:88108
synaptic vesicle localization0.00014163595050308716MGI:107363 MGI:109355 MGI:1277959 MGI:1349763 MGI:1920211 MGI:1930705 MGI:700009
cellular ion homeostasis0.00013290538838264896MGI:103286 MGI:105368 MGI:1277959 MGI:1349482 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
establishment of synaptic vesicle localization0.00012839305114723746MGI:107363 MGI:109355 MGI:1277959 MGI:1349763 MGI:1920211 MGI:1930705 MGI:700009
synaptic vesicle transport0.00012839305114723746MGI:107363 MGI:109355 MGI:1277959 MGI:1349763 MGI:1920211 MGI:1930705 MGI:700009
hydrogen transport0.00012054481450797241MGI:103286 MGI:1201778 MGI:1201780 MGI:1349482 MGI:1914864 MGI:88106 MGI:88115
nucleoside monophosphate catabolic process0.0001137174120390001MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115
proton transport0.00011308956929684645MGI:103286 MGI:1201778 MGI:1201780 MGI:1349482 MGI:1914864 MGI:88106 MGI:88115
aromatic compound catabolic process0.00010934531564453567MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781
purine nucleoside monophosphate catabolic process0.00010841018438160754MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115
purine ribonucleoside monophosphate catabolic process0.0001068416420621079MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115
ribonucleoside monophosphate catabolic process0.0001068416420621079MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115
cellular component organization or biogenesis0.0001066383806771792MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107812 MGI:109355 MGI:1095410 MGI:109611 MGI:1196356 MGI:1201778 MGI:1277959 MGI:1344351 MGI:1346065 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1861691 MGI:1890773 MGI:1915472 MGI:1920211 MGI:1930705 MGI:2137336 MGI:2388633 MGI:2441982 MGI:3039563 MGI:3039785 MGI:3528396 MGI:700009 MGI:87904 MGI:88067 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96925 MGI:97623
regulation of postsynaptic membrane potential0.00010282086290560549MGI:107164 MGI:1277959 MGI:1920211 MGI:95819 MGI:95820 MGI:95821
ATP catabolic process0.00009612734653822465MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115
action potential0.00009167755305308728MGI:106925 MGI:109611 MGI:1340046 MGI:88110 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623
carbohydrate derivative metabolic process0.0000766623560662826MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2388633 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
visual behavior0.00007638571316231883MGI:101931 MGI:3039785 MGI:88106 MGI:88107 MGI:95819 MGI:95820
learning0.00007571101558410793MGI:106919 MGI:3039785 MGI:88106 MGI:88107 MGI:95627 MGI:95819 MGI:95820 MGI:95821
behavior0.00006547867926131324MGI:101931 MGI:105368 MGI:106919 MGI:107163 MGI:1277959 MGI:1340046 MGI:1920211 MGI:1929898 MGI:3039785 MGI:88106 MGI:88107 MGI:95627 MGI:95775 MGI:95819 MGI:95820 MGI:95821 MGI:96659
locomotory behavior0.00005567162609805977MGI:105368 MGI:107163 MGI:1277959 MGI:1340046 MGI:1929898 MGI:88106 MGI:88107 MGI:95775 MGI:95819 MGI:95820
cellular chemical homeostasis0.000048909186843065205MGI:103286 MGI:105368 MGI:107163 MGI:107164 MGI:1277959 MGI:1349482 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:95781 MGI:95819
synaptic transmission glutamatergic0.00004752507859010513MGI:1351340 MGI:1920211 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821
cellular component organization0.000047475418460567916MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107812 MGI:109355 MGI:1095410 MGI:109611 MGI:1196356 MGI:1201778 MGI:1277959 MGI:1344351 MGI:1346065 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1861691 MGI:1890773 MGI:1915472 MGI:1920211 MGI:1930705 MGI:2137336 MGI:2388633 MGI:2441982 MGI:3039563 MGI:3039785 MGI:3528396 MGI:700009 MGI:87904 MGI:88067 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96925 MGI:97623
regulation of excitatory postsynaptic membrane potential0.000040503336398267025MGI:107164 MGI:1277959 MGI:1920211 MGI:95819 MGI:95820 MGI:95821
carbohydrate derivative catabolic process0.00003924074396516736MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
organophosphate catabolic process0.00003924074396516736MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
phosphorus metabolic process0.00003053475918062108MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107163 MGI:107164 MGI:107231 MGI:107812 MGI:109486 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1915084 MGI:1915472 MGI:1919228 MGI:1919792 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95775 MGI:95781 MGI:95821 MGI:96247 MGI:97591 MGI:99441
potassium ion import0.000030450568144011903MGI:104743 MGI:88105 MGI:88106 MGI:88107 MGI:88108
regulation of neurotransmitter levels0.000026729641309502923MGI:107363 MGI:107672 MGI:109355 MGI:1920211 MGI:1930705 MGI:2441982 MGI:88106 MGI:88110 MGI:88256
regulation of biological quality0.00002665946266029523MGI:103286 MGI:105368 MGI:106925 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:109486 MGI:109611 MGI:1277959 MGI:1340046 MGI:1349482 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2137336 MGI:2441982 MGI:3039785 MGI:87904 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95739 MGI:95781 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96925 MGI:97623
sodium ion transport0.000026549123791483953MGI:101931 MGI:1349482 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:95627 MGI:95630
phosphate-containing compound metabolic process0.00002202122558578041MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107163 MGI:107164 MGI:107231 MGI:107812 MGI:109486 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1915084 MGI:1915472 MGI:1919228 MGI:1919792 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95775 MGI:95781 MGI:95821 MGI:96247 MGI:97591 MGI:99441
divalent inorganic cation transport0.000019915186391712698MGI:105368 MGI:106919 MGI:107164 MGI:107671 MGI:88106 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95775 MGI:95819 MGI:95820 MGI:95821
cellular potassium ion homeostasis0.000019046097707136378MGI:88105 MGI:88106 MGI:88107 MGI:88108
nucleoside phosphate catabolic process0.000018227346630251273MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
single-organism behavior0.000016627844344996232MGI:101931 MGI:106919 MGI:1277959 MGI:1340046 MGI:1920211 MGI:1929898 MGI:3039785 MGI:88106 MGI:88107 MGI:95627 MGI:95819 MGI:95820 MGI:95821 MGI:96659
cellular monovalent inorganic cation homeostasis0.00001622469238027371MGI:103286 MGI:1920211 MGI:1927555 MGI:88105 MGI:88106 MGI:88107 MGI:88108
nucleotide catabolic process0.000016068915909002517MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
divalent metal ion transport0.000013591385353497697MGI:105368 MGI:106919 MGI:107164 MGI:107671 MGI:88106 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95775 MGI:95819 MGI:95820 MGI:95821
organic cyclic compound catabolic process0.000012518895297289373MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1349763 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781
glycosyl compound catabolic process0.000012296563843686587MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
ribonucleotide catabolic process0.000012296563843686587MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
sodium ion export0.00001225076016529261MGI:88105 MGI:88106 MGI:88107 MGI:88108
purine ribonucleotide catabolic process0.000012233466959364496MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
purine nucleotide catabolic process0.000012199253587709406MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
nucleoside catabolic process0.000011447800544248012MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
ribonucleoside catabolic process0.000011180021025612988MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
purine nucleoside catabolic process0.000010464611654313495MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
purine ribonucleoside catabolic process0.000010464611654313495MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
nucleoside triphosphate catabolic process0.000010028302525523456MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
purine nucleoside triphosphate catabolic process0.000009246239569099924MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
calcium ion transport0.000009185788120317744MGI:105368 MGI:106919 MGI:107164 MGI:107671 MGI:88106 MGI:88108 MGI:88110 MGI:88256 MGI:88257 MGI:95775 MGI:95819 MGI:95820 MGI:95821
purine ribonucleoside triphosphate catabolic process0.000009139980753188906MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
ribonucleotide metabolic process0.000009133564590040161MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
heterocycle catabolic process0.000009131609937379457MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1349763 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781
purine nucleotide metabolic process0.000009129952865778999MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
ribonucleoside triphosphate catabolic process0.000009032179711749167MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781
nucleoside monophosphate metabolic process0.000008999464914011346MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:1201780 MGI:2685080 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:97591
cellular nitrogen compound catabolic process0.000008841851946820866MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1349763 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781
purine ribonucleotide metabolic process0.000008143845551469607MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
sodium ion export from cell0.000007909730674975003MGI:88105 MGI:88106 MGI:88107 MGI:88108
ribonucleoside monophosphate metabolic process0.000007355883528838428MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:1201780 MGI:2685080 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:97591
regulation of long-term neuronal synaptic plasticity0.000006866434484011167MGI:1277959 MGI:3039785 MGI:88257 MGI:95819 MGI:95820 MGI:95821
purine ribonucleoside monophosphate metabolic process0.0000068224292836282415MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:1201780 MGI:2685080 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:97591
purine nucleoside monophosphate metabolic process0.000006790123599720484MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:1201780 MGI:2685080 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:97591
small molecule metabolic process0.000005689536142398404MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107231 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1346858 MGI:1349763 MGI:1913764 MGI:1914195 MGI:1915084 MGI:1915472 MGI:1919792 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95739 MGI:95775 MGI:95781 MGI:97591 MGI:97623
purine-containing compound metabolic process0.000005342872001309135MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781 MGI:97591
purine-containing compound catabolic process0.000004097312403010567MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1915472 MGI:1919792 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781
regulation of neuronal synaptic plasticity0.00000387367432470711MGI:1277959 MGI:3039785 MGI:88256 MGI:88257 MGI:95819 MGI:95820 MGI:95821
ATP metabolic process0.00000331289760086MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:1201778 MGI:1201780 MGI:2685080 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:97591
neurotransmitter transport0.000002976930445381089MGI:107363 MGI:107672 MGI:109355 MGI:1920211 MGI:1930705 MGI:88106 MGI:88110 MGI:88256 MGI:95627 MGI:95630
organonitrogen compound metabolic process0.0000029041307385719007MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107793 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1346858 MGI:1349763 MGI:1913764 MGI:1915084 MGI:1915472 MGI:1919792 MGI:2388633 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95739 MGI:95775 MGI:95781 MGI:95820 MGI:97591
ribose phosphate metabolic process0.000002695731241042412MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
glycosyl compound metabolic process0.000002491130487473125MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
single-organism catabolic process0.000002440968480056341MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107793 MGI:107812 MGI:109486 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1349763 MGI:1913764 MGI:1915472 MGI:1919792 MGI:2441982 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95678 MGI:95775 MGI:95781 MGI:97591
nucleoside metabolic process0.0000020040218593738706MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
ATP hydrolysis coupled proton transport0.0000017748031933409206MGI:103286 MGI:1201778 MGI:1201780 MGI:1914864 MGI:88106 MGI:88115
energy coupled proton transmembrane transport against electrochemical gradient0.0000017748031933409206MGI:103286 MGI:1201778 MGI:1201780 MGI:1914864 MGI:88106 MGI:88115
ionotropic glutamate receptor signaling pathway0.0000017748031933409206MGI:88107 MGI:88256 MGI:95809 MGI:95819 MGI:95820 MGI:95821
neuron-neuron synaptic transmission0.000001731148498107576MGI:106919 MGI:107363 MGI:1351340 MGI:1920211 MGI:95627 MGI:95739 MGI:95809 MGI:95819 MGI:95820 MGI:95821
ribonucleoside metabolic process0.0000017118968364654713MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
organophosphate metabolic process0.0000016855221601326902MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:105992 MGI:107231 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1915084 MGI:1915472 MGI:1919792 MGI:2441982 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
localization0.0000016474578427427677MGI:101931 MGI:103286 MGI:104560 MGI:104743 MGI:105368 MGI:105384 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:109355 MGI:109611 MGI:1201778 MGI:1201780 MGI:1277959 MGI:1344351 MGI:1346065 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1353498 MGI:1890773 MGI:1914195 MGI:1914864 MGI:1920211 MGI:1927555 MGI:1929898 MGI:1930705 MGI:2388633 MGI:3039785 MGI:700009 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659 MGI:96955
purine nucleoside metabolic process0.0000016392083819083274MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
purine ribonucleoside metabolic process0.0000016152391637393588MGI:103286 MGI:104560 MGI:105368 MGI:105384 MGI:107812 MGI:1095410 MGI:1196356 MGI:1201778 MGI:1201780 MGI:1915472 MGI:1919792 MGI:2685080 MGI:3039785 MGI:3528396 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:95775 MGI:95781 MGI:97591
glutamate receptor signaling pathway0.0000015957904434518762MGI:1277959 MGI:1351340 MGI:88107 MGI:88256 MGI:95809 MGI:95819 MGI:95820 MGI:95821
regulation of synaptic plasticity0.000001492507524200447MGI:105368 MGI:107363 MGI:1277959 MGI:2137336 MGI:3039785 MGI:88256 MGI:88257 MGI:95819 MGI:95820 MGI:95821
regulation of localization0.0000013991035549580587MGI:101931 MGI:104560 MGI:104743 MGI:105368 MGI:106919 MGI:107163 MGI:107164 MGI:107231 MGI:107363 MGI:107672 MGI:109355 MGI:109611 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1890773 MGI:1930705 MGI:2388633 MGI:700009 MGI:88105 MGI:88106 MGI:88108 MGI:88110 MGI:88256 MGI:95627 MGI:95739 MGI:95775 MGI:95819 MGI:95820 MGI:95821 MGI:96247 MGI:96659

