G2Cdb::Gene report

Gene id
G00003412
Gene symbol
Nt5c1b (MGI)
Species
Mus musculus
Description
5'-nucleotidase, cytosolic IB
Orthologue
G00006402 (Homo sapiens)

Databases (3)

Gene
ENSMUSG00000020622 (Ensembl mouse gene)
70881 (Entrez Gene)
Marker Symbol
MGI:1918131 (MGI)

Synonyms (1)

  • CN-IB

Literature (1)

Pubmed - other

  • Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein.

    Sala-Newby GB and Newby AC

    Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, BS2 8HW, Bristol, UK. g.newby@bris.ac.uk

    Adenosine production catalysed by cytosolic 5'-nucleotidase (cN-I) regulates diverse physiological processes. We report here a mouse cN-I (mcN-I) cloned from heart and testis. The open reading frame contains several potential translation initiation sites, which yield similarly active 5'-nucleotidases. Using overexpression in COS-7 cells we showed that mcN-I, like the previously cloned pigeon cN-I, is activated by ADP and catalyses adenosine formation during ATP breakdown. The N- and C-termini of mcN-I and pcN-I are divergent. Deletion of the 12 C-terminal amino acids or the first 19 N-terminal amino acids of pcN-I does not diminish activity, although deletion of the first 31 N-terminal amino acids reduces activity by 70%. Overall mcN-I is only 66% identical to pcN-I or the recently cloned human cN-I (hcN-I), while hcN-I and pcN-I are 85% identical. We report here a partial hcN-I sequence that is only 70% identical with the published hcN-I amino acid sequence but is 87% identical with mcN-I. Both hcN-I sequences have perfect matches to distinct human genome sequences. Our data imply the existence of at least two genes for cN-I, cN-I(A), previously cloned from pigeon and human, and cN-I(B) that we report here from mouse and partially from human.

    Biochimica et biophysica acta 2001;1521;1-3;12-8

Gene lists (1)

Gene List Source Species Name Description Gene count
L00000070 G2C Mus musculus BAYES-COLLINS-HUMAN-PSD-FULL Human cortex biopsy PSD full list (ortho) 1461
© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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