G2C::Proteomics
PSD95 mediates assembly of postsynaptic Arc complexes associated with schizophrenia, intellectual disability and cognitive variation.
Esperanza Fernandez1 and Seth GN Grant2*
*Corresponding author: Seth.Grant@ed.ac.uk
- VIB Dept. of Molecular and Developmental Genetics, KU Leuven Medical School, Campus Gasthuisberg, Herestraat 49, Box 602, 3000 Leuven, Belgium
- Genes to Cognition Programme, Molecular Neuroscience, Centre for Clinical Brain Science and Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, UK
Overview
Arc is a highly studied neuronal protein yet little is known about its protein interactions, assembly into multiprotein complexes or role in disease. To address these issues we applied an integrated proteomic and genetic strategy using targeted Tandem Affinity Purification (TAP) tagging in mice, biochemical and proteomic characterization of native complexes in wild type and mutant mice, and human genetic analyses of disease and intelligence.
TAP tagging enabled efficient purification and identification of many novel interacting proteins, of which PSD95/Dlg4 was the most abundant. Arc and PSD95 resided in 1.5 MDa postsynaptic complexes and knockout of PSD95 depleted Arc from the complexes and synapse.
Human genetic studies identified mutations and variants in Arc interacting proteins that are enriched in schizophrenia, intellectual disability, epilepsy and normal variation in intelligence.
These studies reveal that the postsynaptic complexes assembled by Arc and PSD95 are important in the continuum of cognitive variation spanning intelligence and mental illness.
Figures
- Sheet #1
- Combined + Kirov.
Table 1. Human genetics
All Arc interactors N=107 |
Arc interactors with increased expression in PSD95/Dlg4-/- mice
N=11 |
Arc interactors with increased expression in PSD95/Dlg4-/- mice
N=24 |
Arc interactors that are known direct PSD95 interacting proteins
N=18 |
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Mutation class | Disease | Study Design | P | O/E | P | O/E | P | O/E | P | O/E |
LoF | Autism | De novo | 0.00276 | 11/4.0 | 1.00000 | 0/0.4 | 0.00210 | 6/1.2 | 0.00002 | 8/0.8 |
Epilepsy | De novo | 0.00768 | 3/0.4 | 1.00000 | 0/0 | 0.11646 | 1/0.1 | 1.00000 | 0/0.1 | |
ID | De novo | 0.00002 | 8/0.5 | 1.00000 | 0/0 | 0.00002 | 5/0.1 | 0.00018 | 3/0.1 | |
Schizophrenia | De novo | 0.04558 | 3/0.8 | 0.08240 | 1/0.1 | 0.02548 | 2/0.2 | 0.01164 | 2/0.2 | |
Schizophrenia | Case/Control | 0.02900 | 56/38 | 0.34000 | 12/9 | 0.04800 | 15/9 | 0.31000 | 6/6 | |
Nonsyn. | Autism | De novo | 0.00026 | 46/25.9 | 0.71831 | 2/2.5 | 0.02660 | 15/8.5 | 0.00008 | 18/5.8 |
Epilepsy | De novo | 0.00002 | 16/2.5 | 1.00000 | 0/0.3 | 0.05166 | 3/0.8 | 0.11054 | 2/0.6 | |
ID | De novo | 0.00002 | 15/2.0 | 1.00000 | 0/0.2 | 0.00002 | 8/0.6 | 0.00002 | 8/0.4 | |
Schizophrenia | De novo | 0.00228 | 14/5.7 | 0.02022 | 3/0.6 | 0.01130 | 6/1.8 | 0.00920 | 5/1.3 | |
Schizophrenia | Case/Control | 0.02800 | 187/184 | 0.23000 | 22/21 | 0.02000 | 61/48 | 0.01400 | 40/31 | |
Silent | Autism | De novo | 0.69391 | 7/8.1 | 1.00000 | 0/0.7 | 0.51343 | 3/2.7 | 0.57087 | 2/1.9 |
Epilepsy | De novo | 1.00000 | 0/0.7 | 1.00000 | 0/0.1 | 1.00000 | 0/0.2 | 1.00000 | 0/0.2 | |
ID | De novo | 1.00000 | 0/0.4 | 1.00000 | 0/0 | 1.00000 | 0/0.1 | 1.00000 | 0/0.1 | |
Schizophrenia | De novo | 0.51777 | 2/1.7 | 1.00000 | 0/0.2 | 1.00000 | 0/0.6 | 0.34027 | 1/0.4 | |
CNVs | Schizophrenia | De novo | 0.00117 | 0.12553 | 0.00412 | 0.00412 |
(*) For de novo studies, O/E indicates the observed versus expected (under a null model) number of mutations
in that class.
For the SCZ case/control study, O/E indicates the number of case versus control mutations.
Supplementary Tables
- Supplementary Table 1.
- MS data obtained from a single step and tandem affinity purifications.
- Supplementary Table 2.
- Known Arc interactors.
- Supplementary Table 3.
- iBAQ intensity numbers of Arc and PSD95.
- Supplementary Table 4.
- iBAQ intensity numbers of the ARC-core interactors.
- Supplementary Table 5.
- Biological process and Molecular Function of 107 Arc interactors.
- Supplementary Table 6.
- Biological process ontology of 107 Arc interactors.
- Supplementary Table 7.
- MS data obtained from a single step purifications from ArcTAP/+ and ArcTAP/TAP crossed with PSD95/Dlg4 knokout mice.
- Supplementary Table 8.
- Arc gene set enrichment in schizophrenia, epilepsy, autism and intellectual disability.
- Supplementary Table 9.
- Map of Arc complex to OMIM disorders.
- Supplementary Table 10.
- Mammalian Phenotype Ontology of ARC interactors.
- Supplementary Table 11.
- Arc gene set association with general cognitive ability.
- Supplementary Table 12.
- Oligos used in this study.
Supplementary Table 1. Ms data obtained from a single step and tandem affinity purifications.
Protein group ID | Protein IDs | Majority protein IDs | Protein name | Gene names | Gene name representative | Peptides 1S-ARC14 | Peptides 1S-ARC15 | Peptides 1S-Cont16 | Peptides 1S-PSD95mut01 | Peptides 1S-PSD95mut02 | Peptides 1S-PSD95mut03 | Peptides Tandem-ARC02 | Peptides Tandem-ARC03 | Peptides Tandem-ARC05 | Peptides Tandem-Cont01 | Peptides Tandem-Cont02 | Peptides Tandem-Cont03 | PSMs 1S-ARC14 | PSMs 1S-ARC15 | PSMs 1S-Cont16 | PSMs 1S-PSD95mut01 | PSMs 1S-PSD95mut02 | PSMs 1S-PSD95mut03 | PSMs Tandem-ARC02 | PSMs Tandem-ARC03 | PSMs Tandem-ARC05 | PSMs Tandem-Cont01 | PSMs Tandem-Cont02 | PSMs Tandem-Cont03 | Intensity 1S-ARC14 | Intensity 1S-ARC15 | Intensity 1S-Cont16 | Intensity Tandem-ARC02 | Intensity Tandem-ARC03 | Intensity Tandem-ARC05 | Intensity Tandem-Cont01 | Intensity Tandem-Cont02 | Intensity Tandem-Cont03 | Intensity average control | Ratio Intensity Tandem-ARC02/average control | Ratio Intensity Tandem-ARC03/average control | Ratio Intensity Tandem-ARC05/average control | # replicates enriched (Tandem) | Ratio Intensity 1S-ARC14/Cont | Ratio Intensity 1S-ARC15/Cont | Ratio M/L 1S-PSD95mut01 | Ratio M/L 1S-PSD95mut02 | Ratio M/L 1S-PSD95mut03 | Average 1S ratio | # replicates enriched (1 step) | # replicates enriched (1 + Tandem) | Total PSD-95 complex (# replicates) | PSD-95 Core Complex | PSD-95 Interactor |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1001 | Q62108 Q62108-3 Q62108-2 G3UZL5 | Q62108 Q62108-3 Q62108-2 | Disks large homolog 4 | Dlg4 | Dlg4 | 35 | 32 | 0 | 30 | 34 | 32 | 34 | 37 | 35 | 0 | 0 | 0 | 154 | 162 | 190 | 218 | 149 | 116 | 153 | 118 | 46827000 | 30350000 | 26545000 | 34237000 | 31185000 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 13.755 | 23.044 | 19.257 | 18.685 | 5 | 8 | 5 | YES | YES | |||||||||
1263 | Q91XM9 | Q91XM9 | Disks large homolog 2 | Dlg2 | Dlg2 | 19 | 23 | 0 | 18 | 23 | 22 | 16 | 22 | 16 | 0 | 0 | 0 | 52 | 59 | 102 | 97 | 70 | 28 | 31 | 26 | 4595400 | 5040300 | 2719200 | 3814900 | 4644800 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 12.330 | 26.590 | 15.435 | 18.118 | 5 | 8 | 5 | YES | YES | |||||||||
1447 | Q9WV31 | Q9WV31 | Activity-regulated cytoskeleton-associated protein | Arc | Arc | 11 | 16 | 0 | 8 | 10 | 8 | 15 | 19 | 18 | 0 | 0 | 0 | 40 | 62 | 35 | 38 | 22 | 45 | 60 | 64 | 18669000 | 22502000 | 33489000 | 42493000 | 61541000 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 15.660 | 16.483 | 16.433 | 16.192 | 5 | 8 | 5 | YES | ||||||||||
1106 | Q811D0 | Q811D0 | Disks large homolog 1 | Dlg1 | Dlg1 | 11 | 11 | 0 | 15 | 14 | 18 | 8 | 11 | 8 | 1 | 0 | 0 | 12 | 10 | 45 | 38 | 34 | 4 | 7 | 5 | 3 | 1836500 | 680210 | 439750 | 647200 | 823470 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 10.564 | 11.262 | 22.220 | 14.682 | 5 | 8 | 5 | YES | |||||||||
822 | P63017 Q504P4 D3Z5E2 D3YW43 | P63017 Q504P4 | Heat shock cognate 71 kDa protein | Hspa8 | Hspa8 | 11 | 11 | 3 | 6 | 11 | 6 | 5 | 4 | 5 | 0 | 0 | 0 | 13 | 14 | 3 | 21 | 31 | 10 | 5 | 4 | 6 | 983270 | 966660 | 26524 | 246060 | 263660 | 447330 | 2S specific | 2S specific | 2S specific | 3 | 37.071 | 36.445 | 3.364 | 10.420 | 5.409 | 18.542 | 5 | 8 | 1 | |||||||||
390 | Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 D3YUQ0 F6PZ09 F6XIT3 F7CDH3 F7DAP1 F7BZ55 F6VJ78 F6XRZ6 F7AYY9 F6TDF4 F6SK63 F7BXL9 | Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 | Disintegrin and metalloproteinase domain-containing protein 22 | Adam22 | Adam22 | 7 | 6 | 0 | 6 | 14 | 12 | 7 | 10 | 6 | 0 | 0 | 0 | 12 | 9 | 22 | 33 | 26 | 8 | 12 | 7 | 729100 | 256760 | 459960 | 675780 | 364530 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 8.212 | 5.148 | 3.951 | 5.770 | 5 | 8 | 5 | YES | YES | |||||||||
663 | Q80TN1 P11798 F8WIS9 F6WHR9 D3Z7K9 F8WHB5 P11798-2 F8WIR6 D6RDQ8 E9QAJ4 E9PYZ8 | Q80TN1 P11798 F8WIS9 | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Camk2a | Camk2a | 2 | 4 | 0 | 3 | 4 | 4 | 4 | 6 | 3 | 0 | 0 | 0 | 2 | 5 | 7 | 13 | 13 | 8 | 13 | 12 | 104490 | 241630 | 472920 | 1669300 | 1191100 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 7.499 | 7.418 | 5.644 | 6.854 | 5 | 8 | 5 | YES | YES | |||||||||
785 | P60202 F8WGE4 P60202-2 | P60202 F8WGE4 P60202-2 | Myelin proteolipid protein | Plp1 | Plp1 | 3 | 3 | 0 | 4 | 2 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 3 | 4 | 7 | 3 | 3 | 3 | 1 | 2 | 744530 | 613840 | 330850 | 552290 | 530450 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 10.917 | 11.079 | 30.052 | 17.349 | 5 | 8 | 5 | YES | ||||||||||
110 | B1AZP2-2 B1AZP2 B7ZNS2 B1AZP2-3 F6YMR0 E9PUF2 | B1AZP2-2 B1AZP2 B7ZNS2 | Disks large-associated protein 4 | Dlgap4 | Dlgap4 | 2 | 2 | 0 | 3 | 10 | 9 | 1 | 1 | 1 | 0 | 0 | 0 | 2 | 2 | 3 | 17 | 15 | 2 | 1 | 1 | 16791 | 12175 | 71620 | 46670 | 84775 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 3.211 | 6.324 | 12.915 | 7.483 | 5 | 8 | 5 | YES | YES | |||||||||
762 | P52189 Q8R435 | P52189 Q8R435 | Inward rectifier potassium channel 4 | Kcnj4 | Kcnj4 | 1 | 2 | 0 | 2 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 3 | 3 | 5 | 5 | 1 | 1 | 1 | 23037 | 86675 | 41107 | 163280 | 66334 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 2.607 | 2.740 | 6.086 | 3.811 | 5 | 8 | 5 | YES | YES | |||||||||
79 | E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7 | E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7 | IQ motif and SEC7 domain-containing protein 2 | Iqsec2 | Iqsec2 | 9 | 4 | 0 | 19 | 30 | 27 | 3 | 3 | 1 | 0 | 0 | 0 | 10 | 4 | 54 | 83 | 64 | 6 | 4 | 3 | 622910 | 270040 | 70054 | 27132 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 5.969 | 8.629 | 11.019 | 8.539 | 5 | 7 | 5 | YES | ||||||||||||
941 | Q3UVU8 | Q3UVU8 | Disks large-associated protein 1 | Dlgap1 | Dlgap1 | 5 | 5 | 0 | 7 | 11 | 10 | 1 | 2 | 1 | 0 | 0 | 0 | 5 | 7 | 16 | 24 | 20 | 1 | 2 | 1 | 279320 | 140830 | 70581 | 35164 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 4.364 | 8.867 | 7.226 | 6.819 | 5 | 7 | 5 | YES | YES | |||||||||||
342 | P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 D3YYZ2 | P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 | Polyubiquitin-C Ubiquitin Ubiquitin-related 1 Ubiquitin-related 2 Polyubiquitin-B Ubiquitin Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40 | Ubc Ubb 2810422J05Rik Rps27a Uba52 Gm7866 | Ubb | 2 | 3 | 0 | 1 | 2 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 7 | 11 | 5 | 2 | 4 | 2 | 1 | 256070 | 435230 | 156790 | 89003 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 6.324 | 8.243 | 9.393 | 7.987 | 5 | 7 | 1 | ||||||||||||||
725 | P35438 P35438-2 | P35438 P35438-2 | Glutamate [NMDA] receptor subunit zeta-1 | Grin1 | Grin1 | 1 | 4 | 0 | 2 | 5 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 5 | 4 | 6 | 6 | 1 | 1 | 2 | 12662 | 77666 | 77458 | 65004 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 6.500 | 12.953 | 3.557 | 7.670 | 5 | 7 | 5 | YES | YES | |||||||||||
1059 | Q6PIC6 Q8VCE0 Q9WV27 Q9Z1W8 E9QNX7 Q64436 Q91WH7 | Q6PIC6 Q8VCE0 | Sodium/potassium-transporting ATPase subunit alpha-3 | Atp1a3 | Atp1a3 | 8 | 11 | 2 | 9 | 8 | 6 | 3 | 4 | 4 | 0 | 0 | 0 | 15 | 15 | 2 | 16 | 16 | 10 | 6 | 7 | 9 | 1084500 | 1082100 | 55614 | 175770 | 299670 | 488770 | 2S specific | 2S specific | 2S specific | 3 | 19.500 | 19.457 | 2.306 | 7.940 | 3.177 | 10.476 | 4 | 7 | ||||||||||
526 | F8WIG2 Q68EF6 | F8WIG2 Q68EF6 | Brain-enriched guanylate kinase-associated protein | Begain | Begain | 3 | 2 | 0 | 0 | 2 | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 3 | 2 | 4 | 2 | 1 | 2 | 74113 | 17709 | 62085 | 104550 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 5.450 | 6.279 | 5.864 | 4 | 6 | 4 | YES | YES | ||||||||||||||
579 | O08553 | O08553 | Dihydropyrimidinase-related protein 2 | Dpysl2 | Dpysl2 | 18 | 16 | 14 | 7 | 12 | 8 | 4 | 1 | 4 | 0 | 0 | 1 | 37 | 49 | 21 | 25 | 33 | 18 | 4 | 1 | 4 | 1 | 4441900 | 5610100 | 2455600 | 213600 | 79333 | 240480 | 8327.6 | 8327.6 | 25.650 | 9.527 | 28.877 | 3 | 1.809 | 2.285 | 4.299 | 9.000 | 7.792 | 5.037 | 3 | 6 | |||||||
836 | P68369 P05214 Q3UX10 | P68369 P05214 | Tubulin alpha-1A chain Tubulin alpha-3 chain | Tuba1a Tuba3a | Tuba1a | 3 | 5 | 1 | 3 | 2 | 3 | 3 | 4 | 4 | 0 | 0 | 1 | 11 | 18 | 4 | 2 | 2 | 7 | 3 | 4 | 2 | 1 | 2221400 | 4754300 | 829390 | 939190 | 1071200 | 1183300 | 228620 | 228620 | 4.108 | 4.686 | 5.176 | 3 | 2.678 | 5.732 | 9.662 | 6.024 | 3 | 6 | 4 | YES | |||||||
835 | P68368 | P68368 | Tubulin alpha-4A chain | Tuba4a | Tuba4a | 1 | 2 | 0 | 2 | 1 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 1 | 3 | 5 | 1 | 1 | 1 | 1 | 3 | 100040 | 203420 | 409270 | 330930 | 1200400 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 2.180 | 2.501 | 2.341 | 3 | 6 | |||||||||||||
1438 | Q9R111 D3YU09 | Q9R111 D3YU09 | Guanine deaminase | Gda | Gda | 12 | 15 | 0 | 12 | 9 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 17 | 18 | 37 | 20 | 14 | 4753400 | 6853000 | 1S specific | 1S specific | 11.042 | 15.913 | 17.039 | 14.665 | 5 | 5 | 5 | YES | YES | |||||||||||||||||||
1460 | Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 A2A599 | Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 | V-type proton ATPase 116 kDa subunit a isoform 1 | Atp6v0a1 | Atp6v0a1 | 6 | 6 | 1 | 4 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 10 | 2 | 10 | 7 | 11 | 508600 | 418120 | 33512 | 15.177 | 12.477 | 6.652 | 14.089 | 4.784 | 10.636 | 5 | 5 | ||||||||||||||||||||
740 | P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 F6ZRK3 | P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 | Excitatory amino acid transporter 2 | Slc1a2 | Slc1a2 | 5 | 5 | 0 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 10 | 6 | 6 | 4 | 353730 | 276600 | 1S specific | 1S specific | 4.118 | 4.325 | 4.340 | 4.261 | 5 | 5 | 5 | YES | ||||||||||||||||||||
969 | Q5SXR6 Q68FD5 E9Q434 F6Z1R4 | Q5SXR6 Q68FD5 | Clathrin heavy chain 1 | Cltc | Cltc | 4 | 2 | 0 | 3 | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 4 | 14 | 4 | 123220 | 76316 | 1S specific | 1S specific | 3.003 | 4.503 | 3.020 | 3.509 | 5 | 5 | 4 | YES | ||||||||||||||||||||
870 | P99024 G3UZR1 | P99024 | Tubulin beta-5 chain | Tubb5 | Tubb5 | 5 | 8 | 4 | 7 | 7 | 6 | 2 | 5 | 3 | 0 | 0 | 2 | 6 | 8 | 5 | 2 | 3 | 11 | 2 | 1 | 2 | 1 | 1205500 | 2886100 | 933140 | 303000 | 316920 | 504240 | 125620 | 125620 | 2.412 | 2.523 | 4.014 | 2 | 1.292 | 3.093 | 1.961 | 6.512 | 3.581 | 3.288 | 3 | 5 | |||||||
1131 | Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6 | Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6 | Disks large-associated protein 2 | Dlgap2 | Dlgap2 | 0 | 0 | 0 | 3 | 13 | 10 | 2 | 1 | 2 | 0 | 0 | 0 | 6 | 25 | 18 | 2 | 1 | 2 | 45006 | 39202 | 2S specific | 2S specific | 2 | 2.541 | 5.053 | 5.342 | 4.312 | 3 | 5 | 5 | YES | YES | |||||||||||||||||
976 | Q60771 | Q60771 | Claudin-11 | Cldn11 | Cldn11 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 1 | 1 | 1 | 44485 | 90900 | 72482 | 2S specific | 2S specific | 2 | 1S specific | 24.894 | 8.890 | 16.892 | 3 | 5 | |||||||||||||||||||
166 | CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 G3UZ07 E9Q606 E9QAZ1 F8WGM8 E9Q2D1 F6WX90 | CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 | "Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed" | Actb | Actb | 15 | 13 | 13 | 14 | 13 | 9 | 6 | 6 | 7 | 0 | 1 | 3 | 44 | 45 | 43 | 34 | 31 | 33 | 12 | 13 | 14 | 1 | 5 | 11460000 | 14296000 | 11379000 | 3897800 | 6231800 | 2838400 | 69946 | 1458900 | 764423 | 5.099 | 8.152 | 3.713 | 3 | 1.007 | 1.256 | 1.533 | 3.812 | 9.093 | 3.340 | 2 | 5 | |||||
837 | P68372 | P68372 | Tubulin beta-4B chain | Tubb4b | Tubb4b | 7 | 9 | 5 | 9 | 9 | 7 | 2 | 5 | 2 | 0 | 0 | 1 | 11 | 16 | 6 | 19 | 20 | 27 | 2 | 5 | 2 | 1 | 1148400 | 867260 | 523440 | 30212 | 260360 | 32346 | 2S specific | 2S specific | 2S specific | 3 | 2.194 | 1.657 | 2.070 | 3.943 | 5.864 | 3.146 | 2 | 5 | |||||||||
676 | P15105 D3YVK1 D3Z121 | P15105 D3YVK1 | Glutamine synthetase | Glul | Glul | 3 | 3 | 3 | 1 | 1 | 1 | 1 | 3 | 1 | 0 | 0 | 0 | 6 | 10 | 5 | 2 | 1 | 1 | 2 | 3 | 1 | 1092000 | 1701700 | 654680 | 471110 | 787030 | 145080 | 2S specific | 2S specific | 2S specific | 3 | 1.668 | 2.599 | 2.754 | 2.341 | 2 | 5 | 5 | YES | ||||||||||
582 | O08599-2 | O08599-2 | Syntaxin-binding protein 1 | Stxbp1 | Stxbp1 | 1 | 1 | 0 | 0 | 0 | 1 | 3 | 1 | 3 | 0 | 0 | 0 | 1 | 1 | 1 | 3 | 1 | 3 | 20682 | 21313 | 72805 | 26268 | 132030 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 1S specific | 2 | 5 | 5 | YES | |||||||||||||||
461 | F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2 | F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2 | Myelin basic protein | Mbp | Mbp | 0 | 0 | 0 | 3 | 3 | 2 | 2 | 3 | 3 | 0 | 0 | 0 | 5 | 5 | 2 | 2 | 5 | 5 | 52799 | 696770 | 524500 | 2S specific | 2S specific | 2S specific | 3 | 2.771 | 5.123 | 3.947 | 2 | 5 | |||||||||||||||||||
597 | O35449 | O35449 | Proline-rich transmembrane protein 1 | Prrt1 | Prrt1 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 2 | 1 | 1 | 1 | 35022 | 56166 | 43125 | 63148 | 58697 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 1S specific | 2 | 5 | 4 | YES | ||||||||||||||||
30 | A2AHY8 | A2AHY8 | Pet2 protein | Pet2 | Pet2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 2 | 2 | 1 | 1 | 1 | 413560 | 910030 | 160500 | 102590 | 264100 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 1S specific | 2 | 5 | ||||||||||||||||||
574 | G5E902 Q8VEM8 | G5E902 Q8VEM8 | "Phosphate carrier protein, mitochondrial" | Slc25a3 | Slc25a3 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 284240 | 39834 | 48484 | 71652 | 95026 | 2S specific | 2S specific | 2S specific | 3 | 7.136 | 3.484 | 2.279 | 4.300 | 2 | 5 | 1 | |||||||||||||
531 | P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7 | P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7 | Histone H2A.x Histone H2A type 1 Histone H2A type 2-A Histone H2A type 3 Histone H2A type 1-F Histone H2A type 1-K Histone H2A type 2-C Histone H2A Histone H2A.J Histone H2A.Z Histone H2A.V Histone H2A type 1-H Histone H2A type 2-B | H2afx Hist1h2ab Hist2h2aa1 Hist3h2a Hist1h2af Hist1h2ak Hist2h2ac Hist1h2aa H2afj H2afz H2afv Hist1h2ah Hist1h2al Hist2h2ab | H2afx | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 2 | 0 | 0 | 1 | 3 | 2 | 2 | 1 | 3 | 1 | 252220 | 98288 | 431260 | 19187 | 19187 | 13.145 | 5.123 | 22.477 | 3 | 12.924 | 6.884 | 9.904 | 2 | 5 | |||||||||||||||||