Supplementary Table 7. MS data obtained from a single step purifications from ArcTAP/+ and ArcTAP/TAP crossed with PSD95/Dlg4 knokout mice.

idProtein IDMajority protein IDsProtein nameGene namePeptidesPeptides 1S-PSD95mut01Peptides 1S-PSD95mut02Peptides 1S-PSD95mut03Experiment 1S-PSD95mut01Experiment 1S-PSD95mut02Experiment 1S-PSD95mut03# replicates identified inAverage Ratio M/L (ARC/Cont)Total M/L Ratio countRatio M/L 1S-PSD95mut01Ratio M/L count 1S-PSD95mut01Ratio M/L 1S-PSD95mut02Ratio M/L count 1S-PSD95mut02Ratio M/L 1S-PSD95mut03Ratio M/L count 1S-PSD95mut03# replicates enriched (1 + 2 step)Average Ratio H/M (PSD95mut/ARC)Normalised Average Ratio H/M (PSD95mut/ARC)total H/M Ratio count# replicates quantifiedRatio H/M 1S-PSD95mut01Ratio H/M count 1S-PSD95mut01Ratio H/M 1S-PSD95mut02Ratio H/M count 1S-PSD95mut02Ratio H/M 1S-PSD95mut03Ratio H/M count 1S-PSD95mut03Total PSD-95 complex (# replicates)PSD-95 Core ComplexPSD-95 InteractorAv Intensity L (cont)Av Intensity M (ARC)Av Intensity H (PSD95mut)Av Intensity M/L (ARC)Av Intensity H/M (PSD95mut)Intensity 1S-PSD95mut01Intensity L 1S-PSD95mut01Intensity M 1S-PSD95mut01Intensity H 1S-PSD95mut01Intensity 1S-PSD95mut02Intensity L 1S-PSD95mut02Intensity M 1S-PSD95mut02Intensity H 1S-PSD95mut02Intensity 1S-PSD95mut03Intensity L 1S-PSD95mut03Intensity M 1S-PSD95mut03Intensity H 1S-PSD95mut03Av Intensity L (cont)Av Intensity M (ARC)Av Intensity H (PSD95mut)
549G3UYQ4G3UYQ4Adenylate kinase domain-containing 1Akd13111441318.96835.229132.7072020.0720.234320.17010.04520133475.55081773.33328389438.0730.05662992061341507560610181511700020561014404000506770333760333760133475.55081773.333
1001Q62108 Q62108-3 Q62108-2 G3UZL5Q62108 Q62108-3 Q62108-2Disks large homolog 4Dlg496303432190218149318.68523113.7557623.0449719.2575880.0600.19620330.060650.065900.038485YESYES7553633.333125555666718849200166.2190.01512181000008840800118170000027537000225940000010823000222640000022178000368400000299710035857000068326007553633.3331255556667
1263Q91XM9Q91XM9Disks large homolog 2Dlg2631823221029770318.11815112.3306626.5904715.4353880.1390.45314730.292650.201470.061355YESYES4430600301913333.365101033.3368.1430.216384520000531510028443000094774000561680000398870046533000092363000168130000398800015598000081661004430600301913333.3
785P60202 F8WGE4 P60202-2P60202 F8WGE4 P60202-2Myelin proteolipid proteinPlp17421733317.3491210.917711.079330.052280.2540.8301230.33670.11530.56525YES1330330198829007611866.66714.9460.3833951900028150002853000081741001196100090596098967001158500349950002700302122200013503000133033019882900
976Q60771Q60771Claudin-11Cldn113111321316.892424.89428.8902050.5181.693420.16621.389201635654325553.333408410026.4450.944100360001302808623200128300011228000196850414550068852002079602079601635654325553.333
1447Q9WV31Q9WV31Activity-regulated cytoskeleton-associated proteinArc268108353822316.1926815.6602416.4833116.4331380.3061.0006730.779240.305310.141125YES2652690128695666.769652233.3348.5150.5412710700003228100134850000132990000271740000405260019912000068567000601940006773705211700073997002652690128695666.7
1106Q811D0Q811D0Disks large homolog 1Dlg147151418453834314.6828910.5643311.2623422.2202280.7702.5168931.879330.985340.218225YES3057300143151666.7155074333.346.8231.08332240000044797001046900002132400004744000003548000241700000229150000107040000114420083065000228330003057300143151666.7
1438Q9R111 D3YU09Q9R111 D3YU09Guanine deaminaseGda291298372014314.6656111.0423415.9131817.039950.1910.6246130.380340.214180.17095YESYES2753473.33377887666.672475010028.2870.3182107400005638500145230000598700008086000021640006704800011648000245760004579202138500027323002753473.33377887666.67
759P50516 P50516-2 D3Z1B9 D3YWH3 D3YZ23P50516 P50516-2V-type proton ATPase catalytic subunit AAtp6v1a201131210.36910010.369130.1970.64411000.39411116801327006715711.3610.506211540116801327006715711680132700
531P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7Histone H2A.x Histone H2A type 1 Histone H2A type 2-A Histone H2A type 3 Histone H2A type 1-F Histone H2A type 1-K Histone H2A type 2-C Histone H2A Histone H2A.J Histone H2A.Z Histone H2A.V Histone H2A type 1-H Histone H2A type 2-BH2afx Hist1h2ab Hist2h2aa1 Hist3h2a Hist1h2af Hist1h2ak Hist2h2ac Hist1h2aa H2afj H2afz H2afv Hist1h2ah Hist1h2al Hist2h2ab21103229.904512.92436.8842050.0860.282520.16430.0952047654046346507382259.7260.159898650074610070217001218700271230020698022476002577504765404634650
836P68369 P05214 Q3UX10P68369 P05214Tubulin alpha-1A chain Tubulin alpha-3 chainTuba1a Tuba3a832322739.6622009.662260.2050.66921000.41024YES1764502776000104200015.7330.3753994500176450277600010420001764502776000
1409Q9JKC6Q9JKC6Cell cycle exit and neuronal differentiation protein 1Cend121102228.902315.78122.0221020.3421.116320.50220.52410104746.5154860073419514.7840.4743368100111090205760011994001407000984031039600268990104746.51548600
79E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7IQ motif and SEC7 domain-containing protein 2Iqsec27619302754836438.5391235.969358.6294911.0193970.0910.29711430.196320.076470.093355YES4003833.3331005080008228566.66725.1030.0827292100041135006030900084979002082600006191900191490000105800005703900017061004972500056078004003833.333100508000
1460Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 A2A599Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98V-type proton ATPase 116 kDa subunit a isoform 1Atp6v0a1144461071138.508186.652714.08944.784750.3831.2511830.49470.75640.28274264706551533.3333056566.66715.3620.467117380006288007612700349650012188000428020742830043319006177500222590461360013413004264706551533.333
342P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 D3YYZ2P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4Polyubiquitin-C Ubiquitin Ubiquitin-related 1 Ubiquitin-related 2 Polyubiquitin-B Ubiquitin Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40Ubc Ubb 2810422J05Rik Rps27a Uba52 Gm7866512252437.98796.32458.24319.393370.5201.698931.16850.65810.25431290009.33332131936.6671405343.3337.3510.6598351900703140420160034472008403605742846471031822022896001094601729500450610290009.33332131936.667
725P35438 P35438-2P35438 P35438-2Glutamate [NMDA] receptor subunit zeta-1Grin11025346637.670116.500212.95343.557570.1270.416830.16920.08830.25335YESYES224326.33332727966.66729819012.1610.10920674009900916467003217105404100330650471650035699022799002433201820700215870224326.33332727966.667
110B1AZP2-2 B1AZP2 B7ZNS2 B1AZP2-3 F6YMR0 E9PUF2B1AZP2-2 B1AZP2 B7ZNS2Disks large-associated protein 4Dlgap42231093171537.483243.21116.3241412.915980.2200.7182330.53510.214140.13085YESYES116480513045833.331157953.33311.2000.0897999506656562520010819036084000304210030410000263240092213003857508102300733270116480513045833.33
1377Q9DB72Q9DB72BTB/POZ domain-containing protein 17Btbd17824237337.391114.31533.818714.040130.1950.638930.46830.16750.1461735895.33334200566.667548166.66675.7080.1303193700286120202540088217011714000189800091683006474201546500235661408000114910735895.33334200566.667
579O08553O08553Dihydropyrimidinase-related protein 2Dpysl227712825331837.030484.299229.000197.792760.3311.0804830.699220.245190.37973460166.66725682333.33101871007.4220.3975247800067812002731900018379000508520003213900390230008615900146570003854001070500035664003460166.66725682333.33
283E9PUA3 Q8R0S2-2 Q8R0S2E9PUA3 Q8R0S2-2 Q8R0S2IQ motif and SEC7 domain-containing protein 1Iqsec1194105413537.00996.05714.122710.848130.0790.257930.13410.10870.07415YES613146.66677043466.667294131.333311.4870.04215555003255114796004335819299000179430016692000812970299740012589295880026066613146.66677043466.667
457Q9QYS2 F6QVY9Q9QYS2 F6QVY9Metabotropic glutamate receptor 3Grm3522154236.86165.981311.19523.408130.1910.622630.30630.24720.21011121248.33331435096.66729264011.8360.20425910002295701899900461540258170010478020934003836103741502939531199032770121248.33331435096.667
663Q80TN1 P11798 F8WIS9 F6WHR9 D3Z7K9 F8WHB5 P11798-2 F8WIR6 D6RDQ8 E9QAJ4 E9PYZ8Q80TN1 P11798 F8WIS9Calcium/calmodulin-dependent protein kinase type II subunit alphaCamk2a113447131336.854267.49977.418125.644780.1510.4922330.27070.182110.15155YESYES10719307894666.6671662623.3337.3650.211116730001219600789970025538001529400017974001155800019381004921000198790422630049597010719307894666.667
941Q3UVU8Q3UVU8Disks large-associated protein 1Dlgap1287111016242036.819424.364128.867187.2261270.0670.2193330.13570.051170.08295YESYES232839036795666.671101566.66715.8030.03012274000875070106270007714808796900057012008026800020002002043400040890019492000533020232839036795666.67
718P31650P31650Sodium- and chloride-dependent GABA transporter 3Slc6a1131022226.75435.539207.968140.2780.907320.586200.2481131645.5920195558903.56.9900.6072818000238780152390010553004035102451131649062507131645.5920195
1078Q7TNS5Q7TNS5Novel protein similar to F-box and leucine-rich repeat protein 17B630019K06Rik21101226.455106.4551030.1740.5681100.348105YES3449772116512688020.9050.17647110047110011326003449797123012688034497721165
822P63017 Q504P4 D3Z5E2 D3YW43P63017 Q504P4Heat shock cognate 71 kDa proteinHspa823611621311036.398433.3641710.420195.409780.6622.1624331.884170.283190.481712153373.3332064500016685266.679.5870.808577980004149400193260003432200055060000203570039303000137210005593800275020330600020128002153373.33320645000
99Q6PFD5 B1AS06Q6PFD5 B1AS06Disks large-associated protein 3Dlgap32128117162236.385304.31078.864105.9811330.1260.4102630.28760.153100.062105YESYES823253.33331212770090514014.7310.075596310080181042611009002002373600010531002129900013836001186900061485010823000431620823253.333312127700
985Q61171 D3Z4A4Q61171 D3Z4A4Peroxiredoxin-2Prdx220112126.173307.16325.184120.2060.6713200.12420.49313YES12527012323351542609.8370.1252768200210150231350024455025553040390151170639701252701232335
88B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8Glutamate receptor 3 Glutamate receptor 4Gria3 Gria4623124236.00732.91419.0992040.1820.595320.29410.253204YES71310910626.6667149455.512.7700.1648449205664274522043061185730085978151550025585047116047116071310910626.6667
526F8WIG2 Q68EF6F8WIG2 Q68EF6Brain-enriched guanylate kinase-associated proteinBegain40224225.864405.45036.279160.1380.4513200.27120.14314YESYES12247211618751091379.4870.0942231500215910181750019811055545029034506250201641224721161875
