An Integrative Neuroscience Program Linking Mouse Genes to Cognition and Disease

The four main layers of the Genes to Cognition Programme (G2C) are shown as flat planes. The entry point to the programme is primarily via Layer 1 (see Figure 2 for details). In Layer 1, a set of genes is defined according to various criteria and driven by basic neuroscience studies. In Layer 2 (see Figure 3 for details), the genes in Layer 1 are used in human genotyping assays to seek putative functional variants. These variants are examined in biological assays in Layer 3 (see Figure 4 for details). Underpinning and central to the integration of the data in all layers is bioinformatic tools (Layer 4). This information is transferred between layers and is used to modify the experiments as the G2C develops. The arrows indicate the simplest flow of information between layers.