718 | P31650 | P31650 | Sodium- and chloride-dependent GABA transporter 3 | Slc6a11 | Slc6a11 | 5 | 3 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 4 | 2 | 2 | 267740 | 244420 | 1S specific | 1S specific | 5.539 | 7.968 | 6.754 | 4 | 4 | ||||||||||||||||||||||||
661 | P11499 E9PX27 E9Q0C3 E9Q3D6 D3Z1R1 | P11499 | Heat shock protein HSP 90-beta | Hsp90ab1 | Hsp90ab1 | 4 | 3 | 1 | 3 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 1 | 5 | 7 | 4 | 210110 | 167080 | 39258 | 5.352 | 4.256 | 2.692 | 1.880 | 4.588 | 3.754 | 4 | 4 | 1 | |||||||||||||||||||
1138 | Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3 | Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3 | Brain-specific angiogenesis inhibitor 1-associated protein 2 | Baiap2 | Baiap2 | 1 | 5 | 0 | 3 | 8 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 4 | 13 | 2 | 97007 | 187090 | 1S specific | 1S specific | 2.424 | 3.219 | 6.118 | 3.921 | 4 | 4 | 5 | YES | YES | |||||||||||||||||||
426 | P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2 | P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2 | Glutamate receptor 2 | Gria2 | Gria2 | 3 | 3 | 0 | 4 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 7 | 8 | 7 | 96924 | 63890 | 1S specific | 1S specific | 3.826 | 3.769 | 2.083 | 3.226 | 4 | 4 | 5 | YES | ||||||||||||||||||||
465 | F6SEU4 | F6SEU4 | Ras GTPase-activating protein SynGAP | Syngap1 | Syngap1 | 3 | 1 | 0 | 4 | 15 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 9 | 38 | 25 | 35065 | 1S specific | 2.798 | 7.093 | 5.781 | 5.224 | 4 | 4 | 5 | YES | YES | |||||||||||||||||||||
887 | Q3UY21 Q61885 Q29ZQ5 | Q3UY21 Q61885 Q29ZQ5 | Myelin-oligodendrocyte glycoprotein | Mog | Mog | 1 | 2 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 6 | 2 | 76728 | 159010 | 1S specific | 1S specific | 8.131 | 3.384 | 5.757 | 4 | 4 | 2 | |||||||||||||||||||||||
403 | E9Q8N8 O88343 O88343-2 A7E1Z5 | E9Q8N8 O88343 O88343-2 | Electrogenic sodium bicarbonate cotransporter 1 | Slc4a4 | Slc4a4 | 1 | 2 | 0 | 2 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 7 | 7 | 11 | 64249 | 89674 | 1S specific | 1S specific | 0.978 | 4.069 | 5.234 | 3.427 | 4 | 4 | 4 | YES | ||||||||||||||||||||
88 | B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8 | B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8 | Glutamate receptor 3 Glutamate receptor 4 | Gria3 Gria4 | Gria3 | 1 | 2 | 0 | 2 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 4 | 2 | 53363 | 114750 | 1S specific | 1S specific | 2.914 | 9.099 | 6.007 | 4 | 4 | 4 | YES | |||||||||||||||||||||
20 | A2AEG6 P35803 E9QPU6 P35803-8 P35803-3 | A2AEG6 P35803 E9QPU6 P35803-8 P35803-3 | Neuronal membrane glycoprotein M6-b | Gpm6b | Gpm6b | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 2 | 1 | 76939 | 51239 | 1S specific | 1S specific | 3.489 | 3.453 | 3.471 | 4 | 4 | |||||||||||||||||||||||
1237 | Q8VDN2 E9QAV3 | Q8VDN2 E9QAV3 | Sodium/potassium-transporting ATPase subunit alpha-1 | Atp1a1 | Atp1a1 | 6 | 4 | 1 | 4 | 7 | 4 | 2 | 2 | 3 | 0 | 0 | 0 | 1 | 1 | 3 | 2 | 1 | 24696 | 10165 | 17855 | 2S specific | 1 | 1S specific | 1S specific | 3.708 | 3.708 | 3 | 4 | |||||||||||||||||||||
683 | P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 D3Z0Z9 E9PX99 F6QXU4 | P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 | Glyceraldehyde-3-phosphate dehydrogenase | Gapdh Gm10293 Gm4609 Gm10358 Gm2606 Gm5559 Gm10291 Gm6316 Gm10481 Gm10566 Gm8055 Gm10290 Gm3222 Gm6981 Gm7293 Gm5507 Gm10313 | Gapdh | 3 | 3 | 3 | 2 | 2 | 2 | 3 | 3 | 2 | 0 | 1 | 0 | 3 | 7 | 3 | 4 | 6 | 5 | 3 | 3 | 2 | 1 | 92466 | 199070 | 40711 | 38492 | 50532 | 2S specific | 2S specific | 2 | 2.271 | 4.890 | 1.572 | 4.970 | 3.426 | 2 | 4 | 5 | YES | ||||||||||
1036 | Q6P1J1 P97427 E9Q756 | Q6P1J1 P97427 E9Q756 | Dihydropyrimidinase-related protein 1 | Crmp1 | Crmp1 | 4 | 5 | 1 | 0 | 2 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 3 | 3 | 2 | 1 | 1 | 74017 | 73308 | 70557 | 81390 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 1S specific | 2 | 4 | ||||||||||||||||||||
1403 | Q9JIA1 D3YW56 | Q9JIA1 | Leucine-rich glioma-inactivated protein 1 | Lgi1 | Lgi1 | 1 | 3 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3 | 3 | 2 | 1 | 1 | 12155 | 92936 | 45900 | 38921 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 0.706 | 1.481 | 1.094 | 2 | 4 | 5 | YES | |||||||||||||||
754 | P48962 P51881 Q3V132 | P48962 P51881 | ADP/ATP translocase 1 ADP/ATP translocase 2 | Slc25a4 Slc25a5 | Slc25a4 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 2 | 2 | 2 | 1 | 13418 | 68598 | 69530 | 71846 | 2S specific | 2S specific | 2S specific | 3 | 1S specific | 1S specific | 1 | 4 | 4 | YES | |||||||||||||||||||
217 | Q6PIE5 D3YYN7 D3YVX6 | Q6PIE5 D3YYN7 D3YVX6 | Sodium/potassium-transporting ATPase subunit alpha-2 | Atp1a2 | Atp1a2 | 8 | 8 | 2 | 7 | 9 | 6 | 2 | 3 | 3 | 0 | 0 | 0 | 3 | 4 | 7 | 5 | 2 | 142150 | 94212 | 1S specific | 1S specific | 2.486 | 5.106 | 3.796 | 3 | 3 | |||||||||||||||||||||||
833 | P63328 P63328-2 Q4V9X0 | P63328 P63328-2 Q4V9X0 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ppp3ca | Ppp3ca | 7 | 13 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 17 | 3 | 2 | 833470 | 1482400 | 38154 | 21.845 | 38.853 | 3.869 | 21.522 | 3 | 3 | 5 | YES | ||||||||||||||||||||||
693 | P18872 P18872-2 D3Z2M7 F7BLT7 Q66L47 Q8CGK7 P50149 Q3V3I2 Q9DC51 P20612 A2AE32 Q8C040 A2AE31 A2A610 | P18872 P18872-2 D3Z2M7 F7BLT7 | Guanine nucleotide-binding protein G(o) subunit alpha | Gnao1 | Gnao1 | 7 | 5 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 7 | 4 | 2 | 1 | 435650 | 383940 | 98534 | 4.421 | 3.897 | 1.247 | 9.929 | 4.874 | 3 | 3 | 5 | YES | ||||||||||||||||||||
759 | P50516 P50516-2 D3Z1B9 D3YWH3 D3YZ23 | P50516 P50516-2 | V-type proton ATPase catalytic subunit A | Atp6v1a | Atp6v1a | 3 | 6 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 9 | 3 | 1 | 181290 | 506220 | 1S specific | 1S specific | 10.369 | 10.369 | 3 | 3 | 1 | ||||||||||||||||||||||||
800 | P61264 Q00262 Q80W45 Q3TJ55 | P61264 | Syntaxin-1B | Stx1b | Stx1b | 5 | 2 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 5 | 6 | 2 | 514800 | 438580 | 78295 | 6.575 | 5.602 | 2.193 | 3.074 | 4.361 | 3 | 3 | 5 | YES | |||||||||||||||||||
283 | E9PUA3 Q8R0S2-2 Q8R0S2 | E9PUA3 Q8R0S2-2 Q8R0S2 | IQ motif and SEC7 domain-containing protein 1 | Iqsec1 | Iqsec1 | 2 | 0 | 0 | 4 | 10 | 5 | 1 | 3 | 1 | 0 | 0 | 0 | 1 | 4 | 13 | 5 | 6.057 | 4.122 | 10.848 | 7.009 | 3 | 3 | 5 | YES | |||||||||||||||||||||||||
761 | P51863 | P51863 | V-type proton ATPase subunit d 1 | Atp6v0d1 | Atp6v0d1 | 2 | 4 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 2 | 3 | 2 | 62476 | 215750 | 22558 | 2.770 | 9.564 | 3.184 | 5.172 | 3 | 3 | 5 | YES | |||||||||||||||||||||
763 | P52480-2 P52480 G3X925 P53657 E9Q509 | P52480-2 P52480 | Pyruvate kinase isozymes M1/M2 | Pkm2 | Pkm2 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 1 | 2 | 2 | 1 | 126590 | 148760 | 33796 | 3.746 | 4.402 | 0.867 | 3.095 | 3.028 | 3 | 3 | 5 | YES | |||||||||||||||||||
728 | P35802 | P35802 | Neuronal membrane glycoprotein M6-a | Gpm6a | Gpm6a | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 2 | 1 | 66345 | 85439 | 1S specific | 1S specific | 6.937 | 6.937 | 3 | 3 | 1 | ||||||||||||||||||||||||
742 | P46460 G3UX86 G3UX98 | P46460 | Vesicle-fusing ATPase | Nsf | Nsf | 1 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 2 | 32535 | 43838 | 1S specific | 1S specific | 0.947 | 8.510 | 4.728 | 3 | 3 | 5 | YES | ||||||||||||||||||||||
1070 | Q76JQ1 Q8C4G9 E9PYX2 | Q76JQ1 Q8C4G9 E9PYX2 | G protein-coupled receptor 123 | Gpr123 | Gpr123 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 27490 | 13400 | 1S specific | 1S specific | 7.414 | 7.414 | 3 | 3 | 4 | YES | ||||||||||||||||||||||||
1078 | Q7TNS5 | Q7TNS5 | Novel protein similar to F-box and leucine-rich repeat protein 17 | B630019K06Rik | B630019K06Rik | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 2 | 25569 | 37025 | 1S specific | 1S specific | 6.455 | 6.455 | 3 | 3 | 5 | YES | |||||||||||||||||||||||
753 | P48722 P48722-2 E0CY23 F6SMW7 F6TFH3 | P48722 P48722-2 E0CY23 | Heat shock 70 kDa protein 4L | Hspa4l | Hspa4l | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 2 | 21376 | 14260 | 1S specific | 1S specific | 4.230 | 1.526 | 2.878 | 3 | 3 | ||||||||||||||||||||||||
457 | Q9QYS2 F6QVY9 | Q9QYS2 F6QVY9 | Metabotropic glutamate receptor 3 | Grm3 | Grm3 | 0 | 0 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 5.981 | 11.195 | 3.408 | 6.861 | 3 | 3 | 1 | |||||||||||||||||||||||||||
1377 | Q9DB72 | Q9DB72 | BTB/POZ domain-containing protein 17 | Btbd17 | Btbd17 | 0 | 0 | 0 | 2 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 7 | 3 | 4.315 | 3.818 | 14.040 | 7.391 | 3 | 3 | ||||||||||||||||||||||||||||
99 | Q6PFD5 B1AS06 | Q6PFD5 B1AS06 | Disks large-associated protein 3 | Dlgap3 | Dlgap3 | 0 | 0 | 0 | 2 | 8 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 16 | 22 | 4.310 | 8.864 | 5.981 | 6.385 | 3 | 3 | 5 | YES | YES | |||||||||||||||||||||||||
562 | G3X9V4 Q01097 | G3X9V4 Q01097 | Glutamate [NMDA] receptor subunit epsilon-2 | Grin2b | Grin2b | 0 | 0 | 0 | 1 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 3 | 3.820 | 8.747 | 4.751 | 5.773 | 3 | 3 | 5 | YES | YES | |||||||||||||||||||||||||
1163 | Q8BX10 Q8BX10-2 F6YJC6 | Q8BX10 Q8BX10-2 F6YJC6 | "Serine/threonine-protein phosphatase PGAM5, mitochondrial" | Pgam5 | Pgam5 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 0 | 0 | 0 | 1 | 3 | 2 | 1 | 10077 | 164170 | 35799 | 2S specific | 2S specific | 2 | 1S specific | 1S specific | 1 | 3 | 4 | YES | |||||||||||||||||||||
776 | P57780 | P57780 | Alpha-actinin-4 | Actn4 | Actn4 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 5 | 2 | 0 | 0 | 0 | 17 | 5 | 2 | 1306800 | 312770 | 77976 | 2S specific | 2S specific | 2S specific | 3 | 3 | 1 | |||||||||||||||||||||||||
707 | P28652 Q5SVI3 Q5SVJ0 Q5SVI2 Q5SVI0 Q5SVJ1 Q5SVI9 Q5SVI1 Q68EG2 Q3TY93 | P28652 Q5SVI3 Q5SVJ0 Q5SVI2 Q5SVI0 Q5SVJ1 Q5SVI9 Q5SVI1 Q68EG2 Q3TY93 | Calcium/calmodulin-dependent protein kinase type II subunit beta | Camk2b | Camk2b | 1 | 3 | 0 | 1 | 2 | 3 | 2 | 3 | 2 | 0 | 0 | 0 | 1 | 2 | 35653 | 1S specific | 3.838 | 3.838 | 2 | 2 | 5 | YES | |||||||||||||||||||||||||||
281 | P48453 E0CZ78 P48453-2 G3X8U7 E9Q6P2 Q80XK0 P48455 G3X8V4 | P48453 E0CZ78 P48453-2 G3X8U7 E9Q6P2 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatase | Ppp3cb | Ppp3cb | 3 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 61656 | 188120 | 1S specific | 1S specific | 1S specific | 2 | 2 | 5 | YES | ||||||||||||||||||||||||||
1365 | Q9D6R2 Q9D6R2-2 | Q9D6R2 Q9D6R2-2 | "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial" | Idh3a | Idh3a | 2 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 1 | 49155 | 71444 | 13998 | 3.512 | 5.104 | 4.308 | 2 | 2 | 1 | |||||||||||||||||||||||||
271 | O35526 D6RFB9 | O35526 D6RFB9 | Syntaxin-1A | Stx1a | Stx1a | 2 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 1 | 2 | 213540 | 431000 | 58004 | 3.681 | 7.431 | 5.556 | 2 | 2 | |||||||||||||||||||||||||
876 | Q03265 D3Z6F5 D6RJ16 | Q03265 D3Z6F5 | "ATP synthase subunit alpha, mitochondrial ATP synthase subunit alpha" | Atp5a1 | Atp5a1 | 1 | 4 | 2 | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 2 | 1 | 5 | 2 | 105020 | 307730 | 40586 | 2.588 | 7.582 | 2.342 | 2.399 | 3.728 | 2 | 2 | 4 | YES | |||||||||||||||||||
849 | P70441 | P70441 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Slc9a3r1 | Slc9a3r1 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 89028 | 141670 | 1S specific | 1S specific | 1S specific | 2 | 2 | 5 | YES | |||||||||||||||||||||||||
409 | P31648 E9Q9F4 | P31648 E9Q9F4 | Sodium- and chloride-dependent GABA transporter 1 Transporter | Slc6a1 | Slc6a1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 200310 | 321950 | 1S specific | 1S specific | 1S specific | 2 | 2 | ||||||||||||||||||||||||||||
41 | A2ALV3 Q62420 Q8BXU5 F6ZL13 A2ALV1 Q62419 Q62421 | A2ALV3 Q62420 Q8BXU5 F6ZL13 A2ALV1 | Endophilin-A1 | Sh3gl2 | Sh3gl2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 110930 | 69442 | 1S specific | 1S specific | 1S specific | 2 | 2 | 1 | |||||||||||||||||||||||||||
981 | Q60932 Q60932-2 F2Z471 | Q60932 Q60932-2 | Voltage-dependent anion-selective channel protein 1 | Vdac1 | Vdac1 | 1 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 3 | 84551 | 191410 | 61880 | 1.366 | 3.093 | 2.517 | 2.325 | 2 | 2 | 5 | YES | ||||||||||||||||||||||
524 | F8WI94 O55143 O55143-2 Q64518 E9Q559 Q64518-3 B1ATS5 Q64518-2 Q8R429 B1ATS4 | F8WI94 O55143 O55143-2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Atp2a2 | Atp2a2 | 2 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 1 | 40732 | 37306 | 1S specific | 1S specific | 1S specific | 2 | 2 | ||||||||||||||||||||||||||
736 | P40142 | P40142 | Transketolase | Tkt | Tkt | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 11497 | 65964 | 1S specific | 1S specific | 1S specific | 2 | 2 | 1 | |||||||||||||||||||||||||||
1156 | Q8BVE3 | Q8BVE3 | V-type proton ATPase subunit H | Atp6v1h | Atp6v1h | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 75907 | 132160 | 1S specific | 1S specific | 2.347 | 2.347 | 2 | 2 | ||||||||||||||||||||||||||
825 | P63085 E9QAJ2 F6VEI7 | P63085 E9QAJ2 | Mitogen-activated protein kinase 1 | Mapk1 | Mapk1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 33507 | 27653 | 1S specific | 1S specific | 1S specific | 2 | 2 | 5 | YES | ||||||||||||||||||||||||||
1171 | Q8C0M9 | Q8C0M9 | L-asparaginase | Asrgl1 | Asrgl1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 32181 | 47321 | 1S specific | 1S specific | 1S specific | 2 | 2 | 1 | |||||||||||||||||||||||||||
96 | B1AQZ0 B1AQY9 B7ZC46 Q8CHH9-2 Q8CHH9 F7C5C1 E0CYM4 | B1AQZ0 B1AQY9 B7ZC46 Q8CHH9-2 Q8CHH9 | Septin-8 | Sep-08 | sept8 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 28267 | 99895 | 1S specific | 1S specific | 1S specific | 2 | 2 | ||||||||||||||||||||||||||||
873 | Q02053 | Q02053 | Ubiquitin-like modifier-activating enzyme 1 | Uba1 | Uba1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 23619 | 42869 | 1S specific | 1S specific | 1S specific | 2 | 2 | 1 | |||||||||||||||||||||||||||
1034 | Q571J7 Q6P1F6 Q9CWU3 Q8BG02 | Q571J7 Q6P1F6 Q9CWU3 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Ppp2r2a | Ppp2r2a | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 21893 | 21333 | 1S specific | 1S specific | 1S specific | 2 | 2 | |||||||||||||||||||||||||||
1409 | Q9JKC6 | Q9JKC6 | Cell cycle exit and neuronal differentiation protein 1 | Cend1 | Cend1 | 0 | 3 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 793870 | 1S specific | 15.781 | 2.022 | 8.902 | 2 | 2 | |||||||||||||||||||||||||||
295 | E9PV66 | E9PV66 | Myo18b | Myo18b | Myo18b | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 2 | 1 | 1716500 | 1032600 | 58454 | 18812 | 18812 | 29.365 | 17.665 | 23.515 | 2 | 2 | |||||||||||||||||||||||
1203 | Q8K2B3 | Q8K2B3 | "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial" | Sdha | Sdha | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 72706 | 29098 | 1S specific | 1S specific | 1S specific | 2 | 2 | 4 | YES | ||||||||||||||||||||||||||
518 | F8WHB1 Q9R0K7 Q6DIB8 | F8WHB1 Q9R0K7 | Plasma membrane calcium-transporting ATPase 2 | Atp2b2 | Atp2b2 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 64467 | 72908 | 1S specific | 1S specific | 1.930 | 1.930 | 2 | 2 | 1 | YES | ||||||||||||||||||||||||
1368 | Q9D8N0 | Q9D8N0 | Elongation factor 1-gamma | Eef1g | Eef1g | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 41660 | 39339 | 1S specific | 1S specific | 1S specific | 2 | 2 | 1 | |||||||||||||||||||||||||||
501 | F7C0H6 Q5M8N0 | F7C0H6 Q5M8N0 | CB1 cannabinoid receptor-interacting protein 1 | Cnrip1 | Cnrip1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 37567 | 52676 | 1S specific | 1S specific | 1S specific | 2 | 2 | ||||||||||||||||||||||||||||
828 | P63141 | P63141 | Potassium voltage-gated channel subfamily A member 2 | Kcna2 | Kcna2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 35615 | 41818 | 1S specific | 1S specific | 1S specific | 2 | 2 | 5 | YES | YES | |||||||||||||||||||||||||
660 | G3UWA6 P10852 | G3UWA6 P10852 | 4F2 cell-surface antigen heavy chain | Slc3a2 | Slc3a2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 | 3 | 2 | 32826 | 44321 | 61361 | 61361 | 0.000 | 1S specific | 1S specific | 0.379 | 0.379 | 2 | 2 | ||||||||||||||||||||||
1082 | Q7TSJ2 Q7TSJ2-2 D3Z6W1 Q7TSJ2-3 | Q7TSJ2 Q7TSJ2-2 D3Z6W1 Q7TSJ2-3 | Microtubule-associated protein 6 | Map6 Mtap6 | Mtap6 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 20711 | 29865 | 1S specific | 1S specific | 1S specific | 2 | 2 | ||||||||||||||||||||||||||||
816 | P62874 | P62874 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Gnb1 | Gnb1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 16246 | 29801 | 1S specific | 1S specific | 1S specific | 2 | 2 | 3 | |||||||||||||||||||||||||||
1313 | Q9CPQ1 | Q9CPQ1 | Cytochrome c oxidase subunit 6C | Cox6c | Cox6c | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 8079.2 | 24394 | 1S specific | 1S specific | 1S specific | 2 | 2 | ||||||||||||||||||||||||||||
333 | E9Q557 E9PZW0 | E9Q557 E9PZW0 | Desmoplakin | Dsp | Dsp | 0 | 0 | 0 | 1 | 3 | 2 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 5 | 3 | 1 | 1 | 1 | 2 | 1 | 12374 | 29149 | 20505 | 8603 | 14554 | 0.850 | 2.003 | 2.779 | 7.477 | 5.128 | 2 | 2 | |||||||||||||||||
1159 | Q8BWF0 | Q8BWF0 | "Succinate-semialdehyde dehydrogenase, mitochondrial" | Aldh5a1 | Aldh5a1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 16964 | 1S specific | 14.138 | 14.138 | 2 | 2 | 1 | ||||||||||||||||||||||||||||
1197 | Q8K0T0 Q4FZ95 A3QM89 Q7M6W1 | Q8K0T0 | Reticulon-1 | Rtn1 | Rtn1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 13935 | 1S specific | 2.695 | 2.695 | 2 | 2 | |||||||||||||||||||||||||||||
985 | Q61171 D3Z4A4 | Q61171 D3Z4A4 | Peroxiredoxin-2 | Prdx2 | Prdx2 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 1 | 1 | 7.163 | 5.184 | 6.173 | 2 | 2 | 3 | YES | ||||||||||||||||||||||||||
55 | A2ARP8 Q9QYR6-2 Q9QYR6 | A2ARP8 Q9QYR6-2 Q9QYR6 | Microtubule-associated protein 1A MAP1 light chain LC2 | Mtap1a Map1a | Mtap1a | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 6.726 | 1.753 | 7.195 | 5.225 | 2 | 2 | 2 | |||||||||||||||||||||||||||
549 | G3UYQ4 | G3UYQ4 | Adenylate kinase domain-containing 1 | Akd1 | Akd1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | 1 | 5.229 | 32.707 | 18.968 | 2 | 2 | |||||||||||||||||||||||||||||
908 | Q3TXX4 | Q3TXX4 | Vesicular glutamate transporter 1 | Slc17a7 | Slc17a7 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.911 | 3.001 | 3.456 | 2 | 2 | ||||||||||||||||||||||||||||||
472 | F6VAN0 | F6VAN0 | Atf6 | Atf6 | Atf6 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2.587 | 4.500 | 3.543 | 2 | 2 | ||||||||||||||||||||||||||||||
