G2Cdb::Allele report

Mutation type
N

Altered genes (1)

Gene Symbol Species Description
G00001434 RAF1 Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1

Diseases (1)

Disease Description Nervous effect
D00000028 Lung cancer N

Literature (1)

Pubmed - human_disease

  • Absence of activating mutations of the RAF1 protooncogene in human lung cancer.

    Miwa W, Yasuda J, Yashima K, Makino R and Sekiya T

    Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan.

    Recently, the RAF protein has been demonstrated to be a direct effector of RAS protein in a RAS-mediated signal transduction pathway. Activations of the RAF1 gene by small mutations, such as point mutations in the kinase domain and a tetrapeptide insertion into conserved region 2, have been suggested from analyses of chemically induced lung cancers in mice and by site-directed mutagenesis. We investigated the presence of small mutations of the RAF1 gene in human lung carcinomas, especially in those not carrying the mutated RAS gene, expecting that aberrations of the RAF1 gene might play a role complementary to RAS gene mutations in tumorigenesis. Single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction products of DNA samples from 140 patients revealed no tumor specific mutations of the RAF1 gene in any of these specimens. This result suggests that mutations of the RAF1 gene are not involved in tumorigenesis in human lung.

    Biological chemistry Hoppe-Seyler 1994;375;10;705-9

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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