G2Cdb::Gene report

Gene id
G00001410
Gene symbol
CSNK1E (HGNC)
Species
Homo sapiens
Description
casein kinase 1, epsilon
Orthologue
G00000161 (Mus musculus)

Databases (7)

Gene
ENSG00000100181 (Ensembl human gene)
1454 (Entrez Gene)
504 (G2Cdb plasticity & disease)
CSNK1E (GeneCards)
Literature
600863 (OMIM)
Marker Symbol
HGNC:2453 (HGNC)
Protein Sequence
P49674 (UniProt)

Synonyms (1)

  • HCKIE

Literature (78)

Pubmed - human_disease

  • Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.

    Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Schork NJ and Kelsoe JR

    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093-0603, USA.

    Bipolar affective disorder (BPAD) is suspected to arise in part from malfunctions of the circadian system, a system that enables adaptation to a daily and seasonally cycling environment. Genetic variations altering functions of genes involved with the input to the circadian clock, in the molecular feedback loops constituting the circadian oscillatory mechanism itself, or in the regulatory output systems could influence BPAD as a result. Several human circadian system genes have been identified and localized recently, and a comparison with linkage hotspots for BPAD has revealed some correspondences. We have assessed evidence for linkage and association involving polymorphisms in 10 circadian clock genes (ARNTL, CLOCK, CRY2, CSNK1epsilon, DBP, GSK3beta, NPAS2, PER1, PER2, and PER3) to BPAD. Linkage analysis in 52 affected families showed suggestive evidence for linkage to CSNK1epsilon. This finding was not substantiated in the association study. Fifty-two SNPs in 10 clock genes were genotyped in 185 parent proband triads. Single SNP TDT analyses showed no evidence for association to BPAD. However, more powerful haplotype analyses suggest two candidates deserving further studies. Haplotypes in ARNTL and PER3 were found to be significantly associated with BPAD via single-gene permutation tests (PG = 0.025 and 0.008, respectively). The most suggestive haplotypes in PER3 showed a Bonferroni-corrected P-value of PGC = 0.07. These two genes have previously been implicated in circadian rhythm sleep disorders and affective disorders. With correction for the number of genes considered and tests conducted, these data do not provide statistically significant evidence for association. However, the trends for ARNTL and PER3 are suggestive of their involvement in bipolar disorder and warrant further study in a larger sample.

    Funded by: Intramural NIH HHS; NCRR NIH HHS: M01 RR000827, M01 RR00827; NHLBI NIH HHS: HL054998-09, HL064777-06, HL069758-03, HL070137-01A1, HL071123, HL074730-02, HL61280, P50 HL054998, R01 HL070137, R01 HL071123, R01 HL074730, R56 HL071123, R56 HL071123-04, U01 HL064777, U01 HL069758; NIA NIH HHS: AG023122-01, AG12364, AG15763, R01 AG012364, R01 AG015763, U19 AG023122; NIDA NIH HHS: DA13769; NIMH NIH HHS: K08 MH067959, MH059567-05A2, MH067959, MH068503-01A1, MH47612, MH59567, MH68503, R01 MH059567, R01 MH068503, U01 MH46274, UO1 MH46280, UO1 MH46282; PHS HHS: HLMH065571-02

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B;3;234-41

Pubmed - other

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Gene lists (5)

Gene List Source Species Name Description Gene count
L00000009 G2C Homo sapiens Human PSD Human orthologues of mouse PSD adapted from Collins et al (2006) 1080
L00000016 G2C Homo sapiens Human PSP Human orthologues of mouse PSP adapted from Collins et al (2006) 1121
L00000061 G2C Homo sapiens BAYES-COLLINS-MOUSE-PSD-CONSENSUS Mouse cortex PSD consensus (ortho) 984
L00000069 G2C Homo sapiens BAYES-COLLINS-HUMAN-PSD-FULL Human cortex biopsy PSD full list 1461
L00000071 G2C Homo sapiens BAYES-COLLINS-MOUSE-PSD-FULL Mouse cortex PSD full list (ortho) 1556
© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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