1362Q9D6F9Q9D6F9Tubulin beta-4A chainTubb4a217861125.8281005.828110.27211000.5441160132106458235413.1550.391226430226430293220160131948608235416013210645
562G3X9V4 Q01097G3X9V4 Q01097Glutamate [NMDA] receptor subunit epsilon-2Grin2b714227335.77353.82018.74734.751130.1610.5251100.322105YESYES55323.333331286883.33390641.523.2610.0703713101982935148032490001253202957000166680587590208215521701460355323.333331286883.333
390Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 D3YUQ0 F6PZ09 F6XIT3 F7CDH3 F7DAP1 F7BZ55 F6VJ78 F6XRZ6 F7AYY9 F6TDF4 F6SK63 F7BXL9Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18Disintegrin and metalloproteinase domain-containing protein 22Adam22326141222332635.770388.212105.148193.951980.1420.4653230.12380.162180.28465YESYES1027806.66722162366.671164376.66721.5630.053102890005505509215600522600543470002166500497100002469900842850036637075615005006301027806.66722162366.67
887Q3UY21 Q61885 Q29ZQ5Q3UY21 Q61885 Q29ZQ5Myelin-oligodendrocyte glycoproteinMog32106225.75788.13163.3842040.3111.014820.64160.291202690125506085030685757.3330.60615762000113670087666005858800187700024355013551002783506901255060850
1309Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2Protein phosphatase 1BPpm1b41031425.75641.3311010.181310.708421.505100.62032231149297658853904.1670.952115020034893028543051588029264009729815741001254900223114929765
693P18872 P18872-2 D3Z2M7 F7BLT7 Q66L47 Q8CGK7 P50149 Q3V3I2 Q9DC51 P20612 A2AE32 Q8C040 A2AE31 A2A610P18872 P18872-2 D3Z2M7 F7BLT7Guanine nucleotide-binding protein G(o) subunit alphaGnao121012125.58831.247209.929130.3121.018320.575200.36115YES279373.56588103047792.3580.463229590054791011887005593001900201083712892050258279373.5658810
874Q02257Q02257Junction plakoglobinJup807111125.4151005.41510010.1077100.2157091573085069005033859.2900.0591030200091573085069008797701270001270009157308506900
55A2ARP8 Q9QYR6-2 Q9QYR6A2ARP8 Q9QYR6-2 Q9QYR6Microtubule-associated protein 1A MAP1 light chain LC2Mtap1a Map1a421142235.22576.72641.75317.195220.3181.039730.41040.57310.29022116707.66677109502470336.0920.347184490021625011650004637409265301077006271401916804525602617334071085679116707.6667710950
465F6SEU4F6SEU4Ras GTPase-activating protein SynGAPSyngap129415109382535.224452.79877.093235.7811540.1990.6504130.40770.150220.240125YESYES1168583.33317021600135634014.5660.0804500500379200328980083150042460000240190037536000252170011680000724650102390007158201168583.33317021600
333E9Q557 E9PZW0E9Q557 E9PZW0DesmoplakinDsp613215335.12862.77917.4775020.1930.631620.44210.138505358202165603.333413913.33334.0420.191770630145280472340153010746420092636058042007336705753302202703550605358202165603.333
166CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 G3UZ07 E9Q606 E9QAZ1 F8WGM8 E9Q2D1 F6WX90CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4"Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed"Actb361413934313334.813751.533313.812309.0931450.4471.4587531.000310.362300.4251450854393.33141516666.797881333.332.7830.69245396000099869000168310000185770000364010000517190002212500009104900052790000975180349900001682500050854393.33141516666.7
742P46460 G3UX86 G3UX98P46460Vesicle-fusing ATPaseNsf21011224.72820.947108.510130.4431.447220.897100.43215YES89053.3104782.560590.51.1770.57836392017279092145989771449405316.61174202220489053.3104782.5
1059Q6PIC6 Q8VCE0 Q9WV27 Q9Z1W8 E9QNX7 Q64436 Q91WH7Q6PIC6 Q8VCE0Sodium/potassium-transporting ATPase subunit alpha-3Atp1a32398616161034.474412.306167.940153.1771070.5741.8764131.403160.546150.34810187046089822006708566.6674.8020.7471768800028741005716300909780029675000231850017413000994380053201004187803817300108410018704608982200
1131Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6Disks large-associated protein 2Dlgap226313106251834.312252.54125.053155.342850.1690.5522230.19420.209130.27475YESYES780293.333311444866.67822223.333314.6670.0722835100565840212670014256027640000137250024269000199830086672004025407938900325810780293.333311444866.67
740P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 F6ZRK3P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6Excitatory amino acid transporter 2Slc1a2732266434.261144.11864.32564.340250.3121.0201230.55460.40240.29425YES477895.66672985966.6671113026.6676.2480.3735374800778550275570018405007012600595020511560013020001343300601171086600196580477895.66672985966.667
870P99024 G3UZR1P99024Tubulin beta-5 chainTubb520776231134.018101.96126.51233.581550.4301.4051030.93020.42830.36351830233.333634320042871003.4660.67618760000388030071067007773200123960001202300768020035130006225900408100424270015751001830233.3336343200
837P68372P68372Tubulin beta-4B chainTubb4b2599719202733.959282.070123.943115.864550.3431.1202830.618120.402110.35152944223.33310013633.335414866.6673.4010.5412858000061759001252500098787002110400024195001342500052591005434900237270409090011068002944223.33310013633.33
461F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2Myelin basic proteinMbp833255233.94792.77155.1234050.1740.568920.32650.1964020537404481436.66717079402.1820.381133480003118900761550026136007453300988580566240080228016641016641020537404481436.667
1138Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3Brain-specific angiogenesis inhibitor 1-associated protein 2Baiap213382413233.921182.42433.219136.118240.1550.5061830.20830.235130.17725YESYES197240010243966.6715808405.1940.15463829001254100429390083491031294000452380023644000312620037147001393002794000781410197240010243966.67
762P52189 Q8R435P52189 Q8R435Inward rectifier potassium channel 4Kcnj4622235533.811102.60732.74046.086380.2900.9461030.28730.40640.46635YESYES306996.66671426473.333379986.66674.6470.26614660002441409027203191303309800560570217960056965015646001162801197100251180306996.66671426473.333
217Q6PIE5 D3YYN7 D3YVX6Q6PIE5 D3YYN7 D3YVX6Sodium/potassium-transporting ATPase subunit alpha-2Atp1a22279675233.79692.48655.1064030.5121.671920.98350.55340427785183575015378004.2910.8383403800492900142000014910005405800362670345850015846006287506287504277851835750
724P35436P35436Glutamate [NMDA] receptor subunit epsilon-1Grin2a815219333.748703.65063.847120.0990.3246200.14750.15015YESYES259325.52586723.333272830.559.9750.10512609012609081285005057907084400538240569960128615496807421.1259325.52586723.333
735P40124 B1ARS0P40124 B1ARS0Adenylyl cyclase-associated protein 1 Adenylyl cyclase-associated proteinCap11033476633.698171.50661.66267.927510.4261730.86660.34960.489513196973.3335736466.6673901933.3331.7940.68020315000508210075644007668900133280004309600665040023677004863100199220299460016692003196973.3335736466.667
472F6VAN0F6VAN0Atf6Atf621101223.54332.58714.5002020.8092.643320.42412.00420443720181030024031254.0801.327271360049036014805007427506600700397080214010040635004437201810300
969Q5SXR6 Q68FD5 E9Q434 F6Z1R4Q5SXR6 Q68FD5Clathrin heavy chain 1Cltc12372414433.509173.00344.503103.020350.4111.3411730.70940.552100.38234YES761326.666750125002554206.6676.5840.5106869600961760342070024871001559600011959009935200446440025191001263201681600711120761326.66675012500
20A2AEG6 P35803 E9QPU6 P35803-8 P35803-3A2AEG6 P35803 E9QPU6 P35803-8 P35803-3Neuronal membrane glycoprotein M6-bGpm6b311122133.47143.48923.4532040.2460.803420.38020.35820129570898968.33334930106.9380.5482548800151390172540067197012958001077508739703140509753597535129570898968.3333
908Q3TXX4Q3TXX4Vesicular glutamate transporter 1Slc17a721012123.45633.911203.001120.1840.601320.333200.2201162574.58810802322805.4200.264207280027064014146003875904790405450934756076970162574.5881080
403E9Q8N8 O88343 O88343-2 A7E1Z5E9Q8N8 O88343 O88343-2Electrogenic sodium bicarbonate cotransporter 1Slc4a49234771133.42760.97814.06925.234340.3161.031630.50710.30120.45434YES97451.333331124106.667310803.333311.5350.27611462006315869952038354015724001299601151200291280187850099236152160025759097451.333331124106.667
683P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 D3Z0Z9 E9PX99 F6QXU4P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4Glyceraldehyde-3-phosphate dehydrogenaseGapdh Gm10293 Gm4609 Gm10358 Gm2606 Gm5559 Gm10291 Gm6316 Gm10481 Gm10566 Gm8055 Gm10290 Gm3222 Gm6981 Gm7293 Gm5507 Gm10313622246533.27141.57224.9702040.2310.753420.52120.171205YES8653801674876.6677355551.9350.439363530010780001738100819290431800065276030134006518202731302731308653801674876.667
426P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2Glutamate receptor 2Gria21345478733.226123.82643.76952.083340.1970.6431130.22640.27150.29025YES2751502830433.333356706.666710.2870.1263713300292480310260031825048909003884503856000646480178260014452015327001053902751502830433.333
1293Q99KI0Q99KI0"Aconitate hydratase, mitochondrial"Aco230214123.216203.2162010.2172100.434204YES2131603521802142101.6520.6081022600213160595240214210109120109120213160352180
761P51863P51863V-type proton ATPase subunit d 1Atp6v0d142203223.18433.18430030.1950.638310.3913005YES28242011988005708904.2450.476242460028242015713005708908263008263002824201198800
661P11499 E9PX27 E9Q0C3 E9Q3D6 D3Z1R1P11499Heat shock protein HSP 90-betaHsp90ab1833257433.05382.69231.88034.588240.4951.616830.70330.92030.35721208570.33331464456.667624216.66677.0210.4262469300268560138570081504032139002961302036400881290120860061021971270176320208570.33331464456.667
574G5E902 Q8VEM8G5E902 Q8VEM8"Phosphate carrier protein, mitochondrial"Slc25a3311123132.88253.48422.2793050.3841.253520.50120.6503011316250396680021053003.0140.5318630000142040047200002489600614660012121003213600172100013162503966800
753P48722 P48722-2 E0CY23 F6SMW7 F6TFH3P48722 P48722-2 E0CY23Heat shock 70 kDa protein 4LHspa4l21102222.87834.23011.5262031.2694.144321.70112.1062084758.51699004536552.0052.6705040604921710667034817091257012030023313055914084758.5169900
676P15105 D3YVK1 D3Z121P15105 D3YVK1Glutamine synthetaseGlul311121132.75422.75420050.1960.641210.3932005YES2036607251803438403.5610.47420262002036601478700343840382930382930313910313910203660725180
800P61264 Q00262 Q80W45 Q3TJ55P61264Syntaxin-1BStx1b412156232.63382.19333.0745030.2720.888820.50730.309505YES5419751799173.33312249353.3200.681447150051863022522001700700418040056532028659007491702794202794205419751799173.333
680P16388P16388Potassium voltage-gated channel subfamily A member 1Kcna120112122.5821002.582110.26611000.53315YESYES2814657732510745020.5120.1869135009135003767502814624115010745028146577325