724 | P35436 | P35436 | Glutamate [NMDA] receptor subunit epsilon-1 | Grin2a | Grin2a | 0 | 0 | 0 | 1 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 9 | 3 | 3.650 | 3.847 | 3.748 | 2 | 2 | 5 | YES | YES | ||||||||||||||||||||||||||
669 | P14094 | P14094 | Sodium/potassium-transporting ATPase subunit beta-1 | Atp1b1 | Atp1b1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 157650 | 135470 | 2S specific | 2S specific | 2 | 2 | 5 | YES | |||||||||||||||||||||||||||
54 | P30275 A2ARP5 B0R0E9 B0R0E8 B0R0F0 | P30275 A2ARP5 B0R0E9 B0R0E8 | "Creatine kinase U-type, mitochondrial" | Ckmt1 | Ckmt1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 60173 | 32612 | 2S specific | 2S specific | 2 | 2 | 1 | ||||||||||||||||||||||||||||
1362 | Q9D6F9 | Q9D6F9 | Tubulin beta-4A chain | Tubb4a | Tubb4a | 5 | 7 | 4 | 7 | 8 | 6 | 2 | 4 | 2 | 0 | 0 | 1 | 1 | 1 | 5.828 | 5.828 | 1 | 1 | |||||||||||||||||||||||||||||||
237 | P54227 D3Z5N2 D3Z1Z8 | P54227 D3Z5N2 D3Z1Z8 | Stathmin | Stmn1 | Stmn1 | 5 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 7 | 2 | 362320 | 690130 | 159130 | 2.277 | 4.337 | 3.307 | 1 | 1 | ||||||||||||||||||||||||||
1003 | Q62188 E9PWE8 Q3TT92 D3YUS0 D3Z567 | Q62188 E9PWE8 Q3TT92 | Dihydropyrimidinase-related protein 3 | Dpysl3 | Dpysl3 | 4 | 6 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 142810 | 44751 | 3.191 | 3.191 | 1 | 1 | |||||||||||||||||||||||||||||
1108 | Q8BFZ3 | Q8BFZ3 | Beta-actin-like protein 2 | Actbl2 | Actbl2 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 7456900 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
1339 | Q9CYT6 D3YTR7 | Q9CYT6 D3YTR7 | Adenylyl cyclase-associated protein 2 Adenylyl cyclase-associated protein | Cap2 | Cap2 | 2 | 4 | 3 | 8 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 4 | 17 | 12 | 16 | 384790 | 619530 | 410590 | 0.937 | 1.509 | 1.152 | 1.636 | 2.944 | 1.636 | 1 | 1 | ||||||||||||||||||||
979 | Q60864 | Q60864 | Stress-induced-phosphoprotein 1 | Stip1 | Stip1 | 5 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 1 | 291870 | 38065 | 33403 | 8.738 | 1.140 | 4.939 | 1 | 1 | 1 | ||||||||||||||||||||||||
745 | P46660 | P46660 | Alpha-internexin | Ina | Ina | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 118890 | 1S specific | 1S specific | 1 | 1 | 1 | |||||||||||||||||||||||||||||
1253 | Q91V12-4 Q91V12-2 E9PYH2 Q91V12 Q91V12-3 | Q91V12-4 Q91V12-2 E9PYH2 Q91V12 Q91V12-3 | Cytosolic acyl coenzyme A thioester hydrolase | Acot7 | Acot7 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 37526 | 95742 | 23195 | 1.618 | 4.128 | 2.873 | 1 | 1 | 5 | YES | ||||||||||||||||||||||||
692 | F8WGL3 P18760 E9Q1T2 P45591 | F8WGL3 P18760 E9Q1T2 | Cofilin-1 | Cfl1 Gm6180 | Cfl1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 63814 | 1S specific | 1S specific | 1 | 1 | 4 | YES | ||||||||||||||||||||||||||||
735 | P40124 B1ARS0 | P40124 B1ARS0 | Adenylyl cyclase-associated protein 1 Adenylyl cyclase-associated protein | Cap1 | Cap1 | 1 | 1 | 1 | 3 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 7 | 6 | 6 | 52835 | 58487 | 69733 | 0.758 | 0.839 | 1.506 | 1.662 | 7.927 | 2.538 | 1 | 1 | 1 | |||||||||||||||||||
1407 | Q9JJV2 Q9JJV2-3 Q9JJV2-2 D3YWS3 | Q9JJV2 Q9JJV2-3 Q9JJV2-2 D3YWS3 | Profilin-2 Profilin | Pfn2 | Pfn2 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 1 | 17101 | 34110 | 29997 | 0.570 | 1.137 | 3.424 | 1.711 | 1 | 1 | ||||||||||||||||||||||||
1309 | Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2 | Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2 | Protein phosphatase 1B | Ppm1b | Ppm1b | 2 | 0 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 4 | 15522 | 17578 | 0.883 | 1.331 | 10.181 | 4.132 | 1 | 1 | |||||||||||||||||||||||||
1471 | B7ZNM7 Q9Z2Q6 Q52KH2 | B7ZNM7 Q9Z2Q6 Q52KH2 | Septin-5 | Sept5 | Sept5 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 45555 | 1S specific | 1S specific | 1 | 1 | 3 | YES | |||||||||||||||||||||||||||||
806 | P62259 D6REF3 F6WA09 O70456 | P62259 D6REF3 F6WA09 | 14-3-3 protein epsilon | Ywhae | Ywhae | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 42567 | 1S specific | 1S specific | 1 | 1 | 3 | YES | |||||||||||||||||||||||||||||
627 | P00405 Q7JCZ1 | P00405 Q7JCZ1 | Cytochrome c oxidase subunit 2 | Mtco2 mt-Co2 | Mtco2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 27358 | 1S specific | 1S specific | 1 | 1 | ||||||||||||||||||||||||||||||
343 | E9QK41 Q8K4G5 E9Q9C2 E9Q9C1 E9Q9C9 E9Q9C0 E9Q9C8 Q8K4G5-2 E9Q9C4 E9Q1E8 E9Q9C7 Q8K4G5-4 E9Q030 Q8K4G5-3 E9Q9D2 E9Q9D1 E9Q9Q7 F6YHE5 Q8K4G5-5 | E9QK41 Q8K4G5 E9Q9C2 E9Q9C1 E9Q9C9 E9Q9C0 E9Q9C8 Q8K4G5-2 E9Q9C4 E9Q1E8 E9Q9C7 Q8K4G5-4 E9Q030 Q8K4G5-3 E9Q9D2 E9Q9D1 E9Q9Q7 | Actin-binding LIM protein 1 | Ablim1 | Ablim1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 2 | 22113 | 1S specific | 1S specific | 1 | 1 | 5 | YES | ||||||||||||||||||||||||||
726 | P35486 | P35486 | "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial" | Pdha1 | Pdha1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 12671 | 1S specific | 1S specific | 1 | 1 | 5 | YES | ||||||||||||||||||||||||||||
620 | O88737 O88737-2 | O88737 O88737-2 | Protein bassoon | Bsn | Bsn | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 9577.1 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||
1221 | Q8R191 | Q8R191 | Synaptogyrin-3 | Syngr3 | Syngr3 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 9149.7 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||
1293 | Q99KI0 | Q99KI0 | "Aconitate hydratase, mitochondrial" | Aco2 | Aco2 | 1 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4 | 1 | 3.216 | 3.216 | 1 | 1 | 4 | YES | |||||||||||||||||||||||||||
101 | Q60631 B1AT92 Q60631-2 B1AT95 | Q60631 B1AT92 Q60631-2 B1AT95 | Growth factor receptor-bound protein 2 | Grb2 | Grb2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 42273 | 1S specific | 1S specific | 1 | 1 | 2 | ||||||||||||||||||||||||||||||
1145 | Q8BMF4 | Q8BMF4 | "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial" | Dlat | Dlat | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 41802 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
204 | O08788 E9Q3M3 E9Q586 D3YX34 O08788-2 | O08788 E9Q3M3 E9Q586 D3YX34 O08788-2 | Dynactin subunit 1 | Dctn1 | Dctn1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 28723 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
510 | Q62277 F8WGK2 F6VR28 | Q62277 F8WGK2 | Synaptophysin | Syp | Syp | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 28175 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
654 | P09411 P09041 | P09411 | Phosphoglycerate kinase 1 | Pgk1 | Pgk1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 20070 | 1S specific | 1S specific | 1 | 1 | 5 | YES | ||||||||||||||||||||||||||||
1405 | Q9JIS5 | Q9JIS5 | Synaptic vesicle glycoprotein 2A | Sv2a | Sv2a | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 15161 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
332 | E9PZJ8 | E9PZJ8 | Activating signal cointegrator 1 complex subunit 3 | Ascc3 | Ascc3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 19328000 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
1363 | Q9D6J5 | Q9D6J5 | "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial" | Ndufb8 | Ndufb8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 104480 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
613 | Q76LV0 O70325 O70325-2 | Q76LV0 O70325 O70325-2 | "Glutathione peroxidase Phospholipid hydroperoxide glutathione peroxidase, mitochondrial" | Gpx4 | Gpx4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 57612 | 1S specific | 1S specific | 1 | 1 | 3 | YES | |||||||||||||||||||||||||||||
1289 | Q99JI4 | Q99JI4 | 26S proteasome non-ATPase regulatory subunit 6 | Psmd6 | Psmd6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 56143 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
727 | P35762 Q91V78 | P35762 Q91V78 | CD81 antigen | Cd81 | Cd81 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 49096 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
760 | P50518 | P50518 | V-type proton ATPase subunit E 1 | Atp6v1e1 | Atp6v1e1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 39182 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
1199 | Q8K183 D3Z7R1 | Q8K183 | Pyridoxal kinase | Pdxk | Pdxk | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 26919 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
1119 | Q8BGZ1 F2Z3Z1 | Q8BGZ1 F2Z3Z1 | Hippocalcin-like protein 4 | Hpcal4 | Hpcal4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 26647 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
834 | P67778 | P67778 | Prohibitin | Phb | Phb | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 25473 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
212 | P42208 E9Q3V6 D3Z3C0 D3YYB1 F6WYM0 D3Z1S1 D3YZU7 F6UKN5 | P42208 E9Q3V6 D3Z3C0 D3YYB1 F6WYM0 D3Z1S1 D3YZU7 F6UKN5 | Septin-2 | Sept2 | sept2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 24498 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
1262 | Q91X97 | Q91X97 | Neurocalcin-delta | Ncald | Ncald | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 23689 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
544 | O70585 G3UYM7 O70585-2 G3UZ87 Q8C8Z9 Q8K0N0 G3UY34 G3UXK0 G3UZJ3 G3UXI3 E9QAY9 G3UXH9 G3UYK9 G3UYN2 G3UX96 | O70585 G3UYM7 O70585-2 G3UZ87 Q8C8Z9 Q8K0N0 G3UY34 G3UXK0 G3UZJ3 G3UXI3 E9QAY9 G3UXH9 | Dystrobrevin beta | Dtnb | Dtnb | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 19766 | 1S specific | 0.314 | 0.314 | 1 | 1 | ||||||||||||||||||||||||||||
52 | A2AQR0 Q64521 | A2AQR0 Q64521 | "Glycerol-3-phosphate dehydrogenase, mitochondrial" | Gpd2 | Gpd2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 17142 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
858 | P84084 E9Q2C2 D3YV25 | P84084 | ADP-ribosylation factor 5 | Arf5 | Arf5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 15081 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
695 | P19783 | P19783 | "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial" | Cox4i1 | Cox4i1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 14935 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
709 | P28663 D6RHL2 | P28663 D6RHL2 | Beta-soluble NSF attachment protein | Napb | Napb | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 14607 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
387 | Q9D6M3 E9Q6M6 E9PY45 E9PV90 E9Q579 | Q9D6M3 E9Q6M6 E9PY45 E9PV90 E9Q579 | Mitochondrial glutamate carrier 1 | Slc25a22 | Slc25a22 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 12474 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
932 | Q3UNH4 | Q3UNH4 | G protein-regulated inducer of neurite outgrowth 1 | Gprin1 | Gprin1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 12086 | 1S specific | 1S specific | 1 | 1 | ||||||||||||||||||||||||||||||
897 | Q8BW96 Q8BW96-3 Q8BW96-2 Q3TDM2 | Q8BW96 Q8BW96-3 Q8BW96-2 Q3TDM2 | Calcium/calmodulin-dependent protein kinase type 1D | Camk1d | Camk1d | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 11119 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
1302 | Q99M71 Q99M71-2 | Q99M71 Q99M71-2 | Mammalian ependymin-related protein 1 | Epdr1 | Epdr1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 11090 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
1072 | Q76MZ3 G3UWS4 Q3TTF6 Q7TNP2 G3UWL2 G3UXQ1 | Q76MZ3 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | Ppp2r1a | Ppp2r1a | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 11069 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
211 | Q91YS4 D3YXZ3 E9QL75 O88448 D3Z5Y7 Q9DBS5 | Q91YS4 D3YXZ3 E9QL75 O88448 D3Z5Y7 | Kinesin light chain 2 | Klc2 | Klc2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 11038 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
703 | P26443 F7CFA5 | P26443 F7CFA5 | "Glutamate dehydrogenase 1, mitochondrial" | Glud1 | Glud1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 10603 | 1S specific | 0.473 | 0.473 | 1 | 1 | 1 | ||||||||||||||||||||||||||||
739 | P42932 | P42932 | T-complex protein 1 subunit theta | Cct8 | Cct8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 10280 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
852 | P80313 | P80313 | T-complex protein 1 subunit eta | Cct7 | Cct7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 9784.6 | 1S specific | 1S specific | 1 | 1 | ||||||||||||||||||||||||||||||
634 | P03930 Q7JCZ0 | P03930 Q7JCZ0 | ATP synthase protein 8 | Mtatp8 mt-Atp8 | Mtatp8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 9279.2 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
508 | F8WGC2 Q07076 | F8WGC2 Q07076 | Annexin Annexin A7 | Anxa7 | Anxa7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 8668.5 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
278 | P13707 E0CXN5 | P13707 E0CXN5 | "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic" | Gpd1 | Gpd1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 8466.9 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
697 | P20357 Q80ZL4 Q80X35 G3UZK9 Q3TLQ0 G3UZV6 G3UWW1 G3UZE9 F7ALC8 E9Q8Y2 | P20357 | Microtubule-associated protein 2 | Map2 | Map2 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 7799.2 | 1S specific | 1.818 | 1.818 | 1 | 1 | |||||||||||||||||||||||||||||
1269 | Q91YQ5 | Q91YQ5 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | Rpn1 | Rpn1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6705.6 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
666 | P12960 | P12960 | Contactin-1 | Cntn1 | Cntn1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5901.3 | 1S specific | 1S specific | 1 | 1 | 1 | ||||||||||||||||||||||||||||||
840 | P70168 | P70168 | Importin subunit beta-1 | Kpnb1 | Kpnb1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5634 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
1134 | Q8BJY1 | Q8BJY1 | 26S proteasome non-ATPase regulatory subunit 5 | Psmd5 | Psmd5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5490.1 | 1S specific | 1S specific | 1 | 1 | |||||||||||||||||||||||||||||||
874 | Q02257 | Q02257 | Junction plakoglobin | Jup | Jup | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 11 | 1 | 4 | 2 | 363650 | 147130 | 147130 | 2.472 | 5.415 | 5.415 | 1 | 1 | |||||||||||||||||||||||||
1307 | Q99MY8 | Q99MY8 | Histone-lysine N-methyltransferase ASH1L | Ash1l | Ash1l | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 11.799 | 11.799 | 1 | 1 | ||||||||||||||||||||||||||||||||
542 | Q60930 G3UX26 D3YZT5 | Q60930 G3UX26 D3YZT5 | Voltage-dependent anion-selective channel protein 2 | Vdac2 | Vdac2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.536 | 5.536 | 1 | 1 | 5 | YES | ||||||||||||||||||||||||||||||
1023 | Q66JY6 | Q66JY6 | Vav-like protein C9orf100 homolog | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.659 | 2.659 | 1 | 1 | ||||||||||||||||||||||||||||||||||
1267 | Q91YL3 D6RJ84 F7CAK3 | Q91YL3 D6RJ84 F7CAK3 | Uridine-cytidine kinase-like 1 Uridine kinase | Uckl1 | Uckl1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 23.857 | 23.857 | 1 | 1 | ||||||||||||||||||||||||||||||||
986 | Q61176 | Q61176 | Arginase-1 | Arg1 | Arg1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2.737 | 2.737 | 1 | 1 | ||||||||||||||||||||||||||||||||
680 | P16388 | P16388 | Potassium voltage-gated channel subfamily A member 1 | Kcna1 | Kcna1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2.582 | 2.582 | 1 | 1 | 5 | YES | YES | ||||||||||||||||||||||||||||
356 | E9Q2W9 D3Z0L8 D3Z761 | E9Q2W9 D3Z0L8 | Actinin alpha 4 | Actn4 | Actn4 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 0 | 0 | 0 | 1 | 75258 | 2S specific | 1 | 1 | 1 | |||||||||||||||||||||||||||||||
877 | Q04447 | Q04447 | Creatine kinase B-type | Ckb | Ckb | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 91594 | 1249500 | 186400 | 2S specific | 1 | 0.073 | 0.073 | 1 | ||||||||||||||||||||||||||
335 | E9Q019 F6TL02 P11088 F6YPY4 F7BVV1 F7CLU3 | E9Q019 F6TL02 P11088 F6YPY4 F7BVV1 F7CLU3 | Filaggrin | Flg | Flg | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 300350 | 2S specific | 1 | 1 | ||||||||||||||||||||||||||||||||
433 | Q62415 E9QLE7 F6YJV5 E9Q889 | Q62415 E9QLE7 F6YJV5 E9Q889 | Apoptosis-stimulating of p53 protein 1 | Ppp1r13b | Ppp1r13b | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 3 | 211530 | 11578000 | 1995100 | 2650400 | 2108400 | 2251300 | 0.094 | 5.143 | 1 | 1 | |||||||||||||||||||||
560 | Q8CGP2-2 Q921L4 Q8CBB6 P10853 P10854 Q64475 Q64478 Q64524 Q64525 Q6ZWY9 Q8CGP0 Q8CGP1 Q8CGP2 Q9D2U9 G3X9D5 | Q8CGP2-2 Q921L4 Q8CBB6 P10853 P10854 Q64475 Q64478 Q64524 Q64525 Q6ZWY9 Q8CGP0 Q8CGP1 Q8CGP2 Q9D2U9 G3X9D5 | Histone H2B Histone H2B type 1-F/J/L Histone H2B type 1-M Histone H2B type 1-B Histone H2B type 1-H Histone H2B type 2-E Histone H2B type 2-B Histone H2B type 1-C/E/G Histone H2B type 3-B Histone H2B type 1-K Histone H2B type 1-P Histone H2B type 3-A | Gm13646 Hist1h2bf Hist1h2bm Hist1h2bb Hist1h2bh Hist2h2be Hist2h2bb Hist1h2bc Hist3h2bb Hist1h2bk Hist1h2bp Hist3h2ba | Hist1h2bb | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 76997 | 2S specific | 1 | 1 | 2 | |||||||||||||||||||||||||||||||
0 | A0JNY3 Q8BUV3 | A0JNY3 Q8BUV3 | Gephyrin Molybdopterin adenylyltransferase Molybdopterin molybdenumtransferase | Gphn | Gphn | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 62052 | 2S specific | 1 | 1 | ||||||||||||||||||||||||||||||||
830 | P63260 E9Q607 B1ATY1 G3UYG0 | P63260 E9Q607 B1ATY1 | "Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed" | Actg1 | Actg1 | 15 | 13 | 13 | 14 | 13 | 9 | 6 | 6 | 7 | 0 | 1 | 3 | 8 | 10 | 8 | 1 | 2 | 1 | 0 | ||||||||||||||||||||||||||||||
1077 | Q7TMM9 | Q7TMM9 | Tubulin beta-2A chain | Tubb2a | Tubb2a | 5 | 7 | 5 | 7 | 8 | 5 | 2 | 5 | 3 | 0 | 0 | 2 | 1 | 1 | 1 | 4 | 4 | 162900 | 165080 | 72269 | 2.254 | 2.284 | 0.973 | 2.029 | 1.885 | 0 | |||||||||||||||||||||||
348 | E9Q1Z0 | E9Q1Z0 | 4732456N10Rik | 4732456N10Rik | 4732456N10Rik | 3 | 4 | 0 | 0 | 2 | 1 | 1 | 1 | 3 | 2 | 1 | 3 | 1 | 3 | 4 | 4 | 4 | 3 | 3 | 4 | 3 | 0 | |||||||||||||||||||||||||||
90 | P07356 B0V2N7 B0V2N5 B0V2N8 | P07356 B0V2N7 B0V2N5 B0V2N8 | Annexin A2 Annexin | Anxa2 | Anxa2 | 4 | 5 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 6 | 4 | 2 | 136600 | 327760 | 182700 | 0.748 | 1.794 | 1.271 | 0 | ||||||||||||||||||||||||||
773 | P56480 | P56480 | "ATP synthase subunit beta, mitochondrial" | Atp5b | Atp5b | 4 | 3 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 5 | 4 | 3 | 2 | 253680 | 229050 | 204610 | 1.240 | 1.119 | 1.252 | 2.373 | 1.496 | 0 | 3 | YES | |||||||||||||||||||||
770 | Q9CZ46 P55821 | Q9CZ46 P55821 | Stathmin-2 | Stmn2 | Stmn2 | 2 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 267000 | 159920 | 1.670 | 1.670 | 0 | ||||||||||||||||||||||||||||||
1246 | Q8VGN0 | Q8VGN0 | Olfactory receptor 1233 | Olfr1233 | Olfr1233 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 5 | 4 | 12 | 2 | 6 | 6 | 4 | 0 | |||||||||||||||||||||||||||
645 | P07901 B7ZC50 B7ZC49 A2A6A2 | P07901 | Heat shock protein HSP 90-alpha | Hsp90aa1 | Hsp90aa1 | 3 | 2 | 0 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | ||||||||||||||||||||||||||||||||||
