G2Cdb::Human Disease Report


Disease id D00000105
Name Breast carcinoma
Nervous system disease No
Genes
G00001624 (PIK3CA) phosphoinositide-3-kinase
G00001444 (PPP2R1A) protein phosphatase 2 (fo
Literature
(5 items)
human disease
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.
Lee JW, Soung YH, Kim SY, Lee HW, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH
Oncogene. 2005;24;1477-80. PMID: 15608678

Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms.
Calin GA, di Iasio MG, Caprini E, Vorechovsky I, Natali PG, Sozzi G, Croce CM, Barbanti-Brodano G, Russo G, Negrini M
Oncogene. 2000;19;1191-5. PMID: 10713707 DOI: 10.1038/sj.onc.1203389

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, Yu JS, Malmström PO, Mansukhani M, Enoksson J, Hibshoosh H, Borg A, Parsons R
Cancer Res. 2005;65;2554-9. PMID: 15805248

PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma.
Buttitta F, Felicioni L, Barassi F, Martella C, Paolizzi D, Fresu G, Salvatore S, Cuccurullo F, Mezzetti A, Campani D, Marchetti A
J Pathol. 2006;208;350-5. PMID: 16353168 DOI: 10.1002/path.1908

Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women.
Maruyama N, Miyoshi Y, Taguchi T, Tamaki Y, Monden M, Noguchi S
Clin Cancer Res. 2007;13;408-14. PMID: 17202311 DOI: 10.1158/1078-0432.CCR-06-0267