Supplementary Table 8. Map of Arc complex to OMIM disorders.

LoF mut. Nonsynonymous mut. Arc interactor type
Gene name AUT EPI ID SCZ AUT EPI ID SCZ Increased in PSD95-/- Decreased in PSD95-/- Known PSD95 direct interactor
ACTB....x1...NNN
ACTN4....x1..3:5NNN
ADAM22...1:2x1..5:4NYY
ALDH5A1...1:1x2.. x1, 7:2NNN
ASRGL1...0:1...7:6NNN
ATF6...0:2...0:2YNN
ATP1A1x1...x2..3:0NNN
ATP1A2...1:0...4:3YNN
ATP1A3....x1..2:1YNN
ATP1B1x1..1:0x1..2:0NNN
ATP2A2...1:0...2:0NNN
ATP2B2...0:2x1..0:2NNY
ATP5A1...1:0...5:1NNN
ATP6V0A1...1:0...2:1NNN
ATP6V1A....x1..2:2NNN
ATP6V1H...1:0...1:6NNN
BAIAP2...1:0... x2, 1:0 NYY
CAMK2A...1:0x1..2:0NYY
CAMK2B...2:0...2:0NNN
CEND1.......1:0NNN
CLTC.......2:2NNN
CRMP1.......1:5NNN
DDR2....x1...NNN
DLG1...1:0... x1, 5:0 YNN
DLG2...x1x1.. x1, 4:8 NYY
DLG4......x11:2NYY
DLGAP1.......3:2NYY
DLGAP2....x2..1:0NYY
DLGAP3.......3:1NYY
DLGAP4...0:1...4:7NNY
DPYSL2....x2..0:1NNN
DSP..x1...x12:0NYN
GAPDH...1:0...1:0NNN
GDA.......4:1NYY
GLUL.....x1.2:0NNN
GNAO1....x1x2. x1, 0:3NNN
GNB1.......0:2NNN
GPM6A.......2:1NNN
GPM6B.......0:2NNN
GRIA2x1...x1..2:1NYN
GRIA3.......0:1NYN
GRIA4.......2:6NYN
GRIN1.....x1.2:0NYY
GRIN2A...2:0..x2 x1, 2:0NYY
GRIN2Bx3..0:1x4x1x22:3NNY
GRM3.......3:2NYN
H2AFV....x1..x1NYN
H2AFX.......1:0NYN
HIST1H2AA...0:2...0:2NYN
HIST1H2AD...4:3...4:3NYN
HIST1H2AH...3:1...3:1NYN
HIST2H2AB.......0:1NYN
HIST2H2AC.......0:1NYN
HIST3H2A...0:1...3:6NYN
HSPA4L...1:1...2:7YNN
HSPA8...x1...x2YNN
IDH3A.......1:2NNN
IQSEC1.....x1.4:1NYN
IQSEC2.x1x11:0.x1x11:1NYN
KCNA2.......0:1NNY
KCNJ4.......2:0NNY
LGI1.......0:2YNN
MAP1A...2:0...2:0NNN
MAP6...0:1...0:1NNN
MBP...1:0...4:4NYN
MOG.......0:1NNN
MYO18B...0:1x2.. x1, 2:3NNN
NSF.......1:1NNN
PGAM5.......2:2NNN
PKM...6:4x1..6:4YNN
PPP2R2A...2:0...2:0NNN
PPP3CA.....x1.2:3NNN
PRDX2...0:1...0:1NNN
RTN1.....x1.1:1NNN
SDHA...6:4x1..6:4NNN
SEPT8...0:2...5:12NNN
SLC1A2.....x1.3:2NNN
SLC25A3...1:0...1:0NNN
SLC3A2...1:0... x1, 1:0NNN
SLC4A4....x1..3:7NNN
SLC6A1..x1.x4.x11:0NNN
SLC6A11...1:1...1:2NNN
SLC9A3R1...7:2... x1, 10:7NNN
STX1A.......0:1NNN
STX1B.x1...x1.1:2NNN
STXBP1.x1x1.x1x5x3.NNN
SYNGAP1x5.x3 x1, 1:0x8.x3 x1, 4:0 NYY
TKT...0:1...3:7NNN
TUBA1A..x1.x2.x1.NNN
TUBA3E...0:1...0:1NNN
TUBA4A.......0:2NNN
TUBB4B....x1...NNN
UBA1.......2:1NNN
UBA52...1:0...1:0YNN
UBC...2:2...2:2YNN
VDAC1.......1:0NNN

Supplementary Table 9. Map of Arc complex to OMIM disorders.

