G2Cdb::Gene Report


Gene id G00001236
Gene name Adam22 (MGI)
Species Mus musculus
Description a disintegrin and metallopeptidase domain 22
Synonyms MDC2
Databases

Marker Symbol
MGI:1340046 (MGI)

Curated Gene
OTTMUSG00000016341 (Vega mouse gene)

Gene
117 (G2Cdb plasticity & disease)
ENSMUSG00000040537 (Ensembl mouse gene)
11496 (Entrez Gene)

Gene Expression
g02653 (BGEM)
adam22 (gensat)

Protein Protein Interaction
A0373 (ppid)

Literature
603709 (OMIM)

Protein Sequence
Q9R1V6 (UniProt)
Literature
(8 items)
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Mol Cell Proteomics. 2007;6;283-93. PMID: 17114649 DOI: 10.1074/mcp.M600046-MCP200

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.
Yoshida Y, Han B, Mendelsohn M, Jessell TM
Neuron. 2006;52;775-88. PMID: 17145500 DOI: 10.1016/j.neuron.2006.10.032

Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.
Sagane K, Yamazaki K, Mizui Y, Tanaka I
Gene. 1999;236;79-86. PMID: 10433968

Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.
Sagane K, Hayakawa K, Kai J, Hirohashi T, Takahashi E, Miyamoto N, Ino M, Oki T, Yamazaki K, Nagasu T
BMC Neurosci. 2005;6;33. PMID: 15876356 DOI: 10.1186/1471-2202-6-33

Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M
Science. 2006;313;1792-5. PMID: 16990550 DOI: 10.1126/science.1129947

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003;100;14109-14. PMID: 14610273

LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11.
Sagane K, Ishihama Y, Sugimoto H
Int J Biol Sci. 2008;4;387-96. PMID: 18974846

ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.
Ogawa Y, Oses-Prieto J, Kim MY, Horresh I, Peles E, Burlingame AL, Trimmer JS, Meijer D, Rasband MN
J Neurosci. 2010;30;1038-48. PMID: 20089912 DOI: 10.1523/JNEUROSCI.4661-09.2010

Homology
Orthologues
G00002485 (Homo sapiens)
Gene lists Mouse PSD
Mouse NRC
Mouse PSP