G2Cdb::Allele report

Mutation type

Altered genes (1)

Gene Symbol Species Description
G00001369 HOMER1 Homo sapiens homer homolog 1 (Drosophila)

Diseases (1)

Disease Description Nervous effect
D00000276 Preeclampsia N

Literature (1)

Pubmed - human_disease

  • Is preeclampsia associated with higher frequency of HSP70 gene polymorphisms?

    Fekete A, Vér A, Bögi K, Treszl A and Rigó J

    Research Laboratory for Pediatrics and Nephrology, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.

    Aim: To evaluate the possible association of three different HSP70 gene polymorphisms with preeclampsia.

    HSPA1A G(190)C, HSPA1B A(1267)G and HSPA1L T(2437)C polymorphisms were analyzed from blood samples of 72 women with preeclampsia and of 70 healthy pregnant women as controls by PCR-RFLP method.

    Results: HSPA1B (1267)GG and HSPA1L (2437)CC genotypes occurred more frequently in preeclamptic patients compared to healthy controls (p<0.002 [RR: 4.38, 95% CI: 1.56-12.28]) and (p<0.03 [RR: 1.31, 95% CI: 1.03-1.67]), respectively. Significant difference was found in the distribution of HSPA1B A(1267)G genotype between the preeclamptic and control group (p<0.004 [RR: 0.67, 95% CI: 0.51-0.88]). Distribution of HSPA1A G(190)C was similar in the preeclamptic and control group. In controls, genotype distribution of HSPA1A G(190)C and HSPA1L T(2437)C was in Hardy-Weinberg equilibrium, while this criterion was not fulfilled for HSPA1B A(1267)G.

    Conclusion: We concluded that HSPA1B (1267)GG and HSPA1L (2437)CC genotypes were more frequent among preeclamptic than control patients, suggesting that these genotypes may play a role in the susceptibility for preeclampsia.

    European journal of obstetrics, gynecology, and reproductive biology 2006;126;2;197-200

© G2C 2014. The Genes to Cognition Programme received funding from The Wellcome Trust and the EU FP7 Framework Programmes:
EUROSPIN (FP7-HEALTH-241498), SynSys (FP7-HEALTH-242167) and GENCODYS (FP7-HEALTH-241995).

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