Gene nameOMIM IDDisease
Actb243310Baraitser-Winter syndrome 1
Actb607371Dystonia, juvenile-onset
Actn4603278Glomerulosclerosis, focal segmental, 1
Aldh5a1271980Succinic semialdehyde dehydrogenase deficiency
Atp1a2104290Alternating hemiplegia of childhood
Atp1a2602481Migraine, familial basilar
Atp1a2602481Migraine, familial hemiplegic, 2
Atp1a3128235Dystonia-12
Atp1a3601338CAPOS syndrome
Atp1a3614820Alternating hemiplegia of childhood 2
Atp1b1145500Blood pressure regulation QTL
Atp2a2101900Acrokeratosis verruciformis
Atp2a2124200Darier disease
Atp2b2601386Deafness, autosomal recessive 12, modifier of
Atp5a1615228Mitochondrial complex (ATP synthase) deficiency, nuclear type 4
Atp5a1616045Combined oxidative phosphorylation deficiency 22
Dsp605676Cardiomyopathy, dilated, with woolly hair and keratoderma
Dsp607450Arrhythmogenic right ventricular dysplasia 8
Dsp607655Skin fragility-woolly hair syndrome
Dsp609638Epidermolysis bullosa, lethal acantholytic
Dsp612908Keratosis palmoplantaris striata II
Dsp615821Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis
Glul610015Glutamine deficiency, congenital
Gnao1615473Epileptic encephalopathy, early infantile, 17
Grin1614254Mental retardation, autosomal dominant 8
Grin2a245570Epilepsy, focal, with speech disorder and with or without mental retardation
Grin2b613970Mental retardation, autosomal dominant 6
Grin2b616139Epileptic encephalopathy, early infantile, 27
Iqsec2309530Mental retardation, X-linked 1
Lgi1600512Epilepsy, familial temporal lobe, 1
Mog614250Narcolepsy 7
Plp1312080Pelizaeus-Merzbacher disease
Plp1312920Spastic paraplegia 2, X-linked
Sdha252011Mitochondrial respiratory chain complex II deficiency
Sdha256000Leigh syndrome
Sdha613642Cardiomyopathy, dilated, 1GG
Sdha614165Paragangliomas 5
Slc25a3610773Mitochondrial phosphate carrier deficiency
Slc4a4604278Renal tubular acidosis, proximal, with ocular abnormalities
Slc9a3r1612287Nephrolithiasis/osteoporosis, hypophosphatemic, 2
Stxbp1612164Epileptic encephalopathy, early infantile, 4
Syngap1612621Mental retardation, autosomal dominant 5
Tubb5615771Cortical dysplasia, complex, with other brain malformations 6
Uba1301830Spinal muscular atrophy, X-linked 2, infantile

Supplementary Table 10. Mammalian Phenotype Ontology of ARC interactors.

