G2Cdb::Allele report

Mutation type
P

Altered genes (1)

Gene Symbol Species Description
G00000029 DLG4 Homo sapiens discs, large homolog 4 (Drosophila)

Diseases (1)

Disease Description Nervous effect
D00000166 Schizophrenia Y

Literature (1)

Pubmed - human_disease

  • No genetic association between postsynaptic density-95 gene polymorphisms and schizophrenia.

    Kawashima R, Ohnuma T, Shibata N and Arai H

    Department of Psychiatry, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. ritsukok@med.juntendo.ac.jp

    Disturbed glutamatergic neurotransmission, especially disturbed N-methyl-D-aspartate (NMDA) receptor function, has been hypothesized to be involved in the pathophysiology of schizophrenia. It may also involve abnormalities in the intracellular signaling machineries that are linked to the NMDA receptor. Postsynaptic density-95 is known to bind NMDA receptor subunits and is involved in intracellular signal transduction and synaptic plasticity. Recently, we reported that gene expression of postsynaptic density-95 was altered in schizophrenic brains compared to controls. Therefore, in this study, we examined six polymorphisms in and around the postsynaptic density-95 gene in 259 schizophrenic cases and 188 healthy controls using TaqMan technology. The results suggested that these six polymorphisms did not affect risk for schizophrenia.

    Neuroscience letters 2006;400;1-2;168-71

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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