1345 | Q9D051 | Q9D051 | "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial" | Pdhb | Pdhb | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 45046 | 165380 | 78694 | 0.572 | 2.102 | 1.337 | 0 | 5 | YES | |||||||||||||||||||||||||
1301 | Q99LX0 A2A813 A2A815 A2A816 A2A817 | Q99LX0 A2A813 A2A815 A2A816 A2A817 | Protein DJ-1 | Park7 | Park7 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 122270 | 22023 | 114360 | 1.069 | 0.193 | 0.631 | 0 | 4 | YES | ||||||||||||||||||||||||
732 | P38647 Q7TSZ0 | P38647 Q7TSZ0 | "Stress-70 protein, mitochondrial" | Hspa9 | Hspa9 | 2 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 2 | 1 | 62677 | 22095 | 38055 | 1.647 | 0.581 | 2.002 | 1.410 | 0 | 1 | |||||||||||||||||||||||
690 | P17897 | P17897 | Lysozyme C-1 | Lyz1 | Lyz1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 1 | 0 | ||||||||||||||||||||||||||||||||
256 | D3Z623 | D3Z623 | 9330159F19Rik | 9330159F19Rik | 9330159F19Rik | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 5 | 1 | 7 | 0 | |||||||||||||||||||||||||||||||||
848 | P70398 Q4FE56 F8VPU6 | P70398 Q4FE56 | Probable ubiquitin carboxyl-terminal hydrolase FAF-X Ubiquitin carboxyl-terminal hydrolase | Usp9x | Usp9x | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | 1 | 0 | ||||||||||||||||||||||||||||||
712 | Q3U9N4 P28798 | Q3U9N4 P28798 | Granulins Acrogranin Granulin-1 Granulin-2 Granulin-3 Granulin-4 Granulin-5 Granulin-6 Granulin-7 | Grn | Grn | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 170100 | 299990 | 176710 | 0.963 | 1.698 | 1.330 | 0 | |||||||||||||||||||||||||||
978 | Q60829 Q60829-2 | Q60829 Q60829-2 | Protein phosphatase 1 regulatory subunit 1B | Ppp1r1b | Ppp1r1b | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 65732 | 48547 | 59255 | 1.109 | 0.819 | 0.964 | 0 | |||||||||||||||||||||||||||
100 | Q9DCX2 G3X9L6 B1ASE2 | Q9DCX2 G3X9L6 B1ASE2 | "ATP synthase subunit d, mitochondrial" | Atp5h Gm10250 | Atp5h | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 61263 | 59250 | 28664 | 2.137 | 2.067 | 2.102 | 0 | |||||||||||||||||||||||||||
267 | P47754 D6RCW7 | P47754 D6RCW7 | F-actin-capping protein subunit alpha-2 | Capza2 | Capza2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 59873 | 77836 | 49110 | 1.219 | 1.585 | 1.402 | 0 | 4 | YES | |||||||||||||||||||||||||
1180 | Q8C845 Q9D8Y0 Q9D4J1 | Q8C845 Q9D8Y0 | EF-hand domain-containing protein D2 | Efhd2 | Efhd2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 47900 | 38793 | 54086 | 0.886 | 0.717 | 0.801 | 0 | |||||||||||||||||||||||||||
815 | P62814 Q91YH6 | P62814 | "V-type proton ATPase subunit B, brain isoform" | Atp6v1b2 | Atp6v1b2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 44778 | 41603 | 28715 | 1.559 | 1.449 | 1.504 | 0 | 1 | ||||||||||||||||||||||||||
1449 | Q9WV69 Q9WVM2 E9Q1G7 Q8JZV5 | Q9WV69 Q9WVM2 E9Q1G7 Q8JZV5 | Dematin | Epb49 Epb4.9 | Epb49 Epb4.9 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 26818 | 49592 | 28012 | 0.957 | 1.770 | 1.364 | 0 | |||||||||||||||||||||||||||
1076 | Q7TMF3 | Q7TMF3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | Ndufa12 | Ndufa12 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 20586 | 13243 | 15335 | 1.342 | 0.864 | 1.103 | 0 | |||||||||||||||||||||||||||
1316 | Q9CQ75 | Q9CQ75 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Ndufa2 | Ndufa2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 7411.8 | 13436 | 6660.3 | 1.113 | 2.017 | 1.565 | 0 | |||||||||||||||||||||||||||
1344 | Q9CZY3 E9PY39 B7ZBY7 D3Z1I3 D3YXL3 Q9CZY3-2 D3Z6R2 B7ZBY6 | Q9CZY3 E9PY39 B7ZBY7 D3Z1I3 D3YXL3 Q9CZY3-2 | Ubiquitin-conjugating enzyme E2 variant 1 | Ube2v1 Gm20431 Gm8325 Gm5830 | Ube2v1 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 213770 | 172600 | 1.239 | 1.239 | 0 | 3 | |||||||||||||||||||||||||||||
87 | B0QZN5 P63044 F6Q6A5 P63024 D3YTU0 Q62442 Q62442-2 | B0QZN5 P63044 F6Q6A5 P63024 | Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 3 | Vamp2 Vamp3 | Vamp2 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 70060 | 28121 | 2.491 | 2.491 | 0 | 3 | YES | ||||||||||||||||||||||||||||
706 | P27773 F6Q404 | P27773 | Protein disulfide-isomerase A3 | Pdia3 | Pdia3 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 70049 | 51272 | 1.366 | 1.366 | 0 | 1 | ||||||||||||||||||||||||||||
1353 | Q9D2M8 Q9D2M8-2 A6X925 B2KF55 | Q9D2M8 Q9D2M8-2 | Ubiquitin-conjugating enzyme E2 variant 2 | Ube2v2 | Ube2v2 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 24613 | 29597 | 0.832 | 0.832 | 0 | 2 | |||||||||||||||||||||||||||||
793 | P60879 P60879-2 | P60879 P60879-2 | Synaptosomal-associated protein 25 | Snap25 | Snap25 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 0 | 1 | ||||||||||||||||||||||||||||||||
892 | Q3TBD8 | Q3TBD8 | Rhobtb2 | Rhobtb2 | Rhobtb2 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | ||||||||||||||||||||||||||||||||||
864 | P97350 | P97350 | Plakophilin-1 | Pkp1 | Pkp1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 4 | 5 | 3 | 1 | 1 | 0 | |||||||||||||||||||||||||||||||
314 | E9PX96 Q3SXH3 | E9PX96 Q3SXH3 | Seminal vesicle antigen | Sva | Sva | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | |||||||||||||||||||||||||||||||||
867 | P97393 | P97393 | Rho GTPase-activating protein 5 | Arhgap5 | Arhgap5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | ||||||||||||||||||||||||||||||||||
1144 | Q8BMC1 | Q8BMC1 | V-type proton ATPase subunit G 3 | Atp6v1g3 | Atp6v1g3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | ||||||||||||||||||||||||||||||||||
919 | Q3UEB3 Q3UEB3-2 Q3UEB3-3 | Q3UEB3 Q3UEB3-2 Q3UEB3-3 | Poly(U)-binding-splicing factor PUF60 | Puf60 | Puf60 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 26189 | 42444 | 0.617 | 0.617 | 0 | ||||||||||||||||||||||||||||||
750 | P47757 P47757-2 A2AMW0 F7CAZ6 F6YHZ8 F6QJN8 | P47757 P47757-2 A2AMW0 | F-actin-capping protein subunit beta | Capzb | Capzb | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 24651 | 15295 | 1.612 | 1.612 | 0 | ||||||||||||||||||||||||||||||
392 | E9Q793 | E9Q793 | 4931429I11Rik | 4931429I11Rik | 4931429I11Rik | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | ||||||||||||||||||||||||||||||||||
573 | G5E8Z1 | G5E8Z1 | Gm6788 | Gm6788 | Gm6788 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | ||||||||||||||||||||||||||||||||||
341 | Q61699 E9Q0U7 Q61699-2 D3Z027 | Q61699 E9Q0U7 Q61699-2 | Heat shock protein 105 kDa | Hsph1 | Hsph1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
297 | Q61026 E9PV80 | Q61026 E9PV80 | Nuclear receptor coactivator 2 | Ncoa2 | Ncoa2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
1245 | Q8VFH0 | Q8VFH0 | Olfr1361 | Olfr1361 | Olfr1361 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
506 | F8VPQ1 Q8CIQ7 F6VMI1 F7CVM6 | F8VPQ1 Q8CIQ7 F6VMI1 F7CVM6 | Dedicator of cytokinesis protein 3 | Dock3 | Dock3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
647 | P08032 | P08032 | "Spectrin alpha chain, erythrocyte" | Spta1 | Spta1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 0 | |||||||||||||||||||||||||||||||||
638 | A6ZI44 P05064 D3YWI1 D3YV98 Q9CPQ9 D3Z510 A6ZI47 | A6ZI44 P05064 D3YWI1 D3YV98 Q9CPQ9 D3Z510 | Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase A | Aldoa Aldoart1 | Aldoa | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 1 | |||||||||||||||||||||||||||||||||
1127 | Q8BI79-2 Q8BI79 Q8BI79-3 | Q8BI79-2 Q8BI79 Q8BI79-3 | Coiled-coil domain-containing protein 40 | Ccdc40 | Ccdc40 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | ||||||||||||||||||||||||||||||||
1276 | Q91ZX7 Q3U5J2 | Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 Low-density lipoprotein receptor-related protein 1 85 kDa subunit Low-density lipoprotein receptor-related protein 1 515 kDa subunit Low-density lipoprotein receptor-related protein 1 intracellular domain | Lrp1 | Lrp1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 2 | YES | |||||||||||||||||||||||||||||||
1022 | Q64727 | Q64727 | Vinculin | Vcl | Vcl | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
117 | Q9ERG2 B2RQS1 B3STQ1 | Q9ERG2 B2RQS1 B3STQ1 | Striatin-3 | Strn3 | Strn3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
1304 | Q99ML6 | Q99ML6 | Slc25a2 | Slc25a2 | Slc25a2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3 | 2 | 0 | ||||||||||||||||||||||||||||||||||
123 | O88532 B2RUG7 F6V459 | O88532 B2RUG7 F6V459 | Zinc finger RNA-binding protein | Zfr | Zfr | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | ||||||||||||||||||||||||||||||||||
2 | Q05BA5 A2A468 E9QPU8 O09000 | Q05BA5 A2A468 E9QPU8 O09000 | Nuclear receptor coactivator 3 | Ncoa3 | Ncoa3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
206 | D3YX99 Q9CQH3 D3Z6W9 F6Y6V5 D3Z568 | D3YX99 Q9CQH3 D3Z6W9 F6Y6V5 D3Z568 | "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial" | Ndufb5 | Ndufb5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | ||||||||||||||||||||||||||||||||||
847 | P70388 Q5SV02 E9QPC6 P70388-2 P70388-3 | P70388 Q5SV02 E9QPC6 P70388-2 P70388-3 | DNA repair protein RAD50 | Rad50 | Rad50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
940 | Q3UVT7 Q9JHU2 D3Z486 | Q3UVT7 Q9JHU2 D3Z486 | Palmdelphin | Palmd | Palmd | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
973 | Q60604 Q60604-2 | Q60604 Q60604-2 | Adseverin | Scin | Scin | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
245 | D3Z3A8 Q8C170-2 Q8C170 | D3Z3A8 Q8C170-2 Q8C170 | Unconventional myosin-IXa | Myo9a | Myo9a | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |||||||||||||||||||||||||||||||||||
34 | F8WIR7 A2AIY8 Q8VD37 Q8VD37-3 D3YVG6 Q8VD37-4 Q8VD37-2 E9QMC8 F7CPX0 E9PVY1 Q8VD37-5 A2AIY5 | F8WIR7 A2AIY8 Q8VD37 Q8VD37-3 D3YVG6 Q8VD37-4 Q8VD37-2 E9QMC8 F7CPX0 E9PVY1 | SH3-containing GRB2-like protein 3-interacting protein 1 | Sgip1 | Sgip1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 2.120 | 0.975 | 1.548 | 0 | ||||||||||||||||||||||||||||||
571 | G5E8N5 P06151 P00342 D3YZQ9 D3YZE4 D3Z736 D3YVR7 | G5E8N5 P06151 | L-lactate dehydrogenase L-lactate dehydrogenase A chain | Ldha | Ldha | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 2.041 | 2.333 | 2.187 | 0 | 1 | |||||||||||||||||||||||||||||
400 | E9QLA0 Q8CAQ8-5 Q8CAQ8 Q8CAQ8-2 E9QAY3 Q8CAQ8-3 E9Q800 E9QAY6 | E9QLA0 Q8CAQ8-5 Q8CAQ8 Q8CAQ8-2 E9QAY3 Q8CAQ8-3 E9Q800 E9QAY6 | Mitochondrial inner membrane protein | Immt | Immt | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1.992 | 1.992 | 0 | 1 | |||||||||||||||||||||||||||||||
275 | Q9D0M5 D6RIN4 | Q9D0M5 D6RIN4 | "Dynein light chain 2, cytoplasmic" | Dynll2 | Dynll2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1.978 | 1.978 | 0 | |||||||||||||||||||||||||||||||||
1452 | Q9Z0E0 Q9Z0E0-2 | Q9Z0E0 Q9Z0E0-2 | Neurochondrin | Ncdn | Ncdn | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1.823 | 1.823 | 0 | 1 | |||||||||||||||||||||||||||||||
982 | Q61074 | Q61074 | Protein phosphatase 1G | Ppm1g | Ppm1g | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.315 | 1.315 | 0 | |||||||||||||||||||||||||||||||||
1369 | Q9D8U8 | Q9D8U8 | Sorting nexin-5 | Snx5 | Snx5 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.813 | 0.813 | 0 | |||||||||||||||||||||||||||||||||
1308 | Q99N03 Q99N03-2 | Q99N03 Q99N03-2 | Membrane-spanning 4-domains subfamily A member 10 | Ms4a10 | Ms4a10 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.714 | 0.714 | 0 | |||||||||||||||||||||||||||||||||
1173 | Q8C1X1 A6H5Z3 A6H5Z3-2 | Q8C1X1 A6H5Z3 A6H5Z3-2 | Exocyst complex component 6B | Exoc6b | Exoc6b | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 0.625 | 0.684 | 0.655 | 0 | |||||||||||||||||||||||||||||||
1420 | Q9QWK4 | Q9QWK4 | CD5 antigen-like | Cd5l | Cd5l | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.363 | 0.363 | 0 | |||||||||||||||||||||||||||||||||
521 | F8WHW6 O70161 O70161-3 O70161-2 F7C0X9 F6SMP3 | F8WHW6 O70161 O70161-3 O70161-2 F7C0X9 | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | Pip5k1c | Pip5k1c | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0.328 | 1.387 | 0.858 | 0 | |||||||||||||||||||||||||||||||
65 | Q99PL5 A2AVJ7 Q99PL5-2 E9PUZ4 Q99PL5-3 Q99PL5-4 | Q99PL5 A2AVJ7 Q99PL5-2 E9PUZ4 Q99PL5-3 Q99PL5-4 | Ribosome-binding protein 1 | Rrbp1 | Rrbp1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | 3 | 0.158 | 0.326 | 0.090 | 0.191 | 0 | |||||||||||||||||||||||||||||
710 | P28665 P28666 | P28665 P28666 | Murinoglobulin-1 Murinoglobulin-2 | Mug1 Mug2 | Mug1 Mug2 | 0 | 0 | 0 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 2 | 2 | 0.145 | 2.194 | 2.139 | 1.493 | 0 | |||||||||||||||||||||||||||||
651 | P08551 P31001 P20152 E9PZV5 | P08551 | Neurofilament light polypeptide | Nefl | Nefl | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.893 | 1.893 | 0 | 4 | YES | |||||||||||||||||||||||||||||||
733 | P39053-3 | P39053-3 | Isoform 3 of Dynamin-1 | Dnm1 | Dnm1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1.880 | 1.880 | 0 | |||||||||||||||||||||||||||||||||
626 | O89053 G3UYK8 D3YW57 D3YXM2 G3UX53 | O89053 G3UYK8 | Coronin-1A | Coro1a | Coro1a | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.926 | 0.926 | 0 | |||||||||||||||||||||||||||||||||
496 | F7B0R9 E9Q3M9 E9Q887 | F7B0R9 E9Q3M9 E9Q887 | 2010300C02Rik | 2010300C02Rik | 2010300C02Rik | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.861 | 0.861 | 0 | |||||||||||||||||||||||||||||||||
1382 | Q9DBZ5 Q3TY56 Q9DBZ5-2 | Q9DBZ5 Q3TY56 Q9DBZ5-2 | Eukaryotic translation initiation factor 3 subunit K | Eif3k | Eif3k | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.788 | 0.788 | 0 | |||||||||||||||||||||||||||||||||
320 | Q03391 E9PYG0 | Q03391 E9PYG0 | Glutamate [NMDA] receptor subunit epsilon-4 | Grin2d | Grin2d | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0.786 | 0.786 | 0 | 5 | YES | YES | |||||||||||||||||||||||||||||
1176 | Q8C5U4 | Q8C5U4 | Uncharacterized protein C17orf74 homolog | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.784 | 0.784 | 0 |
Supplementary Table 2. Known Arc interactors.
Protein ID | Gene Name | Protein Name | PMID | Interaction Detection Method | ARC Complex |
---|---|---|---|---|---|
P28652 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | 22579289 | Fluorescence resonance energy transfer, pull down, two hybrid, confocal microscopy, anti bait coimmunoprecipitation | Yes |
P35438 P35438-2 | Grin1 | Glutamate [NMDA] receptor subunit zeta-1 | 16635246 10862698 | Anti bait coimmunoprecipitation, affinity chromatography, coimmunoprecipitation | Yes |
G3X9V4 Q01097 | Grin2b | Glutamate [NMDA] receptor subunit epsilon-2 | 10862698 | Affinity chomatography | Yes |
P49768 | Psen1 | Presenilin-1 | 22036569 | Coimmunoprecipitation, anti tag coimmunoprecipitation | No |
Q62108 Q62108-3 Q62108-2 G3UZL5 | Dlg4 | Disks large homolog 4 | 19455133 | Anti tag coimmunoprecipitation anti bait coimmunoprecipitation | Yes |
Q80TN1 P11798 F8WIS9 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 22579289 | Pull down | Yes |
P39054 | Dnm2 | Dynamin-2 | 17088211 | Two hybrid, immunoprecipitation | No |
Q62419 | Sh3gl1 | Endophilin-A2 | 17088211 | Two hybrid, immunoprecipitation | No |
Q62421 | Sh3gl3 | Endophilin-A3 | 17088211 | Immunoprecipitation | No |
Supplementary Table 3. iBAQ intensity numbers of Arc and PSD95.
Gene Name | Protein Name | iBAQ 1S-ARC14 | iBAQ 1S-ARC15 | iBAQ Tandem-ARC02 | iBAQ Tandem-ARC03 | iBAQ Tandem-ARC05 |
---|---|---|---|---|---|---|
Arc | Activity-regulated cytoskeleton-associated protein | 1244600 | 1500100 | 2232600 | 2832800 | 4102700 |
Dlg4 | Disks large homolog 4 | 1463300 | 948450 | 829540 | 1069900 | 974540 |
Supplementary Table 4. iBAQ intensity numbers of the ARC-core interactors.
Gene Name | Protein Name | iBAQ Tandem-ARC02 | iBAQ Tandem-ARC03 | iBAQ Tandem-ARC05 | Average iBAQ |
---|---|---|---|---|---|
Arc | Activity-regulated cytoskeleton-associated protein | 2232600 | 2832800 | 4102700 | 3056033.3 |
Dlg4 | Disks large homolog 4 | 829540.0 | 1069900.0 | 974540.0 | 957993.3 |
Actb | Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed | 194890.0 | 311590.0 | 141920.0 | 216133.3 |
Dlg2 | Disks large homolog 2 | 61800.0 | 86701.0 | 105560.0 | 84687.0 |
Tuba1a;Tuba3a | Tubulin alpha-1A chain;Tubulin alpha-3 chain | 44723.0 | 51008.0 | 56346.0 | 50692.3 |
Plp1 | Myelin proteolipid protein | 33085.0 | 55229.0 | 53045.0 | 47119.7 |
Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 18917.0 | 66774.0 | 47643.0 | 44444.7 |
H2afx* | Histone H2A.x | 36032.0 | 14041.0 | 61609.0 | 37227.3 |
Mbp | Myelin basic protein | 4399.9 | 58064.0 | 43708.0 | 35390.6 |
Tuba4a | Tubulin alpha-4A chain | 19489.0 | 15759.0 | 57612.0 | 30803.3 |
Glul | Glutamine synthetase | 27712.0 | 46296.0 | 8533.8 | 27513.9 |
Tubb5 | Tubulin beta-5 chain | 15150.0 | 15846.0 | 25212.0 | 18736.0 |
Dlg1 | Disks large homolog 1 | 11885.0 | 17492.0 | 22256.0 | 17211.0 |
Adam22 | Disintegrin and metalloproteinase domain-containing protein 22 | 9999.2 | 14691.0 | 7924.5 | 10871.6 |
Actn4 | Alpha-actinin-4 | 23759.0 | 5686.7 | 1417.7 | 10287.8 |
Hspa8 | Heat shock cognate 71 kDa protein | 7456.4 | 7989.8 | 13555.0 | 9667.1 |
Prrt1 | Proline-rich transmembrane protein 1 | 7187.6 | 10525.0 | 9782.9 | 9165.2 |
Atp1b1 | Sodium/potassium-transporting ATPase subunit beta-1 | 0.0 | 13138.0 | 11289.0 | 8142.3 |
Cldn11 | Claudin-11 | 12986.0 | 10355.0 | 0.0 | 7780.3 |
Pet2 | Pet2 protein | 6978.3 | 4460.4 | 11483.0 | 7640.6 |
Atp1a3 | Sodium/potassium-transporting ATPase subunit alpha-3 | 3994.7 | 6810.6 | 11108.0 | 7304.4 |
Dpysl2 | Dihydropyrimidinase-related protein 2 | 6890.4 | 2559.1 | 7757.3 | 5735.6 |
Kcnj4 | Inward rectifier potassium channel 4 | 2569.2 | 10205.0 | 4145.9 | 5640.0 |
Tubb4b | Tubulin beta-4B chain | 1510.6 | 13018.0 | 1617.3 | 5382.0 |
Slc25a3 | Phosphate carrier protein, mitochondrial | 2551.8 | 3771.1 | 5001.4 | 3774.8 |
Slc25a4;Slc25a5 | ADP/ATP translocase 1;ADP/ATP translocase 2 | 3266.6 | 3310.9 | 3421.2 | 3332.9 |
Pgam5 | Serine/threonine-protein phosphatase PGAM5, mitochondrial | 8208.5 | 1790.0 | 0.0 | 3332.8 |
Stxbp1 | Syntaxin-binding protein 1 | 2348.5 | 847.3 | 4259.2 | 2485.0 |
Gapdh* | Glyceraldehyde-3-phosphate dehydrogenase | 2405.7 | 3158.3 | 0.0 | 1854.7 |
Ubc* | Polyubiquitin-C | 3266.5 | 0.0 | 1854.2 | 1706.9 |
Dlgap4 | Disks large-associated protein 4 | 1665.6 | 1085.3 | 1971.5 | 1574.1 |
Ckmt1 | Creatine kinase U-type, mitochondrial | 0.0 | 2865.4 | 1553.0 | 1472.8 |
Begain | Brain-enriched guanylate kinase-associated protein | 1591.9 | 0.0 | 2680.8 | 1424.2 |
Dlgap1 | Disks large-associated protein 1 | 0.0 | 2714.6 | 1352.4 | 1355.7 |
Crmp1 | Dihydropyrimidinase-related protein 1 | 1856.8 | 0.0 | 2141.8 | 1332.9 |
Grin1 | Glutamate [NMDA] receptor subunit zeta-1 | 0.0 | 1518.8 | 1274.6 | 931.1 |
Lgi1 | Leucine-rich glioma-inactivated protein 1 | 0.0 | 1480.6 | 1255.5 | 912.0 |
Dlgap2 | Disks large-associated protein 2 | 865.5 | 753.9 | 0.0 | 539.8 |
Iqsec2 | IQ motif and SEC7 domain-containing protein 2 | 1015.3 | 393.22 | 0.0 | 469.5 |
Supplementary Table 5. Biological process and Molecular Function of 107 Arc interactors.