Mammalian Phenotype Ontologyp valueMatching Genes
abnormal synaptic transmission1.24E-16 MGI:106919 MGI:107363 MGI:107793 MGI:109355 MGI:1196356 MGI:1277959 MGI:1344351 MGI:1861691 MGI:1920211 MGI:1930705 MGI:2137336 MGI:3039563 MGI:3039785 MGI:88067 MGI:88106 MGI:88107 MGI:88256 MGI:88257 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:99441
abnormal CNS synaptic transmission7.85E-15 MGI:106919 MGI:107793 MGI:109355 MGI:1196356 MGI:1277959 MGI:1344351 MGI:1861691 MGI:1920211 MGI:1930705 MGI:2137336 MGI:3039563 MGI:3039785 MGI:88067 MGI:88107 MGI:88256 MGI:88257 MGI:95627 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:99441
abnormal nervous system physiology5.05E-14 MGI:101931 MGI:105368 MGI:106919 MGI:107231 MGI:107363 MGI:107793 MGI:109355 MGI:1196356 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1351340 MGI:1861691 MGI:1920211 MGI:1929898 MGI:1930705 MGI:2137336 MGI:2441982 MGI:3039563 MGI:3039785 MGI:88067 MGI:88106 MGI:88107 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
nervous system phenotype1.97E-13 MGI:101931 MGI:105368 MGI:105992 MGI:106919 MGI:106925 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107793 MGI:109355 MGI:1196356 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1351340 MGI:1861691 MGI:1920211 MGI:1929898 MGI:1930705 MGI:2137336 MGI:2441982 MGI:3039563 MGI:3039785 MGI:87904 MGI:88067 MGI:88106 MGI:88107 MGI:88256 MGI:88257 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
abnormal spatial learning1.33E-12 MGI:106919 MGI:107793 MGI:1277959 MGI:1346858 MGI:1920211 MGI:2137336 MGI:3039785 MGI:88067 MGI:88106 MGI:88107 MGI:88256 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96925 MGI:99441
abnormal glutamate-mediated receptor currents3.35E-11 MGI:1277959 MGI:1861691 MGI:1930705 MGI:3039563 MGI:3039785 MGI:88067 MGI:95809 MGI:95819 MGI:95820 MGI:95821
abnormal behavior4.35E-11 MGI:101931 MGI:105368 MGI:105992 MGI:106919 MGI:106925 MGI:107231 MGI:107363 MGI:107793 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1351340 MGI:1861691 MGI:1920211 MGI:1929898 MGI:1930705 MGI:2137336 MGI:2441982 MGI:3039563 MGI:3039785 MGI:87904 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88256 MGI:88257 MGI:894310 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
behavior/neurological phenotype4.35E-11 MGI:101931 MGI:105368 MGI:105992 MGI:106919 MGI:106925 MGI:107231 MGI:107363 MGI:107793 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1351340 MGI:1861691 MGI:1920211 MGI:1929898 MGI:1930705 MGI:2137336 MGI:2441982 MGI:3039563 MGI:3039785 MGI:87904 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88256 MGI:88257 MGI:894310 MGI:95627 MGI:95630 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
abnormal learning/memory/conditioning1.47E-10 MGI:106919 MGI:107793 MGI:109355 MGI:1277959 MGI:1346858 MGI:1920211 MGI:2137336 MGI:3039785 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88256 MGI:88257 MGI:95627 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96925 MGI:99441
abnormal long term potentiation7.16E-10 MGI:106919 MGI:107793 MGI:109355 MGI:1277959 MGI:1920211 MGI:2137336 MGI:3039785 MGI:88067 MGI:88256 MGI:88257 MGI:95809 MGI:95819 MGI:95820 MGI:95821
abnormal fear/anxiety-related behavior2.11E-09 MGI:109355 MGI:1277959 MGI:1346858 MGI:1351340 MGI:1920211 MGI:3039563 MGI:3039785 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88256 MGI:95809 MGI:95819 MGI:95820 MGI:95821
abnormal motor coordination/ balance2.69E-09 MGI:105368 MGI:106925 MGI:107363 MGI:1277959 MGI:1340046 MGI:1920211 MGI:1929898 MGI:1930705 MGI:2441982 MGI:87904 MGI:88107 MGI:88110 MGI:88256 MGI:88257 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623
convulsive seizures2.74E-09 MGI:101931 MGI:1340046 MGI:1861691 MGI:2441982 MGI:3039785 MGI:88107 MGI:95809 MGI:95819 MGI:95820 MGI:96659 MGI:96925 MGI:97623
abnormal AMPA-mediated synaptic currents3.19E-09 MGI:1277959 MGI:1930705 MGI:3039785 MGI:88067 MGI:95809 MGI:95819 MGI:95821
abnormal anxiety-related response3.32E-09 MGI:109355 MGI:1277959 MGI:1346858 MGI:1351340 MGI:1920211 MGI:3039563 MGI:3039785 MGI:88105 MGI:88106 MGI:88107 MGI:88256 MGI:95809 MGI:95819 MGI:95820 MGI:95821
abnormal locomotor behavior4.25E-09 MGI:101931 MGI:105368 MGI:107363 MGI:109355 MGI:1277959 MGI:1340046 MGI:1349482 MGI:1861691 MGI:1929898 MGI:1930705 MGI:2441982 MGI:3039785 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88256 MGI:88257 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
seizures1.04E-08 MGI:101931 MGI:1340046 MGI:1861691 MGI:1930705 MGI:2441982 MGI:3039785 MGI:88107 MGI:88256 MGI:95630 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:96659 MGI:96925 MGI:97623
abnormal synaptic plasticity1.48E-08 MGI:109355 MGI:1277959 MGI:3039785 MGI:88256 MGI:88257 MGI:95809 MGI:95819 MGI:95821
abnormal emotion/affect behavior3.54E-08 MGI:109355 MGI:1277959 MGI:1346858 MGI:1351340 MGI:1920211 MGI:3039563 MGI:3039785 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88256 MGI:95627 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:99441
abnormal voluntary movement3.67E-08 MGI:101931 MGI:105368 MGI:107363 MGI:109355 MGI:1277959 MGI:1340046 MGI:1349482 MGI:1861691 MGI:1929898 MGI:1930705 MGI:2441982 MGI:3039785 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88256 MGI:88257 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
abnormal temporal memory8.67E-08 MGI:109355 MGI:1277959 MGI:1346858 MGI:1920211 MGI:88067 MGI:88256 MGI:88257 MGI:95627 MGI:95819 MGI:95820 MGI:95821
abnormal nervous system morphology9.81E-08 MGI:101931 MGI:105368 MGI:105992 MGI:106925 MGI:107164 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107793 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1349482 MGI:1349763 MGI:1861691 MGI:1920211 MGI:1929898 MGI:1930705 MGI:2441982 MGI:3039563 MGI:3039785 MGI:87904 MGI:88106 MGI:88107 MGI:88256 MGI:95739 MGI:95781 MGI:95809 MGI:95819 MGI:95821 MGI:96925 MGI:97623
abnormal motor capabilities/coordination/movement1.01E-07 MGI:101931 MGI:105368 MGI:106925 MGI:107363 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1349482 MGI:1861691 MGI:1920211 MGI:1929898 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88256 MGI:88257 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
abnormal associative learning1.04E-07 MGI:106919 MGI:109355 MGI:1277959 MGI:1346858 MGI:3039785 MGI:88067 MGI:88107 MGI:88256 MGI:88257 MGI:95627 MGI:95819 MGI:95820 MGI:95821
abnormal excitatory postsynaptic currents1.04E-07 MGI:1344351 MGI:1920211 MGI:1930705 MGI:3039785 MGI:88256 MGI:95809 MGI:95819 MGI:95820 MGI:95821
abnormal neuron morphology1.39E-07 MGI:101931 MGI:105368 MGI:106925 MGI:107231 MGI:107363 MGI:107671 MGI:107672 MGI:107793 MGI:109355 MGI:1277959 MGI:1340046 MGI:1346858 MGI:1349763 MGI:1920211 MGI:1929898 MGI:1930705 MGI:3039785 MGI:87904 MGI:88107 MGI:88256 MGI:95781 MGI:95809 MGI:95819 MGI:95821 MGI:96925 MGI:97623
reduced long term potentiation1.87E-07 MGI:106919 MGI:109355 MGI:1920211 MGI:3039785 MGI:88067 MGI:88256 MGI:88257 MGI:95819 MGI:95820 MGI:95821
mortality/aging2.53E-07 MGI:101931 MGI:105992 MGI:106919 MGI:107164 MGI:107231 MGI:107363 MGI:107422 MGI:109355 MGI:109611 MGI:1277959 MGI:1340046 MGI:1346858 MGI:1349482 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1921626 MGI:1926157 MGI:1927555 MGI:1930705 MGI:2137336 MGI:2441982 MGI:3039785 MGI:87904 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88108 MGI:88110 MGI:88115 MGI:88256 MGI:95630 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95821 MGI:96247 MGI:96659 MGI:96925 MGI:96955 MGI:97591 MGI:97623
abnormal startle reflex3.62E-07 MGI:105368 MGI:109355 MGI:1277959 MGI:1920211 MGI:3039785 MGI:88107 MGI:95627 MGI:95819 MGI:95820 MGI:95821 MGI:97623 MGI:99441
abnormal miniature excitatory postsynaptic currents8.23E-07 MGI:1861691 MGI:1920211 MGI:1930705 MGI:3039785 MGI:88067 MGI:95819 MGI:95820 MGI:95821
abnormal involuntary movement9.87E-07 MGI:105368 MGI:106925 MGI:109355 MGI:1277959 MGI:1344351 MGI:1920211 MGI:3039785 MGI:88106 MGI:88107 MGI:88110 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623 MGI:99441
abnormal excitatory postsynaptic potential1.23598E-06 MGI:109355 MGI:1344351 MGI:1920211 MGI:3039563 MGI:3039785 MGI:88256 MGI:95809 MGI:95821
abnormal survival1.49768E-06 MGI:101931 MGI:105992 MGI:106919 MGI:107164 MGI:107231 MGI:107363 MGI:109355 MGI:109611 MGI:1277959 MGI:1340046 MGI:1346858 MGI:1349482 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1921626 MGI:1927555 MGI:1930705 MGI:2137336 MGI:2441982 MGI:3039785 MGI:87904 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88115 MGI:88256 MGI:95630 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95821 MGI:96247 MGI:96659 MGI:96925 MGI:96955 MGI:97591 MGI:97623
decreased body weight2.63623E-06 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:2441982 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
decreased total tissue mass2.63623E-06 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:2441982 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
preweaning lethality3.30138E-06 MGI:101931 MGI:105992 MGI:106919 MGI:107231 MGI:107363 MGI:109355 MGI:109611 MGI:1277959 MGI:1340046 MGI:1346858 MGI:1349482 MGI:1861691 MGI:1890773 MGI:1921626 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:88067 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88115 MGI:95630 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95821 MGI:96247 MGI:96659 MGI:96955 MGI:97591 MGI:97623
abnormal contextual conditioning behavior3.5357E-06 MGI:109355 MGI:1277959 MGI:1346858 MGI:88067 MGI:88256 MGI:88257 MGI:95627 MGI:95819 MGI:95820
abnormal object recognition memory3.53711E-06 MGI:1920211 MGI:2137336 MGI:88067 MGI:88256 MGI:95627 MGI:95819 MGI:95821
abnormal cued conditioning behavior4.04487E-06 MGI:106919 MGI:109355 MGI:1346858 MGI:3039785 MGI:88067 MGI:88256 MGI:95627 MGI:95821
abnormal reflex4.09965E-06 MGI:105368 MGI:109355 MGI:1277959 MGI:1344351 MGI:1920211 MGI:3039785 MGI:88106 MGI:88107 MGI:88110 MGI:95627 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:97623 MGI:99441
abnormal seizure response to inducing agent5.68476E-06 MGI:101931 MGI:1861691 MGI:3039785 MGI:88107 MGI:95630 MGI:95819 MGI:95820 MGI:96659 MGI:96925 MGI:97623
decreased body size6.78824E-06 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:107231 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
abnormal spatial working memory8.254E-06 MGI:109355 MGI:1277959 MGI:3039785 MGI:95627 MGI:95809 MGI:95819 MGI:95821
abnormal locomotor activation1.03729E-05 MGI:101931 MGI:105368 MGI:109355 MGI:1277959 MGI:1861691 MGI:3039785 MGI:88105 MGI:88106 MGI:88107 MGI:88110 MGI:88256 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:97623 MGI:99441
abnormal NMDA-mediated synaptic currents1.11924E-05 MGI:1277959 MGI:3039563 MGI:95819 MGI:95820 MGI:95821
abnormal sensory capabilities/reflexes/nociception1.37773E-05 MGI:105368 MGI:109355 MGI:1277959 MGI:1344351 MGI:1920211 MGI:3039785 MGI:88106 MGI:88107 MGI:88110 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:97623 MGI:99441
ataxia1.97566E-05 MGI:105368 MGI:107363 MGI:1340046 MGI:1930705 MGI:2441982 MGI:88257 MGI:95627 MGI:95819 MGI:96659 MGI:96925 MGI:97623
