G2C::Proteomics

Targeted tandem affinity purification of PSD-95 recovers core
postsynaptic complexes and schizophrenia susceptibility proteins
Esperanza Fernandez, Mark O Collins, Rachel T Uren, Maksym V Kopanitsa, Noboru H Komiyama,
Mike DR Croning, Lysimachos Zografos, J Douglas Armstrong, Jyoti S Choudhary and Seth GN Grant


Table 3. Genes associated with neurological and psychiatric diseases.

Disease association data for proteins in the tandem purification was mined from the Genetic Association Database, CiteXplore and manually curated. References are provided below.

MGI symbolDiseaseMGI symbolDisease
Adam22Epilepsy1Grin2dSchizophrenia2
Acot7Schizophrenia3Kcnj4Schizophrenia4
Atp1b1Rett syndrome5Kcna1Episodic ataxia, type 16
Neurodegeneration7Kcnj10Epilepsy8
Atp5a1Alzheimer's9Seizure10
Atp5c1Bipolar afective disorder11, 12Lgi1Epilepsy1
Cacng2Bipolar disorder13Mapk1Schizophrenia15, 16
CamKIIaBipolar disorder14Depression18
CamKIIbSchizophrenia17Msrb2Bipolar afective disorder11
Depression17
Capza2Mental retardation19NeflCMT120
CltcMental retardation21Schizophrenia3
Cnp1Schizophrenia3, 22Bipolar23
Dlg1Schizophrenia24CMT225, 26
Dlg2Schizophrenia22ALS27, 28
Dlg3Schizophrenia23, 24Nrxn1Autism29
Bipolar disorder23Schizophrenia22
Depression23NsfSchizophrenia30
X-Mental retardation31Pdha1Depression32
Dlg4Schizophrenia33Pgk1Parkinson's5
Bipolar disorder23Mental retardation34
Dlgap1Schizophrenia35Bipolar disorder36
GapdhAlzheimer's39Plp1Pelizaeus-Merzbacher disease38
GdaSchizophrenia37Depression40
Gnao1Schizophrenia41Multiple sclerosis42-45
Gria1Schizophrenia46-50Demyelinating disease51-54
Alzheimer's55-59Spastic paraplegia60
Epilepsy61, 62Pppp3caSchizophrenia63
Gria2Schizophrenia4, 64Prdx1Alzheimer's65
Epilepsy66-71Prdx2Parkinson's72
Gria3Schizophrenia47Sl1a2Schizophrenia22
X-Mental retardation73ALS74
Gria4Schizophrenia22Slc25a4Bipolar afective disorder12
Grik2Mental retardation75Ophtalmoplegia76
Schizophrenia22Stxbp1Schizophrenia77
Grin1Attention disorder78Vdac1Alzheimer's9
Bipolar afective disorder80Schizophrenia3
Schizophrenia81Bipolar afective disorder12
Seizure82Vdac2Bipolar afective disorder12
Grin2aAlzheimer's83YwhaeMiller-Dieker lissencephaly85
Huntington disease84
Schizophrenia33
Grin2bSchizophrenia22, 23
Bipolar afective disorder86-88
Epilepsy11, 89
Huntington disease84, 90

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