Gene name | Protein ID | Protein names | Biological Process | Molecular Function | Replicates enriched (1S) | Replicates enriched (Tandem) | Replicates enriched (1S plus Tandem) |
---|---|---|---|---|---|---|---|
Dlg1 | Q811D0 | Disks large homolog 1 | Adaptor/ Regulatory | Transmembrane receptor regulatory/adaptor | 5 | 3 | 8 |
Dlg2 | Q91XM9 | Disks large homolog 2 | Adaptor/ Regulatory | Transmembrane receptor regulatory/adaptor | 5 | 3 | 8 |
Dlg4 | Q62108 Q62108-3 Q62108-2 G3UZL5 | Disks large homolog 4 | Adaptor/ Regulatory | Transmembrane receptor regulatory/adaptor | 5 | 3 | 8 |
Dlgap1 | Q3UVU8 | Disks large-associated protein 1 | Adaptor/ Regulatory | Transmembrane receptor regulatory/adaptor | 5 | 2 | 7 |
Dlgap2 | Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6 | Disks large-associated protein 2 | Adaptor/ Regulatory | Transmembrane receptor regulatory/adaptor | 3 | 2 | 5 |
Dlgap3 | Q6PFD5 B1AS06 | Disks large-associated protein 3 | Adaptor/ Regulatory | Transmembrane receptor regulatory/adaptor | 3 | 3 | |
Dlgap4 | B1AZP2-2 B1AZP2 B7ZNS2 B1AZP2-3 F6YMR0 E9PUF2 | Disks large-associated protein 4 | Adaptor/ Regulatory | Transmembrane receptor regulatory/adaptor | 5 | 3 | 8 |
Lgi1 | Q9JIA1 D3YW56 | Leucine-rich glioma-inactivated protein 1 | Adaptor/ Regulatory | Receptor binding protein Extracellular matrix | 2 | 2 | 4 |
Prrt1 | O35449 | Proline-rich transmembrane protein 1 | Adaptor/ Regulatory | AMPA receptor function modulator | 2 | 3 | 5 |
Rtn1 | Q8K0T0 Q4FZ95 A3QM89 Q7M6W1 | Reticulon-1 | Adaptor/ Regulatory | Protein binding | 2 | 2 | |
Slc9a3r1 | P70441 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Adaptor/ Regulatory | Scaffold protein | 2 | 2 | |
Hsp90ab1 | P11499 E9PX27 E9Q0C3 E9Q3D6 D3Z1R1 | Heat shock protein HSP 90-beta | Chaperone/ Protein folding/ Signaling | Hsp 90 family chaperone | 4 | 4 | |
Hspa4l | P48722 P48722-2 E0CY23 F6SMW7 F6TFH3 | Heat shock 70 kDa protein 4L | Chaperone/ Protein folding/ Signaling | ATP binding Chaperone activity | 3 | 3 | |
Hspa8 | P63017 Q504P4 D3Z5E2 D3YW43 | Heat shock cognate 71 kDa protein | Chaperone/ Protein folding/ Signaling | Hsp 70 family chaperone | 5 | 3 | 8 |
Actb | CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 G3UZ07 E9Q606 E9QAZ1 F8WGM8 E9Q2D1 F6WX90 | Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed" | Cytoeskeletal/ Structural/ Cell adhesion | Intracellular protein transport | 2 | 3 | 5 |
Actn4 | P57780 | Alpha-actinin-4 | Cytoeskeletal/ Structural/ Cell adhesion | structural constituent of cytoskeleton actin binding | 3 | 3 | |
Adam22 | Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 D3YUQ0 F6PZ09 F6XIT3 F7CDH3 F7DAP1 F7BZ55 F6VJ78 F6XRZ6 F7AYY9 F6TDF4 F6SK63 F7BXL9 | Disintegrin and metalloproteinase domain-containing protein 22 | Cytoeskeletal/ Structural/ Cell adhesion | Metalloprotease | 5 | 3 | 8 |
Arc | Q9WV31 | Activity-regulated cytoskeleton-associated protein | Cytoeskeletal/ Structural/ Cell adhesion | Unclassified | 5 | 3 | 8 |
Begain | F8WIG2 Q68EF6 | Brain-enriched guanylate kinase-associated protein | Cytoeskeletal/ Structural/ Cell adhesion | cytoskeletal adaptor activity | 4 | 2 | 6 |
Cldn11 | Q60771 | Claudin-11 | Cytoeskeletal/ Structural/ Cell adhesion | Structural molecule activity | 3 | 2 | 5 |
Crmp1 | Q6P1J1 P97427 E9Q756 | Dihydropyrimidinase-related protein 1 | Cytoeskeletal/ Structural/ Cell adhesion | Hydrolase activity | 2 | 2 | 4 |
Dsp | E9Q557 E9PZW0 | Desmoplakin | Cytoeskeletal/ Structural/ Cell adhesion | structural constituent of cytoskeleton actin binding | 2 | 2 | |
Gpm6a | P35802 | Neuronal membrane glycoprotein M6-a | Cytoeskeletal/ Structural/ Cell adhesion | Myelin protein | 3 | 3 | |
Gpm6b | A2AEG6 P35803 E9QPU6 P35803-8 P35803-3 | Neuronal membrane glycoprotein M6-b | Cytoeskeletal/ Structural/ Cell adhesion | Myelin protein | 4 | 4 | |
Mbp | F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2 | Myelin basic protein | Cytoeskeletal/ Structural/ Cell adhesion | structural constituent of myelin sheath | 2 | 3 | 5 |
Mtap1a Map1a | A2ARP8 Q9QYR6-2 Q9QYR6 | Microtubule-associated protein 1A MAP1 light chain LC2 | Cytoeskeletal/ Structural/ Cell adhesion | Non-motor microtubule binding protein | 2 | 2 | |
Map6 Mtap6 | Q7TSJ2 Q7TSJ2-2 D3Z6W1 Q7TSJ2-3 | Microtubule-associated protein 6 | Cytoeskeletal/ Structural/ Cell adhesion | Microtubule binding protein | 2 | 2 | |
Myo18b | E9PV66 | Myo18b | Cytoeskeletal/ Structural/ Cell adhesion | Motor activity structural constituent of cytoskeleton protein binding enzyme regulator activity | 2 | 2 | |
Plp1 | P60202 F8WGE4 P60202-2 | Myelin proteolipid protein | Cytoeskeletal/ Structural/ Cell adhesion | Myelin protein | 5 | 3 | 8 |
Sept8 | B1AQZ0 B1AQY9 B7ZC46 Q8CHH9-2 Q8CHH9 F7C5C1 E0CYM4 | Septin-8 | Cytoeskeletal/ Structural/ Cell adhesion | GTPase activity protein binding structural constituent of cytoskeleton | 2 | 2 | |
Tuba1a Tuba3a | P68369 P05214 Q3UX10 | Tubulin alpha-1A chain Tubulin alpha-3 chain | Cytoeskeletal/ Structural/ Cell adhesion | Tubulin | 3 | 3 | 6 |
Tuba4a | P68368 | Tubulin alpha-4A chain | Cytoeskeletal/ Structural/ Cell adhesion | Tubulin | 3 | 3 | 6 |
Tubb4b | P68372 | Tubulin beta-4B chain | Cytoeskeletal/ Structural/ Cell adhesion | Tubulin | 2 | 3 | 5 |
Tubb5 | P99024 G3UZR1 | Tubulin beta-5 chain | Cytoeskeletal/ Structural/ Cell adhesion | Tubulin | 3 | 2 | 5 |
Baiap2 | Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3 | Brain-specific angiogenesis inhibitor 1-associated protein 2 | Cytoeskeletal/ Structural/ Cell adhesion | Cytoskeletal Adaptor activity | 4 | 4 | |
Atf6 | F6VAN0 | Atf6 | DNA/RNA binding | sequence-specific DNA binding transcription factor activity | 2 | 2 | |
Eef1g | Q9D8N0 | Elongation factor 1-gamma | DNA/RNA binding | translation elongation factor activity | 2 | 2 | |
H2afx Hist1h2ab Hist2h2aa1 Hist3h2a Hist1h2af Hist1h2ak Hist2h2ac Hist1h2aa H2afj H2afz H2afv Hist1h2ah Hist1h2al Hist2h2ab | P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7 | Histone H2A.x Histone H2A type 1 Histone H2A type 2-A Histone H2A type 3 Histone H2A type 1-F Histone H2A type 1-K Histone H2A type 2-C Histone H2A Histone H2A.J Histone H2A.Z Histone H2A.V Histone H2A type 1-H Histone H2A type 2-B | DNA/RNA binding | DNA binding | 2 | 3 | 5 |
Ckmt1 | P30275 A2ARP5 B0R0E9 B0R0E8 B0R0F0 | "Creatine kinase U-type, mitochondrial" | Enzyme | kinase activity transferase activity | 2 | 2 | |
Cox6c | Q9CPQ1 | Cytochrome c oxidase subunit 6C | Enzyme | cytochrome-c oxidase activity | 2 | 2 | |
Akd1 | G3UYQ4 | Adenylate kinase domain-containing 1 | Enzyme | nucleotide kinase activity | 2 | 2 | |
Aldh5a1 | Q8BWF0 | "Succinate-semialdehyde dehydrogenase, mitochondrial" | Enzyme | oxidoreductase activity | 2 | 2 | |
Asrgl1 | Q8C0M9 | L-asparaginase | Enzyme | Arginase activity | 2 | 2 | |
Dpysl2 | O08553 | Dihydropyrimidinase-related protein 2 | Enzyme | Hydrolase activity | 3 | 3 | 6 |
Gapdh Gm10293 Gm4609 Gm10358 Gm2606 Gm5559 Gm10291 Gm6316 Gm10481 Gm10566 Gm8055 Gm10290 Gm3222 Gm6981 Gm7293 Gm5507 Gm10313 | P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 D3Z0Z9 E9PX99 F6QXU4 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | oxidoreductase activity | 2 | 2 | 4 |
Gda | Q9R111 D3YU09 | Guanine deaminase | Enzyme | Guanine deaminase activity Hydrolase activity | 5 | 5 | |
Glul | P15105 D3YVK1 D3Z121 | Glutamine synthetase | Enzyme | Synthetase Other ligase | 2 | 3 | 5 |
Idh3a | Q9D6R2 Q9D6R2-2 | "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial" | Enzyme | oxidoreductase activity | 2 | 2 | |
Mapk1 | P63085 E9QAJ2 F6VEI7 | Mitogen-activated protein kinase 1 | Enzyme | protein kinase activity | 2 | 2 | |
Pkm2 | P52480-2 P52480 G3X925 P53657 E9Q509 | Pyruvate kinase isozymes M1/M2 | Enzyme | pyruvate kinase activity | 3 | 3 | |
Prdx2 | Q61171 D3Z4A4 | Peroxiredoxin-2 | Enzyme | Peroxidase | 2 | 2 | |
Sdha | Q8K2B3 | "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial" | Enzyme | oxidoreductase activity | 2 | 2 | |
Tkt | P40142 | Transketolase | Enzyme | oxidoreductase activity transketolase activity | 2 | 2 | |
Uba1 | Q02053 | Ubiquitin-like modifier-activating enzyme 1 | Enzyme | ligase activity | 2 | 2 | |
Ubc Ubb 2810422J05Rik Rps27a Uba52 Gm7866 | P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 D3YYZ2 | Polyubiquitin-C Ubiquitin Ubiquitin-related 1 Ubiquitin-related 2 Polyubiquitin-B Ubiquitin Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40 | Enzyme | structural constituent of ribosome nucleic acid binding | 5 | 2 | 7 |
Gnao1 | P18872 P18872-2 D3Z2M7 F7BLT7 Q66L47 Q8CGK7 P50149 Q3V3I2 Q9DC51 P20612 A2AE32 Q8C040 A2AE31 A2A610 | Guanine nucleotide-binding protein G(o) subunit alpha | G-protein signaling | Large G-protein | 3 | 3 | |
Gnb1 | P62874 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | G-protein signaling | GTPase activity protein binding | 2 | 2 | |
Grm3 | Q9QYS2 F6QVY9 | Metabotropic glutamate receptor 3 | G-protein signaling | G-protein coupled receptor activity | 3 | 3 | |
Syngap1 | F6SEU4 | Ras GTPase-activating protein SynGAP | G-protein signaling | Unclassified | 4 | 4 | |
Atp1a2 | Q6PIE5 D3YYN7 D3YVX6 | Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | Ion channel Cation transporter Other hydrolase | 3 | 3 | |
Atp1a3 | Q6PIC6 Q8VCE0 Q9WV27 Q9Z1W8 E9QNX7 Q64436 Q91WH7 | Sodium/potassium-transporting ATPase subunit alpha-3 | Ion channel | Ion channel Cation transporter Other hydrolase | 4 | 3 | 7 |
Atp1b1 | P14094 | Sodium/potassium-transporting ATPase subunit beta-1 | Ion channel | Cation transporter | 2 | 2 | |
Atp2a2 | F8WI94 O55143 O55143-2 Q64518 E9Q559 Q64518-3 B1ATS5 Q64518-2 Q8R429 B1ATS4 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Ion channel | Ion channel activity hydrolase activity | 2 | 2 | |
Atp2b2 | F8WHB1 Q9R0K7 Q6DIB8 | Plasma membrane calcium-transporting ATPase 2 | Ion channel | Ion channel Cation transporter Other hydrolase | 2 | 2 | |
Atp5a1 | Q03265 D3Z6F5 D6RJ16 | "ATP synthase subunit alpha, mitochondrial ATP synthase subunit alpha" | Ion channel | Proton transport other hydrolase | 2 | 2 | |
Atp6v0a1 | Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 A2A599 | V-type proton ATPase 116 kDa subunit a isoform 1 | Ion channel | Hydrogen transporter Synthase Other hydrolase | 5 | 5 | |
Atp6v0d1 | P51863 | V-type proton ATPase subunit d 1 | Ion channel | Hydrogen transporter Synthase Other hydrolase | 3 | 3 | |
Atp6v1a | P50516 P50516-2 D3Z1B9 D3YWH3 D3YZ23 | V-type proton ATPase catalytic subunit A | Ion channel | "hydrolase activity receptor activity anion channel activity ligand-gated ion channel activity | |||
cation transmembrane transporter activity proton-transporting ATP synthase activity rotational mechanism single-stranded DNA binding" | 3 | 3 | |||||
Atp6v1h | Q8BVE3 | V-type proton ATPase subunit H | Ion channel | hydrolase activity cation transmembrane transporter activity proton-transporting ATP synthase activity rotational mechanism | 2 | 2 | |
Kcna2 | P63141 | Potassium voltage-gated channel subfamily A member 2 | Ion channel | voltage-gated potassium channel activity cation channel activity cation transmembrane transporter activity | 2 | 2 | |
Kcnj4 | P52189 Q8R435 | Inward rectifier potassium channel 4 | Ion channel | Potassium channel | 5 | 3 | 8 |
Vdac1 | Q60932 Q60932-2 F2Z471 | Voltage-dependent anion-selective channel protein 1 | Ion channel | Anion channel Voltage-gated ion channel | 2 | 2 | |
Atp1a1 | Q8VDN2 E9QAV3 | Sodium/potassium-transporting ATPase subunit alpha-1 | Ion channel | Ion channel Cation transporter Other hydrolase | 3 | 1 | 4 |
Pgam5 | Q8BX10 Q8BX10-2 F6YJC6 | "Serine/threonine-protein phosphatase PGAM5, mitochondrial" | Phosphatase | GTPase activator activity phosphatase activity | 1 | 2 | 3 |
Ppp2r2a | Q571J7 Q6P1F6 Q9CWU3 Q8BG02 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Phosphatase | Protein phosphatase | 2 | 2 | |
Ppp3ca | P63328 P63328-2 Q4V9X0 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Phosphatase | Protein phosphatase Calcium binding protein | 3 | 3 | |
Ppp3cb | P48453 E0CZ78 P48453-2 G3X8U7 E9Q6P2 Q80XK0 P48455 G3X8V4 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatase | Phosphatase | Protein phosphatase Calcium binding protein | 2 | 2 | |
Gpr123 | Q76JQ1 Q8C4G9 E9PYX2 | G protein-coupled receptor 123 | Receptor/ Transporter | G-protein coupled receptor | 3 | 3 | |
Gria2 | P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2 | Glutamate receptor 2 | Receptor/ Transporter | Glutamate receptor Ion channel | 4 | 4 | |
Gria3 Gria4 | B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8 | Glutamate receptor 3 Glutamate receptor 4 | Receptor/ Transporter | Glutamate receptor Ion channel | 4 | 4 | |
Grin1 | P35438 P35438-2 | Glutamate [NMDA] receptor subunit zeta-1 | Receptor/ Transporter | Glutamate receptor Ion channel | 5 | 2 | 7 |
Grin2a | P35436 | Glutamate [NMDA] receptor subunit epsilon-1 | Receptor/ Transporter | Glutamate receptor Ion channel | 2 | 2 | |
Grin2b | G3X9V4 Q01097 | Glutamate [NMDA] receptor subunit epsilon-2 | Receptor/ Transporter | Glutamate receptor Ion channel | 3 | 3 | |
Slc17a7 | Q3TXX4 | Vesicular glutamate transporter 1 | Receptor/ Transporter | Cation transport | 2 | 2 | |
Slc1a2 | P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 F6ZRK3 | Excitatory amino acid transporter 2 | Receptor/ Transporter | Cation transport | 5 | 5 | |
Slc25a3 | G5E902 Q8VEM8 | "Phosphate carrier protein, mitochondrial" | Receptor/ Transporter | Transporter Mitochondrial carrier protein | 2 | 3 | 5 |
Slc25a4 Slc25a5 | P48962 P51881 Q3V132 | ADP/ATP translocase 1 ADP/ATP translocase 2 | Receptor/ Transporter | Transporter Mitochondrial carrier protein | 1 | 3 | 4 |
Slc3a2 | G3UWA6 P10852 | 4F2 cell-surface antigen heavy chain | Receptor/ Transporter | Amino acid transporter | 2 | 2 | |
Slc4a4 | E9Q8N8 O88343 O88343-2 A7E1Z5 | Electrogenic sodium bicarbonate cotransporter 1 | Receptor/ Transporter | Sodium anion transporter | 4 | 4 | |
Slc6a1 | P31648 E9Q9F4 | Sodium- and chloride-dependent GABA transporter 1 Transporter | Receptor/ Transporter | amino acid transmembrane transporter activity | 2 | 2 | |
Slc6a11 | P31650 | Sodium- and chloride-dependent GABA transporter 3 | Receptor/ Transporter | amino acid transmembrane transporter activity cation transmembrane transporter activity | 4 | 4 | |
Camk2a | Q80TN1 P11798 F8WIS9 F6WHR9 D3Z7K9 F8WHB5 P11798-2 F8WIR6 D6RDQ8 E9QAJ4 E9PYZ8 | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Ser/Thr Kinase | Non-receptor serine/threonine protein kinase | 5 | 3 | 8 |
Camk2b | P28652 Q5SVI3 Q5SVJ0 Q5SVI2 Q5SVI0 Q5SVJ1 Q5SVI9 Q5SVI1 Q68EG2 Q3TY93 | Calcium/calmodulin-dependent protein kinase type II subunit beta | Ser/Thr Kinase | Non-receptor serine/threonine protein kinase | 2 | 2 | |
B630019K06Rik | Q7TNS5 | Novel protein similar to F-box and leucine-rich repeat protein 17 | Unclassified | Unclassified | 3 | 3 | |
Btbd17 | Q9DB72 | BTB/POZ domain-containing protein 17 | Unclassified | Unclassified | 3 | 3 | |
Cend1 | Q9JKC6 | Cell cycle exit and neuronal differentiation protein 1 | Unclassified | Unclassified | 2 | 2 | |
Cnrip1 | F7C0H6 Q5M8N0 | CB1 cannabinoid receptor-interacting protein 1 | Unclassified | Unclassified | 2 | 2 | |
Mog | Q3UY21 Q61885 Q29ZQ5 | Myelin-oligodendrocyte glycoprotein | Unclassified | Myelin protein | 4 | 4 | |
Cltc | Q5SXR6 Q68FD5 E9Q434 F6Z1R4 | Clathrin heavy chain 1 | Vesicular/ Trafficking/ Transport | Structural molecule activity | 5 | 5 | |
Iqsec1 | E9PUA3 Q8R0S2-2 Q8R0S2 | IQ motif and SEC7 domain-containing protein 1 | Vesicular/ Trafficking/ Transport | Guanyl-nucleotide exchange factor | 3 | 3 | |
Iqsec2 | E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7 | IQ motif and SEC7 domain-containing protein 2 | Vesicular/ Trafficking/ Transport | Guanyl-nucleotide exchange factor | 5 | 2 | 7 |
Nsf | P46460 G3UX86 G3UX98 | Vesicle-fusing ATPase | Vesicular/ Trafficking/ Transport | protein binding syntaxin binding | 3 | 3 | |
Pet2 | A2AHY8 | Pet2 protein | Vesicular/ Trafficking/ Transport | GTPase activity protein binding | 2 | 3 | 5 |
Sh3gl2 | A2ALV3 Q62420 Q8BXU5 F6ZL13 A2ALV1 Q62419 Q62421 | Endophilin-A1 | Vesicular/ Trafficking/ Transport | structural constituent of cytoskeleton | 2 | 2 | |
Stx1a | O35526 D6RFB9 | Syntaxin-1A | Vesicular/ Trafficking/ Transport | protein binding | 2 | 2 | |
Stx1b | P61264 Q00262 Q80W45 Q3TJ55 | Syntaxin-1B | Vesicular/ Trafficking/ Transport | SNARE protein | 3 | 3 | |
Stxbp1 | O08599-2 | Syntaxin-binding protein 1 | Vesicular/ Trafficking/ Transport | transmembrane transporter activity | 2 | 3 | 5 |
Supplementary Table 6. Biological process ontology of 107 Arc interactors.
Supplementary Table 7. MS data obtained from a single step purifications from ArcTAP/+ and ArcTAP/TAP crossed with PSD95/Dlg4 knokout mice.