impaired coordination1.9832E-05 MGI:106925 MGI:1277959 MGI:1920211 MGI:1929898 MGI:88257 MGI:95775 MGI:95809 MGI:95819 MGI:95820 MGI:95821 MGI:96659 MGI:96925 MGI:97623
abnormal body weight2.07649E-05 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:107422 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:2441982 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:96955 MGI:97623
abnormal neurite morphology2.13135E-05 MGI:106925 MGI:107231 MGI:107672 MGI:1277959 MGI:1349763 MGI:1920211 MGI:1929898 MGI:3039785 MGI:88256 MGI:95821 MGI:96925 MGI:97623
abnormal social investigation2.13909E-05 MGI:109355 MGI:1277959 MGI:1346858 MGI:3039785 MGI:95775 MGI:95819 MGI:95821
increased startle reflex3.00325E-05 MGI:109355 MGI:1920211 MGI:3039785 MGI:95627 MGI:95819 MGI:95820 MGI:95821
abnormal body size3.02202E-05 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:107231 MGI:107422 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:96955 MGI:97623
impaired conditioning behavior3.05474E-05 MGI:109355 MGI:1346858 MGI:3039785 MGI:88257 MGI:95627 MGI:95819 MGI:95820
abnormal discrimination learning3.06408E-05 MGI:1277959 MGI:3039785 MGI:95809 MGI:95819 MGI:95821
complete postnatal lethality3.48379E-05 MGI:101931 MGI:1340046 MGI:1861691 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:95739 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
social withdrawal3.71859E-05 MGI:1346858 MGI:3039785 MGI:95819 MGI:95821
abnormal synaptic depression3.84908E-05 MGI:109355 MGI:1196356 MGI:88256 MGI:88257 MGI:95809 MGI:95819 MGI:95821
impaired synaptic plasticity4.62327E-05 MGI:109355 MGI:3039785 MGI:95809 MGI:95819 MGI:95821
abnormal social/conspecific interaction4.77424E-05 MGI:105992 MGI:109355 MGI:1277959 MGI:1346858 MGI:3039785 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96925
enhanced long term potentiation4.79042E-05 MGI:1277959 MGI:2137336 MGI:88067 MGI:88256 MGI:95809 MGI:95821
abnormal postnatal growth/weight/body size6.84153E-05 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:107231 MGI:107422 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:96955 MGI:97623
abnormal nervous system electrophysiology6.98149E-05 MGI:105368 MGI:1861691 MGI:1920211 MGI:2441982 MGI:88067 MGI:88106 MGI:95809 MGI:95819 MGI:96659 MGI:97623
abnormal total tissue mass7.83106E-05 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:2441982 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
abnormal body composition9.19764E-05 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:107671 MGI:109355 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:2441982 MGI:87904 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
environmentally induced seizures9.82402E-05 MGI:1861691 MGI:3039785 MGI:88107 MGI:96925 MGI:97623
abnormal behavioral response to xenobiotic0.000106103 MGI:101931 MGI:1277959 MGI:1861691 MGI:3039563 MGI:3039785 MGI:88105 MGI:88107 MGI:95627 MGI:95630 MGI:95819 MGI:96659
abnormal telencephalon morphology0.000114178 MGI:101931 MGI:105368 MGI:107164 MGI:107793 MGI:1277959 MGI:1346858 MGI:1861691 MGI:3039563 MGI:3039785 MGI:88106 MGI:88107 MGI:95781 MGI:95809 MGI:95819 MGI:95821
lethality during fetal growth through weaning0.000118607 MGI:101931 MGI:107231 MGI:107363 MGI:109355 MGI:1277959 MGI:1340046 MGI:1346858 MGI:1861691 MGI:1890773 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:88106 MGI:88107 MGI:88110 MGI:95739 MGI:95775 MGI:95781 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
decreased anxiety-related response0.000120249 MGI:109355 MGI:1346858 MGI:3039785 MGI:88107 MGI:88256 MGI:95820 MGI:95821
abnormal cerebrum morphology0.000142191 MGI:101931 MGI:105368 MGI:107164 MGI:107793 MGI:1277959 MGI:1346858 MGI:1861691 MGI:3039785 MGI:88107 MGI:95781 MGI:95809 MGI:95819 MGI:95821
abnormal brain morphology0.000165824 MGI:101931 MGI:105368 MGI:105992 MGI:107164 MGI:107363 MGI:107793 MGI:1277959 MGI:1346858 MGI:1349482 MGI:1861691 MGI:1929898 MGI:3039563 MGI:3039785 MGI:88106 MGI:88107 MGI:95739 MGI:95781 MGI:95809 MGI:95819 MGI:95821 MGI:96925 MGI:97623
abnormal long term depression0.000176793 MGI:1196356 MGI:88256 MGI:88257 MGI:95809 MGI:95819 MGI:95821
increased anxiety-related response0.000311268 MGI:1277959 MGI:1920211 MGI:3039563 MGI:88105 MGI:88106 MGI:95809 MGI:95819 MGI:95821
abnormal locomotor coordination0.000343954 MGI:105368 MGI:107363 MGI:1340046 MGI:1929898 MGI:1930705 MGI:2441982 MGI:88107 MGI:88257 MGI:95627 MGI:95819 MGI:95821 MGI:96659 MGI:96925 MGI:97623
tonic seizures0.00039965 MGI:1861691 MGI:2441982 MGI:96659 MGI:96925
abnormal miniature inhibitory postsynaptic currents0.000551313 MGI:1930705 MGI:3039785 MGI:88107 MGI:96659
abnormal response to novel object0.000568716 MGI:109355 MGI:1346858 MGI:88107 MGI:95627 MGI:95809
abnormal neuron physiology0.00067767 MGI:105368 MGI:107793 MGI:109355 MGI:1351340 MGI:1929898 MGI:1930705 MGI:3039785 MGI:88107 MGI:95781 MGI:95809 MGI:95819 MGI:96925
abnormal dendrite morphology0.000768388 MGI:107231 MGI:1277959 MGI:1349763 MGI:1929898 MGI:3039785 MGI:88256 MGI:95821
abnormal hippocampus neuron morphology0.000903073 MGI:101931 MGI:107793 MGI:1277959 MGI:3039785 MGI:88107 MGI:95809
absent long term depression0.000936514 MGI:1196356 MGI:95809 MGI:95819 MGI:95821
abnormal hippocampus pyramidal cell morphology0.000950393 MGI:101931 MGI:107793 MGI:1277959 MGI:3039785 MGI:88107
abnormal response to novelty0.000959482 MGI:109355 MGI:1346858 MGI:88105 MGI:88107 MGI:95627 MGI:95809 MGI:95819 MGI:99441
abnormal synaptic vesicle number0.001335686 MGI:109355 MGI:1920211 MGI:1930705 MGI:88256
abnormal forebrain morphology0.001347697 MGI:101931 MGI:105368 MGI:107164 MGI:107793 MGI:1277959 MGI:1346858 MGI:1861691 MGI:3039563 MGI:3039785 MGI:88106 MGI:88107 MGI:95781 MGI:95809 MGI:95819 MGI:95821
abnormal temporal lobe morphology0.00150677 MGI:101931 MGI:105368 MGI:107164 MGI:107793 MGI:1277959 MGI:1861691 MGI:3039785 MGI:88107 MGI:95809
abnormal prepulse inhibition0.001586833 MGI:3039785 MGI:88107 MGI:95627 MGI:95819 MGI:95821 MGI:99441
growth/size/body phenotype0.001607266 MGI:101931 MGI:105368 MGI:105992 MGI:107163 MGI:107164 MGI:107231 MGI:107422 MGI:107671 MGI:109355 MGI:109611 MGI:1277959 MGI:1340046 MGI:1344351 MGI:1346858 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:88067 MGI:88107 MGI:88110 MGI:88115 MGI:894310 MGI:95627 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:96955 MGI:97623
absence seizures0.001797991 MGI:1861691 MGI:2441982 MGI:88107 MGI:95775
absence of NMDA-mediated synaptic currents0.001867303 MGI:95819 MGI:95821
abnormal neurotransmitter level0.002126119 MGI:107363 MGI:1277959 MGI:1920211 MGI:88106 MGI:95627
abnormal hippocampus pyramidal cell layer0.002239716 MGI:101931 MGI:107793 MGI:1277959 MGI:3039785 MGI:88107
abnormal synaptic vesicle morphology0.002635749 MGI:109355 MGI:1920211 MGI:1930705 MGI:88256
postnatal lethality0.003301945 MGI:101931 MGI:1277959 MGI:1340046 MGI:1861691 MGI:1927555 MGI:1930705 MGI:2441982 MGI:3039785 MGI:87904 MGI:95739 MGI:95775 MGI:95809 MGI:95819 MGI:95821 MGI:96659 MGI:97623
nonconvulsive seizures0.003450684 MGI:1861691 MGI:2441982 MGI:88107 MGI:95775
abnormal seizure response to pharmacological agent0.003539018 MGI:101931 MGI:1861691 MGI:3039785 MGI:95630 MGI:95819 MGI:96659
abnormal limbic system morphology0.00369354 MGI:101931 MGI:107164 MGI:107793 MGI:1277959 MGI:1861691 MGI:3039785 MGI:88106 MGI:88107 MGI:95809
hyperactivity0.003851662 MGI:101931 MGI:109355 MGI:3039785 MGI:88107 MGI:88256 MGI:95627 MGI:95775 MGI:95809 MGI:95819 MGI:95821
abnormal conditioned taste aversion behavior0.004724535 MGI:88067 MGI:95627 MGI:95819
enhanced AMPA-mediated synaptic currents0.005032885 MGI:3039785 MGI:95809
abnormal hippocampus layer morphology0.006138937 MGI:101931 MGI:107793 MGI:1277959 MGI:3039785 MGI:88107
premature death0.007053645 MGI:101931 MGI:107164 MGI:1349482 MGI:1861691 MGI:1890773 MGI:1920211 MGI:1930705 MGI:87904 MGI:88107 MGI:88110 MGI:88256 MGI:95775 MGI:95809 MGI:95819 MGI:96659 MGI:96925 MGI:97623
increased susceptibility to pharmacologically induced seizures0.007631063 MGI:101931 MGI:1861691 MGI:3039785 MGI:95819 MGI:96659
increased susceptibility to induction of seizure by inducing agent0.007631063 MGI:101931 MGI:1861691 MGI:3039785 MGI:95819 MGI:96659
abnormal hippocampus morphology0.007725007 MGI:101931 MGI:107164 MGI:107793 MGI:1277959 MGI:1861691 MGI:3039785 MGI:88107 MGI:95809
audiogenic seizures0.008527918 MGI:1861691 MGI:3039785 MGI:96925
abnormal brain wave pattern0.00874501 MGI:1861691 MGI:2441982 MGI:95819 MGI:96659
abnormal paired-pulse facilitation0.009288012 MGI:109355 MGI:1277959 MGI:88256 MGI:95809
abnormal spike wave discharge0.009574916 MGI:1861691 MGI:88107 MGI:95775
impaired contextual conditioning behavior0.0096768 MGI:109355 MGI:1346858 MGI:88257 MGI:95820
abnormal eating behavior0.009763618 MGI:107231 MGI:1861691 MGI:1920211 MGI:3039785 MGI:87904 MGI:95627 MGI:95739 MGI:95781 MGI:95819 MGI:95821
enhanced behavioral response to xenobiotic0.010007874 MGI:1277959 MGI:3039563 MGI:88105 MGI:88107 MGI:95627
tonic-clonic seizures0.011578497 MGI:1861691 MGI:95809 MGI:95819 MGI:97623
unresponsive to tactile stimuli0.01196145 MGI:1344351 MGI:1920211 MGI:88106
tremors0.012186901 MGI:105368 MGI:106925 MGI:3039785 MGI:95627 MGI:95775 MGI:96659 MGI:96925 MGI:97623
abnormal single cell response0.016830971 MGI:1920211 MGI:95819 MGI:96659
abnormal maternal nurturing0.018521588 MGI:1277959 MGI:1346858 MGI:95809 MGI:95819 MGI:96925
analgesia0.018632201 MGI:1344351 MGI:1920211 MGI:88106
abnormal long term object recognition memory0.020371495 MGI:1920211 MGI:88067 MGI:88256
jumpy0.020826106 MGI:95809 MGI:95820
abnormal calcium ion homeostasis0.024745315 MGI:105368 MGI:107164 MGI:107422 MGI:1927555 MGI:88110
abnormal maternal behavior0.024745315 MGI:1277959 MGI:1346858 MGI:95809 MGI:95819 MGI:96925
abnormal behavioral response to addictive substance0.026027636 MGI:1277959 MGI:88105 MGI:88107 MGI:95627 MGI:95819
abnormal myelin sheath morphology0.027289777 MGI:106925 MGI:107672 MGI:96925 MGI:97623
long stride length0.02791987 MGI:1929898 MGI:96659
abnormal auditory brainstem response waveform shape0.027941893 MGI:105368 MGI:106925 MGI:96925
abnormal touch/ nociception0.027965998 MGI:1277959 MGI:1344351 MGI:1920211 MGI:88106 MGI:95775 MGI:95809 MGI:95820
abnormal avoidance learning behavior0.027979176 MGI:88067 MGI:88256 MGI:95627 MGI:95819
enhanced behavioral response to addictive substance0.035846951 MGI:1277959 MGI:88105 MGI:88107 MGI:95627
abnormal neurotransmitter uptake0.035978426 MGI:1920211 MGI:95627
abnormal latent inhibition of conditioning behavior0.035978426 MGI:109355 MGI:95627
impaired muscle contractility0.036815245 MGI:107231 MGI:1346858 MGI:87904 MGI:88105 MGI:88106 MGI:88108 MGI:88110
abnormal synapse morphology0.039643234 MGI:109355 MGI:1920211 MGI:1930705 MGI:88256 MGI:95821
abnormal ion homeostasis0.042205367 MGI:105368 MGI:107164 MGI:107422 MGI:109486 MGI:1349482 MGI:1927555 MGI:88110 MGI:95739
decreased prepulse inhibition0.043189962 MGI:3039785 MGI:88107 MGI:95627 MGI:95819

