G2Cdb::Human Disease Report


Disease id D00000021
Name Colon cancer
Nervous system disease No
Genes
G00001624 (PIK3CA) phosphoinositide-3-kinase
G00002207 (CTTN) cortactin
G00002164 (IRS1) insulin receptor substrat
G00002137 (SRC) v-src sarcoma (Schmidt-Ru
Literature
(5 items)
human disease
Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array.
Gardina PJ, Clark TA, Shimada B, Staples MK, Yang Q, Veitch J, Schweitzer A, Awad T, Sugnet C, Dee S, Davies C, Williams A, Turpaz Y
BMC Genomics. 2006;7;325. PMID: 17192196 DOI: 10.1186/1471-2164-7-325

Oncogenic mutations of PIK3CA in human cancers.
Samuels Y, Velculescu VE
Cell Cycle. 2004;3;1221-4. PMID: 15467468

Activating SRC mutation in a subset of advanced human colon cancers.
Irby RB, Mao W, Coppola D, Kang J, Loubeau JM, Trudeau W, Karl R, Fujita DJ, Jove R, Yeatman TJ
Nat Genet. 1999;21;187-90. PMID: 9988270

Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.
Slattery ML, Samowitz W, Curtin K, Ma KN, Hoffman M, Caan B, Neuhausen S
Cancer Epidemiol Biomarkers Prev. 2004;13;1206-14. PMID: 15247132

Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer.
Samowitz WS, Wolff RK, Ma KN, Andersen K, Caan B, Slattery ML
Mutat Res. 2006;595;117-24. PMID: 16448675 DOI: 10.1016/j.mrfmmm.2005.10.014