G2C::Proteomics

Targeted tandem affinity purification of PSD-95 recovers core
postsynaptic complexes and schizophrenia susceptibility proteins
Esperanza Fernandez, Mark O Collins, Rachel T Uren, Maksym V Kopanitsa, Noboru H Komiyama,
Mike DR Croning, Lysimachos Zografos, J Douglas Armstrong, Jyoti S Choudhary and Seth GN Grant


Supplementary Table 3. List of known PSD-95 primary interactors extracted from UniHI database and
manually curated.

The HGNC symbols and number of peptides obtained in the single step and four tandem replicates are shown.
The PubMed ID and the method used to see the interaction with PSD-95 are also shown.

HGNC symbol
Number of Peptides
Interaction DatabasePubMed IDDetermination Method
S
T1
T2
T3
T4
ADAM22
4
12
16
24
31
HPRD-Binary|BioGrid18206289|16990550In vivo|In vitro
ATP2B2
6
BIND|HPRD-Binary|BioGrid11274188In vitro
ATP2B4
5
HPRD-Binary|BioGrid11274188In vitro
BAIP2
14
20
12
13
13
HPRD-Binary|BioGrid11937501In vivo|In vitro
BEGAIN
4
8
12
16
HPRD-Binary|HPRD-Complex|BioGrid9756850Y2H|In vitro|In vivo
CACNG2
2
2
2
3
HPRD-Binary|BioGrid12359873|11805122Y2H|In vitro|In vivo
CAMKIIa
7|2
11
3
4
11
manually curated17156196In vitro|In vivo
CIT
11
HPRD-Binary|BioGrid9870942Y2H|In vivo
DLG1
17
24
42
34
42
HPRD-Binary|BioGrid16332687 |17855605Y2H|In vivo
DLG2
42
49
67
69
80
HPRD-Binary|BioGrid9182804|17855605In vivo
DLG3
16
27
17
14
22
HPRD-Binary|HPRD-Complex|BioGrid10026200|9808460Y2H|In vivo|In vitro
DLGAP1
10
11
9
14
24
HOMOMINT|HPRD-Binary|HPRD-Complex|BioGrid16351748|9115257|9024696|9286858|10844022Computational prediction|Y2H|In vivo|In vitro
DLGAP2
9
18
12
19
24
HPRD-Binary|BioGrid9286858|9115257In vitro|Y2H|In vivo
DLGAP3
3
16
8
7
15
BioGrid9115257In vitro
DLGAP4
12
14
9
7
14
HPRD-Binary|BioGrid9115257Y2H|In vitro
DYNLL1
5
HPRD-Binary|BioGrid14760703In vitro
GDA
29|4
29
26
29
31
HPRD-Binary|BioGrid10595517In vitro|Y2H|In vivo
GRIK2
2
4
6
HPRD-Binary|BioGrid11276111|12597860|9808460|11744724In vitro|In vivo
GRIK5
2
3
7
HPRD-Complex|HPRD-Binary|BioGrid9808460|11279111In vivo|In vitro
GRIN1
31
29
40
50
55
HOMOMINT|HPRD-Binary16351748|15030493|12068077|11506858|9009191|14732708|Computational prediction|In vivo|In vitro
GRIN2A
15
24
31
36
46
HOMOMINT|HPRD-Binary|BioGrid16351748|11937501|12419528|7569905|11222640|10336672Computational prediction|In vitro|In vivo|Y2H
GRIN2B
32
44
54
67
78
HOMOMINT|HPRD-Binary|HPRD-Complex|BioGrid16351748|9581762|7569905|10488080|8601796|11937501|11029657Computational prediction|Y2H|In vitro|In vivo
GRIN2C
5
HPRD-Binary|BioGrid11937501|7569905In vitro|Y2H|In vivo
GRIN2D
2
3
6
9
10
HPRD-Binary|BioGrid7569905Y2H|In vitro|In vivo
KCNA1
2
6
5
5
6
HPRD-Binary|BioGrid12435606|8938729|7477295Y2H|In vitro
KCNA2
3
4
5
7
6
HPRD-Binary|BioGrid7477295|8938729|12435606In vitro|Y2H
KCNA3
1
3
4
6
5
HPRD-Binary8938729|12435606In vitro|Y2H
KCNA4
2
3
5
5
HOMOMINT|HPRD-Binary|BioGrid16351748|11723117|11744724|9581762|7477295|8601796|8938729Computational prediction|In vivo|In vitro|Y2H
KCNJ10
5
3
3
4
6
HPRD-Binary|BioGrid9148889In vitro|Y2H|In vivo
KCNJ4
1
4
6
6
8
HPRD-Binary|BioGrid10627592Y2H|In vivo
LRP1
2
3
HPRD-Binary|BioGrid10827173|10880444In vitro|Y2H|In vivo
NLGN2
2
HPRD-Binary|BioGrid9278515Y2H|In vitro
NLGN3
2
HPRD-Binary|BioGrid9278515Y2H|In vitro
SHANK1
4
HPRD-Binary|BioGrid10433268In vitro|In vivo
SYNGAP1
14
21
15
17
38
HPRD-Binary|BioGrid9581761In vitro|In vivo|Y2H