id | Protein ID | Majority protein IDs | Protein name | Gene name | Peptides | Peptides 1S-PSD95mut01 | Peptides 1S-PSD95mut02 | Peptides 1S-PSD95mut03 | Experiment 1S-PSD95mut01 | Experiment 1S-PSD95mut02 | Experiment 1S-PSD95mut03 | # replicates identified in | Average Ratio M/L (ARC/Cont) | Total M/L Ratio count | Ratio M/L 1S-PSD95mut01 | Ratio M/L count 1S-PSD95mut01 | Ratio M/L 1S-PSD95mut02 | Ratio M/L count 1S-PSD95mut02 | Ratio M/L 1S-PSD95mut03 | Ratio M/L count 1S-PSD95mut03 | # replicates enriched (1 + 2 step) | Average Ratio H/M (PSD95mut/ARC) | Normalised Average Ratio H/M (PSD95mut/ARC) | total H/M Ratio count | # replicates quantified | Ratio H/M 1S-PSD95mut01 | Ratio H/M count 1S-PSD95mut01 | Ratio H/M 1S-PSD95mut02 | Ratio H/M count 1S-PSD95mut02 | Ratio H/M 1S-PSD95mut03 | Ratio H/M count 1S-PSD95mut03 | Total PSD-95 complex (# replicates) | PSD-95 Core Complex | PSD-95 Interactor | Av Intensity L (cont) | Av Intensity M (ARC) | Av Intensity H (PSD95mut) | Av Intensity M/L (ARC) | Av Intensity H/M (PSD95mut) | Intensity 1S-PSD95mut01 | Intensity L 1S-PSD95mut01 | Intensity M 1S-PSD95mut01 | Intensity H 1S-PSD95mut01 | Intensity 1S-PSD95mut02 | Intensity L 1S-PSD95mut02 | Intensity M 1S-PSD95mut02 | Intensity H 1S-PSD95mut02 | Intensity 1S-PSD95mut03 | Intensity L 1S-PSD95mut03 | Intensity M 1S-PSD95mut03 | Intensity H 1S-PSD95mut03 | Av Intensity L (cont) | Av Intensity M (ARC) | Av Intensity H (PSD95mut) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
549 | G3UYQ4 | G3UYQ4 | Adenylate kinase domain-containing 1 | Akd1 | 3 | 1 | 1 | 1 | 4 | 4 | 1 | 3 | 18.968 | 3 | 5.229 | 1 | 32.707 | 2 | 0 | 2 | 0.072 | 0.234 | 3 | 2 | 0.170 | 1 | 0.045 | 2 | 0 | 133475.5 | 5081773.333 | 283894 | 38.073 | 0.056 | 629920 | 61341 | 507560 | 61018 | 15117000 | 205610 | 14404000 | 506770 | 333760 | 333760 | 133475.5 | 5081773.333 | ||||||||
1001 | Q62108 Q62108-3 Q62108-2 G3UZL5 | Q62108 Q62108-3 Q62108-2 | Disks large homolog 4 | Dlg4 | 96 | 30 | 34 | 32 | 190 | 218 | 149 | 3 | 18.685 | 231 | 13.755 | 76 | 23.044 | 97 | 19.257 | 58 | 8 | 0.060 | 0.196 | 203 | 3 | 0.060 | 65 | 0.065 | 90 | 0.038 | 48 | 5 | YES | YES | 7553633.333 | 1255556667 | 18849200 | 166.219 | 0.015 | 1218100000 | 8840800 | 1181700000 | 27537000 | 2259400000 | 10823000 | 2226400000 | 22178000 | 368400000 | 2997100 | 358570000 | 6832600 | 7553633.333 | 1255556667 | |
1263 | Q91XM9 | Q91XM9 | Disks large homolog 2 | Dlg2 | 63 | 18 | 23 | 22 | 102 | 97 | 70 | 3 | 18.118 | 151 | 12.330 | 66 | 26.590 | 47 | 15.435 | 38 | 8 | 0.139 | 0.453 | 147 | 3 | 0.292 | 65 | 0.201 | 47 | 0.061 | 35 | 5 | YES | YES | 4430600 | 301913333.3 | 65101033.33 | 68.143 | 0.216 | 384520000 | 5315100 | 284430000 | 94774000 | 561680000 | 3988700 | 465330000 | 92363000 | 168130000 | 3988000 | 155980000 | 8166100 | 4430600 | 301913333.3 | |
785 | P60202 F8WGE4 P60202-2 | P60202 F8WGE4 P60202-2 | Myelin proteolipid protein | Plp1 | 7 | 4 | 2 | 1 | 7 | 3 | 3 | 3 | 17.349 | 12 | 10.917 | 7 | 11.079 | 3 | 30.052 | 2 | 8 | 0.254 | 0.830 | 12 | 3 | 0.336 | 7 | 0.115 | 3 | 0.565 | 2 | 5 | YES | 1330330 | 19882900 | 7611866.667 | 14.946 | 0.383 | 39519000 | 2815000 | 28530000 | 8174100 | 11961000 | 905960 | 9896700 | 1158500 | 34995000 | 270030 | 21222000 | 13503000 | 1330330 | 19882900 | ||
976 | Q60771 | Q60771 | Claudin-11 | Cldn11 | 3 | 1 | 1 | 1 | 3 | 2 | 1 | 3 | 16.892 | 4 | 24.894 | 2 | 8.890 | 2 | 0 | 5 | 0.518 | 1.693 | 4 | 2 | 0.166 | 2 | 1.389 | 2 | 0 | 163565 | 4325553.333 | 4084100 | 26.445 | 0.944 | 10036000 | 130280 | 8623200 | 1283000 | 11228000 | 196850 | 4145500 | 6885200 | 207960 | 207960 | 163565 | 4325553.333 | ||||||||
1447 | Q9WV31 | Q9WV31 | Activity-regulated cytoskeleton-associated protein | Arc | 26 | 8 | 10 | 8 | 35 | 38 | 22 | 3 | 16.192 | 68 | 15.660 | 24 | 16.483 | 31 | 16.433 | 13 | 8 | 0.306 | 1.000 | 67 | 3 | 0.779 | 24 | 0.305 | 31 | 0.141 | 12 | 5 | YES | 2652690 | 128695666.7 | 69652233.33 | 48.515 | 0.541 | 271070000 | 3228100 | 134850000 | 132990000 | 271740000 | 4052600 | 199120000 | 68567000 | 60194000 | 677370 | 52117000 | 7399700 | 2652690 | 128695666.7 | ||
1106 | Q811D0 | Q811D0 | Disks large homolog 1 | Dlg1 | 47 | 15 | 14 | 18 | 45 | 38 | 34 | 3 | 14.682 | 89 | 10.564 | 33 | 11.262 | 34 | 22.220 | 22 | 8 | 0.770 | 2.516 | 89 | 3 | 1.879 | 33 | 0.985 | 34 | 0.218 | 22 | 5 | YES | 3057300 | 143151666.7 | 155074333.3 | 46.823 | 1.083 | 322400000 | 4479700 | 104690000 | 213240000 | 474400000 | 3548000 | 241700000 | 229150000 | 107040000 | 1144200 | 83065000 | 22833000 | 3057300 | 143151666.7 | ||
1438 | Q9R111 D3YU09 | Q9R111 D3YU09 | Guanine deaminase | Gda | 29 | 12 | 9 | 8 | 37 | 20 | 14 | 3 | 14.665 | 61 | 11.042 | 34 | 15.913 | 18 | 17.039 | 9 | 5 | 0.191 | 0.624 | 61 | 3 | 0.380 | 34 | 0.214 | 18 | 0.170 | 9 | 5 | YES | YES | 2753473.333 | 77887666.67 | 24750100 | 28.287 | 0.318 | 210740000 | 5638500 | 145230000 | 59870000 | 80860000 | 2164000 | 67048000 | 11648000 | 24576000 | 457920 | 21385000 | 2732300 | 2753473.333 | 77887666.67 | |
759 | P50516 P50516-2 D3Z1B9 D3YWH3 D3YZ23 | P50516 P50516-2 | V-type proton ATPase catalytic subunit A | Atp6v1a | 2 | 0 | 1 | 1 | 3 | 1 | 2 | 10.369 | 1 | 0 | 0 | 10.369 | 1 | 3 | 0.197 | 0.644 | 1 | 1 | 0 | 0 | 0.394 | 1 | 1 | 11680 | 132700 | 67157 | 11.361 | 0.506 | 211540 | 11680 | 132700 | 67157 | 11680 | 132700 | ||||||||||||||||
531 | P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7 | P27661 P22752 Q6GSS7 Q8BFU2 Q8CGP5 Q8CGP7 Q64523 Q8CGP4 Q8R1M2 P0C0S6 Q3THW5 Q8CGP6 F8WIX8 Q64522 Q3UA95 Q5NC91 Q8R029 G3UWL7 | Histone H2A.x Histone H2A type 1 Histone H2A type 2-A Histone H2A type 3 Histone H2A type 1-F Histone H2A type 1-K Histone H2A type 2-C Histone H2A Histone H2A.J Histone H2A.Z Histone H2A.V Histone H2A type 1-H Histone H2A type 2-B | H2afx Hist1h2ab Hist2h2aa1 Hist3h2a Hist1h2af Hist1h2ak Hist2h2ac Hist1h2aa H2afj H2afz H2afv Hist1h2ah Hist1h2al Hist2h2ab | 2 | 1 | 1 | 0 | 3 | 2 | 2 | 9.904 | 5 | 12.924 | 3 | 6.884 | 2 | 0 | 5 | 0.086 | 0.282 | 5 | 2 | 0.164 | 3 | 0.095 | 2 | 0 | 476540 | 4634650 | 738225 | 9.726 | 0.159 | 8986500 | 746100 | 7021700 | 1218700 | 2712300 | 206980 | 2247600 | 257750 | 476540 | 4634650 | |||||||||||
836 | P68369 P05214 Q3UX10 | P68369 P05214 | Tubulin alpha-1A chain Tubulin alpha-3 chain | Tuba1a Tuba3a | 8 | 3 | 2 | 3 | 2 | 2 | 7 | 3 | 9.662 | 2 | 0 | 0 | 9.662 | 2 | 6 | 0.205 | 0.669 | 2 | 1 | 0 | 0 | 0.410 | 2 | 4 | YES | 176450 | 2776000 | 1042000 | 15.733 | 0.375 | 3994500 | 176450 | 2776000 | 1042000 | 176450 | 2776000 | ||||||||||||||
1409 | Q9JKC6 | Q9JKC6 | Cell cycle exit and neuronal differentiation protein 1 | Cend1 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 8.902 | 3 | 15.781 | 2 | 2.022 | 1 | 0 | 2 | 0.342 | 1.116 | 3 | 2 | 0.502 | 2 | 0.524 | 1 | 0 | 104746.5 | 1548600 | 734195 | 14.784 | 0.474 | 3368100 | 111090 | 2057600 | 1199400 | 1407000 | 98403 | 1039600 | 268990 | 104746.5 | 1548600 | |||||||||||
79 | E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7 | E9QAD8 A4GZ26 Q5DU25 D3Z5I6 D3Z6V7 | IQ motif and SEC7 domain-containing protein 2 | Iqsec2 | 76 | 19 | 30 | 27 | 54 | 83 | 64 | 3 | 8.539 | 123 | 5.969 | 35 | 8.629 | 49 | 11.019 | 39 | 7 | 0.091 | 0.297 | 114 | 3 | 0.196 | 32 | 0.076 | 47 | 0.093 | 35 | 5 | YES | 4003833.333 | 100508000 | 8228566.667 | 25.103 | 0.082 | 72921000 | 4113500 | 60309000 | 8497900 | 208260000 | 6191900 | 191490000 | 10580000 | 57039000 | 1706100 | 49725000 | 5607800 | 4003833.333 | 100508000 | ||
1460 | Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 A2A599 | Q9Z1G4 Q9Z1G4-2 Q9Z1G4-3 Q3TY98 | V-type proton ATPase 116 kDa subunit a isoform 1 | Atp6v0a1 | 14 | 4 | 4 | 6 | 10 | 7 | 11 | 3 | 8.508 | 18 | 6.652 | 7 | 14.089 | 4 | 4.784 | 7 | 5 | 0.383 | 1.251 | 18 | 3 | 0.494 | 7 | 0.756 | 4 | 0.282 | 7 | 426470 | 6551533.333 | 3056566.667 | 15.362 | 0.467 | 11738000 | 628800 | 7612700 | 3496500 | 12188000 | 428020 | 7428300 | 4331900 | 6177500 | 222590 | 4613600 | 1341300 | 426470 | 6551533.333 | ||||
342 | P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 D3YYZ2 | P0CG50 Q8VC46 Q922Z8 P0CG49 Q5SX22 E9QNP0 E9Q5F6 E9Q4P0 P62983 E9Q0Z8 P62984 E9Q9J0 F6X7C4 | Polyubiquitin-C Ubiquitin Ubiquitin-related 1 Ubiquitin-related 2 Polyubiquitin-B Ubiquitin Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a Ubiquitin-60S ribosomal protein L40 Ubiquitin 60S ribosomal protein L40 | Ubc Ubb 2810422J05Rik Rps27a Uba52 Gm7866 | 5 | 1 | 2 | 2 | 5 | 2 | 4 | 3 | 7.987 | 9 | 6.324 | 5 | 8.243 | 1 | 9.393 | 3 | 7 | 0.520 | 1.698 | 9 | 3 | 1.168 | 5 | 0.658 | 1 | 0.254 | 3 | 1 | 290009.3333 | 2131936.667 | 1405343.333 | 7.351 | 0.659 | 8351900 | 703140 | 4201600 | 3447200 | 840360 | 57428 | 464710 | 318220 | 2289600 | 109460 | 1729500 | 450610 | 290009.3333 | 2131936.667 | |||
725 | P35438 P35438-2 | P35438 P35438-2 | Glutamate [NMDA] receptor subunit zeta-1 | Grin1 | 10 | 2 | 5 | 3 | 4 | 6 | 6 | 3 | 7.670 | 11 | 6.500 | 2 | 12.953 | 4 | 3.557 | 5 | 7 | 0.127 | 0.416 | 8 | 3 | 0.169 | 2 | 0.088 | 3 | 0.253 | 3 | 5 | YES | YES | 224326.3333 | 2727966.667 | 298190 | 12.161 | 0.109 | 2067400 | 99009 | 1646700 | 321710 | 5404100 | 330650 | 4716500 | 356990 | 2279900 | 243320 | 1820700 | 215870 | 224326.3333 | 2727966.667 | |
110 | B1AZP2-2 B1AZP2 B7ZNS2 B1AZP2-3 F6YMR0 E9PUF2 | B1AZP2-2 B1AZP2 B7ZNS2 | Disks large-associated protein 4 | Dlgap4 | 22 | 3 | 10 | 9 | 3 | 17 | 15 | 3 | 7.483 | 24 | 3.211 | 1 | 6.324 | 14 | 12.915 | 9 | 8 | 0.220 | 0.718 | 23 | 3 | 0.535 | 1 | 0.214 | 14 | 0.130 | 8 | 5 | YES | YES | 1164805 | 13045833.33 | 1157953.333 | 11.200 | 0.089 | 799950 | 66565 | 625200 | 108190 | 36084000 | 3042100 | 30410000 | 2632400 | 9221300 | 385750 | 8102300 | 733270 | 1164805 | 13045833.33 | |
1377 | Q9DB72 | Q9DB72 | BTB/POZ domain-containing protein 17 | Btbd17 | 8 | 2 | 4 | 2 | 3 | 7 | 3 | 3 | 7.391 | 11 | 4.315 | 3 | 3.818 | 7 | 14.040 | 1 | 3 | 0.195 | 0.638 | 9 | 3 | 0.468 | 3 | 0.167 | 5 | 0.146 | 1 | 735895.3333 | 4200566.667 | 548166.6667 | 5.708 | 0.130 | 3193700 | 286120 | 2025400 | 882170 | 11714000 | 1898000 | 9168300 | 647420 | 1546500 | 23566 | 1408000 | 114910 | 735895.3333 | 4200566.667 | ||||
579 | O08553 | O08553 | Dihydropyrimidinase-related protein 2 | Dpysl2 | 27 | 7 | 12 | 8 | 25 | 33 | 18 | 3 | 7.030 | 48 | 4.299 | 22 | 9.000 | 19 | 7.792 | 7 | 6 | 0.331 | 1.080 | 48 | 3 | 0.699 | 22 | 0.245 | 19 | 0.379 | 7 | 3460166.667 | 25682333.33 | 10187100 | 7.422 | 0.397 | 52478000 | 6781200 | 27319000 | 18379000 | 50852000 | 3213900 | 39023000 | 8615900 | 14657000 | 385400 | 10705000 | 3566400 | 3460166.667 | 25682333.33 | ||||
283 | E9PUA3 Q8R0S2-2 Q8R0S2 | E9PUA3 Q8R0S2-2 Q8R0S2 | IQ motif and SEC7 domain-containing protein 1 | Iqsec1 | 19 | 4 | 10 | 5 | 4 | 13 | 5 | 3 | 7.009 | 9 | 6.057 | 1 | 4.122 | 7 | 10.848 | 1 | 3 | 0.079 | 0.257 | 9 | 3 | 0.134 | 1 | 0.108 | 7 | 0.074 | 1 | 5 | YES | 613146.6667 | 7043466.667 | 294131.3333 | 11.487 | 0.042 | 1555500 | 32551 | 1479600 | 43358 | 19299000 | 1794300 | 16692000 | 812970 | 2997400 | 12589 | 2958800 | 26066 | 613146.6667 | 7043466.667 | ||
457 | Q9QYS2 F6QVY9 | Q9QYS2 F6QVY9 | Metabotropic glutamate receptor 3 | Grm3 | 5 | 2 | 2 | 1 | 5 | 4 | 2 | 3 | 6.861 | 6 | 5.981 | 3 | 11.195 | 2 | 3.408 | 1 | 3 | 0.191 | 0.622 | 6 | 3 | 0.306 | 3 | 0.247 | 2 | 0.210 | 1 | 1 | 121248.3333 | 1435096.667 | 292640 | 11.836 | 0.204 | 2591000 | 229570 | 1899900 | 461540 | 2581700 | 104780 | 2093400 | 383610 | 374150 | 29395 | 311990 | 32770 | 121248.3333 | 1435096.667 | |||
663 | Q80TN1 P11798 F8WIS9 F6WHR9 D3Z7K9 F8WHB5 P11798-2 F8WIR6 D6RDQ8 E9QAJ4 E9PYZ8 | Q80TN1 P11798 F8WIS9 | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Camk2a | 11 | 3 | 4 | 4 | 7 | 13 | 13 | 3 | 6.854 | 26 | 7.499 | 7 | 7.418 | 12 | 5.644 | 7 | 8 | 0.151 | 0.492 | 23 | 3 | 0.270 | 7 | 0.182 | 11 | 0.151 | 5 | 5 | YES | YES | 1071930 | 7894666.667 | 1662623.333 | 7.365 | 0.211 | 11673000 | 1219600 | 7899700 | 2553800 | 15294000 | 1797400 | 11558000 | 1938100 | 4921000 | 198790 | 4226300 | 495970 | 1071930 | 7894666.667 | |
941 | Q3UVU8 | Q3UVU8 | Disks large-associated protein 1 | Dlgap1 | 28 | 7 | 11 | 10 | 16 | 24 | 20 | 3 | 6.819 | 42 | 4.364 | 12 | 8.867 | 18 | 7.226 | 12 | 7 | 0.067 | 0.219 | 33 | 3 | 0.135 | 7 | 0.051 | 17 | 0.082 | 9 | 5 | YES | YES | 2328390 | 36795666.67 | 1101566.667 | 15.803 | 0.030 | 12274000 | 875070 | 10627000 | 771480 | 87969000 | 5701200 | 80268000 | 2000200 | 20434000 | 408900 | 19492000 | 533020 | 2328390 | 36795666.67 | |
718 | P31650 | P31650 | Sodium- and chloride-dependent GABA transporter 3 | Slc6a11 | 3 | 1 | 0 | 2 | 2 | 2 | 2 | 6.754 | 3 | 5.539 | 2 | 0 | 7.968 | 1 | 4 | 0.278 | 0.907 | 3 | 2 | 0.586 | 2 | 0 | 0.248 | 1 | 131645.5 | 920195 | 558903.5 | 6.990 | 0.607 | 2818000 | 238780 | 1523900 | 1055300 | 403510 | 24511 | 316490 | 62507 | 131645.5 | 920195 | |||||||||||
1078 | Q7TNS5 | Q7TNS5 | Novel protein similar to F-box and leucine-rich repeat protein 17 | B630019K06Rik | 2 | 1 | 1 | 0 | 1 | 2 | 2 | 6.455 | 1 | 0 | 6.455 | 1 | 0 | 3 | 0.174 | 0.568 | 1 | 1 | 0 | 0.348 | 1 | 0 | 5 | YES | 34497 | 721165 | 126880 | 20.905 | 0.176 | 471100 | 471100 | 1132600 | 34497 | 971230 | 126880 | 34497 | 721165 | |||||||||||||
822 | P63017 Q504P4 D3Z5E2 D3YW43 | P63017 Q504P4 | Heat shock cognate 71 kDa protein | Hspa8 | 23 | 6 | 11 | 6 | 21 | 31 | 10 | 3 | 6.398 | 43 | 3.364 | 17 | 10.420 | 19 | 5.409 | 7 | 8 | 0.662 | 2.162 | 43 | 3 | 1.884 | 17 | 0.283 | 19 | 0.481 | 7 | 1 | 2153373.333 | 20645000 | 16685266.67 | 9.587 | 0.808 | 57798000 | 4149400 | 19326000 | 34322000 | 55060000 | 2035700 | 39303000 | 13721000 | 5593800 | 275020 | 3306000 | 2012800 | 2153373.333 | 20645000 | |||
99 | Q6PFD5 B1AS06 | Q6PFD5 B1AS06 | Disks large-associated protein 3 | Dlgap3 | 21 | 2 | 8 | 11 | 7 | 16 | 22 | 3 | 6.385 | 30 | 4.310 | 7 | 8.864 | 10 | 5.981 | 13 | 3 | 0.126 | 0.410 | 26 | 3 | 0.287 | 6 | 0.153 | 10 | 0.062 | 10 | 5 | YES | YES | 823253.3333 | 12127700 | 905140 | 14.731 | 0.075 | 5963100 | 801810 | 4261100 | 900200 | 23736000 | 1053100 | 21299000 | 1383600 | 11869000 | 614850 | 10823000 | 431620 | 823253.3333 | 12127700 | |
985 | Q61171 D3Z4A4 | Q61171 D3Z4A4 | Peroxiredoxin-2 | Prdx2 | 2 | 0 | 1 | 1 | 2 | 1 | 2 | 6.173 | 3 | 0 | 7.163 | 2 | 5.184 | 1 | 2 | 0.206 | 0.671 | 3 | 2 | 0 | 0.124 | 2 | 0.493 | 1 | 3 | YES | 125270 | 1232335 | 154260 | 9.837 | 0.125 | 2768200 | 210150 | 2313500 | 244550 | 255530 | 40390 | 151170 | 63970 | 125270 | 1232335 | |||||||||
88 | B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8 | B0QZW1 Q9Z2W9 F2Z488 E9PVT4 G5E863 Q9Z2W8 | Glutamate receptor 3 Glutamate receptor 4 | Gria3 Gria4 | 6 | 2 | 3 | 1 | 2 | 4 | 2 | 3 | 6.007 | 3 | 2.914 | 1 | 9.099 | 2 | 0 | 4 | 0.182 | 0.595 | 3 | 2 | 0.294 | 1 | 0.253 | 2 | 0 | 4 | YES | 71310 | 910626.6667 | 149455.5 | 12.770 | 0.164 | 844920 | 56642 | 745220 | 43061 | 1857300 | 85978 | 1515500 | 255850 | 471160 | 471160 | 71310 | 910626.6667 | ||||||
526 | F8WIG2 Q68EF6 | F8WIG2 Q68EF6 | Brain-enriched guanylate kinase-associated protein | Begain | 4 | 0 | 2 | 2 | 4 | 2 | 2 | 5.864 | 4 | 0 | 5.450 | 3 | 6.279 | 1 | 6 | 0.138 | 0.451 | 3 | 2 | 0 | 0.271 | 2 | 0.143 | 1 | 4 | YES | YES | 122472 | 1161875 | 109137 | 9.487 | 0.094 | 2231500 | 215910 | 1817500 | 198110 | 555450 | 29034 | 506250 | 20164 | 122472 | 1161875 | ||||||||
1362 | Q9D6F9 | Q9D6F9 | Tubulin beta-4A chain | Tubb4a | 21 | 7 | 8 | 6 | 1 | 1 | 2 | 5.828 | 1 | 0 | 0 | 5.828 | 1 | 1 | 0.272 | 1 | 1 | 0 | 0 | 0.544 | 1 | 16013 | 210645 | 82354 | 13.155 | 0.391 | 226430 | 226430 | 293220 | 16013 | 194860 | 82354 | 16013 | 210645 | ||||||||||||||||
562 | G3X9V4 Q01097 | G3X9V4 Q01097 | Glutamate [NMDA] receptor subunit epsilon-2 | Grin2b | 7 | 1 | 4 | 2 | 2 | 7 | 3 | 3 | 5.773 | 5 | 3.820 | 1 | 8.747 | 3 | 4.751 | 1 | 3 | 0.161 | 0.525 | 1 | 1 | 0 | 0.322 | 1 | 0 | 5 | YES | YES | 55323.33333 | 1286883.333 | 90641.5 | 23.261 | 0.070 | 371310 | 19829 | 351480 | 3249000 | 125320 | 2957000 | 166680 | 587590 | 20821 | 552170 | 14603 | 55323.33333 | 1286883.333 | ||||
