G2Cdb::Gene report

Gene id
G00002164
Gene symbol
IRS1 (HGNC)
Species
Homo sapiens
Description
insulin receptor substrate 1
Orthologue
G00000915 (Mus musculus)

Databases (7)

Gene
ENSG00000169047 (Ensembl human gene)
3667 (Entrez Gene)
157 (G2Cdb plasticity & disease)
IRS1 (GeneCards)
Literature
147545 (OMIM)
Marker Symbol
HGNC:6125 (HGNC)
Protein Sequence
P35568 (UniProt)

Synonyms (1)

  • HIRS-1

Diseases (12)

Disease Nervous effect Mutations Found Literature Mutations Type Genetic association?
D00000140: Diabetes mellitus Type 1 N Y (14988278) Single nucleotide polymorphism (SNP) N
D00000140: Diabetes mellitus Type 1 N Y (15059616) Single nucleotide polymorphism (SNP) Y
D00000022: Colorectal cancer N Y (15066917) Single nucleotide polymorphism (SNP) Y
D00000021: Colon cancer N Y (15247132) Single nucleotide polymorphism (SNP) Y
D00000042: Breast cancer N Y (15308584) Single nucleotide polymorphism (SNP) N
D00000142: Diabetes mellitus Type 2 N Y (15561966) Single nucleotide polymorphism (SNP) N
D00000324: Longevity N Y (15582274) Single nucleotide polymorphism (SNP) N
D00000057: Prostate cancer N Y (15678496) Single nucleotide polymorphism (SNP) Y
D00000150: Polycystic ovary syndrome N Y (15705377) Single nucleotide polymorphism (SNP) Y
D00000319: Adrenal androgen excess N Y (15705377) Single nucleotide polymorphism (SNP) Y
D00000153: Obesity N Y (16030120) Single nucleotide polymorphism (SNP) Y
D00000277: Diabetes mellitus (gestational) N Y (16320083) Polymorphism (P) Y
D00000140: Diabetes mellitus Type 1 N Y (16367885) Single nucleotide polymorphism (SNP) N
D00000021: Colon cancer N Y (16448675) Polymorphism (P) Y
D00000022: Colorectal cancer N Y (16489531) Single nucleotide polymorphism (SNP) ?
D00000166: Schizophrenia Y Y (17044098) Single nucleotide polymorphism (SNP) N
D00000042: Breast cancer N Y (17051426) Polymorphism (P) Y

References

Literature (312)

Pubmed - human_disease

Pubmed - other

Gene lists (3)

Gene List Source Species Name Description Gene count
L00000015 G2C Homo sapiens Human NRC Human orthologues of mouse NRC adapted from Collins et al (2006) 186
L00000016 G2C Homo sapiens Human PSP Human orthologues of mouse PSP adapted from Collins et al (2006) 1121
L00000034 G2C Homo sapiens Pocklington H3 Human orthologues of cluster 3 (mouse) from Pocklington et al (2006) 30
© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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