Supplementary Table 11. Arc gene set association with general cognitive ability.

ChrGSEA_Arc gene setStartStopBATS nSNPsBATS P ValueCAGES nSNPsCAGES P Value
7ACTB55333045536758180.814680.08662
19ACTN44383016643913010200.2681140.53
7ADAM228740163787664385430.1331900.416
6ALDH5A12460317524645414620.9951950.161
8ARC143689411143692835150.764810.62
11ASRGL16186134961917463360.9761360.52
1ATF6160002707160195476720.9913820.98
1ATP1A111671735811674891980.312640.461
1ATP1A2158352171158379998490.5271230.233
19ATP1A3471625734719022290.07962210.593
1ATP1B1167342570167368584380.5271880.988
12ATP2A210920341410927328060.244330.608
3ATP2B210340706105222681230.6143760.326
18ATP5A14191810741938197170.99650.564
17ATP6V0A13786438737928123120.148560.575
16ATP6V0D1660294176607259040.283380.887
3ATP6V1A11494859711501359380.893600.149
8ATP6V1H5479066754918403210.028081220.276
17BAIAP27662355676705827240.8581070.563
14BEGAIN10007324010010588490.506480.818
6C6orf199110059592110119108200.981540.04747
6C6orf224109920756109934386120.956940.03276
5CAMK2A149579247149649529610.2272030.575
7CAMK2B4422541944331749320.4791050.214
11CEND1777109780126120.0735400.178
15CKMT1A417723754177871220.193170.533
3CLDN11171619358171634579220.907820.12
17CLTC5505183155129099110.722920.967
2CNRIP16836480668400687250.8571630.371
8COX6C100959547100975071140.05835460.469
4CRMP158733915945686750.8882150.535
3DLG1198253827198509844430.2551500.309
11DLG282843700843121133800.20417370.412
17DLG470339337063781130.23450.95
18DLGAP1348883638701351290.3914020.46
8DLGAP214369751644049810.1673210.05153
1DLGAP33510362335143571250.516910.689
20DLGAP43435771634590454240.6851030.485
8DPYSL22649133726571610670.6782790.0496
6DSP74868687531945490.6552140.785
11EEF1G620836486209803650.984310.489
12GAPDH65139176517797180.06199780.549
9GDA7395411274056960450.9261990.00248
1GLUL180618291180627573300.092981200.555
16GNAO15478275154948857480.021732410.06971
1GNB117065881812355110.914520.795
4GPM6A176791081177160642970.9914050.586
10GPR123134751398134795169230.3931080.134
4GRIA2158361185158506676180.07661150.186
9GRIN113915342913918302940.725260.97
16GRIN2A9762922101841121680.4548840.605
12GRIN2B13605676140242891880.3366840.734
7GRM38611116586332128460.6162600.000262
11H2AFX11846979411847138790.752590.591
6HSP90AB14432282644329592190.926630.592
4HSPA4L128922902128973976100.125530.663
11HSPA8122433409122438054210.622930.963
15IDH3A7622877376249939370.6931020.711
3IQSEC11291437312983960350.2081320.42
1KCNA2110947298110949868300.7231100.09731
22KCNJ43715227837181149230.107870.07837
10LGI19550755595547906370.2891980.824
17LOC3884196986415069869553250.165700.591
15MAP1A4159709741611110160.525420.469
11MAP67497561075057127390.6591750.905
22MAPK12044394620551970240.351340.965
18MBP72819776729737621060.7683540.04364
6MOG2973278729748128350.5032440.365
22MYO18B24468119247570071410.3855640.7
17NSF4202335342190000150.151770.56
12PGAM5131797508131805825110.548620.934
15PKM2702784237031073850.06398570.751
8PPP2R2A2620495026284563400.1291300.932
4PPP3CA102163609102487376700.092373230.785
10PPP3CB748666177492576060.551440.695
19PRDX2127686331277369440.506360.003882
6PRRT13222411732227698490.00732960.03797
14RTN15913244659407310510.1062660.161
5SDHA271355309814190.2721090.411
5SEPT8132114407132141460120.192780.363
9SH3GL217569193177871221060.6595110.586
19SLC17A75462446954636596160.208700.869
11SLC1A23522932735397681990.4893440.547
12SLC25A39751153397519909230.707560.565
4SLC25A4186301391186305419180.02448670.906
11SLC3A26238009362412929180.865680.699
4SLC4A47227186672656663870.2153650.467
3SLC6A11100941911055935540.5611750.712
3SLC6A111083291610955146750.9912930.528
17SLC9A3R17025637870277089250.131810.509
7STX1A7275147572771924130.258400.417
16STX1B309108683092933050.02932290.597
9STXBP1129414388129494816160.772680.07996
6SYNGAP1334958243352944480.704630.697
3TKT5323470353264998260.011881130.53
12TUBA1A478648494786912860.01126270.819
2TUBA4A219823244219826882110.347540.906
6TUBB3079613530801174490.021331060.339
9TUBB2C13925553113925798010.86620.958
17UBB162250911622677980.395450.436
5VDAC1133335505133368332170.01141630.869

Supplementary Table 12. Oligos used in this study.

Oligo nameSequence 5'3
ArcHA1XbaRCTGC TCT AGA TTC AGG CTG GGT CCT GTC ACT G
ArcHA1XhoFATC TCG CTC GAG GGG AGG TCT TCT ACC GTC TGG AG
ArcHA2BglRGACCT AGA TCT GC GGCC GC GGG GCC AGG AGG TGC CAG GAT GTC AGG TC
ArcHA2Acc65FCTACGG GGT ACC AGG GGC CAG CCC AGG GTC CCC AG
ArcHA3NdeFGGG TAA TCTC CA TAT G GGA GGC TTA GGC TAG GCA CAG AC
ArcHA3PmlRCCG GCG TA CAC GTG CCC TGG TCC CAG CCA TGA TTC ATA AG
ArcHA4AscFCATTT G GCG CGC C CCA ATA GGT CAT CAC AAC TGC CAT G
ArcHA4PmeRAGC TTT G TTT AAA C GCC CTT GCA CCT CTT GCT GCA C
Pneo3FGCC TCT GAG CTA TTC CAG AAG TAG
Pneo3RCCT GAC TAG GGG AGG AGT AGA AG
Arc10RGGG CTT CTT ATG TTC AGT C
Arc1FCGG GAC CTG TAC CAG ACA CTG
Arc1RGCC ATG GCT GAG TCA CGG AG
Arc2FGGA GCG AGA GCT GAA AGG GTT G
Arc2RGGG GCC AGG AGG TGC CAG GAT GTC
Arc3RCCC TCA GCA TCT CTG CTT TAG C
Arc4RGCC AGG ACT AGG TTG GAC AGT CTG
Arc5FCCC TCC TGG ATC TAG TGG TGA GC
Arc5RGGGCATCCACTCACATAACTACTCG
Arc6FGCC CCT GCC CAG CCT GAT CTT TC
Arc6RCCC CGA GAC ACT ACT CTG AGC
Arc7FGGG TGG ACA GTT GGT CAG AAG G
Arc7RCCC TCT GAC CAC TGC ATT TTC C
Arc8FCCC AGT GCT TTC TCA GCC TTC ATG
Arc8RGGT CAG TGG GTG AGT AGA TGT CTG
Arc9FCGG AGG CAC TCA CAC CTG
Arc9RGGT TGT GTG GCA GTT GTG AGT C
Arc10FGCT CTT ACC AGC GAG
Arc11FGGG CAG ATG CTA AAG CAG
Arc11RCGG CTG GGT GTG AGG ACT CAG

Supplementary Information

Supplementary Information.

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File contents


1. TAP tagged Arc vector and gene targeting.

2. TAP tagged Arc transgenic mice.

3. TAP tagged Arc distribution and subcellular localization.

4. Electrophysiological parameters measured in the CA1 area of ArcTAP/TAP hippocampal slices.

5. Classification of Arc interactors according to their gene ontology process.

6. Arc protein levels in the forebrain of PSD93/Dlg2 and SAP102/Dlg3 knockout mice.

7. Arc binding to PSD95/Dlg4 protein is independent of PSD93/Dlg2.

8. Isolation of TAP tagged Arc complexes from PSD95/Dlg4 mutant mice.

9. Methods

9.1. Tandem Affinity Purification

9.2. Proteomic analysis.

9.3. Network building.

9.4. Genetic analysis.

9.5. Human cognitive ability phenotype.

9.6. Cellular fractionation.

9.7. Statistics.

10. Supplementary Table legends

11. References.

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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