390 | Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 D3YUQ0 F6PZ09 F6XIT3 F7CDH3 F7DAP1 F7BZ55 F6VJ78 F6XRZ6 F7AYY9 F6TDF4 F6SK63 F7BXL9 | Q9R1V6-12 Q9R1V6-11 Q9R1V6-14 Q9R1V6-8 Q9R1V6-15 Q9R1V6-13 E9Q767 Q9R1V6 E9QLC5 Q9R1V6-10 Q9R1V6-7 Q9R1V6-6 D3YUP9 Q9R1V6-17 Q9R1V6-4 Q9R1V6-5 Q9R1V6-9 Q9R1V6-1 Q9R1V6-20 Q9R1V6-2 Q9R1V6-19 Q9R1V6-16 Q9R1V6-21 Q9R1V6-18 | Disintegrin and metalloproteinase domain-containing protein 22 | Adam22 | 32 | 6 | 14 | 12 | 22 | 33 | 26 | 3 | 5.770 | 38 | 8.212 | 10 | 5.148 | 19 | 3.951 | 9 | 8 | 0.142 | 0.465 | 32 | 3 | 0.123 | 8 | 0.162 | 18 | 0.284 | 6 | 5 | YES | YES | 1027806.667 | 22162366.67 | 1164376.667 | 21.563 | 0.053 | 10289000 | 550550 | 9215600 | 522600 | 54347000 | 2166500 | 49710000 | 2469900 | 8428500 | 366370 | 7561500 | 500630 | 1027806.667 | 22162366.67 | |
887 | Q3UY21 Q61885 Q29ZQ5 | Q3UY21 Q61885 Q29ZQ5 | Myelin-oligodendrocyte glycoprotein | Mog | 3 | 2 | 1 | 0 | 6 | 2 | 2 | 5.757 | 8 | 8.131 | 6 | 3.384 | 2 | 0 | 4 | 0.311 | 1.014 | 8 | 2 | 0.641 | 6 | 0.291 | 2 | 0 | 2 | 690125 | 5060850 | 3068575 | 7.333 | 0.606 | 15762000 | 1136700 | 8766600 | 5858800 | 1877000 | 243550 | 1355100 | 278350 | 690125 | 5060850 | ||||||||||
1309 | Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2 | Q99NF7 P36993-5 P36993-3 P36993 P36993-4 P36993-2 | Protein phosphatase 1B | Ppm1b | 4 | 1 | 0 | 3 | 1 | 4 | 2 | 5.756 | 4 | 1.331 | 1 | 0 | 10.181 | 3 | 1 | 0.708 | 4 | 2 | 1.505 | 1 | 0 | 0.620 | 3 | 223114 | 929765 | 885390 | 4.167 | 0.952 | 1150200 | 348930 | 285430 | 515880 | 2926400 | 97298 | 1574100 | 1254900 | 223114 | 929765 | ||||||||||||
693 | P18872 P18872-2 D3Z2M7 F7BLT7 Q66L47 Q8CGK7 P50149 Q3V3I2 Q9DC51 P20612 A2AE32 Q8C040 A2AE31 A2A610 | P18872 P18872-2 D3Z2M7 F7BLT7 | Guanine nucleotide-binding protein G(o) subunit alpha | Gnao1 | 2 | 1 | 0 | 1 | 2 | 1 | 2 | 5.588 | 3 | 1.247 | 2 | 0 | 9.929 | 1 | 3 | 0.312 | 1.018 | 3 | 2 | 0.575 | 2 | 0 | 0.361 | 1 | 5 | YES | 279373.5 | 658810 | 304779 | 2.358 | 0.463 | 2295900 | 547910 | 1188700 | 559300 | 190020 | 10837 | 128920 | 50258 | 279373.5 | 658810 | |||||||||
874 | Q02257 | Q02257 | Junction plakoglobin | Jup | 8 | 0 | 7 | 1 | 11 | 1 | 2 | 5.415 | 10 | 0 | 5.415 | 10 | 0 | 1 | 0.107 | 7 | 1 | 0 | 0.215 | 7 | 0 | 915730 | 8506900 | 503385 | 9.290 | 0.059 | 10302000 | 915730 | 8506900 | 879770 | 127000 | 127000 | 915730 | 8506900 | ||||||||||||||||
55 | A2ARP8 Q9QYR6-2 Q9QYR6 | A2ARP8 Q9QYR6-2 Q9QYR6 | Microtubule-associated protein 1A MAP1 light chain LC2 | Mtap1a Map1a | 4 | 2 | 1 | 1 | 4 | 2 | 2 | 3 | 5.225 | 7 | 6.726 | 4 | 1.753 | 1 | 7.195 | 2 | 2 | 0.318 | 1.039 | 7 | 3 | 0.410 | 4 | 0.573 | 1 | 0.290 | 2 | 2 | 116707.6667 | 710950 | 247033 | 6.092 | 0.347 | 1844900 | 216250 | 1165000 | 463740 | 926530 | 107700 | 627140 | 191680 | 452560 | 26173 | 340710 | 85679 | 116707.6667 | 710950 | |||
465 | F6SEU4 | F6SEU4 | Ras GTPase-activating protein SynGAP | Syngap1 | 29 | 4 | 15 | 10 | 9 | 38 | 25 | 3 | 5.224 | 45 | 2.798 | 7 | 7.093 | 23 | 5.781 | 15 | 4 | 0.199 | 0.650 | 41 | 3 | 0.407 | 7 | 0.150 | 22 | 0.240 | 12 | 5 | YES | YES | 1168583.333 | 17021600 | 1356340 | 14.566 | 0.080 | 4500500 | 379200 | 3289800 | 831500 | 42460000 | 2401900 | 37536000 | 2521700 | 11680000 | 724650 | 10239000 | 715820 | 1168583.333 | 17021600 | |
333 | E9Q557 E9PZW0 | E9Q557 E9PZW0 | Desmoplakin | Dsp | 6 | 1 | 3 | 2 | 1 | 5 | 3 | 3 | 5.128 | 6 | 2.779 | 1 | 7.477 | 5 | 0 | 2 | 0.193 | 0.631 | 6 | 2 | 0.442 | 1 | 0.138 | 5 | 0 | 535820 | 2165603.333 | 413913.3333 | 4.042 | 0.191 | 770630 | 145280 | 472340 | 153010 | 7464200 | 926360 | 5804200 | 733670 | 575330 | 220270 | 355060 | 535820 | 2165603.333 | |||||||
166 | CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 G3UZ07 E9Q606 E9QAZ1 F8WGM8 E9Q2D1 F6WX90 | CON__P60712 P60710 F8WI82 E9Q1F2 E9Q5F4 | "Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed" | Actb | 36 | 14 | 13 | 9 | 34 | 31 | 33 | 3 | 4.813 | 75 | 1.533 | 31 | 3.812 | 30 | 9.093 | 14 | 5 | 0.447 | 1.458 | 75 | 3 | 1.000 | 31 | 0.362 | 30 | 0.425 | 14 | 50854393.33 | 141516666.7 | 97881333.33 | 2.783 | 0.692 | 453960000 | 99869000 | 168310000 | 185770000 | 364010000 | 51719000 | 221250000 | 91049000 | 52790000 | 975180 | 34990000 | 16825000 | 50854393.33 | 141516666.7 | ||||
742 | P46460 G3UX86 G3UX98 | P46460 | Vesicle-fusing ATPase | Nsf | 2 | 1 | 0 | 1 | 1 | 2 | 2 | 4.728 | 2 | 0.947 | 1 | 0 | 8.510 | 1 | 3 | 0.443 | 1.447 | 2 | 2 | 0.897 | 1 | 0 | 0.432 | 1 | 5 | YES | 89053.3 | 104782.5 | 60590.5 | 1.177 | 0.578 | 363920 | 172790 | 92145 | 98977 | 144940 | 5316.6 | 117420 | 22204 | 89053.3 | 104782.5 | |||||||||
1059 | Q6PIC6 Q8VCE0 Q9WV27 Q9Z1W8 E9QNX7 Q64436 Q91WH7 | Q6PIC6 Q8VCE0 | Sodium/potassium-transporting ATPase subunit alpha-3 | Atp1a3 | 23 | 9 | 8 | 6 | 16 | 16 | 10 | 3 | 4.474 | 41 | 2.306 | 16 | 7.940 | 15 | 3.177 | 10 | 7 | 0.574 | 1.876 | 41 | 3 | 1.403 | 16 | 0.546 | 15 | 0.348 | 10 | 1870460 | 8982200 | 6708566.667 | 4.802 | 0.747 | 17688000 | 2874100 | 5716300 | 9097800 | 29675000 | 2318500 | 17413000 | 9943800 | 5320100 | 418780 | 3817300 | 1084100 | 1870460 | 8982200 | ||||
1131 | Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6 | Q8BJ42 Q0VF59 Q8BJ42-2 F6WK46 F6WQI6 | Disks large-associated protein 2 | Dlgap2 | 26 | 3 | 13 | 10 | 6 | 25 | 18 | 3 | 4.312 | 25 | 2.541 | 2 | 5.053 | 15 | 5.342 | 8 | 5 | 0.169 | 0.552 | 22 | 3 | 0.194 | 2 | 0.209 | 13 | 0.274 | 7 | 5 | YES | YES | 780293.3333 | 11444866.67 | 822223.3333 | 14.667 | 0.072 | 2835100 | 565840 | 2126700 | 142560 | 27640000 | 1372500 | 24269000 | 1998300 | 8667200 | 402540 | 7938900 | 325810 | 780293.3333 | 11444866.67 | |
740 | P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 F6ZRK3 | P43006 A2APL5 E9PVV4 P43006-2 P43006-3 F7CAM6 | Excitatory amino acid transporter 2 | Slc1a2 | 7 | 3 | 2 | 2 | 6 | 6 | 4 | 3 | 4.261 | 14 | 4.118 | 6 | 4.325 | 6 | 4.340 | 2 | 5 | 0.312 | 1.020 | 12 | 3 | 0.554 | 6 | 0.402 | 4 | 0.294 | 2 | 5 | YES | 477895.6667 | 2985966.667 | 1113026.667 | 6.248 | 0.373 | 5374800 | 778550 | 2755700 | 1840500 | 7012600 | 595020 | 5115600 | 1302000 | 1343300 | 60117 | 1086600 | 196580 | 477895.6667 | 2985966.667 | ||
870 | P99024 G3UZR1 | P99024 | Tubulin beta-5 chain | Tubb5 | 20 | 7 | 7 | 6 | 2 | 3 | 11 | 3 | 4.018 | 10 | 1.961 | 2 | 6.512 | 3 | 3.581 | 5 | 5 | 0.430 | 1.405 | 10 | 3 | 0.930 | 2 | 0.428 | 3 | 0.363 | 5 | 1830233.333 | 6343200 | 4287100 | 3.466 | 0.676 | 18760000 | 3880300 | 7106700 | 7773200 | 12396000 | 1202300 | 7680200 | 3513000 | 6225900 | 408100 | 4242700 | 1575100 | 1830233.333 | 6343200 | ||||
837 | P68372 | P68372 | Tubulin beta-4B chain | Tubb4b | 25 | 9 | 9 | 7 | 19 | 20 | 27 | 3 | 3.959 | 28 | 2.070 | 12 | 3.943 | 11 | 5.864 | 5 | 5 | 0.343 | 1.120 | 28 | 3 | 0.618 | 12 | 0.402 | 11 | 0.351 | 5 | 2944223.333 | 10013633.33 | 5414866.667 | 3.401 | 0.541 | 28580000 | 6175900 | 12525000 | 9878700 | 21104000 | 2419500 | 13425000 | 5259100 | 5434900 | 237270 | 4090900 | 1106800 | 2944223.333 | 10013633.33 | ||||
461 | F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2 | F6RT34 F7A0B0 P04370-4 F6VME3 P04370-10 P04370-9 P04370-5 P04370-7 F6ZIA4 P04370 F6TYB7 P04370-11 P04370-6 F6RWW8 P04370-13 P04370-8 P04370-14 P04370-2 | Myelin basic protein | Mbp | 8 | 3 | 3 | 2 | 5 | 5 | 2 | 3 | 3.947 | 9 | 2.771 | 5 | 5.123 | 4 | 0 | 5 | 0.174 | 0.568 | 9 | 2 | 0.326 | 5 | 0.196 | 4 | 0 | 2053740 | 4481436.667 | 1707940 | 2.182 | 0.381 | 13348000 | 3118900 | 7615500 | 2613600 | 7453300 | 988580 | 5662400 | 802280 | 166410 | 166410 | 2053740 | 4481436.667 | ||||||||
1138 | Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3 | Q8BKX1-2 Q8BKX1-4 Q8BKX1 B1AZ46 Q8BKX1-3 | Brain-specific angiogenesis inhibitor 1-associated protein 2 | Baiap2 | 13 | 3 | 8 | 2 | 4 | 13 | 2 | 3 | 3.921 | 18 | 2.424 | 3 | 3.219 | 13 | 6.118 | 2 | 4 | 0.155 | 0.506 | 18 | 3 | 0.208 | 3 | 0.235 | 13 | 0.177 | 2 | 5 | YES | YES | 1972400 | 10243966.67 | 1580840 | 5.194 | 0.154 | 6382900 | 1254100 | 4293900 | 834910 | 31294000 | 4523800 | 23644000 | 3126200 | 3714700 | 139300 | 2794000 | 781410 | 1972400 | 10243966.67 | |
762 | P52189 Q8R435 | P52189 Q8R435 | Inward rectifier potassium channel 4 | Kcnj4 | 6 | 2 | 2 | 2 | 3 | 5 | 5 | 3 | 3.811 | 10 | 2.607 | 3 | 2.740 | 4 | 6.086 | 3 | 8 | 0.290 | 0.946 | 10 | 3 | 0.287 | 3 | 0.406 | 4 | 0.466 | 3 | 5 | YES | YES | 306996.6667 | 1426473.333 | 379986.6667 | 4.647 | 0.266 | 1466000 | 244140 | 902720 | 319130 | 3309800 | 560570 | 2179600 | 569650 | 1564600 | 116280 | 1197100 | 251180 | 306996.6667 | 1426473.333 | |
217 | Q6PIE5 D3YYN7 D3YVX6 | Q6PIE5 D3YYN7 D3YVX6 | Sodium/potassium-transporting ATPase subunit alpha-2 | Atp1a2 | 22 | 7 | 9 | 6 | 7 | 5 | 2 | 3 | 3.796 | 9 | 2.486 | 5 | 5.106 | 4 | 0 | 3 | 0.512 | 1.671 | 9 | 2 | 0.983 | 5 | 0.553 | 4 | 0 | 427785 | 1835750 | 1537800 | 4.291 | 0.838 | 3403800 | 492900 | 1420000 | 1491000 | 5405800 | 362670 | 3458500 | 1584600 | 628750 | 628750 | 427785 | 1835750 | ||||||||
724 | P35436 | P35436 | Glutamate [NMDA] receptor subunit epsilon-1 | Grin2a | 8 | 1 | 5 | 2 | 1 | 9 | 3 | 3 | 3.748 | 7 | 0 | 3.650 | 6 | 3.847 | 1 | 2 | 0.099 | 0.324 | 6 | 2 | 0 | 0.147 | 5 | 0.150 | 1 | 5 | YES | YES | 259325.5 | 2586723.333 | 272830.55 | 9.975 | 0.105 | 126090 | 126090 | 8128500 | 505790 | 7084400 | 538240 | 569960 | 12861 | 549680 | 7421.1 | 259325.5 | 2586723.333 | |||||
735 | P40124 B1ARS0 | P40124 B1ARS0 | Adenylyl cyclase-associated protein 1 Adenylyl cyclase-associated protein | Cap1 | 10 | 3 | 3 | 4 | 7 | 6 | 6 | 3 | 3.698 | 17 | 1.506 | 6 | 1.662 | 6 | 7.927 | 5 | 1 | 0.426 | 17 | 3 | 0.866 | 6 | 0.349 | 6 | 0.489 | 5 | 1 | 3196973.333 | 5736466.667 | 3901933.333 | 1.794 | 0.680 | 20315000 | 5082100 | 7564400 | 7668900 | 13328000 | 4309600 | 6650400 | 2367700 | 4863100 | 199220 | 2994600 | 1669200 | 3196973.333 | 5736466.667 | ||||
472 | F6VAN0 | F6VAN0 | Atf6 | Atf6 | 2 | 1 | 1 | 0 | 1 | 2 | 2 | 3.543 | 3 | 2.587 | 1 | 4.500 | 2 | 0 | 2 | 0.809 | 2.643 | 3 | 2 | 0.424 | 1 | 2.004 | 2 | 0 | 443720 | 1810300 | 2403125 | 4.080 | 1.327 | 2713600 | 490360 | 1480500 | 742750 | 6600700 | 397080 | 2140100 | 4063500 | 443720 | 1810300 | |||||||||||
969 | Q5SXR6 Q68FD5 E9Q434 F6Z1R4 | Q5SXR6 Q68FD5 | Clathrin heavy chain 1 | Cltc | 12 | 3 | 7 | 2 | 4 | 14 | 4 | 3 | 3.509 | 17 | 3.003 | 4 | 4.503 | 10 | 3.020 | 3 | 5 | 0.411 | 1.341 | 17 | 3 | 0.709 | 4 | 0.552 | 10 | 0.382 | 3 | 4 | YES | 761326.6667 | 5012500 | 2554206.667 | 6.584 | 0.510 | 6869600 | 961760 | 3420700 | 2487100 | 15596000 | 1195900 | 9935200 | 4464400 | 2519100 | 126320 | 1681600 | 711120 | 761326.6667 | 5012500 | ||
20 | A2AEG6 P35803 E9QPU6 P35803-8 P35803-3 | A2AEG6 P35803 E9QPU6 P35803-8 P35803-3 | Neuronal membrane glycoprotein M6-b | Gpm6b | 3 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 3.471 | 4 | 3.489 | 2 | 3.453 | 2 | 0 | 4 | 0.246 | 0.803 | 4 | 2 | 0.380 | 2 | 0.358 | 2 | 0 | 129570 | 898968.3333 | 493010 | 6.938 | 0.548 | 2548800 | 151390 | 1725400 | 671970 | 1295800 | 107750 | 873970 | 314050 | 97535 | 97535 | 129570 | 898968.3333 | ||||||||
908 | Q3TXX4 | Q3TXX4 | Vesicular glutamate transporter 1 | Slc17a7 | 2 | 1 | 0 | 1 | 2 | 1 | 2 | 3.456 | 3 | 3.911 | 2 | 0 | 3.001 | 1 | 2 | 0.184 | 0.601 | 3 | 2 | 0.333 | 2 | 0 | 0.220 | 1 | 162574.5 | 881080 | 232280 | 5.420 | 0.264 | 2072800 | 270640 | 1414600 | 387590 | 479040 | 54509 | 347560 | 76970 | 162574.5 | 881080 | |||||||||||
403 | E9Q8N8 O88343 O88343-2 A7E1Z5 | E9Q8N8 O88343 O88343-2 | Electrogenic sodium bicarbonate cotransporter 1 | Slc4a4 | 9 | 2 | 3 | 4 | 7 | 7 | 11 | 3 | 3.427 | 6 | 0.978 | 1 | 4.069 | 2 | 5.234 | 3 | 4 | 0.316 | 1.031 | 6 | 3 | 0.507 | 1 | 0.301 | 2 | 0.454 | 3 | 4 | YES | 97451.33333 | 1124106.667 | 310803.3333 | 11.535 | 0.276 | 1146200 | 63158 | 699520 | 383540 | 1572400 | 129960 | 1151200 | 291280 | 1878500 | 99236 | 1521600 | 257590 | 97451.33333 | 1124106.667 | ||
683 | P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 D3Z0Z9 E9PX99 F6QXU4 | P16858 E9Q0E3 E9Q1S8 E9Q5U3 E9PX42 E9PX72 D3YUV0 F8WJL5 D3YU05 E9Q9E5 E9PZH9 E9Q1F8 D3YV03 F6ZQM8 D3Z1B7 D3YYI5 E9PYX4 E9PZP4 | Glyceraldehyde-3-phosphate dehydrogenase | Gapdh Gm10293 Gm4609 Gm10358 Gm2606 Gm5559 Gm10291 Gm6316 Gm10481 Gm10566 Gm8055 Gm10290 Gm3222 Gm6981 Gm7293 Gm5507 Gm10313 | 6 | 2 | 2 | 2 | 4 | 6 | 5 | 3 | 3.271 | 4 | 1.572 | 2 | 4.970 | 2 | 0 | 4 | 0.231 | 0.753 | 4 | 2 | 0.521 | 2 | 0.171 | 2 | 0 | 5 | YES | 865380 | 1674876.667 | 735555 | 1.935 | 0.439 | 3635300 | 1078000 | 1738100 | 819290 | 4318000 | 652760 | 3013400 | 651820 | 273130 | 273130 | 865380 | 1674876.667 | ||||||
426 | P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2 | P23819-4 E9QKC0 G5E8H1 P23819 P23819-3 P23819-2 | Glutamate receptor 2 | Gria2 | 13 | 4 | 5 | 4 | 7 | 8 | 7 | 3 | 3.226 | 12 | 3.826 | 4 | 3.769 | 5 | 2.083 | 3 | 4 | 0.197 | 0.643 | 11 | 3 | 0.226 | 4 | 0.271 | 5 | 0.290 | 2 | 5 | YES | 275150 | 2830433.333 | 356706.6667 | 10.287 | 0.126 | 3713300 | 292480 | 3102600 | 318250 | 4890900 | 388450 | 3856000 | 646480 | 1782600 | 144520 | 1532700 | 105390 | 275150 | 2830433.333 | ||
1293 | Q99KI0 | Q99KI0 | "Aconitate hydratase, mitochondrial" | Aco2 | 3 | 0 | 2 | 1 | 4 | 1 | 2 | 3.216 | 2 | 0 | 3.216 | 2 | 0 | 1 | 0.217 | 2 | 1 | 0 | 0.434 | 2 | 0 | 4 | YES | 213160 | 352180 | 214210 | 1.652 | 0.608 | 1022600 | 213160 | 595240 | 214210 | 109120 | 109120 | 213160 | 352180 | ||||||||||||||
761 | P51863 | P51863 | V-type proton ATPase subunit d 1 | Atp6v0d1 | 4 | 2 | 2 | 0 | 3 | 2 | 2 | 3.184 | 3 | 3.184 | 3 | 0 | 0 | 3 | 0.195 | 0.638 | 3 | 1 | 0.391 | 3 | 0 | 0 | 5 | YES | 282420 | 1198800 | 570890 | 4.245 | 0.476 | 2424600 | 282420 | 1571300 | 570890 | 826300 | 826300 | 282420 | 1198800 | |||||||||||||
661 | P11499 E9PX27 E9Q0C3 E9Q3D6 D3Z1R1 | P11499 | Heat shock protein HSP 90-beta | Hsp90ab1 | 8 | 3 | 3 | 2 | 5 | 7 | 4 | 3 | 3.053 | 8 | 2.692 | 3 | 1.880 | 3 | 4.588 | 2 | 4 | 0.495 | 1.616 | 8 | 3 | 0.703 | 3 | 0.920 | 3 | 0.357 | 2 | 1 | 208570.3333 | 1464456.667 | 624216.6667 | 7.021 | 0.426 | 2469300 | 268560 | 1385700 | 815040 | 3213900 | 296130 | 2036400 | 881290 | 1208600 | 61021 | 971270 | 176320 | 208570.3333 | 1464456.667 | |||
574 | G5E902 Q8VEM8 | G5E902 Q8VEM8 | "Phosphate carrier protein, mitochondrial" | Slc25a3 | 3 | 1 | 1 | 1 | 2 | 3 | 1 | 3 | 2.882 | 5 | 3.484 | 2 | 2.279 | 3 | 0 | 5 | 0.384 | 1.253 | 5 | 2 | 0.501 | 2 | 0.650 | 3 | 0 | 1 | 1316250 | 3966800 | 2105300 | 3.014 | 0.531 | 8630000 | 1420400 | 4720000 | 2489600 | 6146600 | 1212100 | 3213600 | 1721000 | 1316250 | 3966800 | |||||||||
753 | P48722 P48722-2 E0CY23 F6SMW7 F6TFH3 | P48722 P48722-2 E0CY23 | Heat shock 70 kDa protein 4L | Hspa4l | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 2.878 | 3 | 4.230 | 1 | 1.526 | 2 | 0 | 3 | 1.269 | 4.144 | 3 | 2 | 1.701 | 1 | 2.106 | 2 | 0 | 84758.5 | 169900 | 453655 | 2.005 | 2.670 | 504060 | 49217 | 106670 | 348170 | 912570 | 120300 | 233130 | 559140 | 84758.5 | 169900 | |||||||||||
676 | P15105 D3YVK1 D3Z121 | P15105 D3YVK1 | Glutamine synthetase | Glul | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 2.754 | 2 | 2.754 | 2 | 0 | 0 | 5 | 0.196 | 0.641 | 2 | 1 | 0.393 | 2 | 0 | 0 | 5 | YES | 203660 | 725180 | 343840 | 3.561 | 0.474 | 2026200 | 203660 | 1478700 | 343840 | 382930 | 382930 | 313910 | 313910 | 203660 | 725180 | ||||||||||
800 | P61264 Q00262 Q80W45 Q3TJ55 | P61264 | Syntaxin-1B | Stx1b | 4 | 1 | 2 | 1 | 5 | 6 | 2 | 3 | 2.633 | 8 | 2.193 | 3 | 3.074 | 5 | 0 | 3 | 0.272 | 0.888 | 8 | 2 | 0.507 | 3 | 0.309 | 5 | 0 | 5 | YES | 541975 | 1799173.333 | 1224935 | 3.320 | 0.681 | 4471500 | 518630 | 2252200 | 1700700 | 4180400 | 565320 | 2865900 | 749170 | 279420 | 279420 | 541975 | 1799173.333 | ||||||
680 | P16388 | P16388 | Potassium voltage-gated channel subfamily A member 1 | Kcna1 | 2 | 0 | 1 | 1 | 2 | 1 | 2 | 2.582 | 1 | 0 | 0 | 2.582 | 1 | 1 | 0.266 | 1 | 1 | 0 | 0 | 0.533 | 1 | 5 | YES | YES | 28146 | 577325 | 107450 | 20.512 | 0.186 | 913500 | 913500 | 376750 | 28146 | 241150 | 107450 | 28146 | 577325 |
Supplementary Table 8. Map of Arc complex to OMIM disorders.
LoF mut. | Nonsynonymous mut. | Arc interactor type | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Gene name | AUT | EPI | ID | SCZ | AUT | EPI | ID | SCZ | Increased in PSD95-/- | Decreased in PSD95-/- | Known PSD95 direct interactor |
ACTB | . | . | . | . | x1 | . | . | . | N | N | N |
ACTN4 | . | . | . | . | x1 | . | . | 3:5 | N | N | N |
ADAM22 | . | . | . | 1:2 | x1 | . | . | 5:4 | N | Y | Y |
ALDH5A1 | . | . | . | 1:1 | x2 | . | . | x1, 7:2 | N | N | N |
ASRGL1 | . | . | . | 0:1 | . | . | . | 7:6 | N | N | N |
ATF6 | . | . | . | 0:2 | . | . | . | 0:2 | Y | N | N |
ATP1A1 | x1 | . | . | . | x2 | . | . | 3:0 | N | N | N |
ATP1A2 | . | . | . | 1:0 | . | . | . | 4:3 | Y | N | N |
ATP1A3 | . | . | . | . | x1 | . | . | 2:1 | Y | N | N |
ATP1B1 | x1 | . | . | 1:0 | x1 | . | . | 2:0 | N | N | N |
ATP2A2 | . | . | . | 1:0 | . | . | . | 2:0 | N | N | N |
ATP2B2 | . | . | . | 0:2 | x1 | . | . | 0:2 | N | N | Y |
ATP5A1 | . | . | . | 1:0 | . | . | . | 5:1 | N | N | N |
ATP6V0A1 | . | . | . | 1:0 | . | . | . | 2:1 | N | N | N |
ATP6V1A | . | . | . | . | x1 | . | . | 2:2 | N | N | N |
ATP6V1H | . | . | . | 1:0 | . | . | . | 1:6 | N | N | N |
BAIAP2 | . | . | . | 1:0 | . | . | . | x2, 1:0 | N | Y | Y |
CAMK2A | . | . | . | 1:0 | x1 | . | . | 2:0 | N | Y | Y |
CAMK2B | . | . | . | 2:0 | . | . | . | 2:0 | N | N | N |
CEND1 | . | . | . | . | . | . | . | 1:0 | N | N | N |
CLTC | . | . | . | . | . | . | . | 2:2 | N | N | N |
CRMP1 | . | . | . | . | . | . | . | 1:5 | N | N | N |
DDR2 | . | . | . | . | x1 | . | . | . | N | N | N |
DLG1 | . | . | . | 1:0 | . | . | . | x1, 5:0 | Y | N | N |
DLG2 | . | . | . | x1 | x1 | . | . | x1, 4:8 | N | Y | Y |
DLG4 | . | . | . | . | . | . | x1 | 1:2 | N | Y | Y |
DLGAP1 | . | . | . | . | . | . | . | 3:2 | N | Y | Y |
DLGAP2 | . | . | . | . | x2 | . | . | 1:0 | N | Y | Y |
DLGAP3 | . | . | . | . | . | . | . | 3:1 | N | Y | Y |
DLGAP4 | . | . | . | 0:1 | . | . | . | 4:7 | N | N | Y |
DPYSL2 | . | . | . | . | x2 | . | . | 0:1 | N | N | N |
DSP | . | . | x1 | . | . | . | x1 | 2:0 | N | Y | N |
GAPDH | . | . | . | 1:0 | . | . | . | 1:0 | N | N | N |
GDA | . | . | . | . | . | . | . | 4:1 | N | Y | Y |
GLUL | . | . | . | . | . | x1 | . | 2:0 | N | N | N |
GNAO1 | . | . | . | . | x1 | x2 | . | x1, 0:3 | N | N | N |
GNB1 | . | . | . | . | . | . | . | 0:2 | N | N | N |
GPM6A | . | . | . | . | . | . | . | 2:1 | N | N | N |
GPM6B | . | . | . | . | . | . | . | 0:2 | N | N | N |
GRIA2 | x1 | . | . | . | x1 | . | . | 2:1 | N | Y | N |
GRIA3 | . | . | . | . | . | . | . | 0:1 | N | Y | N |
GRIA4 | . | . | . | . | . | . | . | 2:6 | N | Y | N |
GRIN1 | . | . | . | . | . | x1 | . | 2:0 | N | Y | Y |
GRIN2A | . | . | . | 2:0 | . | . | x2 | x1, 2:0 | N | Y | Y |
GRIN2B | x3 | . | . | 0:1 | x4 | x1 | x2 | 2:3 | N | N | Y |
GRM3 | . | . | . | . | . | . | . | 3:2 | N | Y | N |
H2AFV | . | . | . | . | x1 | . | . | x1 | N | Y | N |
H2AFX | . | . | . | . | . | . | . | 1:0 | N | Y | N |
HIST1H2AA | . | . | . | 0:2 | . | . | . | 0:2 | N | Y | N |
HIST1H2AD | . | . | . | 4:3 | . | . | . | 4:3 | N | Y | N |
HIST1H2AH | . | . | . | 3:1 | . | . | . | 3:1 | N | Y | N |
HIST2H2AB | . | . | . | . | . | . | . | 0:1 | N | Y | N |
HIST2H2AC | . | . | . | . | . | . | . | 0:1 | N | Y | N |
HIST3H2A | . | . | . | 0:1 | . | . | . | 3:6 | N | Y | N |
HSPA4L | . | . | . | 1:1 | . | . | . | 2:7 | Y | N | N |
HSPA8 | . | . | . | x1 | . | . | . | x2 | Y | N | N |
IDH3A | . | . | . | . | . | . | . | 1:2 | N | N | N |
IQSEC1 | . | . | . | . | . | x1 | . | 4:1 | N | Y | N |
IQSEC2 | . | x1 | x1 | 1:0 | . | x1 | x1 | 1:1 | N | Y | N |
KCNA2 | . | . | . | . | . | . | . | 0:1 | N | N | Y |
KCNJ4 | . | . | . | . | . | . | . | 2:0 | N | N | Y |
LGI1 | . | . | . | . | . | . | . | 0:2 | Y | N | N |
MAP1A | . | . | . | 2:0 | . | . | . | 2:0 | N | N | N |
MAP6 | . | . | . | 0:1 | . | . | . | 0:1 | N | N | N |
MBP | . | . | . | 1:0 | . | . | . | 4:4 | N | Y | N |
MOG | . | . | . | . | . | . | . | 0:1 | N | N | N |
MYO18B | . | . | . | 0:1 | x2 | . | . | x1, 2:3 | N | N | N |
NSF | . | . | . | . | . | . | . | 1:1 | N | N | N |
PGAM5 | . | . | . | . | . | . | . | 2:2 | N | N | N |
PKM | . | . | . | 6:4 | x1 | . | . | 6:4 | Y | N | N |
PPP2R2A | . | . | . | 2:0 | . | . | . | 2:0 | N | N | N |
PPP3CA | . | . | . | . | . | x1 | . | 2:3 | N | N | N |
PRDX2 | . | . | . | 0:1 | . | . | . | 0:1 | N | N | N |
RTN1 | . | . | . | . | . | x1 | . | 1:1 | N | N | N |
SDHA | . | . | . | 6:4 | x1 | . | . | 6:4 | N | N | N |
SEPT8 | . | . | . | 0:2 | . | . | . | 5:12 | N | N | N |
SLC1A2 | . | . | . | . | . | x1 | . | 3:2 | N | N | N |
SLC25A3 | . | . | . | 1:0 | . | . | . | 1:0 | N | N | N |
SLC3A2 | . | . | . | 1:0 | . | . | . | x1, 1:0 | N | N | N |
SLC4A4 | . | . | . | . | x1 | . | . | 3:7 | N | N | N |
SLC6A1 | . | . | x1 | . | x4 | . | x1 | 1:0 | N | N | N |
SLC6A11 | . | . | . | 1:1 | . | . | . | 1:2 | N | N | N |
SLC9A3R1 | . | . | . | 7:2 | . | . | . | x1, 10:7 | N | N | N |
STX1A | . | . | . | . | . | . | . | 0:1 | N | N | N |
STX1B | . | x1 | . | . | . | x1 | . | 1:2 | N | N | N |
STXBP1 | . | x1 | x1 | . | x1 | x5 | x3 | . | N | N | N |
SYNGAP1 | x5 | . | x3 | x1, 1:0 | x8 | . | x3 | x1, 4:0 | N | Y | Y |
TKT | . | . | . | 0:1 | . | . | . | 3:7 | N | N | N |
TUBA1A | . | . | x1 | . | x2 | . | x1 | . | N | N | N |
TUBA3E | . | . | . | 0:1 | . | . | . | 0:1 | N | N | N |
TUBA4A | . | . | . | . | . | . | . | 0:2 | N | N | N |
TUBB4B | . | . | . | . | x1 | . | . | . | N | N | N |
UBA1 | . | . | . | . | . | . | . | 2:1 | N | N | N |
UBA52 | . | . | . | 1:0 | . | . | . | 1:0 | Y | N | N |
UBC | . | . | . | 2:2 | . | . | . | 2:2 | Y | N | N |
VDAC1 | . | . | . | . | . | . | . | 1:0 | N | N | N |
Supplementary Table 9. Map of Arc complex to OMIM disorders.
Gene name | OMIM ID | Disease |
---|---|---|
Actb | 243310 | Baraitser-Winter syndrome 1 |
Actb | 607371 | Dystonia, juvenile-onset |
Actn4 | 603278 | Glomerulosclerosis, focal segmental, 1 |
Aldh5a1 | 271980 | Succinic semialdehyde dehydrogenase deficiency |
Atp1a2 | 104290 | Alternating hemiplegia of childhood |
Atp1a2 | 602481 | Migraine, familial basilar |
Atp1a2 | 602481 | Migraine, familial hemiplegic, 2 |
Atp1a3 | 128235 | Dystonia-12 |
Atp1a3 | 601338 | CAPOS syndrome |
Atp1a3 | 614820 | Alternating hemiplegia of childhood 2 |
Atp1b1 | 145500 | Blood pressure regulation QTL |
Atp2a2 | 101900 | Acrokeratosis verruciformis |
Atp2a2 | 124200 | Darier disease |
Atp2b2 | 601386 | Deafness, autosomal recessive 12, modifier of |
Atp5a1 | 615228 | Mitochondrial complex (ATP synthase) deficiency, nuclear type 4 |
Atp5a1 | 616045 | Combined oxidative phosphorylation deficiency 22 |
Dsp | 605676 | Cardiomyopathy, dilated, with woolly hair and keratoderma |
Dsp | 607450 | Arrhythmogenic right ventricular dysplasia 8 |
Dsp | 607655 | Skin fragility-woolly hair syndrome |
Dsp | 609638 | Epidermolysis bullosa, lethal acantholytic |
Dsp | 612908 | Keratosis palmoplantaris striata II |
Dsp | 615821 | Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis |
Glul | 610015 | Glutamine deficiency, congenital |
Gnao1 | 615473 | Epileptic encephalopathy, early infantile, 17 |
Grin1 | 614254 | Mental retardation, autosomal dominant 8 |
Grin2a | 245570 | Epilepsy, focal, with speech disorder and with or without mental retardation |
Grin2b | 613970 | Mental retardation, autosomal dominant 6 |
Grin2b | 616139 | Epileptic encephalopathy, early infantile, 27 |
Iqsec2 | 309530 | Mental retardation, X-linked 1 |
Lgi1 | 600512 | Epilepsy, familial temporal lobe, 1 |
Mog | 614250 | Narcolepsy 7 |
Plp1 | 312080 | Pelizaeus-Merzbacher disease |
Plp1 | 312920 | Spastic paraplegia 2, X-linked |
Sdha | 252011 | Mitochondrial respiratory chain complex II deficiency |
Sdha | 256000 | Leigh syndrome |
Sdha | 613642 | Cardiomyopathy, dilated, 1GG |
Sdha | 614165 | Paragangliomas 5 |
Slc25a3 | 610773 | Mitochondrial phosphate carrier deficiency |
Slc4a4 | 604278 | Renal tubular acidosis, proximal, with ocular abnormalities |
Slc9a3r1 | 612287 | Nephrolithiasis/osteoporosis, hypophosphatemic, 2 |
Stxbp1 | 612164 | Epileptic encephalopathy, early infantile, 4 |
Syngap1 | 612621 | Mental retardation, autosomal dominant 5 |
Tubb5 | 615771 | Cortical dysplasia, complex, with other brain malformations 6 |
Uba1 | 301830 | Spinal muscular atrophy, X-linked 2, infantile |
Supplementary Table 10. Mammalian Phenotype Ontology of ARC interactors.
Supplementary Table 11. Arc gene set association with general cognitive ability.
Chr | GSEA_Arc gene set | Start | Stop | BATS nSNPs | BATS P Value | CAGES nSNPs | CAGES P Value |
---|---|---|---|---|---|---|---|
7 | ACTB | 5533304 | 5536758 | 18 | 0.814 | 68 | 0.08662 |
19 | ACTN4 | 43830166 | 43913010 | 20 | 0.268 | 114 | 0.53 |
7 | ADAM22 | 87401637 | 87664385 | 43 | 0.133 | 190 | 0.416 |
6 | ALDH5A1 | 24603175 | 24645414 | 62 | 0.995 | 195 | 0.161 |
8 | ARC | 143689411 | 143692835 | 15 | 0.764 | 81 | 0.62 |
11 | ASRGL1 | 61861349 | 61917463 | 36 | 0.976 | 136 | 0.52 |
1 | ATF6 | 160002707 | 160195476 | 72 | 0.991 | 382 | 0.98 |
1 | ATP1A1 | 116717358 | 116748919 | 8 | 0.312 | 64 | 0.461 |
1 | ATP1A2 | 158352171 | 158379998 | 49 | 0.527 | 123 | 0.233 |
19 | ATP1A3 | 47162573 | 47190222 | 9 | 0.07962 | 21 | 0.593 |
1 | ATP1B1 | 167342570 | 167368584 | 38 | 0.527 | 188 | 0.988 |
12 | ATP2A2 | 109203414 | 109273280 | 6 | 0.244 | 33 | 0.608 |
3 | ATP2B2 | 10340706 | 10522268 | 123 | 0.614 | 376 | 0.326 |
18 | ATP5A1 | 41918107 | 41938197 | 17 | 0.99 | 65 | 0.564 |
17 | ATP6V0A1 | 37864387 | 37928123 | 12 | 0.148 | 56 | 0.575 |
16 | ATP6V0D1 | 66029417 | 66072590 | 4 | 0.283 | 38 | 0.887 |
3 | ATP6V1A | 114948597 | 115013593 | 8 | 0.893 | 60 | 0.149 |
8 | ATP6V1H | 54790667 | 54918403 | 21 | 0.02808 | 122 | 0.276 |
17 | BAIAP2 | 76623556 | 76705827 | 24 | 0.858 | 107 | 0.563 |
14 | BEGAIN | 100073240 | 100105884 | 9 | 0.506 | 48 | 0.818 |
6 | C6orf199 | 110059592 | 110119108 | 20 | 0.98 | 154 | 0.04747 |
6 | C6orf224 | 109920756 | 109934386 | 12 | 0.956 | 94 | 0.03276 |
5 | CAMK2A | 149579247 | 149649529 | 61 | 0.227 | 203 | 0.575 |
7 | CAMK2B | 44225419 | 44331749 | 32 | 0.479 | 105 | 0.214 |
11 | CEND1 | 777109 | 780126 | 12 | 0.0735 | 40 | 0.178 |
15 | CKMT1A | 41772375 | 41778712 | 2 | 0.193 | 17 | 0.533 |
3 | CLDN11 | 171619358 | 171634579 | 22 | 0.907 | 82 | 0.12 |
17 | CLTC | 55051831 | 55129099 | 11 | 0.722 | 92 | 0.967 |
2 | CNRIP1 | 68364806 | 68400687 | 25 | 0.857 | 163 | 0.371 |
8 | COX6C | 100959547 | 100975071 | 14 | 0.05835 | 46 | 0.469 |
4 | CRMP1 | 5873391 | 5945686 | 75 | 0.888 | 215 | 0.535 |
3 | DLG1 | 198253827 | 198509844 | 43 | 0.255 | 150 | 0.309 |
11 | DLG2 | 82843700 | 84312113 | 380 | 0.204 | 1737 | 0.412 |
17 | DLG4 | 7033933 | 7063781 | 13 | 0.23 | 45 | 0.95 |
18 | DLGAP1 | 3488836 | 3870135 | 129 | 0.391 | 402 | 0.46 |
8 | DLGAP2 | 1436975 | 1644049 | 81 | 0.167 | 321 | 0.05153 |
1 | DLGAP3 | 35103623 | 35143571 | 25 | 0.516 | 91 | 0.689 |
20 | DLGAP4 | 34357716 | 34590454 | 24 | 0.685 | 103 | 0.485 |
8 | DPYSL2 | 26491337 | 26571610 | 67 | 0.678 | 279 | 0.0496 |
6 | DSP | 7486868 | 7531945 | 49 | 0.655 | 214 | 0.785 |
11 | EEF1G | 62083648 | 62098036 | 5 | 0.984 | 31 | 0.489 |
12 | GAPDH | 6513917 | 6517797 | 18 | 0.06199 | 78 | 0.549 |
9 | GDA | 73954112 | 74056960 | 45 | 0.926 | 199 | 0.00248 |
1 | GLUL | 180618291 | 180627573 | 30 | 0.09298 | 120 | 0.555 |
16 | GNAO1 | 54782751 | 54948857 | 48 | 0.02173 | 241 | 0.06971 |
1 | GNB1 | 1706588 | 1812355 | 11 | 0.914 | 52 | 0.795 |
4 | GPM6A | 176791081 | 177160642 | 97 | 0.991 | 405 | 0.586 |
10 | GPR123 | 134751398 | 134795169 | 23 | 0.393 | 108 | 0.134 |
4 | GRIA2 | 158361185 | 158506676 | 18 | 0.0766 | 115 | 0.186 |
9 | GRIN1 | 139153429 | 139183029 | 4 | 0.725 | 26 | 0.97 |
16 | GRIN2A | 9762922 | 10184112 | 168 | 0.454 | 884 | 0.605 |
12 | GRIN2B | 13605676 | 14024289 | 188 | 0.336 | 684 | 0.734 |
7 | GRM3 | 86111165 | 86332128 | 46 | 0.616 | 260 | 0.000262 |
11 | H2AFX | 118469794 | 118471387 | 9 | 0.752 | 59 | 0.591 |
6 | HSP90AB1 | 44322826 | 44329592 | 19 | 0.926 | 63 | 0.592 |
4 | HSPA4L | 128922902 | 128973976 | 10 | 0.125 | 53 | 0.663 |
11 | HSPA8 | 122433409 | 122438054 | 21 | 0.622 | 93 | 0.963 |
15 | IDH3A | 76228773 | 76249939 | 37 | 0.693 | 102 | 0.711 |
3 | IQSEC1 | 12914373 | 12983960 | 35 | 0.208 | 132 | 0.42 |
1 | KCNA2 | 110947298 | 110949868 | 30 | 0.723 | 110 | 0.09731 |
22 | KCNJ4 | 37152278 | 37181149 | 23 | 0.107 | 87 | 0.07837 |
10 | LGI1 | 95507555 | 95547906 | 37 | 0.289 | 198 | 0.824 |
17 | LOC388419 | 69864150 | 69869553 | 25 | 0.165 | 70 | 0.591 |
15 | MAP1A | 41597097 | 41611110 | 16 | 0.525 | 42 | 0.469 |
11 | MAP6 | 74975610 | 75057127 | 39 | 0.659 | 175 | 0.905 |
22 | MAPK1 | 20443946 | 20551970 | 24 | 0.35 | 134 | 0.965 |
18 | MBP | 72819776 | 72973762 | 106 | 0.768 | 354 | 0.04364 |
6 | MOG | 29732787 | 29748128 | 35 | 0.503 | 244 | 0.365 |
22 | MYO18B | 24468119 | 24757007 | 141 | 0.385 | 564 | 0.7 |
17 | NSF | 42023353 | 42190000 | 15 | 0.151 | 77 | 0.56 |
12 | PGAM5 | 131797508 | 131805825 | 11 | 0.548 | 62 | 0.934 |
15 | PKM2 | 70278423 | 70310738 | 5 | 0.06398 | 57 | 0.751 |
8 | PPP2R2A | 26204950 | 26284563 | 40 | 0.129 | 130 | 0.932 |
4 | PPP3CA | 102163609 | 102487376 | 70 | 0.09237 | 323 | 0.785 |
10 | PPP3CB | 74866617 | 74925760 | 6 | 0.551 | 44 | 0.695 |
19 | PRDX2 | 12768633 | 12773694 | 4 | 0.506 | 36 | 0.003882 |
6 | PRRT1 | 32224117 | 32227698 | 49 | 0.00732 | 96 | 0.03797 |
14 | RTN1 | 59132446 | 59407310 | 51 | 0.106 | 266 | 0.161 |
5 | SDHA | 271355 | 309814 | 19 | 0.272 | 109 | 0.411 |
5 | SEPT8 | 132114407 | 132141460 | 12 | 0.192 | 78 | 0.363 |
9 | SH3GL2 | 17569193 | 17787122 | 106 | 0.659 | 511 | 0.586 |
19 | SLC17A7 | 54624469 | 54636596 | 16 | 0.208 | 70 | 0.869 |
11 | SLC1A2 | 35229327 | 35397681 | 99 | 0.489 | 344 | 0.547 |
12 | SLC25A3 | 97511533 | 97519909 | 23 | 0.707 | 56 | 0.565 |
4 | SLC25A4 | 186301391 | 186305419 | 18 | 0.02448 | 67 | 0.906 |
11 | SLC3A2 | 62380093 | 62412929 | 18 | 0.865 | 68 | 0.699 |
4 | SLC4A4 | 72271866 | 72656663 | 87 | 0.215 | 365 | 0.467 |
3 | SLC6A1 | 11009419 | 11055935 | 54 | 0.561 | 175 | 0.712 |
3 | SLC6A11 | 10832916 | 10955146 | 75 | 0.991 | 293 | 0.528 |
17 | SLC9A3R1 | 70256378 | 70277089 | 25 | 0.131 | 81 | 0.509 |
7 | STX1A | 72751475 | 72771924 | 13 | 0.258 | 40 | 0.417 |
16 | STX1B | 30910868 | 30929330 | 5 | 0.02932 | 29 | 0.597 |
9 | STXBP1 | 129414388 | 129494816 | 16 | 0.772 | 68 | 0.07996 |
6 | SYNGAP1 | 33495824 | 33529444 | 8 | 0.704 | 63 | 0.697 |
3 | TKT | 53234703 | 53264998 | 26 | 0.01188 | 113 | 0.53 |
12 | TUBA1A | 47864849 | 47869128 | 6 | 0.01126 | 27 | 0.819 |
2 | TUBA4A | 219823244 | 219826882 | 11 | 0.347 | 54 | 0.906 |
6 | TUBB | 30796135 | 30801174 | 49 | 0.02133 | 106 | 0.339 |
9 | TUBB2C | 139255531 | 139257980 | 1 | 0.866 | 2 | 0.958 |
17 | UBB | 16225091 | 16226779 | 8 | 0.395 | 45 | 0.436 |
5 | VDAC1 | 133335505 | 133368332 | 17 | 0.01141 | 63 | 0.869 |
Supplementary Table 12. Oligos used in this study.
Oligo name | Sequence 5'3 |
---|---|
ArcHA1XbaR | CTGC TCT AGA TTC AGG CTG GGT CCT GTC ACT G |
ArcHA1XhoF | ATC TCG CTC GAG GGG AGG TCT TCT ACC GTC TGG AG |
ArcHA2BglR | GACCT AGA TCT GC GGCC GC GGG GCC AGG AGG TGC CAG GAT GTC AGG TC |
ArcHA2Acc65F | CTACGG GGT ACC AGG GGC CAG CCC AGG GTC CCC AG |
ArcHA3NdeF | GGG TAA TCTC CA TAT G GGA GGC TTA GGC TAG GCA CAG AC |
ArcHA3PmlR | CCG GCG TA CAC GTG CCC TGG TCC CAG CCA TGA TTC ATA AG |
ArcHA4AscF | CATTT G GCG CGC C CCA ATA GGT CAT CAC AAC TGC CAT G |
ArcHA4PmeR | AGC TTT G TTT AAA C GCC CTT GCA CCT CTT GCT GCA C |
Pneo3F | GCC TCT GAG CTA TTC CAG AAG TAG |
Pneo3R | CCT GAC TAG GGG AGG AGT AGA AG |
Arc10R | GGG CTT CTT ATG TTC AGT C |
Arc1F | CGG GAC CTG TAC CAG ACA CTG |
Arc1R | GCC ATG GCT GAG TCA CGG AG |
Arc2F | GGA GCG AGA GCT GAA AGG GTT G |
Arc2R | GGG GCC AGG AGG TGC CAG GAT GTC |
Arc3R | CCC TCA GCA TCT CTG CTT TAG C |
Arc4R | GCC AGG ACT AGG TTG GAC AGT CTG |
Arc5F | CCC TCC TGG ATC TAG TGG TGA GC |
Arc5R | GGGCATCCACTCACATAACTACTCG |
Arc6F | GCC CCT GCC CAG CCT GAT CTT TC |
Arc6R | CCC CGA GAC ACT ACT CTG AGC |
Arc7F | GGG TGG ACA GTT GGT CAG AAG G |
Arc7R | CCC TCT GAC CAC TGC ATT TTC C |
Arc8F | CCC AGT GCT TTC TCA GCC TTC ATG |
Arc8R | GGT CAG TGG GTG AGT AGA TGT CTG |
Arc9F | CGG AGG CAC TCA CAC CTG |
Arc9R | GGT TGT GTG GCA GTT GTG AGT C |
Arc10F | GCT CTT ACC AGC GAG |
Arc11F | GGG CAG ATG CTA AAG CAG |
Arc11R | CGG CTG GGT GTG AGG ACT CAG |
Supplementary Information
Supplementary Information.
Download supplementary information fileFile contents
1. TAP tagged Arc vector and gene targeting.
2. TAP tagged Arc transgenic mice.
3. TAP tagged Arc distribution and subcellular localization.
4. Electrophysiological parameters measured in the CA1 area of ArcTAP/TAP hippocampal slices.
5. Classification of Arc interactors according to their gene ontology process.
6. Arc protein levels in the forebrain of PSD93/Dlg2 and SAP102/Dlg3 knockout mice.
7. Arc binding to PSD95/Dlg4 protein is independent of PSD93/Dlg2.
8. Isolation of TAP tagged Arc complexes from PSD95/Dlg4 mutant mice.
9. Methods
9.1. Tandem Affinity Purification
9.2. Proteomic analysis.
9.3. Network building.
9.4. Genetic analysis.
9.5. Human cognitive ability phenotype.
9.6. Cellular fractionation.
9.7. Statistics.
10. Supplementary Table legends
11. References.